WO2008036375A3 - Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents - Google Patents

Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents Download PDF

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Publication number
WO2008036375A3
WO2008036375A3 PCT/US2007/020418 US2007020418W WO2008036375A3 WO 2008036375 A3 WO2008036375 A3 WO 2008036375A3 US 2007020418 W US2007020418 W US 2007020418W WO 2008036375 A3 WO2008036375 A3 WO 2008036375A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
active agents
cellular response
impedance
exposure
Prior art date
Application number
PCT/US2007/020418
Other languages
French (fr)
Other versions
WO2008036375A2 (en
Inventor
Xiaobo Wang
Yama A Abassi
Wenfu Zhang
Xiao Xu
Original Assignee
Acea Biosciences Corp
Xiaobo Wang
Yama A Abassi
Wenfu Zhang
Xiao Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acea Biosciences Corp, Xiaobo Wang, Yama A Abassi, Wenfu Zhang, Xiao Xu filed Critical Acea Biosciences Corp
Priority to EP07838594A priority Critical patent/EP2064644A4/en
Publication of WO2008036375A2 publication Critical patent/WO2008036375A2/en
Publication of WO2008036375A3 publication Critical patent/WO2008036375A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
PCT/US2007/020418 2006-09-20 2007-09-20 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents WO2008036375A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07838594A EP2064644A4 (en) 2006-09-20 2007-09-20 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84606706P 2006-09-20 2006-09-20
US60/846,067 2006-09-20

Publications (2)

Publication Number Publication Date
WO2008036375A2 WO2008036375A2 (en) 2008-03-27
WO2008036375A3 true WO2008036375A3 (en) 2008-10-16

Family

ID=39201101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020418 WO2008036375A2 (en) 2006-09-20 2007-09-20 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents

Country Status (2)

Country Link
EP (1) EP2064644A4 (en)
WO (1) WO2008036375A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120015846A1 (en) * 2010-07-16 2012-01-19 Ye Fang Label-free Cellular Pharmacology For Drug Antitarget Assessment
GB201522323D0 (en) * 2015-12-17 2016-02-03 Vrije Universiteit Brussel And Katholieke Universiteit Leuven Systems and methods for conducting electrochemical impedance spectroscopy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051422A (en) * 1997-05-30 2000-04-18 Board Of Trustees, Leland Stanford, Jr., University Hybrid biosensors
WO2005077104A2 (en) * 2004-02-09 2005-08-25 Xiao Xu Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US20060050596A1 (en) * 2002-12-20 2006-03-09 Abassi Yama A Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6377057B1 (en) * 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
ATE371865T1 (en) * 2003-07-14 2007-09-15 Mds Inc Dba Mds Sciex MARKER-FREE METHOD FOR CLASSIFICATION AND CHARACTERIZATION OF CELLULAR EVENTS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051422A (en) * 1997-05-30 2000-04-18 Board Of Trustees, Leland Stanford, Jr., University Hybrid biosensors
US20060050596A1 (en) * 2002-12-20 2006-03-09 Abassi Yama A Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
WO2005077104A2 (en) * 2004-02-09 2005-08-25 Xiao Xu Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XING ET AL.: "Dynamic Monitoring of Cytotoxicity on Microelectronic Sensors", CHEMICAL RESEARCH IN TOXICOLOGY, vol. 18, 2005, pages 154 - 161, XP008104930 *

Also Published As

Publication number Publication date
WO2008036375A2 (en) 2008-03-27
EP2064644A2 (en) 2009-06-03
EP2064644A4 (en) 2010-12-29

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