WO2008021969A2 - Methods, systems and devices for reducing the size of an internal tissue opening - Google Patents
Methods, systems and devices for reducing the size of an internal tissue opening Download PDFInfo
- Publication number
- WO2008021969A2 WO2008021969A2 PCT/US2007/075608 US2007075608W WO2008021969A2 WO 2008021969 A2 WO2008021969 A2 WO 2008021969A2 US 2007075608 W US2007075608 W US 2007075608W WO 2008021969 A2 WO2008021969 A2 WO 2008021969A2
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- Prior art keywords
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- medical device
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- closure device
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Definitions
- the present invention relates generally to medical devices and methods of use for treating an internal tissue structure. More particularly, the present invention relates to medical devices, systems, and methods for reducing the size of an internal tissue opening. 2. The Relevant Technology
- a PFO is an example of a cardiac birth defect that can be problematic and even result in death when combined with other factors such as blood clots or other congenital heart defects.
- a PFO occurs when an opening between the upper two chambers of the heart fail to close after birth.
- a blood clot in the left atrium can be passed through the aorta and travel to the brain or other organs, and cause embolization, stroke, or a heart attack.
- a PFO can be treated by being closed by a surgical procedure.
- other similar defects e.g., septal or otherwise
- septal defects where some tissue needs to be closed in order to function properly can include the general categories of atrial-septal defects ("ASDs"), ventricular-septal defects (“VSD's”) and patent ductus arteriosus (“PDA”), and the like.
- FIGS 1A-1C depict various views of a heart having a PFO.
- the heart 10 is shown in a cross-section view in Figure IA.
- the right atrium 30 receives systemic venous blood from the superior vena cava 15 and the inferior vena cava 25, and then delivers the blood via the tricuspid valve 35 to the right ventricle 60.
- a septal defect which is shown as a PFO 50, is present between right atrium 30 and left atrium 40.
- the PFO 50 is depicted as an open flap on the septum between the heart's right atrium 30 and left atrium 40.
- the left atrium 40 receives oxygenated blood from the lungs via pulmonary artery 75, and then delivers the blood to the left ventricle 80 via the mitral valve 45.
- some systemic venous blood can also pass from the right atrium 30 through the PFO 50 and mixes with the oxygenated blood in left atrium 40, and then is routed to the body from left ventricle 80 via aorta 85.
- the interventricular septum 70 divides the right ventricle 60 and left ventricle 80.
- the atrium is only partially partitioned into right and left chambers during normal fetal development, which results in a foramen ovale fluidly connecting the right and left atrial chambers.
- Figure IB when the septum primum 52 incompletely fuses with the septum secundum 54 of the atrial wall, the result can be a tunnel 58 depicted as a PFO 50.
- Figure 1C provides a view of the crescent-shaped, overhanging configuration of the septum secundum 54 from within the right atrium 30 in a heart 10 having a PFO 50.
- the septum secundum 54 is defined by its inferior aspect 55, corresponding with the solid line in Figure 1C, and its superior aspect 53 represented by the phantom line, which is its attachment location to the septum primum 52.
- the septum secundum 54 and septum primum 52 blend together at the ends of the septum secundum 54.
- the anterior end 56a and posterior end 56p are referred to herein as "merger points" for the septum secundum 54 and septum primum 52.
- the length of the overhang of the septum secundum 54 which is the distance between superior aspect 53 and inferior aspect 55, increases towards the center portion of the septum secundum as shown.
- the tunnel 58 between the right atrium 30 and left atrium 40 is defined by portions of the septum primum 52 and septum secundum 54 between the merger points 56a and 56p which have failed to fuse.
- the tunnel 58 is often at the apex of the septum secundum 54 as shown.
- the portion of the septum secundum 54 to the left of tunnel 58 which is referred to herein as the posterior portion 57p of the septum secundum, is longer than the portion of the septum secundum 54 to the right of tunnel 58, which is referred to herein as the anterior portion 57a of the septum secundum 54.
- the posterior portion 57p also typically has a more gradual taper than the anterior portion 57a as shown.
- the anterior pocket 59a is the area defined by the overhang of the anterior portion 57a of the septum secundum 54 and the septum primum 52, and it extends from the anterior merger point 56a toward the tunnel 58.
- the posterior pocket 59p is the area defined by the overhang of the posterior portion 57p of septum secundum 54 and the septum primum 52, and it extends from the posterior merger point 56p toward the tunnel 58.
- Conventional treatments for PFO, and other related conditions have generally involved invasive surgery, which also presents a risks to a patient.
- the invention relates to a medical system, devices and methods of use for reducing the size of an internal tissue opening, such as a Patent Foramen Ovale ("PFO").
- the medical system can include a closure device and an associated delivery device.
- the medical system can be configured to enable a practitioner to selectively position and deploy the closure device in an internal tissue opening to approximate the tissue of the opening.
- the closure device can include a multi-cellular body portion operatively associated with a first anchor and a second anchor.
- the multi-cellular body portion can be configured to enable the closure device to collapse into a relatively narrow non-deployed orientation and expand into a non-deployed orientation without plastic deformation or failure of the closure device.
- the first and second anchors can be configured to engage at least a portion of a wall of the internal tissue opening and/or tissue, such as tunnel tissue, of the opening.
- the closure device can include an ingrowth material to facilitate tissue growth.
- the closure device can also include one or more indicators to facilitate the estimation of the position and/or orientation of the closure device with respect to the internal tissue opening.
- the delivery device can include a delivery assembly, an actuating assembly, and a release assembly operatively associated with a handle body.
- the delivery assembly facilitates selective delivery of the closure device from the delivery device, and is operatively associated with the actuating assembly and the release assembly.
- the actuating assembly interacts with the handle body to selectively deploy the closure device from the delivery assembly.
- the actuating assembly can be configured to deploy at least a portion of the closure device by a first movement and deploy a second portion of the closure device by a second movement.
- the release assembly can be linked to the handle body to facilitate detachment of the closure device from the delivery device.
- the closure device is linked to the delivery device by one or more tethers and one or more wires, the tethers being coupled to the handle body and the wires being coupled to a biasing member of the release assembly.
- the tethers can be configured to receive a portion of the closure device therein to facilitate securement of the closure device to the delivery device.
- the wires can be detachably coupled to the closure device to enable selective detachment of the closure device from the delivery device by movement of the biasing member.
- Fig. 2 is a flowchart illustrating a method of reducing the size of an internal tissue opening according to one example
- Fig. 3A is a schematic diagram illustrating a step for locating a closure device with respect to an internal tissue opening using a delivery device according to one example
- Fig. 3B is a schematic diagram illustrating a step for deploying a first portion of a closure device according to one example
- Fig. 3C is a schematic diagram illustrating a step for deploying a second portion of a closure device and an internal tissue opening having a reduced size according to one example
- Fig. 3D is a schematic diagram illustrating release of a closure element from a delivery device according to one example
- Fig. 4 illustrates a medical system according to one example
- Figs. 5A-5C illustrate a closure device in accordance with the present invention
- Fig. 6 illustrates a delivery device according to one example
- Figs. 7A-7D illustrate cross-sectional views of a delivery device according to one example
- Fig. 8 illustrates an exploded view of a delivery device according to one example
- Fig. 9A illustrates an embodiment of a closure device being partially deployed in an internal tissue opening
- Fig. 9B illustrates a delivery device in an orientation corresponding to the partially deployed closure device of Fig. 8A according to one example
- Figs. 1OA and 1OB illustrate an exploded view of a delivery device according to one example
- Fig. 11 illustrates the state of the delivery device upon releasing a closure device according to one example
- FIGs. 12A-21B are schematic diagrams of closure devices in accordance with the present invention
- Figs. 22A-25B illustrate delivery of closure device using distal and/or proximal locator devices according to the present invention
- Figs. 25C-25G illustrate inflatable closure devices according to the present invention
- Figs. 26A-27N illustrate release mechanisms according to several examples
- Figs. 28-38B illustrate a delivery device according to the present invention
- Figs. 39A-39M illustrate configuration to promote tissue growth according to several examples.
- the present invention extends to medical systems, methods, and apparatus for reducing the size of an internal tissue opening.
- the devices disclosed herein can be used to treat a variety of internal tissue openings, such as a left atrial appendage, paravalvular leaks, PDA's, and VSD's, for example.
- internal tissue openings such as a left atrial appendage, paravalvular leaks, PDA's, and VSD's, for example.
- PFO Patent Foramen Ovale
- references to PFO openings are not limiting of the invention.
- a closure device is disclosed herein that is configured to acutely provide forces to close the opening associated with a PFO and allow the natural healing processes to effect a chronic closure.
- the closure device when deployed, can have a flat aspect having a width and length, but a small thickness.
- the length of the device may correspond to a length of the internal tissue opening or the tunnel length of the internal tissue opening.
- the width of the device may correspond to a dimension that is generally transverse to the length.
- the closure device may have an expandable, multi-cellular structure that is configured to exert a lateral force on the walls of the internal tissue opening.
- the lateral force expands the width dimension of the tunnel a sufficient amount to reduce the height of the tunnel to thereby reduce the size of the tunnel and thereby close the internal tissue opening.
- the structural properties of the device can resist bending or curling out of plane to prevent or substantially limit the tendency of the device to prop the PFO open rather than closing it. This property may be achieved be utilizing struts with a preferential bending direction that is oriented parallel to the plane of the device and a non- preferential bending direction that is oriented perpendicular to the plane of the device, as is shown in Fig. IE and will be described in more detail hereinafter.
- Fig. 2 is a flowchart illustrating a method of reducing the size of an internal tissue opening according to one example. Each of the steps will be introduced generally, followed by a discussion of each step with respect to the schematic diagrams illustrated in Figs. 3A-3D.
- the method begins at step S80 by initially locating a closure device with respect to the internal tissue opening.
- initially locating a closure device with respect to an internal issue opening includes using a delivery device that is configured to retain the closure device in a distal end while allowing a user to control the deployment of a closure device at a proximal end.
- the closure devices described herein include collapsible multi-cellular closure devices that are configured to be stored in a collapsed state within the delivery device while the closure device is located relative to the internal tissue opening. Further, the configuration of the closure devices described herein can enable the closure device to be movable between a non-deployed or compressed state and a deployed or decompressed state without causing failure or plastic deformation of the closure device.
- step S81 by deploying a first portion of the closure device using the delivery device.
- Deployment of the first portion of the closure device may include expanding at least one of the cellular portions from the collapsed position within the delivery device to an expanded state.
- the method may further optionally include the deployment of a second portion of the closure device may include expanding additional cellular portions from the previously described collapsed position with the delivery device to an expanded state. As many cellular portions may be deployed in as many steps as desired.
- Fig. 3 A is a schematic diagram illustrating the step of locating a closure device
- the internal tissue opening 91 may be described as an opening having a tunnel that extends between a proximal surface and through a distal surface of tissue.
- the distance between the proximal surface and the distal surface may be described as a length of the internal tissue opening 91.
- the dimension of the closure device 90 that corresponds to the length of the internal tissue opening 91 is referred to as the length of the closure device 90.
- the closure device 90 expands to apply a lateral force on the wall(s) of the internal tissue opening 91 to thereby reduce the size thereof.
- the direction in which the closure device 90 expands may be referred to as the width of the closure device 90.
- the closure device 90 may be generally flat across its width both when in the collapsed state as well as in the expanded state illustrated and described below.
- the delivery device 92 includes a distal end 92a and a proximal end 92b.
- the delivery device 92 further includes delivery assembly 93 near distal end 92a, and an actuation assembly 94 and a release assembly 95 near the proximal end 92b.
- the closure device 90 is a multi-cellular device that includes a plurality of collapsible cells that may expand to an expanded state described above.
- the closure device 90 is illustrated in a collapsed state within the delivery assembly 93. Accordingly, locating the closure device 90 relative to the internal tissue opening 91 may include locating a distal end 93a of the delivery assembly 93 near the internal tissue opening 31.
- the closure device 90 While located within the delivery assembly 93, the closure device 90 is coupled to a push member 96 which in turn is coupled to a control anchor 97.
- the delivery assembly 93 is coupled to control assemblies 98a, b, which may be part of the closure device 90.
- the control assemblies 98a, b and delivery assembly 93 may be held in a fixed relationship relative to each other as the control anchor 97 is advanced.
- control anchor 97 drives the push member 96 which in turn pushes the closure device 90 distally relative to the delivery assembly 93. As illustrated in Fig.
- the control anchor 97 may be thus advanced until the control anchor 97 comes into contact with first control assembly 38a while driving a first portion 90a of the closure device 90 from the distal end 93a of the delivery assembly 93.
- the first portion 90a of the closure device 30 is thus driven from the delivery assembly 93, the first portion 90a is deployed by expanding from the compressed state illustrated in Fig. 3A to the expanded state illustrated in Fig. 3B.
- the delivery assembly 93 may extend at least partially through the internal tissue opening 91 to deliver the first portion 90a of the closure device 90 distally of the internal tissue opening 91 (step S81).
- the first portion 90a may then be drawn into contact with the distal opening of the internal tissue opening 91.
- the control anchor 97 in contact with the first control assembly
- control anchor 97 and the first control assembly 98a may be moved together relative to the second control assembly 98b and the delivery assembly 93 to drive the closure device 90 further from the delivery assembly 93.
- control anchor 97 and the first control assembly 98a may be driven until the first control assembly 98a comes into contact with the second control assembly 98b. In at least one example, this distance may be sufficient for the push member 96 to push the closure device 90 clear of the distal end 93a of the delivery assembly 93 to thereby fully deploy closure device 90 (step S82).
- a second portion 90b of the closure device 90 expands outwardly within the internal tissue opening 91.
- the width of the second portion 90b expands to apply a lateral force on the internal tissue opening 91, the force being generally along the width of the internal tissue opening 91.
- the portions of the internal tissue opening 91 illustrated as the sides are drawn apart while the portion of the internal tissue opening illustrated as the top and bottom are approximated. The overall result is that the internal tissue opening 91 is constricted to close down the internal tissue opening 91.
- a third portion 90c of the closure device 90 may be deployed proximally of the internal tissue opening 91 as the closure device 90 is fully deployed. As previously introduced, the first portion of the closure device 90 may be deployed distally of the internal tissue opening 91. Once fully deployed, the third portion 90c may be deployed proximally of the internal tissue opening 91. Such a configuration may reduce the likelihood that the closure device 90 will migrate through the internal tissue opening 91.
- the closure device 90 is released from the delivery device 92 as in Fig. 3D (step S83).
- the release portion 95 of the delivery device 92 moves in concert with the push member 96 during the deployment of the closure device 90.
- a release coupler 99 links the release assembly 95 to the closure device 90.
- the release assembly 95 is moved proximally relative to the actuation assembly 94.
- the release coupler 99 releases the closure device 90 from the delivery device 92 and from the delivery assembly 93 in particular.
- the system is configured to deploy a closure device to close an internal tissue opening.
- a closure device to close an internal tissue opening.
- One medical system will now be described in more detail that includes a detailed discussion of one exemplary delivery device and exemplary closure device. Additional closure devices will then be discussed, followed by a discussion of in-growth material configurations that may be used with closure devices. Next, additional delivery devices will be discussed as well as several release assemblies that may be used with delivery and closure devices.
- One configuration of relative movement between several control assemblies and a control anchor have been described for multi-stage deployment of the closure device 90, which includes a plurality of cells. In addition to the movement described above, movements may be performed in any order with any number of control assemblies and/or control anchors to deploy the closure device 90.
- Several delivery devices will be described herein which are configured to fully deploy the closure device 90. Each of the components may be combined and as desired and are not limited to the use with devices or assemblies that may be discussed for context.
- Fig. 4 is a perspective view of a medical system 100 configured to facilitate closure of an internal tissue opening according to one embodiment of the present invention.
- the medical system 100 comprises a closure device 200 adapted to reduce the size of the internal tissue opening and a delivery device 300 adapted to facilitate placement and deployment of the closure device 200 with respect to the internal tissue opening.
- the medical system 100 of the present invention can provide benefits.
- the medical system 100 can be configured to be used with different sizes, shapes and types of internal tissue openings.
- the medical system 100 can provide various safety measures to increase the safety and effectiveness of positioning the closure device 200.
- the medical system 100 can be configured to provide distributed lateral force to tissue of the internal tissue opening.
- delivery device 300 comprises a handle body 302, an actuating assembly 320 operatively associated with handle body 302, a release assembly 340 operatively associated with the handle body 302 and a delivery assembly 360 operatively associated with the actuating assembly 320, the release assembly 340 and the handle body 302.
- Handle body 302 can be configured to provide a gripping surface for a user.
- Handle body 302 can be used to position closure device 200, as well as facilitate deployment of the closure device 200 from the delivery assembly 360.
- Actuating assembly 320 can be moved with respect to handle body 302 to selectively deploy portions of the closure device 200 from the delivery assembly 360.
- the actuation assembly 320 is configured to receive actuation inputs from a user to deploy the closure device 200 in one or more stages, as will be discussed more fully herein below.
- Delivery assembly 360 can house closure device 200 in a non-deployed orientation and facilitate deployment of closure device 200.
- Delivery assembly 360 can include one or more tethers 364 linked to the closure device 200 to facilitate selective deployment of the closure device 200 as well as the selective detachment of the closure device 200 from the closure device 200.
- the configuration of the closure device 200 will first be discussed in more detail, followed by a discussion of deploying the closure device 200 with the delivery device 300.
- the closure device 200 is illustrated in a fully deployed, expanded, relaxed or non-constrained orientation.
- the closure device 200 can be configured to close an internal tissue opening, or to reduce the size of an internal tissue opening so as to close the internal tissue opening.
- the closure device 200 can reduce the size of an internal tissue opening by approximating, or in other words bringing together tissue of the internal tissue opening, such as tunnel tissue in a PFO.
- the closure device 200 can approximate tissue by applying lateral force to tissue of the internal tissue opening, as will be discussed more fully herein after.
- the closure device 200 can be configured to enable a user to estimate the position and/or orientation of the closure device 200 with respect to an internal tissue opening, during and after positioning of the closure device 200 in the internal tissue opening.
- the closure device 200 can be a non-tubular stent.
- the closure device 200 can be configured to assume a substantially flat configuration, or in other words be configured to be substantially planar, such as illustrated in Figures 5 A and 39M for example.
- the closure device 200 can be configured to resist movement out of plane, such as plane 260 of Figure 39M.
- the closure device 200 may bend out of plane when positioned in a tissue opening.
- the closure device 200 has many advantages.
- the closure device 200 can be configured to be reliable and compliant.
- the configuration of the closure device 200 can enable the closure device 200 to be movable between a non-deployed orientation and a deployed orientation without causing failure or plastic deformation of the closure device 200.
- the closure device 200 can be used to close various types, shapes and sizes of internal tissue openings.
- the closure device 200 can accommodate for a range of PFO tunnel lengths, for example.
- the closure device 200 can be partially or fully deployed from or received back into the delivery device 300.
- Closure device 200 can be configured to substantially conform to the size and shape of a tissue opening.
- the undulations on the distal and proximal anchors can enable the anchors to substantially, or to a certain degree, conform to the anatomy of a tissue opening.
- the closure device 200 can have a substantially flat aspect having a length and height greater than its depth or depth thickness.
- the closure device 200 has an overall length of 22mm, a height of 7.5mm and a depth thickness of 0.4mm.
- the distance between the opposing ends of the proximal anchor 218 can be about 22mm
- the distance between the most proximal attachment member 240 of the body portion 202 and the most distal indicator 220 of the body portion 202 can be about 7.5mm
- the depth thickness, designated as DT in Figure 39M, of the closure device 200 can be about 0.4mm.
- the majority of segments comprising the closure device 200 can have a thickness or width that is substantially less than the depth thickness of the segments.
- the closure device 200 can resist out of plane movement due to the size and configuration of the segments.
- the closure device 200 can be configured to assume a substantially flat configuration in a first plane.
- the configuration of the segments for example the segments having a certain depth thickness, can facilitate the closure device 200 resisting movement out of the first plane in a manner similar to an I beam resisting bending in the direction of the web of the beam.
- the first plane can be plane 260 as illustrated in Figure 39M.
- the closure device 200 can have a unitary construction or may be formed from multiple pieces. If the closure device 200 has a unitary construction, the closure device 200 can be cut from a single piece of material, such as cut by a laser, thereby removing the need to assemble or join different segments together. The closure device may also be formed of multiple pieces of material.
- a unitary construction can provide advantages, such as ease of manufacturing and reliability. For example, assembly is not required for a closure device having a unitary construction. Also, a closure device having a unitary construction may not include distinct elements or segments which require joining by joints, thereby reducing a likelihood of failure.
- the closure device 200 can be made from a super-elastic material, such as a super-elastic metal or a super-elastic polymer. Furthermore, the closure device 200 can be made from NiTiNoI, stainless steel alloys, magnesium alloys, and polymers including bio-resorbable polymers.
- the closure device can be formed by utilizing a pressurized stream of water, such as a water jet, to remove material from a piece of material to form the closure device.
- a pressurized stream of water such as a water jet
- the closure device can be formed by utilizing one or more of the following: die casting, chemical etching, photolithography, electrical discharge machining, or other manufacturing techniques. It is contemplated that the closure device can be formed through use of a mill or some other type of device adapted to remove material to form a desired shape.
- the closure device 200 can comprise multiple segments joined together by a known joining process, such as by an adhesive, by interference fits, crimping, by fasteners, or a weld, or some combination thereof.
- the closure device can include multiple segments joined together by various welds to form a closure device according to the present invention.
- the segments can be joined together by a plurality of means, such as by the combination of welding, fasteners, and/or adhesives.
- the segments can be a wire or multiple joined or rolled wires crimped together or joined by a joining process to form the closure device 200.
- the closure device 200 includes a body portion 202, a first anchor 204 operatively associated with the body portion 202 and a second anchor 206 operatively associated with the body portion 202.
- the body portion 202 can be configured to facilitate application of lateral force against tissue of an internal tissue opening.
- the body portion 202 can be configured to enable the closure device 200 be movable between a non-deployed and deployed orientation.
- the closure device 200 can be configured to be self-expanding from the constrained or non-deployed orientation, as illustrated in Figure 5B for example, to the relaxed orientation, as illustrated in Figure 5A.
- the closure device 200 can have a preferential orientation, such that movement of the closure device 200 from a first orientation to a second orientation can create internal stresses in the closure device 200. These internal stresses can serve to bias the closure device 200 to the first orientation.
- the closure device 200 can have a preferential orientation of the relaxed or fully deployed orientation as illustrated in Figure 5A.
- movement of the closure device 200 to a constrained orientation such as illustrated in Figure 5B for example, can create internal stresses in the closure device 200, thereby creating in the closure device 200 a bias to return to the relaxed orientation.
- body portion 202 includes one or more cells
- the body portion 202 can include one or more apertures.
- an aperture is defined by the cell 208, or in other words by the plurality of segments 210.
- segment 210 can be a strut or a body support segment.
- Cells 208 can be distinct, or can be at least partially defined by a common segment.
- cell 208A as the distal most cell
- cell 208C as the proximal most cell of body portion 202
- cell 208B is partially defined by a segment 210C which also defines a portion of cell 208A.
- cell 208B is partially defined by a segment 210G which also partially defines cell 208C.
- cell 208D shares a segment 210D with cell 208A and shares a segment 210H with cell 208C.
- Segments 210 can be shaped and configured to have a substantially uniform stress at any given point along a certain length, when the segment 210 is deflected.
- segment 210A can include a first portion 230 having a width or thickness greater than a second portion 232, wherein the width or thickness decreases from the first portion 230 to the second portion 232, or in other words is tapered, in a manner which provides for substantially uniform stress levels along the certain length.
- segments can have a substantially constant width along their length.
- Figure 5C is a cut-out view of a portion of the closure device 200, including the first portion 230 and the second portion 232 of segment 210A.
- the width or thickness of the segment 210A varies along the portion of the segment 210A from the location where segment 210A extends from the portion 254 which joins segment 210A to segment 210C to the intermediate portion 234.
- the segments 210 are deflected, with the highest levels of stress in the segment 210 being concentrated at the joining portion 254 and decreasing towards the intermediate portion 234.
- the segments 210 can be configured in a manner so as to have a substantially equal stress level along the length of the segment 210 between the joining portion 254 and the intermediate portion 234.
- the uniform stress level can be accomplished by having the width of the segment 210 vary from the first portion 230 to the second portion 232 in a calculated manner.
- the width of the first portion 230 of the segment can be about . lmm and the taper to a width of about .05mm at the second portion 232 of the segment.
- the uniform stress level can be accomplished by utilizing a gradient of material having varying properties.
- the segment 210 can have varying widths along its length and comprise a gradient of material sufficient to achieve a substantially uniform stress level between the first portion 230 and the second portion 232 of the segment.
- the first portion is adjacent the joining portion 254 and the second portion is adjacent the intermediate portion 234.
- the joints of the interconnecting segments can include a biasing member, such as a spring, thereby enabling the segments to move relative to each other to collapse or expand the closure device 200.
- the biasing member of the joint can cause the segments to have a preferential orientation with respect to each other.
- segments 210 can also be configured to have a rectangular cross-section. In other embodiments, segments 210 can have an oval shaped cross section. In yet another embodiment, sections 210 can have a round or rounded cross section.
- the ratio, or aspect ratio, of the thickness or width to the depth thickness of the first and second portions 230, 232 can range between at least about 1 :2 to about 1 :20. In one embodiment, the aspect ratio of the width to the depth thickness of the first portion 230 can be at least 1 :2 and the ratio of the width to the depth thickness of the second portion 232 can be at least 1 :4.
- the aspect ratio of the first portion 230 can be about 1 :4 and the aspect ratio of the second portion 232 can be about 1 :8. In this manner, the closure device 200 can substantially resist out of plane movement, while allowing in-plane movement during reorientation of various portions of the closure device 200.
- Segments 210 can be configured to be compliant. Compliancy of segments 210 can enable cells 208, and thus the body portion 202, to be oriented in various orientations. For example, body portion 202 can be oriented, or in other words moved, between a non-deployed orientation, such as illustrated in Fig. 5B, and a fully deployed orientation, such as illustrated in Fig. 5 A.
- the compliancy of segments 210 can facilitate the accommodation by the closure device 200 of a variety of types, shapes and sizes of internal tissue openings. For example, the size and configuration of the first and second anchors 204, 206 and the body portion 202 can enable the closure device 200 to accommodate varying sizes, shapes and types of internal tissue openings.
- the first anchor 204 can engage wall tissue of an internal tissue opening and the second anchor 206 can engage only the tunnel tissue of the internal tissue opening to approximate tissue.
- the second anchor 206 can engage the tunnel tissue and an opposing wall of the internal tissue opening to approximate tissue.
- Segments 210 can include an intermediate portion 234 configured to facilitate securement of ingrowth materials to the closure device 200, or can be used as an indicator 220 to facilitate estimation of the position of the closure device 200 with respect to an internal tissue opening. Furthermore, intermediate portion 234 can be configured to facilitate measuring of a characteristic of an internal tissue opening. In one embodiment, intermediate portion 234 can include one or more apertures. The apertures can be configured to receive a securing element, such as a thread, therethrough to facilitate securing an ingrowth material to the closure device 200. Intermediate portion 234 can be configured to be stiffer or more rigid than first portion 230, second portion 232, or both. A stiffer intermediate portion 234 can increase the reliability of segments 210.
- the intermediate portion 234 can include an indicator 220, such as a dense metallic rivet or concentration of dense material, for use in estimating the orientation and/or position of the closure device 200.
- an indicator 220 such as a dense metallic rivet or concentration of dense material
- Understanding of the orientation and/or position of the closure device 200 can facilitate estimating a physical characteristic of an internal tissue opening and/or the relative position of the closure device 200 with respect to the internal tissue opening. For example, if the distance between the indicators 220 is known, a practitioner can estimate a physical characteristic, such as the opening or tunnel width, by determining the new distance between the indicators 220 when the closure device 200 is positioned in the tissue opening.
- indicators 220 can be positioned on the first and second anchors 04, 206. The indicators 220 can be configured and arranged on the closure device 200 such that when the first anchor 204 is deployed the indicators 220 are substantially aligned. In this manner, a practitioner can estimate whether the first anchor 204 has fully deployed.
- segments 210 along a similar or common lateral plane can have substantially equal lengths. Substantially equal lengths of segments 210 in this manner can enable body portion 202 to be moved between the non-deployed and deployed orientation without failure of the segments 210.
- segments 210A and 210B have substantially the same length
- segments 210E, 210C, 210D, and 210K have substantially the same length
- segments 210F, 210G, 210H and 210L have substantially the same length
- segments 2101 and 210J have substantially the same length.
- body portion 202 can be collapsed or oriented into the non-deployed orientation, as illustrated in Fig. 5B, without causing damage to the body portion 202 of closure device.
- the closure device 200 can be configured to have a preferential orientation of the fully deployed orientation as illustrated in Fig. 5A. As the closure device 200 is deployed from the delivery device 300, the configuration of closure device 200 can cause the closure device 200 to preferentially move toward the fully deployed orientation.
- the preferential orientation of the closure device 200 can cause the closure device 200 to apply lateral force to the tissue of the internal tissue opening.
- the body portion 202, first anchor 204 and the second anchor 206 are deflected by an applied force in order to reorient the closure device 200 from the fully deployed orientation to a non-deployed orientation, for example.
- the closure device 200 because of the deflection of the body portion 202, first anchor 204 and the second anchor 206, will have tendency to return to the fully deployed orientation.
- the deflected body portion 202, first anchor 204 and the second anchor 206 can have a tendency to apply a lateral force to tissue of the opening as the closure device 200 attempts to return to the fully deployed orientation.
- Body portion 202 can be operatively associated with the first anchor 204 and the second anchor 206.
- First and second anchors 204, 206 can be configured to move between a deployed and non-deployed orientation.
- First and second anchors 204, 206 can be configured to apply lateral force to tissue of an internal tissue opening, and to engage and/or contact a portion of wall tissue and/or tunnel tissue of an internal tissue opening.
- the first anchor 204 can be a left atrial anchor
- the second anchor 206 can be a right atrial anchor.
- the first anchor 204 can include a first anchor segment 212 and an opposing second anchor segment 214.
- the second anchor 206 can include a first anchor member 216 and an opposing second anchor member 218.
- the first anchor segment 212 can be configured to move relative to the second anchor segment 214.
- the first anchor member 216 can be configured to move relative to the second anchor member 218.
- the closure device 200 can accommodate for a variety of types, shapes and sizes of internal tissue openings.
- the first anchor segment 212 and the second anchor segment 214 can be configured to be substantially similar in size, shape and configuration. As such, reference to the configuration and/or function of one of the first or second anchor segments can apply to the other anchor segment.
- the first anchor 204 and/or the second anchor 206 can include one or more undulations.
- the undulations can facilitate reorienting or movement of the anchors with respect to the body portion 202, for example, from a deployed to a non-deployed configuration. Furthermore, the undulations can facilitate the anchor substantially conforming to the anatomy of the tissue opening.
- the first anchor segment 212 can include a distal end 224 and a proximal end 226.
- the first anchor segment 212 can be defined by various segments and can include reinforced segments 228 and one or more engaging members 222.
- the first anchor segment 212 is at least partially defined by segment 210K of cell 208D.
- the engaging members 222 can be microposts or tines configured to contact and/or engage tissue.
- the engaging members 222 can include a sharp tip or can be blunt.
- the engaging members 222 can be configured to provide a degree of surface texture in order to increase engagement of the first anchor 204 with tissue.
- the first anchor segment 212 can be configured to be moved between a non- deployed orientation, as illustrated in Fig. 5B, and a fully deployed orientation, as illustrated in Fig. 5 A.
- the first anchor segment 212 can be configured such that the distance from the proximal end 226 to the distal end 224 of the segment which includes the engaging members 222 is substantially equal to the distance from the proximal end 226 to the distal end 224 of the segment which includes the reinforced segments 228 and segment 210K.
- the second anchor segment 214 can be configured similar to the first anchor segment 212.
- First anchor segment 212 can be configured to define a closed periphery.
- first anchor segment 212 can include the reinforced segment 228 extending from the body portion 202 to the segment having the engaging members 222 which is connected to segments 210K, 210L to define a closed periphery with segment 210K.
- two reinforced segments 228 can extend from the joining portion 254 of the body portion 202 and join together near the distal end 224 of the first anchor 204.
- anchors of the present invention are reinforced to provide greater rigidity and strength to facilitate stabilization and maintenance of the closure device 200 within a tissue structure.
- First anchor member 216 can include a distal end 236 and a proximal end 238.
- the first anchor member 216 can be defined by various segments and can include one or more engaging members 222.
- the first anchor member 216 is at least partially defined by segment 210L of cell 208D.
- the engaging members 222 can be microposts or tines configured to contact and/or engage tissue.
- the engaging members 222 can include a sharp tip or can be blunt.
- the engaging members 222 can be configured to provide a degree of surface texture to increase engagement of the second anchor 206 with tissue. It will be understood by one of ordinary skill in the art in view of the disclosure provided herein that the engaging members 222 can vary in size and shape, and can be positioned at various locations on the closure device 200.
- one or more engaging members can extend out of plane of the closure device so as to contact tissue which is perpendicular, for example, to the substantially flat plane, such as plane 260 of Figure 1 IB, of the closure device 200.
- the first anchor member 216 can be configured to be moved between a non- deployed orientation, as illustrated in Fig. 5B, and a fully deployed orientation, as illustrated in Fig. 5 A.
- the first anchor member 216 can be configured such that the distance from the proximal end 238 to the distal end 236 of the segment which includes the engaging members 222 is substantially equal to the distance from the proximal end 238 to the distal end 236 of the segment which includes segment 210L. In this manner, first anchor member 216 can be detachably coupled to the delivery device 300 when in a non-deployed orientation inside the delivery device 300 as illustrated in Fig. 5B.
- the second anchor member 218 can be configured similar to the first anchor member 216.
- the first anchor segment 212 can also include a first portion 256 and a second portion 258 configured to facilitate engagement of the internal tissue opening.
- first anchor segment 212 can be configured to include one or more undulations causing the first portion 256 to be positioned in close proximity with second portion 258. In this manner, as tissue is positioned between the first and second portions 256, 258, the configuration of the first anchor segment 212 can engage, or to some degree, pinch the tissue therebetween to facilitate maintenance of the position of the closure device 200 with respect to the tissue opening.
- the closure device 200 can also include attachment members 240 for use in detachably linking the closure device 200 to the delivery device 300, as will be discussed more fully herein after.
- the attachment members 240 can include an aperture 242 for use in facilitating the linking of the closure device 200 to the delivery device 300.
- Fig. 5B illustrates the closure device 200 in a non-deployed or constrained orientation.
- the configuration of the body portion 202, and the first and second anchors 204, 206 enables the closure device 200 be reoriented from the fully deployed and preferential orientation, as illustrated in Fig. 5A, to the non-deployed or collapsed orientation as illustrated.
- the first anchor 204 extends distally and the second anchor 206 extends proximally, with the attachment members 240 being the proximal most portions of the second anchor 206 and the body portion 202.
- the closure device 200 is positioned inside of a delivery portion 366 of the delivery device 300.
- the configuration of the closure device 200 can cause portions of the closure device to apply force to the wall of the delivery portion 366 due to the preferential orientation of the closure device 200.
- the closure device 200 is configured to be received into and deployable from the delivery portion 366.
- Fig. 6 illustrates one embodiment of the delivery device 300.
- the delivery assembly 360 includes a catheter 362 having a delivery portion 366, and a plurality of tethers 364 at least partially housed by the catheter 362.
- the tethers 364 can be configured to facilitate selective detachment of the closure device 200 from the delivery device 300.
- the delivery portion 366 can be configured to receive the closure device 200 therein.
- the catheter 362 can be coupled to the actuating assembly 320, such that movement of the actuating assembly 320 can cause movement of the catheter 362.
- the actuating assembly 320 includes a first member 322 operatively associated with the handle body 302, a second member 324 operatively associated with the first member 322 and the handle body 302, and a knob 338 linked to the first member 322.
- the actuating assembly 320 can be utilized by a user to selectively deploy the closure device 200 from the catheter 362.
- a practitioner can move the knob 338, which is coupled to the first member 322, in the proximal direction to deploy first anchors 204 (Fig. 4).
- the second member 324 can be rotated in order to selectively deploy the remaining portions of the closure device 200 from the delivery portion 366 of the delivery device 300.
- the exemplary delivery device 300 illustrated in Fig. 6 is also configured to allow a practitioner to estimate the progress of the deployment process.
- the handle body 302 can include indicia 304 to enable a user to estimate the degree of deployment of the closure device 200 from the delivery device 300, as well as predict detachment of the closure device 200 from the delivery device 300.
- indicia 304 can include deployment indicia 306 and release indicia 308.
- Deployment indicia 306 can be utilized to enable a user to estimate the degree of deployment of the closure device 200 from the catheter 362, and the release indicia 308 can be utilized to predict the detachment of the closure device 200 from the delivery device 300.
- the handle body 302 can also include a release pin groove 310.
- the release pin groove 310 can be operatively associated with the release assembly 340 to facilitate the selective detachment of the closure device 200 from the tethers 364.
- the release assembly 340 can include a biasing member 342 operatively associated with the handle body 302 to facilitate detachment of the closure device 200.
- a release knob 346 can be provided to manipulate the position of biasing member 342 in order to release or detach the closure device 200.
- the release knob 346 is coupled to the biasing member 342, such that movement of the release knob 346 can cause movement of the biasing member 342 relative to the handle body 302 to thereby cause separation between the handle body 302 and the release knob 346.
- release knob 346 is operatively associated with the tethers 364A-C such that as the release knob moves proximally relative to the handle body 302 the tethers 364 A-C are drawn proximally to release closure device 200.
- release assembly 340 and other release assemblies will be discussed in more detail below.
- Fig. 7A is a cross-sectional view of the distal end of the catheter 362.
- the catheter 362 includes a delivery portion 366 for use in positioning the catheter 362.
- the catheter 362 can be made from a resilient material having sufficient axial stiffness to allow a practitioner to position the catheter 362 with respect to an internal tissue opening, and sufficient rotational stiffness to allow a practitioner to rotate the catheter 362 by rotating the handle body 302.
- the catheter 362 comprises a braided polyimide.
- the catheter 362 can be made from a material having a sufficient axial stiffness, such as a braid reinforced polymer, axially reinforced polymer, metal reinforced polymer, carbon reinforced polymer, or some other type of axially stiff material.
- the delivery portion 366 can be made from a thermoplastic elastomer, such as PEBAX®. In other embodiments, the delivery portion or tip portion 366 can be made from a material having sufficient flexible properties, such as a polymeric material. In other embodiments, the delivery portion 366 can include a combination of materials, such as metallic materials and polymeric materials.
- the delivery portion 366 can define a lumen 368 to facilitate placement of the catheter 362.
- a guidewire can be received in the lumen 368 to guide the catheter 362 to a desired location.
- the closure device 200 can be located proximate to the internal tissue opening in a quick and efficient manner.
- the delivery portion 366 can be shaped, such as including a bend, in order to facilitate placement of the delivery portion 366 through a PFO, for example.
- the catheter 362 can be considered a rapid exchange catheter wherein the delivery or tip portion 366 enables a guidewire to be linked to the catheter 362 in a quick and efficient manner for placement of the catheter 362.
- the catheter 362 and delivery portion 366 can be configured to at least partially house tethers 364 in a lumen which is distinct and separate from lumen 368.
- lumen 368 can be in a spaced apart, non-coaxial arrangement from the lumen which houses tethers 364, such that a guidewire can be received through lumen 368 without being introduced into the lumen or space in which the tethers 364 are housed.
- a user can introduce a guidewire into the lumen 368 at the distal end of the catheter 362, rather than the lumen which at least partially houses the tethers 364 which would require the guidewire to be introduced into the lumen at the proximal end of the catheter 362.
- the lumen 368 configured to receive the guidewire therein can be positioned inside the lumen which houses the tethers 364.
- lumen 368 would include an opening and an exit at the distal end of the catheter 362 in order to facilitate the quick placement of a guidewire through the lumen 368.
- catheter 362 can include a rounded cross-section and the delivery portion 366 can include a rectangular cross-section.
- the rectangular cross- section of the delivery portion 366 can facilitate proper deployment of the closure device 200 from the delivery device 300, as well as facilitate the closure device 200 being reintroduced back into the delivery portion 366.
- the rectangular cross-section of the delivery portion 366 can be sized to orient the tethers 364 next to each other in a linear fashion. In this manner, the likelihood that the tethers 364 cross each other upon reintroduction of the closure device 200 into the delivery portion 366 can be reduced.
- tethers 364 includes three tethers 364A- C, each tether 364 being sized and configured to attach to and/or accommodate therein an attachment member 240 of the closure device 200.
- a tether is a line or hollow tube coupled to the handle body 302.
- the tether 364 can comprise a flexible, hollow shaft having sufficient stiffness such that as actuating assembly 320 moves the catheter 362 proximally with respect to the handle body 302, the closure device 200 is forced out of the delivery portion 366.
- the tether 364 can be configured to pull the closure device 200 back into the delivery portion 366 as the actuating assembly 320 is moved distally with respect to the handle body 302.
- the tethers 364 can be a coil of stainless steel covered by a heat shrunk tubing to give the coil a degree of tensile strength and rigidity.
- the tether 364 can be a polymeric tube.
- the tether 364 can be a combination of polymeric materials and metallic materials.
- additional heat shrunk tubing covers a proximal segment of the three tethers 364A-C. The heat shrunk covering can increase the column strength of the tether 364, which can enable the tethers 364 to assist with deployment and reintroduction of the closure device 200 from and into the delivery portion 366.
- the tethers 364 can have a distal tip configured to correspond to the shape and size of the attachment members 240 of the closure device, such that the attachment member 240 can be received into the distal tip of the tether 364, as illustrated in Fig. 7B.
- Tethers 364 can be made from a material having sufficient flexibility to substantially prevent distortion or otherwise influence the orientation of the closure device 200 when the closure device is deployed from the catheter 362, yet have sufficient axial strength to facilitate deployment of the closure device 200 when the catheter 362 is moved proximally with respect to the closure device 200.
- the tethers 364 can have a lumen extending therethrough of sufficient size and configuration to enable a plurality of wires 378 to be housed and movable therein. Illustrated in Fig.
- FIG. 7B is a cross-sectional view of attachment member 240 of the closure device 200 received into a tether 364 and coupled by first and second wires 378a, 378b.
- a second wire 378b can extend through and out of the tether 364 and form a loop.
- the loop can extend through an aperture 242 of the attachment member 240 of the closure device 200.
- a first wire 378a which extends through and out of the tether 364, can extend through the loop of the second wire 378b to form a locking feature.
- the closure device 200 can remain coupled to the delivery device 300 until the first wire 378a is pulled through the loop of the second wire 378b, and the second wire 378b is pulled out of the aperture 242 of the attachment member 240.
- the first wire 378a and the second wire 378b can be attached at their proximal ends to the biasing member 342 (Fig. 6). Accordingly, the first and second wires 378a, b extend from the distal end of the closure device 200 through the tethers 364a- c to the biasing member 342 In this manner, movement of the biasing member 342 in the proximal direction can cause movement of the wires 378a, b also in the proximal direction.
- Figs. 7C-7D are cross-sectional views illustrating the delivery assembly 360 in association with the actuating assembly 320.
- Fig. 7C does not include the biasing member 342, release wires 378a, b and associated release knob 346
- Fig. 7D illustrates details about the interaction between the delivery assembly 360 and the actuating assembly 320 without illustrating the first member 322 and details about the handle body 302 and the second member 324.
- the proximal end of the catheter 362 is coupled to the distal end of the second member 324. In this manner, movement of the second member 324 can cause a corresponding movement in the catheter 362.
- the catheter 362 move proximally with respect to the handle body 302.
- the tethers 364 can extend from the delivery portion 366, through the catheter 362 and the second member 324 and are coupled to the handle body 302.
- the tethers 364 are coupled to the handle body 302 while the first and second members 322, 324 may be coupled to the catheter 362 such that movement of the first and second members 322, 324 causes relative movement between the catheter 362 and handle body 302, which results in movement between the catheter 362 and the tethers 364a-c.
- the tethers 364a-c are secured to the closure device 200, such that movement of the tethers 364a- c results in deployment of the closure device.
- movement of the first and second members 322, 324 deploys the closure device 200, as will now be discussed in more detail.
- the tethers 364 can be secured to the handle body 302 by, for example, an intermediate member 376.
- the tethers 364 can be covered with a first and second housing 370, 372 to provide a degree of rigidity to the portions of the tethers 364 located inside of the handle body 302 and the second member 324.
- the first housing 370 comprises a rigid, hollow, metal rod configured to house the three tethers 364a-c therein.
- the first housing 370 can extend from the intermediate member 376, which facilitates securement of the tethers 364 to the handle body 302, and terminate at some point beyond the handle body 302.
- the second housing 372 can extend from the distal end of the first housing 370 and extend into the catheter 362.
- the second housing 372 can comprise a resilient material configured to resist axial stretching while allowing a degree of bending.
- the second housing 372 comprises a coil of metal, such as stainless steel, configured to resist axial stretching, yet allow a degree of bending.
- the second housing 372 can allow a practitioner to bend a portion of the catheter 362, if needed, in order to manipulate delivery device 300 for placement of the closure device 200.
- a seal 374 can be provided between the first housing 372 and the second member 324 in order to reduce or substantially prevent bodily fluid, which may have entered the catheter 362, from entering the handle body 302 or otherwise inappropriately being expelled from the delivery device 300.
- the second member 324 can comprise an elongate shaft defining an axial lumen 348 and a lumen 350 in fluid communication therewith.
- Lumen 350 can be configured to couple to a medical device for removal of fluid from the delivery device 300.
- the axial lumen 348 can be sized to accommodate and allow movement of the tethers 362, the first housing 370 and the second housing 372 therein.
- the second member 324 can include a guide 326.
- the guide 326 can be configured to cooperate with a first pin 352 and a second pin 354 to influence movement of the second member 324 with respect to the handle body 302, as will be discussed more fully herein below.
- the first member 322 comprises a hollow elongate tube sized and configured to enable the second member 324 to be received into and moveable within the first member 322.
- the first member 322 can be operatively associated with the handle body 302 and the second member 324 to facilitate deployment of the closure device 200.
- the first member 322 is linked to the handle body 302 by a third pin 356.
- the third pin 356 is received in a guide 358 of the first member 322.
- the guide 358 is configured to interact with the third pin 356 in order to influence the movement of the first member 322 with respect to the handle body 302.
- the first pin 352 can link the first member 322 to the second member 324.
- the second pin 354 links the handle body 302 to the second member 324
- the third pin 356 links the handle body 302 to the second member 322
- movement of the first member 322 can selectively deploy the closure device 200 from the delivery portion 366.
- Fig. 8 is an exploded view of the actuating assembly 320 and the release assembly 340. The second member 324 is received into the first member 322, and the first member 322 is received into the knob 338 and the handle body 302.
- the second member 324 can include a guide 326 having a first portion 326a and a second portion 326b, which guide 326 can be defined by a slot formed on the outer surface of the second member 324.
- the first portion 326a is straight and extends along at least a portion of the length of the first member 324 and joins with the second portion 326b of the guide 326.
- the second portion 326b can include a helical groove or slot that begins with and is contiguous with the first portion 326a and extends distally therefrom.
- the guide 326 of the second member 324 is configured to interact with the handle body 302 and the first member 322 to selectively retract the catheter 362 in order to deploy the closure device 200.
- the first portion 326a of the guide 326 is configured to interact with the second pin 354, which is secured into the handle body 302 by means of threads and extend into the first portion 326a of the guide 326.
- the second member 324 can move laterally with respect to the handle body 302.
- rotation of the handle body 302 can translate to rotation of the second member 324, and thus, the catheter 362 and the delivery portion 366.
- the second portion 326b of the guide 326 is configured to interact with the first pin 352, which is secured to the first member 322 by means of threads and extends into the second portion 326b of the guide 326. In this manner, as the first member 322 is rotated, the first pin 352 will interact with the second portion 326b to move the second member 324 in the proximal direction. As the second member 324 is moved in the proximal direction with respect to the handle body 302, the catheter 362 moves proximal Iy with respect to the handle body 302 thereby exposing or deploying the closure device 200 from the delivery portion 366.
- the first member 322 can include a guide 358 defined by a slot or groove formed in the outer surface of the first member 322.
- the guide 358 can include a first portion 358a connected to a second portion 358b.
- the first portion 358a of guide 358 can be straight and extend along at least a portion of the length of the first member 322, and then join and be contiguous with the second portion 358b.
- the second portion 358b of the guide 358 can be a helical groove that wraps around at least a portion of the outer surface of the first member 322 and extends along at least a portion of the length of the first member 322.
- the closure device 200 is completely received into and enclosed by the delivery portion 366.
- the third pin 356 moves in the first portion 358a of the guide 358 to deploy the first anchor 204 of the closure device 200 from the delivery portion 366.
- the length of the first portion 358a can correspond with the distance that the first member 322, and thus the catheter 362, must move in order to deploy the first anchor 204 of the closure device 200 from the delivery portion 366.
- a practitioner can move the knob 338, which is coupled to the first member 322, in the proximal direction. Movement of the knob 338 in the proximal direction can cause the third pin 356 to move linearly in the first portion 358a of the guide 358. In this manner, the second member 324 can move correspondingly with the first member 322 because of the first pin 352, which links the first member 322 to the second member 324.
- the first member 322 can be rotated in order to selectively deploy the remaining portions of the closure device 200 from the delivery portion 366 of the delivery device 300.
- the third pin 356 is positioned in the second portion 358b to influence movement of the first member 322 with respect to the handle body 302, and the first pin 352, which is coupled to the first member 322, interacts with the second portion 326b of the guide 326 to move the second member 324 in the proximal direction with respect to the handle body 302. Movement of the second member 324 in the proximal direction in this manner can cause further deployment of the closure device 200 from the delivery portion 366.
- the knob 338 can be coupled to the first member 322 to facilitate and enable movement of the first member 322 with respect to the handle body 302.
- the dual movement required to deploy the closure device 200 can provide some efficiency and safety advantages.
- a practitioner can move the knob 338 in a first direction (i.e., proximally in a linear fashion) to deploy the first anchor 204 from the delivery portion 366. Thereafter, the practitioner can move the handle body 302 to position the first anchor 204 against the wall tissue of an internal tissue opening, such as against the left atrial wall of a heart, for example. Once the first anchor 204 is positioned against the wall, the practitioner can move the knob 338 in a second direction (i.e., rotate the knob) to further deploy the closure device 200 from the delivery portion 366.
- the dual movement enables a user to predict the deployment of the closure device 200 to reduce the risk of premature deployment of the closure device.
- a structure configured to substantially restrict or control movement of the first element with respect to the second element and/or handle body can be utilized.
- the structure can include a cam and a follower.
- the structure can include a slider.
- the release assembly 340 can be configured to be received in the proximal end of the handle body 302.
- the release assembly 340 can be configured to provide additional safety features for the practitioner and patient by reducing the risk of premature detachment of the closure device 200 before it is positioned appropriately in an internal tissue opening.
- a practitioner using the medical system 100 of the present invention can manipulate the actuating assembly 320 to deploy the closure device 200 for positioning in an internal tissue opening.
- a user can move the knob 338, and thus the first member 322, in the proximal direction with a first movement, which is a linear movement, and then deploy the remaining portions of the closure device 200 by a rotational movement.
- the practitioner can be required to move their hands in order to utilize the release assembly 340 to release the closure device 200 from the delivery device 300.
- the release assembly 340 can include a release knob 346 coupled to a biasing member 342, which is received into the proximal end of the handle body 302.
- the biasing member 342 can be configured to include a plurality of slots 318 configured and arranged to act similar to a spring.
- the slots 318 can be configured and arranged in the biasing member 342 to enable at least a portion of the biasing member 342 to be compressed. Compression of the biasing member 342 can cause the release pin 344 to move toward the distal end of the biasing member 342.
- the biasing member 342 can be configured such that when biasing member 342 is positioned in the handle body 302, the biasing member 342 naturally tends to maintain its position with the release pin 344 in the release pin groove 310 as illustrated in Fig. 8. As force is applied to the release knob 346 in the distal direction (i.e., compress the biasing member 342), the release pin 344 can be moved out of a terminating portion of the release pin groove 310 and rotated and moved into a proximal terminating portion of the release pin groove 310 to release the closure device 200 from the delivery device 300. The closure device 200 is released from the delivery device 300 by moving a plurality of wires 378 which are housed by a tether 364 and coupled to the biasing member 342.
- FIG. 7 Illustrated in Figure 7 is a cross-sectional view of attachment member 240 of the closure device 200 received into a tether 364 and coupled by first and second wires 378a, 378b.
- a second wire 378b can extend through and out of the tether 364 and form a loop.
- the loop can extend through an aperture 242 of the attachment member 240 of the closure device 200.
- a first wire 378a With the loop of second wire 378b positioned through the aperture 242 of the attachment member 240, a first wire 378a, which extends through and out of the tether 364, can extend through the loop of the second wire 378b to form a locking feature.
- the closure device 200 can remain coupled to the delivery device 300 until the first wire 378a is pulled through the loop of the second wire 378b, and the second wire 378b is pulled out of the aperture 242 of the attachment member 240.
- the first wire 378a and the second wire 378b can be attached at their proximal ends to the biasing member 342. In this manner, movement of the biasing member 342 in the proximal direction can cause movement of the wires 378 also in the proximal direction.
- the wires 378 can be coupled to the biasing member 342 such that movement of the biasing member 342 will cause the first wire 378a to move a distance sufficient to be removed from the loop of second wire 378b before the second wire 378b is moved by the biasing member 342.
- the wire 378 can comprise a metallic wire such as NiTiNoI wire.
- the wire 378 can also include a stainless steel wire or some other type of metal or stiff polymer.
- the wires 378 can be made from a material having a sufficient tensile strength to secure the closure device 200 to the tethers 364 without causing the wires 378 to fail or substantially deform.
- the wire 378B can include a stainless steal wire and wire 378A can include a NiTiNoI wire.
- the release assembly can include a rotating member coupled to the securing elements. In this embodiment, rotation of the rotating member can cause the securing elements to wind around the rotating member thereby causing the distal ends of the securing elements to move proximally with respect to the handle body.
- the closure device 200 is released from the delivery device 300 by moving a plurality of wires 378 which are housed by a tether 364 and coupled to the biasing member 342.
- Fig. 9A illustrates the positioning of the catheter 362 through the tunnel 58 of a PFO with the first anchor 204 of the closure device 200 deployed.
- the medical system 100 is utilized to close an internal tissue opening by positioning the catheter 362 through an internal tissue opening and moving the first member 322 by a first movement (i.e., linearly) in the proximal direction to deploy the first anchor 204 of the closure device 200.
- the delivery device 300 can be moved in the proximal direction in order to seat the first anchor 204 against the wall of the tissue opening or otherwise engage the wall of the internal tissue opening, as illustrated in Fig.
- the knob 338 can be moved by a second movement, or in other words, rotated to deploy additional portions of the closure device 200 as illustrated in Fig. 9B.
- the release assembly 340 can be actuated to selectively detach the delivery device 300 from the closure device 200 as illustrated in Figs. 10 and 11.
- the release assembly 340 can be actuated by moving the biasing member 342 distally with respect to the handle body 302, then rotating the biasing member with respect to the handle body 302, and then moved proximally with respect to the handle body 302.
- closure device 200 substantially conforms to the anatomy of the internal tissue opening.
- the configuration of the closure device 200 is such that when positioned in the internal tissue opening as illustrated, the members of the closure device 200 apply lateral force to the tissue of the internal tissue opening, such as the tunnel 58 of the PFO, to approximate tissue of the PFO for closure.
- the delivery device 300 may be configured to deliver closure devices with additional configurations.
- Figs 12A-12N illustrate additional configurations for closure devices 200a-n utilizing various patterns and sizes of cells, the patterns being selected to conform with typical PFO anatomy. Potential regularly- sized cell structures are shown in Fig. 12A- 12N. The use of a multiple cellular structure may allow the closure elements 12A-12N to exhibit features that will increase the ability of the closure devices 200a-n to conform to typical PFO anatomy while being collapsible within a catheter-based delivery system.
- Fig. 12A depicts a closure element 200a having a five-cell design which is narrower in a middle portion 1205 than at the distal and proximal ends 1210a, 1210b respectively.
- This basic design exhibits the ability to extend the cells on the distal end 1210a and cells on the proximal end 1210b outside a PFO tunnel having a relative narrow waist.
- Fig. 12B illustrates a closure device 200b having a five-cell design which constrains the degree to which the device would extend into the atria of the heart while still providing wider anchoring points at the top and bottom-most cells.
- Figs 12C-E show additional closure devices 200c-e having varied cell configurations which include cells of different sizes. The different size cells may provide stiffness to selected areas of the structure which in turn may result in the application of varying amounts of force to an internal tissue opening.
- closure device 200c illustrated in Fig. 12C may provide additional stiffness at the anchoring points by providing relatively smaller cells located on or near the distal and proximal ends 1210a, b.
- Fig. 12D may provide additional stiffness at the portion of the closure device 20Od configured to be located in the tunnel, such as the middle portion 1205; therefore, smaller cells may be utilized in the middle portion 1205 as illustrated in Fig. 12D.
- Fig. 12E illustrates a closure device 20Oe that includes a combination of the structures depicted in Fig. 12B and Fig. 12D. Other combinations of cell-size and placement may be envisioned. Each of the combinations may be tailored to specific desired properties of the device.
- Figs 12F-N illustrate closure devices 200f-n having additional cell structures that may provide adaptability to the varying needs of different PFOs of varying widths and lengths while still providing for their typical shape.
- FIG. 120-T illustrate closure devices 200o-t having cell structures that have been adapted to further allow for proximal and distal anchoring and may also be adapted for varying-length PFO tunnels.
- Fig. 120 shows a closure device 20Oo having a single central cell structure with elongated arms 1220a-d at each corner designed to proximally and distally anchor the structure within an internal tissue opening, such as a PFO tunnel.
- the elongated arms 1220a-d may be considered as additional cells that are collapsible as the closure device 20Oo is collapsed within a delivery device.
- Figs. 12P and 12Q illustrate closure devices 20Op and 20Oq in which additional central cells are added to provide additional width and length to the structure respectively.
- the elongate arms 1220a-d of the closure devices 200o-q may include serrated edges. When the closure devices 20Op, q are deployed, the serrated edges on the elongate arms 1220a-d may provide anchoring to the tissue.
- Figs. 12R-T depict single-cell designs with smoother arms. These designs may provide a less aggressive anchoring to the internal tissue opening and surrounding tissues while still utilizing elongate arms 1220a-d, which may provide adaptability to accommodate length variations in the internal tissue openings.
- Figs. 12U-X illustrates closure devices 200u-x having cell structures that are similar to the cellular structures illustrated in Figs. 12U-X. These are examples of designs that will have adaptability to specific PFO anatomies.
- FIGs. 12Y-Z The creation of cell structures that lend themselves to accommodating PFO 's of varying lengths while maintaining anchoring features as well as the desired lateral force is possible and shown in Figs. 12Y-Z.
- a closure device 120Oy that makes use of the addition of cells with a wider aspect than taller aspect as shown in Fig. 12y.
- Such a configuration may create a structure that exhibits the ability to foreshorten while maintaining approximately the same width.
- Fig. 12Z depicts a cell structure that also has the ability to foreshorten while coupling the forces from the top and bottom of the structure by a larger amount by moving the attachment points from the middle of the structure to the edges of the waist. This provides for varying tunnel lengths while limiting the forces applied within the internal tissue opening as well as allowing the right and left anchoring features to operate more independently on one side without interference from the other side.
- Fig. 13A shows a closure device 200a' that includes a cell structure in which an anchor 1300a on the right (bottom) side is relatively smaller than an anchor 1300b on the left side.
- Figs. 13B-C illustrate closure devices 200b', 200c' respectively that include anchors 1300 only on the left side or right side respectively. Including anchors on only one side of the internal tissue opening will adapt to internal tissue opening with tapered tunnels on which it may be desirable to close only the wider side of the tunnel.
- FIG. 14A illustrates a closure device 20Od' that includes small barbs 1400 that are inclusive to the cell structure along the sides of the closure device 20Od'. When deployed, the small barbs 1400 may aggressively engage the tissue and prevent migration of the closure device 20Od' through the internal tissue opening.
- Fig. 14B illustrates separate, deployable structures 1410 which may be added the structure of a closure device 20Oe' and expand into the width of the internal tissue opening when the device is deployed.
- the anchors may be simple wire ends as shown or more aggressive, pointed or barbed features to engage the tissues associated with a tunnel of an internal tissue opening.
- a closure device may be constructed of rectangular cross-section wire that is bent to shape and join as shown in Figs 15A-15B.
- Figs 15A-15B One particular aspect ratio and bending of a single closure device element 1500 is shown Fig. 15A, and two of these components are shown connected in Fig. 15B where a row of cells 1510 is shown. Additions to this starting structure can be added to provide the desired, complete cellular structure.
- Starting wire may be made from metals, such as stainless steel (SS) and stainless steel alloys, tantalum, biocompatible metals, nickel titanium (NiTi), or polymer extrusions of various polymers or bioresorbable polymers.
- Shape memory materials such as NiTi, and shape-memory polymers could be heat-set into the bent configurations as shown in Fig. 15A.
- connection of the components may be accomplished by small coils of wire held captive at the joint due to the bending of the components or with biocompatible solders or adhesives, resistance or laser welding in the case of metallic components or simply melting of polymer materials at the required junctions by application of heat directly or by ultrasonic heating. Combinations of these connections methods may be used to provide additional joint support or properties.
- coils may be made of radiopaque material such as platinum or platinum alloys, which in addition to providing fixation of the components will provide for visualization by fluoroscope and X-ray.
- Closure devices may also be cut from flat sheets of starting materials.
- cutting of the structure may be accomplished mechanically for larger cells and structures and/or by laser or photo-lithography for smaller structures. Cutting of these materials may be done with the device in the deployed, expanded form for materials without shape-memory.
- shape-memory metals such as NiTi
- the constrained shape may be cut followed by heat-setting the device to the expanded shape, which will provide for more efficient packing of the component when constrained for delivery.
- Another method of creating the desired structure for the closure device is the utilization of a woven mesh of wires or polymer filaments which create a flat sheet.
- the cellular structure would exist as the voids between the woven wires and the structure would be collapsible for delivery through a catheter.
- Wire ends which extend from this construction method may be managed by tucking them back into the woven mesh, or by leaving them exposed and allowing them, when deployed in the internal tissue opening, to engage the surrounding tissues for fixation. They may also be terminated by creating interlocking loops at the edge intersections.
- Figs 16A-16C illustrate a closure device that is configured to self-adjust according to a tunnel length of an internal tissue opening.
- Fig. 16A illustrates a closure device 20Of that includes anchoring features 1600 located on the distal end 1210a.
- the distal end 1210a and the proximal end 1210b are both illustrated as being wider than the central portion 1205, which may be a relative narrow waist portion.
- the closure device 20Of expands from a compressed state within the delivery device to an expanded state in which the closure device 20Of becomes wider as it is deployed.
- the length of the closure device 20Of is reduced to more closely approximate the length of the tunnel length of the internal tissue opening.
- the width of the closure device 20Of is in an expanded state while the overall length of the closure device 20Of is in an expanded state.
- the proximal portion 1210b may be configured to be reduced in length, such as through rolling.
- Fig. 16A illustrates the closure device 20Of in a default, unconstrained state.
- the proximal portion 1210b rolls onto itself toward the central portion 1205.
- the proximal portion 1210b shown in Fig. 16B can roll up to a PFO tunnel entry point in the right atrium and then provide an anchor which may reduce the possibility of migration of the closure device 20Of through the tunnel.
- Fig. 16C illustrates a closure device 20Of in which the proximal end 1210b of the structure comprises a coiled wire rather than coiling the entire structure.
- the closure devices 20Of, g' may be formed of metallic materials, including NiTi with its shape memory set to the configurations of Fig. 16B and/or Fig. 16C.
- FIG 17A Yet another closure device 20Oh' is shown in Fig 17A.
- a central portion 1205 of the closure device 20Oh' includes a mechanical relief point 1700 that may provide the distal and proximal ends 1210a, 1210b additional flexibility to adapt to variable anatomy of internal tissue openings. This flexibility may allow the distal end 1210a to rotate with respect to the proximal end 1210b as shown in Fig 17B as well as allowing out-of-plane rotation.
- Figs. 18A-18B illustrates closure devices 20Oi' in which a portion of the device intended to be deployed in the right atrium of the heart employs a proximal anchor 1800 that may be a rigid structural member.
- the proximal anchor 1800 may be attached to the rest of the closure device 20Oi' by a spring member 1810 which may allow the deployed position of the proximal anchor 1800 to vary according to the length of the PFO tunnel.
- the proximal anchor 1800 illustrated may be solid in this embodiment, it may be folded length-wise for delivery, as shown in Fig. 18B.
- the solid proximal anchor 1800 may further have configurations not shown which are specifically designed to have conformance to the anatomy found on the right side of the atrial septum, including the ability to locate itself tucked under the typical arch of the septum secundum.
- closure devices have been discussed in the context of closure devices that expand from a compressed state to a default or decompressed state in which the expansion occurs due to the resiliency of the material used to form the closure device and/or to the shape of the closure device.
- Other configurations may be utilized in which the closure device is mechanically driven from the compressed to the decompressed state by forces apart from and/or in addition to spring forces associated with compression of the closure device.
- Figs. 19A and 19B are schematic diagrams of a closure element 20Oj'.
- the closure element 20Oj' includes expansion members 1920 with outwardly biased ends 1921, connecting members 1922, and pinned joints 1923.
- the connecting members 1922 are coupled the opposing expansion members 1920 by way of the pinned points 1923.
- Such a configuration allows the closure element 20Oj' to expand and collapse from a collapsed state as illustrated in Fig. 19A to an expanded state as illustrated in Fig. 19B. Further, the closure element 20Oj' may be further collapsed to fit within a delivery device.
- the expansion members 1920 may exert a lateral force on the walls of the tunnel of an internal tissue opening in a similar manner as described above.
- the expansion members 1920 include outwardly biased ends 1921. The outwardly biased ends 1921 may promote fixation of the expansion members 1920 to the internal tissue opening and/or fit the desired anatomy.
- the closure element 20Oj' may be expanded by moving the central portions of the connecting members 1922 in opposing directions designated by arrows 1924.
- the connecting members 1922 move in opposing directions from the expansion members 1920, which are driving in an outward direction, 1925.
- the connecting members 1922 may be locked into place by an over-center latching of the connecting members 1922 when the connecting members 1922 are forced apart from each other in directions 1924.
- Fig. 19C illustrates a partial view of a connecting member 1922 in isolation.
- the connecting member 1922 may have engagement features 1927 at the interface of the pinned joints 1923 which will interlock at various angles allowing the separation between the expansion members 1920 to be varied.
- the features 1927 may include ramped tabs.
- Fig. 19D illustrates the interaction between connecting members 1922.
- the features 1927 may allow adjacent connecting members to be rotated relative to one another in one direction while prevent rotation in the opposite direction. In one example, the features 1927 may interact in a ratcheting manner.
- Fig. 20 illustrates a closure device 200k'.
- the closure device 200k' includes expansion members 1920 that are coupled together with struts 2000 positioned at least partially within tubes 2010. At the end of the struts 2000, outwardly biased biasing elements 2020 are constrained by the tubes 2010. Upon deployment of the closure device 200k', such as when the closure device 200k' is freed from a delivery device, the biasing elements 2020 allow a sliding fit, but resist compression due to their outward bias. The outward bias of the biasing elements 2020 secure the closure device 200k' in the expanded state to secure the closure device 200k' to the walls of an internal tissue opening.
- Figs. 21 A and 21B illustrate a closure device 2001' that may be mechanically deployed.
- the closure device 2001' with pinned joints 1923 and rigid connecting members 1923 are initially expanded along the axial direction 2198 of the structure.
- the expansion members 1920 are forced outward by the operation of a tether 2196 that is rigidly connected to a distal connecting member 1922a at point 2191 and extends through an opening 2192 in a proximal connecting member 1922b.
- Tension is maintained in the tether 2196 and a clasp 2193 is slid distally along the tether 2196 until connecting with the proximal connecting member 1922b to force the proximal connecting member 1922b proximally.
- the proximal connecting member 1922b moves proximally.
- the proximal connecting member 1922b moves the expansion members 1920 outwardly.
- Fig. 21B shows a cross section of the clasp 2193 in relation to the opening
- a proximal connecting member 1922b in which a barbed surface 2195 is configured to secure the clasp 2193 from proximal movement in relation to the tether, 2196.
- the tether 2196 is cut proximally relative to the clasp 2193 thereby releasing the closure device 2001' in its expanded position.
- Figs. 22A and 22B illustrate a closure device 200m' that can be deformed from an inline shape (Fig. 22A) to a "T" shape (Fig. 22b).
- the closure device 200m' includes anchoring arms 2200 that may be expanded to close the internal issue opening as described above and/or to locate the system relative to the internal tissue opening.
- the closure device 200m' includes alternating thick portions 2204 and thin portions 2208 to form flexural hinges.
- the closure device 200m' further includes an actuation member 2210 that is secured to a distal end 1210a and extends from the distal end 1210a through a hole 2220 defined in the proximal end 1210b.
- the distal end 1210a is drawn toward the proximal end 1210b by drawing the actuation member 2210 toward the proximal end 1210b.
- the configuration of the closure device 200m' and of the anchoring arms 200m' in particular causes the anchoring arms 200m' to expand as illustrated in Fig. 22B.
- the closure device 200m' may be made of NiTiNoI, stainless steel or other material that is capable of elastic recovery from large deformations.
- the actuation member may be made of metal or polymeric materials with one or more strands.
- the flexural structure may be fabricated from tubing or from flat sheet.
- Figs. 23A-23D illustrate a closure device 20On' that make use of a combination of flexural hinges and pivot points.
- the closure device 20On' generally includes anchoring arms 2200, an actuation member 2210, and a body 2300.
- the anchoring arms 2200 are coupled to the actuation member 2210 by pivots 2310.
- Such a configuration may allow the actuation member 2210 to either pull the anchoring arms 2200 toward the proximal end 1210b to deploy the anchoring arms 2200, as illustrated in Fig. 23A, or push the anchoring arms 2200 away from the proximal end 1210b to deploy the anchoring arms 2200 as illustrated in Fig. 23B. Accordingly, the anchoring arms 2200 may be deployed by either pushing or pulling the actuation member 2210.
- the body 2300 includes flexing sections 2320 by which the pivots 2310 couple the anchoring arms 2200 to the body 2300. As illustrated in Fig. 23C, as the anchoring arms 2200 are deployed, the flexing sections 2320 flex outwardly to accommodate the expansion of the anchoring arms 2200 relative to the body 2300.
- the body 2300 may be tubular and may be made of NiTiNoI or stainless steel or other material that is capable of recovering elastically from large strains.
- the anchoring arms 2200 and pivots 2310 may be made from stainless steel or any other material with sufficient strength and rigidity to resist the delivery and stent opening forces.
- the actuation member 2210 may be made of metal or polymeric materials with one or more strands.
- the flexural structure may be fabricated from tubing or from flat sheet.
- Fig. 23C illustrates a closure device 200o' which includes all pivots 2310 rather than a combination of pivots and flexing sections 2320.
- closure devices 200 may be opened mechanically using a combination of actuation members, pivots, and/or flexing sections.
- Closure devices may also be used as part of a system with other closure devices in which one or more of the closure devices are deployed as a locator device to locate the system relative to an internal tissue opening and while additional closure devices are used to close the internal tissue opening.
- Figs. 24A and 24B illustrate a medical system 100' configured to locate one or more closure devices relative to an internal tissue opening and to close the internal tissue opening.
- the most distal end 1210a of the system 100' includes a distal locator device 2400a, which may be similar in operation to closure device 200m' illustrated in Figs. 22A-22B.
- the system 100' further includes a closure device 200 as well as a proximal locator device 2400b.
- the closure device 200 may be similar to the closure device illustrated in Fig. 5A while the proximal locator device 2400b may function in an analogous manner as the distal locator device 2400b.
- the distal locator device 2400a includes anchor arms 2200a.
- the anchor arms 2200a may be coupled to a first anchor 204. In one example, the anchor arms 2200a are coupled to the first anchor 204 by way of a distal stent compression tab 2410a.
- the closure device 200 is further coupled to the proximal locator device 2400b. In one example, anchor arms 2200b on the proximal locator device 2400b are coupled to a second anchor 206, such as by way of a proximal stent compression tab 2410b. In order to deploy the distal locator device 2400a, the distal locator device
- the distal locator device 2400a may first be located beyond the distal surface of an internal tissue opening.
- the distal locator device 2400a may then be deployed to expand the anchor arms 2200a as well as the first anchor 204.
- the system 100 may be drawn proximally to bring the closure device 200, and the first anchor 204 in particular, into contact with the tissue on the distal side of the internal tissue opening.
- the first anchor 204 can be drawn into contact with the septum primum.
- the proximal locator device 2400b and the second anchor 206 of the closure device 200 are then unsheathed from the delivery catheter 2410 while maintaining tension on the distal locator device 2400a.
- the second anchor 206 expands.
- the proximal locator device 2400b is pushed toward the distal end 1210a.
- the proximal locator device 2400b may be deployed to expand the anchoring arms 2200b into position against tissue on the proximal side of the internal tissue opening, such as the septum secundum in the left atrium.
- the proximal locator device 2400b can then be pulled proximally to release the second anchor 206 while the proximal locator device 2400b can then be collapsed into its linear configuration.
- the distal locator device 2400a can then be pushed distally to release the first anchor 204.
- the distal locator device 2400a may then be collapsed and the entire system, less the deployed closure device 200, may be withdrawn.
- Figs. 25A and 25B illustrate a partial view of a medical system 100" for delivering a closure device 20Op' in which the closure device 20Op' itself does not have proximal or distal anchoring arms.
- the closure device 20Op' is retained by features 2500, such as lateral extending barbs that embed into the tissue of the PFO tunnel due to the lateral force that is applied by the closure device 20Op'.
- the proximal anchor-expander has been omitted and replaced by a tab 2502 that is used to compress the closure device 20Op' to deploy the closure device 20Op' in the tunnel of an internal tissue opening, such as in the tunnel of a PFO.
- Figs. 25C-25F illustrate balloon-type closure devices for closing internal tissue openings.
- Fig. 25C illustrates a balloon-type closure device 20Oq' that includes a plurality of interconnected chambers 2505.
- Fig. 25D illustrates a view of the balloon-type closure device 20Oq' taken along section A-A. As illustrated in Figs.
- interconnected chambers 2505 can be relatively long, thin chambers that are arranged in a side-by-side configuration.
- the interconnected chambers 2505 are in fluid communication with a manifold portion 2510.
- the manifold portion 2510 receives fluid from a fill port 2515. Fluid entering the manifold portion 2510 from the fill port is then distributed to the interconnected chambers 2505 to fill the interconnected chambers 2505 with fluid.
- the interconnected chambers 2505 are configured to expand as they are filled with fluid in order to close an internal tissue opening.
- the configuration of the interconnected chambers 2505 allows the balloon-type closure device 20Oq' to have a relatively large lateral expansion relative to a thickness expansion as the interconnected chambers 2505 are inflated.
- the relatively large lateral expansion of the balloon-type closure device 20Oq' may exert a lateral force on the tunnel of an internal tissue opening to close the internal tissue opening as described above. Accordingly, the configuration of the interconnected chambers 2505 allows the closure device 20Oq' to close an internal tissue opening such as a PFO.
- Fig. 25E illustrates a balloon-type closure device 20Or' that includes flared interconnected chambers 2520. At least one of the flared interconnected chambers 2520 includes a tunnel section 2525 and a flared distal portion 2530. The flared distal portion 2530 may be configured to be expanded distally of an internal tissue opening to thereby provide a distal anchor for the closure device 20Or' . Portions similar to the flared distal portion 2530 may also be provided on the proximal ends of the interconnected chambers 2520 to thereby provide proximal anchors for the closure device 20Or'.
- Figs. 25F illustrates a closure device 200s' that includes isolated chambers
- the isolated chambers 2535 form a first anchor 2540 and a second anchor 2545.
- the isolated chambers 2535 may be inflated in a specific sequence in order to locate and deploy the closure device 200s' in a desired manner.
- an isolate chamber or chambers corresponding with the first anchor 2540 may be inflated first to locate the closure device 200s' in the entrance to the internal tissue opening.
- the first anchor 2540 may be inflated in the left atrium.
- a central chamber may be inflated next to expand the central portion 2550 of the closure device 200s' to close the tunnel of the internal tissue opening.
- a proximal chamber may then be inflated to expand the second anchor 2545.
- balloon-type closure device configurations described above and otherwise may be formed of a resorbable or non-resorbable biocompatible material. Such a configuration may allow a practitioner to leave the inflated balloon in the PFO as an occlusive implant. While specific configurations are illustrated, balloon-type closure devices may be utilized that include any number of chambers that may include any combination of isolated and interconnected chambers that may be inflated in any number of stages.
- the closure device after the closure device has been deployed, the closure device is released from the rest of the system by a release mechanism. Accordingly, several release mechanisms may be provided to release the closure devices from locator devices and/or delivery devices once the closure device has been deployed to close an internal tissue opening such as a PFO.
- the systems 100', 100" illustrated in Figs. 24A-B and 25A-B respectively may make use a post-in-hole configuration of connecting the closure devices 200 and 200o' to the medical system 100', 100" .
- Other configurations may be utilized to selectively release the closure device from the delivery system.
- Generalized attachment points will be illustrated and described for closure devices as well as generalized delivery points for the delivery devices. It will be understood that the various configurations illustrated and described below may be adapted to use with any number of delivery devices in combination with any number of closure devices.
- Figs. 26A-E illustrate several release mechanisms 2600a-e for releasing a closure device 90 from a delivery device 92.
- closure devices 90 may include an attachment member 240a-e that couples the closure device 90 to a portion of the delivery device 92.
- push members 96a-e will be described as the portion of the delivery device to which the attachment member 240 is selectively secured.
- Fig. 26A illustrates a release mechanism 2600a in which the attachment member 240a includes a post 2602 formed on the closure device 90 that engages a hole 2605 formed in the corresponding portion of the push member 96a.
- Fig. 26B illustrates release mechanism 2600b that includes an attachment member 240b and push member 96b for retaining and selectively releasing a closure device 90 from a delivery device.
- the release mechanism 2600b illustrated includes a flexible loop 2610 attached to the push member 96.
- the loop 2610 extends through a hole 2615 formed in the attachment member 364b.
- the loop 2610 is retained in position by release wire 2620.
- the release wire 2620 is pulled out of the tether loop 2610. Releasing the loop 2610 allows the closure device 90 to be released by sliding away the loop 2610 from the delivery device 300.
- Fig. 26C shows a release mechanism 2600c that makes use of an attachment member 240c that includes a tab 2622.
- the tab 2622 is configured to engage a push member 96c.
- the tab 2622 may have a dog-leg shape that is configured to extend into a slot 2624 formed in the push member 96c.
- a release wire 2625 extends into the push member 96c and maintains the tab 2622 in engagement with the slot 2624 as illustrated.
- the release wire 2625 is pulled proximally, the release wire 2625 is withdrawn from engagement with the tab 2622.
- the tab 2622 is then freed from the slot 2620 and the push member 96c may then be withdrawn from the attachment member 240c to thereby release the closure device 90.
- Fig. 26D illustrates a release mechanism 260Od that includes an attachment member 24Od and push member 96d configuration that includes flexible filament 2630.
- the flexible filament 2630 extends through a cross hole 2635 formed in the push member 96d, distally through a hole 2640 in the attachment member 24Od, and back into the push member 96d as illustrated.
- a cutting slug 2645 is also operatively associated with the push member 96d. The cutting slug 2645 is configured to be moved distally past the cross hole 2635 to thereby cut flexible filament 2630.
- the attachment member 24Od is thereby freed from the push member 96d.
- Fig. 26E illustrates a release mechanism 260Oe that has an attachment member
- nesting tab 2650 may be part of the attachment member 24Oe while nesting tab 2655 may be operative associated with the push member 96e. While the nesting tabs 2650, 2655 the attachment member 24Oe remains coupled to the push member 96e. In order to release the attachment member 24Oe, the nesting tabs 2650, 2655 are moved distally relative to the push member 96e. Once the nesting tabs 2650, 2655 are outside of the push member 96e the nesting tabs 2650, 2655 are allowed to separate to thereby release the attachment member 24Oe from the push member 96e.
- a release mechanism 260Of includes a push member 96f that is formed of a meltable material, such as, but not limited to, a polymer filament made from either a single polymer fiber or a bundle or braid of multiple fibers.
- the push member 96f may be secured to an attachment member 24Of.
- the push member 96f can be passed through a coil 2600 of electrically conductive wire.
- the coil 2700 can be attached to a current source through less resistive leads 2705.
- the current source 2705 may be configured to provide a direct current to perform the resistive heating of the coil 2700. It may also be desirable for the current source 2705 to provide alternating current with the alternating current ranging up to radio frequencies.
- the coil 2700 may also be covered with an optional insulating layer 2710. The inclusion of an insulating layer 2710 may aid with transfer of heat from the coil 2700 as it is heated to the surrounding tissues or fluids.
- a release mechanism 260Of the resistive coil 2700 forms a resistive temperature device (RTD) which provides feedback with respect to the temperature of the push member 96f while a current is applied to the coil 2700.
- the coil 2700 in this case may be made of a metal that exhibits a relatively large change in resistance as it is heated such as, but not limited to, nickel, copper, or platinum.
- the actual temperature of the push member 96f may be monitored at intervals during heating by removal of the heating current, and then applying a known voltage through the delivery mechanism 260Of, which may include the coil 2700. The resulting resistance measurement may then be proportional to the temperature of the coil as with a conventional RTD.
- Fig. 27B is a schematic diagram of a release mechanism 260Og that includes a bimetallic actuator 2720.
- the bimetallic actuator 2720 may be configured to provide for mechanical detachment of a closure device (not shown) from a delivery device at a specified temperature or temperature range.
- the bimetallic actuator 2720 includes a coiled, bimetallic strip 2725 that can be connected to a securing member 2730, which couples an attachment member 24Og to a push member 96g.
- the securing member 2730 allows the push member 96g to drive the attachment member 24Og when the securing member 2730 is in place.
- the securing member 2730 engages both the attachment member 24Og and the push member 96g such that movement of the push member 96g is transferred from the push member 96g to the securing member 2730 and thence to the attachment member 24Og.
- the bimetallic strip 2725 is configured to uncoil at elevated temperatures. As the bimetallic strip 2725 uncoils, the securing member 2730 is drawn from its connection to the push member 96g. After the securing member 2730 is drawn from engagement with the attachment member 24Og, the attachment member 24Og may move freely and thus be released from the release mechanism 260Og. Further movement of the bimetallic strip 2725 may release the push member 96g, which may then be withdrawn proximally as desired.
- Fig. 27C is a schematic diagram of a release mechanism 260Oh that includes a bimetallic coil 2725.
- the bimetallic coil 2725 is coupled to a lever arm 2735 which in turn is coupled to a securing member 2730.
- the lever arm 2735 rotates about a pivot point 2740.
- the lever arm 2725 includes a relatively short portion 2745a proximate to the bimetallic coil 2725 and a relatively long portion 2745b proximate the securing member 2730.
- Such a configuration may amplify the amount of movement that is realized by the uncoiling of bimetallic coil 2725.
- Figs. 27D-27H illustrate release mechanisms 260Oi-I that may make use of shape memory materials.
- the release mechanism 260Oi includes a shape memory actuator 2750.
- the shape memory actuator 2750 is secured to a closure device 90.
- a first portion 2750a of the shape memory actuator 2750 is secured to an attachment member 240i of the closure device 90.
- the closure device 90 further has a recess 2755 defined therein opposite the attachment member 24Oi.
- the shape memory actuator 2750 extends from the attachment member 24Oi through a push member 96i and into engagement with the recess 2755.
- the shape memory actuator 2750 extends through a loop 2757 in the push member 96i while in the secured position illustrated in Fig. 27D a second portion 2750b of the shape memory actuator 2750 extends into the recess 2755 to retain the push member 96i to the closure device 90.
- the recess 2755 may also be made formed a wire loop or other securing point for the shape memory actuator 2750.
- the shape memory actuator 2750 may also have a shape that will adapt to be secured within the recess 2755. While a pin and loop configuration is described in this and other examples, other pin and receiving member configurations may also be utilized to retain a closure device until the closure device is selectively released.
- Fig. 27E depicts the release of the push member 96i by heating the shape memory actuator 2750. More specifically, as the shape memory actuator 2750 is heated to a temperature above the transition temperature of the shape memory material, the shape memory actuator 2750 may then recover to the preset shape illustrated in Fig. 27E.
- the preset shape of the shape memory actuator 2750 may be a coiled configuration such that the shape memory actuator 2750 may be drawn toward the attachment member 24Oi to release the push member 96i. As the push member 96i is released, the closure device 90 is free to move relative to the push member 96i and is thereby released as well.
- Figs. 27F and 27G are schematic views of a release mechanism 260Oj that includes a plurality of shape memory actuators 2750a, 2750b.
- the shape memory actuators 2750a, 2750b may extend in opposing directions from opposing portions of a closure device 90 while the shape memory actuators 2750a, 2750b remain below the transition temperatures of the shape memory materials of which the shape memory actuators 2750a, 2750b are formed.
- at least a portion of each of the shape memory actuators 2750a, 2750 b extend through a loop 2757 formed in a push member 96j .
- Fig. 27G illustrates the shape memory actuators 2750a, 2750b that have been heated to a temperature above the transition temperature of the shape memory material.
- the shape memory actuators 2750a, 2750b return to their preset states, which may be the coiled configurations illustrated in Fig. 27G.
- the shape memory actuators 2750a, 2750b return to their preset states, the shape memory actuators 2750a, 2750b are removed from their securing positions relative to a loop 2757 in the push member 96j to release the push member 96j as shown in Fig. 27G.
- the heat input for heating shape memory actuators 2750, 2750a, 2750b may be provided by external exposure to elevated temperatures, radio frequency heating or applying an electrical current through the actuator member.
- multiple shape memory securing members may be made to release the push member.
- these multiple shape memory securing members may have actuators that transition at different temperatures which can allow for one part of the device to be released at one temperature and another portion of the device to be released at a second temperature.
- the push member or push members may comprise of a conductive material and an electrical connection to the implant may also be severed during the release of the push member. Combinations of the above embodiments may be utilized to provide both the desired mechanical detachment from the implant as well as to cause the actuation to occur at a pre-defined temperature or temperatures.
- the push member may include a central portion that includes one or more filaments, such as a polymer filament, or a bundle of filaments or braid.
- filaments such as a polymer filament, or a bundle of filaments or braid.
- Polymers may include, without limitation nylons, Dacron, polyester, polyethylene, Teflon, PTFE, Kevlar, Spectra or the like. These materials may also be components of a larger push member system which extends to the proximal, operable end of the device and consist of a polymer catheter or metallic hypotube of stainless steel or other biocompatible alloys.
- Figs. 271 and 27J illustrate a release mechanism 2600k that includes a cutting feature 2760.
- the cutting feature 2760 is coupled to a shape memory actuator 2750c.
- the shape memory actuator 2750c in turn is secured to a first portion 2765 of a closure device 90.
- a push member 96j is secured to a second portion 2770b of the closure device 90.
- the push member 96j extends away from the second portion 2770b and through an opening 2772 formed in the cutting feature 2760 while the shape memory actuator 2750c remains below the transition temperature and thus in an initial position.
- the shape memory actuator 2750c moves to the preset shape illustrated in Fig. 27J.
- the shape memory actuator 2750c is drawn toward the first portion 2765 of the closure device 90.
- Drawing the shape memory actuator 2750c toward the first portion 2765 of the closure device also draws the cutting feature 2760 in the same direction, which causes the cutting feature 2760 to sever the push member 96j.
- the closure device 90 is thereby released from the push member 96j.
- shape memory alloys may also be used to actuate the release of a securing member 2730 as illustrated in the release mechanism 2600k' in Figs. 27K and 27L.
- a shape memory actuator 275Od is secured to a closure device 90, which is depicted as ground.
- a linkage 2775 is coupled at a first end 2775a to the shape memory actuator 275Od and at a second end 2775b to the securing member 2730.
- the linkage 2775 is configured to rotate about a pivot 2735, the pivot 2735 being secured to the closure device 90.
- the linkage 2775 is configured to rotate in response to movement of the shape memory actuator 275Od such that movement of the shape memory actuator 275Od is transferred by the linkage to the securing member 2730.
- Fig. 27L illustrates the shape memory actuator 275Od returning to a preset state that corresponds to the shape memory material of the shape memory actuator 275Od being heated to a temperature above the transition temperature. As illustrated in Fig.
- the shape memory actuator 275Od returns to its preset state, the first end 2775a is drawn toward the closure device 90 thereby drawing the securing member 2730 first from engagement with the push member 96k' and then engagement with the attachment member 240k'. As a result, heating the shape memory actuator 275Od releases the closure device 90 from the push member 96k'.
- a phase change of a material in an enclosed space may also provide for the actuation of a release mechanism 26501, as shown in 27M and 27N.
- Fig. 27M depicts a cylinder 2780 and piston 2785 attached to a closure device 90.
- the cylinder 2780 and piston 2785 are operative associated with a linkage 2775 that is coupled to a securing member 2730.
- the securing member 2730 secures the push member 961 to an attachment member 2401, the attachment member 2401 being part of the closure device 90.
- Heating the material within the cylinder 2780 generates pressure which drives the piston 2785 away from the cylinder 2780.
- the piston 2780 drives the linkage 2775 and thus the securing member 2730.
- the push member 961 is released from the closure device 90.
- phase change materials that may be utilized in this system for expansion upon heating may include, without limitation, various hydro-carbon fluids such as heptane, isopropyl alcohol and the like. Formulations of waxes such as those used in the thermostats of common automotive engine thermostats may also be utilized.
- portions of the release mechanism such as the shape memory actuators
- portions of the release mechanism are attached to the closure device. Such attachment may be switched and/or altered as desired.
- shape memory actuators may be attached to the push member.
- shape memory actuators may be attached in combination to the closure device and the push member.
- shape memory actuators may be attached to other portions of the medical system.
- delivery device 2800 which can be used to deploy a closure device 90 (. Furthermore, the method of using delivery device 2800 will also be described.
- delivery device 2800 can include a main handle 2802, a guide catheter 2818 coupled to and extending distally from main handle 2802, a pusher handle 2820 coupled to main handle 2802, a release knob 2826 coupled to pusher handle 2820 and an end cap 2832.
- Main handle 2802 can have an elongated cylindrical shape and can be substantially hollow.
- Main handle 2802 can be configured to assist a user in placing closure device 100.
- a flush line 2816 In fluid communication with a portion of the main handle 2802 can be a flush line 2816, while selectively movable relative to the main handle 2802 can be first and second stops 2812, 2814.
- Flush line 2816 can be configured to be in fluid communication with guide catheter 2818.
- First stop 2812 can be configured to be received in a first groove 2804 (Fig. 29) and second stop 2814 can be configured to be received and at least partially movable in a second groove 2806 (Fig. 29).
- First groove 2804 can extend radially along the circumference of main handle 2802.
- First groove 2804 can be configured to receive first stop 2812 therein and allow first stop 2812 to at least partially rotate therein.
- First groove 2804 can include a first opening 2808.
- First opening 2808 can extend through the wall of main handle 2802.
- First opening 2808 can be configured to receive a set screw (not shown) positioned in a hole disposed through first stop 2812. This hole enables the set screw to be received within first opening 2808 can limit rotational movement of first stop 2812 relative to main handle 2802. It will be understood that a portion of the first stop 2812, instead of or in addition to the set screw, can extend into first opening 2808.
- second groove 2806 can extend radially along the circumference of main handle 2802. Second groove 2806 can be configured to receive second stop 2814 therein and allow second stop 2814 to at least partially rotate therein. Second groove 2806 can include a second opening 2810. Second opening 2810 can extend through the wall of main handle 2802. Second opening 2810 can be configured to receive a set screw (not shown) positioned in a hole disposed through second stop 2814. This hole enables the set screw to be received within second opening 2810 can limit rotational movement of second stop 2814 relative to main handle 2802. It will be understood that a portion of the second stop 2814, instead of or in addition to the set screw, can extend into second opening 2810
- First stop 2812 can be received in first groove 2804 and can at least partially rotate circumferential Iy in first groove 2804. At least a portion of first stop 2812, or the set screw passing through the first stop 2812, can extend in and through first opening 2808. First stop 2812 can be configured to enable selective deployment of PFO closure device 3000, as will be discussed more fully herein below.
- second stop 2814 can be received in second groove 2806 and can at least partially rotate circumferentially in second groove 2806. At least a portion of second stop 2814, or the set screw passing through the second stop 2814, can extend in and through second opening 2810. Second stop 2814 can be configured to enable selective deployment of PFO closure device 3000, as will be discussed more fully herein below.
- first and second stops 2812 and 2814 can correspond to the distance sufficient to expose and deploy distal anchors 3006 from guide catheter 2818 as pusher handle 2820 moves with respect to main handle 2802 in the distal direction while maintaining proximal anchors 3008 within guide catheter 2818.
- PFO closure device 3000 can be inserted into the distal end of a guide catheter 2818 in a manner such that proximal anchors 3008 extend proximally and distal anchors 3006 extend distally within guide catheter 2818. PFO closure device 3000 can be attached to delivery device 2800 through use of tabs 3012.
- Delivery device 2800 can further include a pusher tube 2834 (Fig. 31).
- Pusher tube 2834 can be received and movable in guide catheter 2818 (Fig. 28) and can substantially extend from the distal end of guide catheter 2818 to pusher handle 2820.
- Pusher tube 2834 can be coupled to pusher handle 2820, such that movement of pusher handle 2820 relative to main handle 2802 can result in movement of PFO closure device 3000 out of the distal end of catheter shaft.
- delivery device 2800 can include one or more flexible tubes 2836 (Figs. 30A-31).
- the number of flexible tubes 2836 can optionally correspond with the number of tabs 3012 of PFO closure device 100.
- flexible tube 2836 can be coupled to pusher tube 2834 such that movement of pusher tube 2834 can result in movement of flexible tube 2836.
- pusher tube 2834 can receive various wires, tubes, etc. of delivery device 2800 and the aid with deploying device 3000.
- pusher tube 2834 can receive a thermocouple, a tubular member receiving the thermocouple and associated electrically communicating wire(s), RF energy delivery and return wire(s) or conductor(s), or the like.
- one flexible lube 2836 is spaced apart from two adjacently positioned flexible tubes 2836.
- the resultant gap can receive a portion of the wires, tubes, etc. received by the pusher tube 2834.
- the thermocouple, the tubular member receiving the thermocouple and associated electrically communicating wire(s), the RF energy delivery and return wire(s) or conductor(s), or the like can exit from the pusher tube 2834 and pass to the closure device 3000.
- each flexible tube 2836 can include a tube cap 2840, as illustrated in Figure 30A-30C.
- Tube cap 2840 can be sized and configured to receive tab 3012 therein.
- Tube cap 2840 can include a slot 2842 sized and configured to receive a foot 3014 of tab 3012 therein. The size and configuration of tube cap 2840 can be such that with foot 3014 of tab 3012 is in slot 2842, a detachment wire 2838 can extend through and out of the distal end of tube cap 2840.
- detachment wire 2838 can serve to bias and substantially hold tab 3012 in tube cap 2840 and thus substantially prevent detachment of PFO closure device 3000 from delivery device 2800 until detachment wire 2838 is moved away from foot 3014, as will be described herein below.
- Fig. 30A-C illustrate a single flexible tube 2836 as detachment wire 2838 is sequentially moved proximally to enable foot 3014 to be removed from tube cap 2840.
- Guide catheter 2818 can be coupled to main handle 2802.
- Guide catheter 2818 can be configured to house at least a portion of pusher tube 2834 and other portions of the device 2800 therein.
- Guide catheter 2818 can further be configured to allow pusher tube 2834 to rotate and translate therein.
- the distal end of guide catheter 2818 can be configured to receive PFO closure device 3000 therein.
- pusher handle 2820 can be a substantially hollow, rigid generally cylindrical member.
- Pusher tube 2834 can be coupled to pusher handle 2820.
- pusher handle 2820 can include a first portion 2820a and a second portion 2820b.
- First portion 2820a can be sized and configured to be received and movable within at least a portion of main housing 2802.
- First portion 2820a can include a track 2822.
- Track 2822 can be configured to serve as a guide for stops 2812 and 2814.
- Track 2822 can be configured to receive set screws of stops 2812 and 2814 therein, such that set screws can translate along track 2822.
- Track 2822 can include various points, generally labeled as Point #1, Point #2, Point #3 and Point #4.
- the distance between Points #3 & #1 can correspond to the distance sufficient to expose and deploy distal anchors 3006 from guide catheter 2818 as pusher handle 2820 moves with respect to main handle 2802 in the distal direction. Furthermore, this distance can be sufficient to maintain proximal anchors 3008 within guide catheter 2818.
- the distance between Point #2 and the most proximal point in track 2822 can correspond with a distance sufficient to enable the entire PFO closure device 3000 to deploy from guide catheter 2818.
- First and second stops 2812 and 2814 can be movable between a closed and open position.
- first stop 2812 is in a closed position when the set screw of first stop 2812 is at Point #1 and in an open position when the set screw is at either of Points # 2 or #4.
- Second stop 2814 is in the closed position when the set screw of second stop 2814 is either at Points #3 or #1, and in the open position when the set screw of second stop 2814 is at either of Points #2 or #4.
- first and second stops 2812 & 2814 are in the closed position; as illustrated in Figures 34A & 35A, first stop 2812 is in the open position and second stop 2814 is in the closed position; as illustrated in Figs. 36 & 37A, first and second stops 2812 & 2814 are both in the open position.
- Second portion 2820b of pusher handle 2820 can be configured to receive at least a portion of release knob 2826 therein.
- Second portion 2820b can include a pin hole 2824 through which a pin 2824a can be received.
- Pin 2824a can be configured to be received and movable along a track 2828 of release knob 2826.
- the various pin and groove configurations serve as a guide and that other configurations can perform the same function without departing from the scope and spirit of the invention.
- the pin and groove configurations may be replaced by various linkages which allow movement sufficient to enable the various elements of the invention to function correctly.
- Release knob 2826 can be configured to facilitate detachment of the closure device 3000 from delivery device 2800. At least a portion of release knob 2826 can be sized and configured to be received and movable within the proximal end of pusher handle 2820. Detachment wires 2838 can be coupled to release knob 2826. In this manner, movement of release knob 2826 relative to pusher handle 2820 in the proximal direction can result in detachment of PFO closure device 3000 from delivery device 2800.
- Release knob 2826 can include a track 2828.
- Track 2828 can be configured to receive a portion of the pin 2824a (Fig. 32) from second portion 2820b of pusher handle 2820 therein and serve as a guide for movement of the pin 2824a.
- Track 2828 can be configured to allow release knob 2826 rotate and/or translate relative to pusher handle 2820 in either clockwise or counterclockwise directions.
- the configuration of track 2828 can constrain the movement of release knob 2826 relative to pusher handle 2820 such that the path of movement of release knob 2826 relative to pusher handle 2820 is prescribed by the configuration of track 2828.
- Track 2828 can include a detent 2830.
- Detent 2830 can be configured to reduce movement of release knob 2826 relative to pusher handle 2820, such that release knob 2826 does not inadvertently move detachment wires 2836 relative to tube cap 2840 thus enabling displacement of foot 3014 of PFO closure device 3000 out of slot 2842 of tube cap 2840.
- Delivery device 2800 can further include an end cap 2832, as illustrated in Figure 34A.
- End cap 2832 can be coupled to the proximal end of release knob 2826.
- End cap 2832 can be configured to allow various wires and/or tubes to extend therethrough, such as, but not limited to, a thermocouple, electrode wires, RF wire(s) or conductor(s).
- Guide catheter 2818, main handle 2802, pusher handle 2820 and release knob 2826 can also be configured to allow various wires to extend therethrough, such as a thermocouple, electrode wires, and/or RF wire(s) or conductor(s).
- guide catheter 2818 and main handle 2802 can further be configured to allow pusher shaft 2836 to extend therethrough and be moveable therein.
- the guide catheter 2818 is adapted to be positioned through the PFO such that the distal end of guide catheter 2818 is in the left atrium.
- the PFO closure device 3000 can then be deployed from guide catheter 2818 by moving pusher handle 2820 relative to main handle 2802, whether such movement includes moving pusher handle 2820 toward main handle 2802, main handle 2802 toward pusher handle 2820, or a combination thereof. This can be accomplished by the following procedure. First, first stop 2812 can be moved from the closed position to the open position, thus moving the set screw of first stop 2812 from Point #1 to Point #2, as illustrated in Figure 34A.
- main handle 2802 can be moved proximally with respect to pusher handle 2820 such that the set screw of first stop 2812 moves from Point #2 to Point #4 and the set screw of second stop 2814 moves from Point #3 to Point #1, as illustrated in Figure 35 A.
- This movement of main handle 2802 relative to pusher handle 2820 can be sufficient to cause distal anchors 3006 of closure device 3000 to extend out from the distal end of guide catheter 2818 and deploy into the left atrium.
- a user can then manipulate the main handle 2802 until distal anchors 3006 are positioned against tissue adjacent the PFO in the left atrium.
- proximal anchors 3004 a user can move second stop 2814 to the open position (set screw of second stop 2814 moves from Point #1 to Point #2) as illustrated in Figure 36, and then further proximally move main handle 2802 relative to pusher handle 2820, as illustrated in Figure 37A.
- the length of track 2822 from Point #2 to the terminating proximal point can be sufficient so as to allow main handle 2802 to move enough for proximal anchors 3008 to fully extend out of the distal end of guide catheter 2818 and deploy, thus engaging the tissue adjacent the PFO in the right atrium.
- PFO closure device 3000 can be detached from delivery device 2800 through use of release knob 2826.
- Moving release knob 2826 proximally with respect to pusher handle 2820, as illustrated in Figure 38A, can cause detachment wire 2838 to be pulled proximally through tube cap 2840.
- the configuration of track 2828 of release knob 2826 and pin of pusher handle 2820 enable release knob 2826 to be moved relative to pusher handle 2820 sufficiently to cause detachment wire 2838 to move proximally past foot 3014 of tab 3012.
- foot 3014 can be moved out of slot 2842 via the ramp 3014a of foot 3014.
- tab 3012 can be detached from flexible tube 2836, and thus detached from delivery device 2800.
- PFO closure device 3000 is positioned and delivery device 2800 can be removed from the patient.
- the present invention can more generally apply to the delivery and positioning of a structure disposable within a body lumen, where the structure can optionally receive RF or other electromagnetic energy to aid with implanting the structure, whether or not the structure is a generally planar structure. Additional information regarding the structures, functions, use and operation of the closure device 3000, delivery device 2800, and the inventions disclosed herein are disclosed in Exhibits A, B and C attached hereto and by reference incorporated herein.
- Fig. 39A illustrates a closure device 90 that includes an in-growth media configuration 3900 attached thereto.
- the closure device 90 includes a plurality of cells 3902.
- the in-growth configuration 3900a may include filament 3905 secured to a central portion of the closure device 90. Securing filament 3905 to the central portion of the closure device 90 may encourage tissue in-growth into the closure device 90 within the center of the closure device 90 rather than the perimeter portions of the closure device 90 that may be exposed to flowing blood.
- the filaments 3905 are coiled around portions of one or more of the cells 3902.
- In-grown material in this embodiment can include fibers of bio-compatible polymers such as Dacron (polyester),PTFE, or other filaments that provide a relatively large amount of surface area into which tissue can grow.
- the filament 3905 is depicted as a single fiber. While a single fiber may be used, the filament 3905 may also represent a fiber bundle which may have a braided structure, or a twisted structure. The surface of the fiber bundle may have many protruding ends of the individual fibers as a result of a looser braid or twist. The additional fiber ends can provide surfaces for in-growth as tissue forms around them. The fiber or fiber bundle may be secured to the structure of the cell 3910 by thermal bonding or adhesives.
- An in-growth configuration 3900b that includes filament 3905 is shown in Fig.
- the closure device 90 may include features 3910, such as holes, formed into the closure device 90.
- the features 3915 may provide additional anchoring points for the filament 3905 additional anchoring points.
- the filament 3905 may be loosely sewn through these points, or fixed by adhesive or knots in the filament near each feature 3910 through which the filament 3905 passes.
- the filament 3905 may extend over only a single cell or throughout all of the cells of the structure. Further, the path of the filament 3905 is shown being weaved to alternating sides of the structure. In such a configuration, the 3905 may have the ability to take up space out of the plane of the structure. Additionally, when the closure device 90 is in a compressed state for delivery, all of the fiber material may be kept out from between the struts of the closure device 90, which may allow for more efficient packing of the compressed structure for delivery through or by way of a catheter.
- in-growth media such as in-growth filaments
- in-growth media may be attached to the closure device by way of loops of wire, suture material or threads of in-growth material.
- the in-growth media may be attached to one side of the closure device structure.
- the in-growth media may be sandwiched between two PFO closure devices that are connected. The use of multiple closure devices may provide for the separation of functions of the structure (e.g. anchoring and tissue expansion) while also providing a secure place for the media.
- the in-growth media may be woven through the cells of the closure device and can be secured by the weaving or additional securing techniques or members could be provided as well.
- the in-growth configuration 3900c includes filament 3905 secured to the closure device 90 in a pattern.
- the pattern of the in-growth configuration may increase the relative amount of in-growth media that is secured to the closure device 90.
- the points at which the filaments 3905 are attached are maintained at a constant distance from each other as the closure device 90 is deployed.
- Such a configuration may provide for a degree of tightness of the filament 3905 remains relatively constant over a wide range of deployment.
- Fig. 39D illustrates an in-growth configuration 390Od in which the points at which the filament 3905 is secured to the closure device 90 are not maintained at a constant distance from each other as the closure device 90 is deployed.
- Fig. 39E illustrates an in-growth configuration 390Oe in which strips 3915 ingrowth media are secured to the closure device 90.
- the strips 3915 of ingrowth media may be secured to opposite sides of a cellular portion of the closure device 90.
- the strips 3915 may be loosely woven gauze-like material that is woven into an interlocking structure.
- the strips 3915 may be secured to the closure device 90 in any suitable manner.
- Fig. 39F in one configuration 390Of the strips 3915 may be wrapped around a cellular portion of the closure device 90 and back onto the strips 3915. The overlapping portions of the strips 3915 may then be secured to each other.
- Fig. 39G illustrates an in-growth configuration in which one or more membrane 3920 are secured to a closure device 90.
- the membrane 3920 may include a number of materials, including, without limitation, fibers of Dacron (polyester), PTFE, or bio-absorbable polymers which are formed into a membrane through weaving, knitting, or some other manner.
- the membrane patterns may be precut as desired and secured to the closure device 90 in any suitable manner.
- in-growth media may also be secured to multiple closure devices that are configured to be deployed in concert.
- Fig. 39H illustrates an in-growth configuration in which the membrane 3920 is sandwiched between two closure devices 90a, 90b that have been crimped together. The use of multiple closure devices 90a, 90b may increase the stiffness of the two devices when used together while allowing secure attachment of the membrane 3920.
- Figs. 391 and 39J also illustrate additional configurations in which multiple closure devices are used in concert.
- the closure devices 90c, 9Od are configured differently.
- Fig. 39K illustrates a similar configuration in which closure devices 9Oe, 9Of are different.
- the second closure device 9Of may be biased out-of- plane relative to the first closure device 9Oe.
- Such a configuration may also provide out-of-plane structure to contact surrounding tissues to thereby secure the closure device 9Oe in the internal tissue opening.
- Figure 39K illustrates one embodiment of a closure device 200 that can include a member 250, such as an ingrowth material.
- the member 250 can be configured to induce tissue growth.
- the member 250 can be fixed to the closure device 200 by means of a securing element, such as a thread 252.
- the thread 252 can extend through the member 250 and through the apertures in the intermediate portions 234 in order to secure the member 250 to the closure device 200.
- the member 250 can be secured to the closure device 220 by a known securing means, such as by an adhesive, a heat weld, or some other known or hereafter developed means for securement.
- the member 250 and the thread 252 can include a bio-resorbable material, such as polylactide or polyglycolide or collagen.
- the member 250 can be sized and configured to enable the closure device 200 to be deployed from and received into the delivery portion 366 of the delivery device 300.
- the member 250 can be configured to interact with tissue of the internal tissue opening to stimulate growth of tissue for closure of the internal tissue opening.
- the member 250 can interact with the tunnel tissue 58 of a PFO in order to stimulate growth of tissue in the PFO tunnel 58.
- the member 250 can be any suitable material which can or tends to promote tissue growth. Examples of such material can include a polymeric material, or a woven material, such as a woven metallic or biological material.
- the member 250 can be a piece of foam.
- the member 250 can be a piece of yarn, fabric or string, or some combination thereof.
- Other tissue growth promoting members can include a coating disposed on the closure device 200.
- the member 250 can be a piece of foam, braided material such as a piece of yarn or string, or fabric which has a coating disposed thereon.
- the member 250 can include materials such as a piece of polyurethane or some other biocompatible polymer, including bioresorbable polymers.
- the member 250 can also include Dacron or polymeric threaded material which have been woven or knitted, or formed into compressed, non-woven fabrics.
- the member 250 can also include a metallic material, such as a NiTiNoI, stainless steal or some other biocompatible alloy or bioresorbable metal, such as magnesium alloy, or some combination thereof.
- the member 250 comprises a metallic wire.
- Figure 39M illustrates a side view of the closure device 200, and illustrates one example of the closure device having a substantially flat configuration.
- the closure device 200 can include a depth or depth thickness designated as DT, and a plane 260 extending perpendicular into and out of the plane of the page.
- the member 250 can extend beyond at least a first edge 262 of the closure device 200. Furthermore, the member 250 can extend beyond both the first edge 262 and a second edge 264 of the closure device 200. In this manner, member 250 can contact tissue adjacent the closure device 200 to promote tissue growth in the tissue opening.
- the member 250 can be sized and configured to extend beyond at least the first edge 262 of the closure device 200 a sufficient distance to contact tissue of the tissue opening. In one embodiment, the member 250 can extend beyond at least the first edge 262 a sufficient distance to contact tissue adjacent the first edge 262, thereby causing the end of the member 250 which is in contact with the tissue to deflect or bend. In this manner, more surface area of the member 250 can be in contact with tissue to thereby facilitate an increase in tissue growth. In other embodiments, the member 250 can extend beyond both the first edge 262 and the second edge 264 a sufficient distance to cause both ends of the member 250 to bend, which can result in more surface area contacting the tissue. In one embodiment, the member 250 can extend between at least .5mm and 5mm beyond the first edge 262.
- the member 250 can extend between at least .5mm and 5mm beyond the first edge 262, and can extend between at least .5mm and 5mm beyond the second edge 264. Furthermore, the member 250 can have a thickness of between at least .25mm and 2mm.
- the member 250 can be configured to decrease the size of a remaining void in the tissue opening after the closure device 200 has been positioned in the tissue opening.
- Member 250 extending beyond the first edge 262 of the closure device 200 is an example of the member 250 extending substantially out of plane of the substantially flat configuration.
- cell structures may be variable and/or irregular. A completely random structure of very small cells can also have properties that provide the correct force to the internal tissue opening. These structures may be constructed of fine wire that has been shaped into the desired flat form but has sufficient voids to allow for compressibility within a delivery system. Other random celled structures may be constructed from polymer foams such as but not limited to ePTFE or polyurethane.
- the surface finish may be electo- polished.
- all, or specific portions of the device may be electro- polished to provide a smooth and trauma-free surface.
- the edges of the device may be specifically designed to contact the inner side walls of the tunnel may be electro- polished to prevent sharp edges of the structure from puncturing the tissues except for specific locations where it is desired for anchoring.
- a smooth surface on the edge can also be amenable to coating which can add lubricity for ease of delivery.
- Rougher surfaces on surfaces of the device other than the outer edge may be desirable and can aid in providing anchoring locations and/or locations for more aggressive tissue in- growth after implantation. In portions of the structure where more roughness is desired, the roughness may be added by grit-blasting, chemical etching or other mechanical means using appropriate abrasives.
- Polymer structures may be similarly smooth or textured as desired for fixation and in-growth.
- Closure devices can also be adapted to serve as a drug delivery platform and/or the placement of other substances that can enhance the closing of internal tissue openings.
- drugs may be delivered by elution, such as from a polymer-based coating.
- Such drugs may include, without limitation, drugs that can induce the closing of an internal tissue opening, such as vascular endothelial growth factor, synthetic or naturally occurring proteins, and/or refined proteins such as collagen or bovine serum albumin.
- Structures that perform the same functions as the multi-celled structures may also be constructed from a single member.
- the single- member structure may include anchoring features as shown in where anchor is made to anchor the device from the distal side of its deployment. After the waist of the structure, a portion of the member is constructed to provide lateral and anchoring force within the opening. The bottommost portion of the device will provide the support for the distal anchors as well as the lateral force exerted through the waist of the device.
- a relief in the most proximal portion of the member may be provided to allow the closure device to be collapsed within a catheter for delivery. Other means of providing this relief may be used such as a coil spring or a localized material property modification of that section of the member.
- a single member structure may also have integral, more complex anchors (3) as depicted in Fig. 14B.
- Threads or fabric of polymeric materials such as Dacron felt, fabrics or filaments, PTFE, ePTFE or the like may be wrapped around the struts of the PFO closure device or woven through the cells to provide more aggressive tissue in-growth surfaces where desired.
- Fine metallic wires, meshes or braids may also be used.
- fabric or thin membranes may be sewn, welded, or adhered to the struts to cover any desired part of the PFO closure device.
- a medical device that has a multi-cellular structure being configured to be moved from a collapsed state to an expanded state, the multi-cellular structure including a waist portion and at least one anchor portion, wherein the anchor portion is wider in the expanded state of the device than the waist portion and the waist portion is configured to engage a tunnel of an internal tissue opening in the expanded state to close the internal tissue opening.
- This device can also include one or more distal anchors and/or proximal anchors. These anchors can be substantially the same width, or one may be wider than the other. These anchors may also include a plurality of elongate arms.
- One or more of the elongate arms may have a serrated edge, such as a serrated edge is configured to face toward the center of a tunnel of an internal tissue opening when the medical device is deployed.
- the elongate arms may also have smooth edges.
- the multicellular structure may include a plurality of cellular portions having substantially the same size or the cellular portions may be of different sizes.
- the medical device may also be configured to shorten its overall length dimension upon deployment. If the medical device has a distal anchor and a proximal anchor, the proximal anchor may be configured to roll at least partially onto itself upon deployment to shorten the overall length of the medical device upon deployment.
- the medical device may a spring member secured to the waist and a solid anchor portion.
- the solid anchor portion may be a solid proximal anchor portion.
- the waist portion of the medical device may also include a hinged portion.
- the medical device may be formed of a resilient material such that the medical device is configured to expand from the compressed state to the expanded state due at least in part to spring forces associated with the resilient material.
- the medical device may also be configured to be expanded from the compressed state to the expanded state mechanically.
- a medical device according to one example includes opposing expansion members and at least one connecting member coupling the opposing expansion members.
- the connecting member may be configured to move the opposing expansion members from a compressed state to an expanded state to seal an internal tissue opening.
- the medical device may also include a plurality of connecting members and pinned joints between adjacent connecting members and between the connecting members and the opposing expansion arms.
- the pinned joints may include a ratcheting mechanism configured to allow the connecting members to move relative to each other to allow expansion of the expansion members during deployment but to prevent the expansion members to collapse after deployment of the medical device.
- the medical device may further include an actuation member, such as a cable or tether, coupled to at least one connecting member.
- the expansion arms may be configured to be expanded from the compressed to the expanded state by drawing the actuation member proximally.
- the medical device may also include a locking member configured to lock the expansion member in the expanded state.
- the locking member may include a clasp operatively associated actuation member.
- the connecting member may have a strut and piston configuration.
- a medical device in yet another configuration, includes a plurality of elongate arms and an actuation member coupled to the elongate arms, the actuation member being configured to mechanically expand the elongate arms from a collapsed position to an expanded position.
- the actuation member may include alternating thinner portions between relatively thicker portions. Further, the actuation member may be configured to be drawn proximally and/or moved distally to mechanically expand the elongate arms.
- the medical device may also include a body portion operative associated with the elongate arms. The body portion may include flexing sections and/or pivots coupling the elongate arms to the body portion.
- the medical device may be a distal locator device, a proximal locator device, and/or a closure device.
- a medical system includes a first medical device having expandable elongate arms, the expandable elongate arms being configured to expand from a collapsed state to an expanded state and to locate an opening of an internal tissue opening, and a second medical device operatively associated with the first medical device, the second medical device having a multi-cellular structure being configured to be moved from a collapsed state to an expanded state, the multi-cellular structure including a waist portion configured to engage a tunnel of an internal tissue opening in the expanded state to close the internal tissue opening.
- the first medical device may be a distal locator device or a proximal locator device.
- the first medical device may be configured to locate a distal opening of the internal tissue opening.
- the system may further include a third medical device operatively associated with the second medical device, wherein the third medical device includes expandable elongate arms, the expandable elongate arms being to expand from a collapsed state to an expanded state and to locate a proximal opening of the internal tissue opening.
- the second medical device may include outwardly facing tines, first anchor portions, and/or second anchor portions.
- a device for releasing an implant within a body lumen includes an attachment member coupled to the implant, a push member operatively associated with the attachment member.
- the device may be configured to secure the implant to a delivery device before release of the implant and to selectively release the attachment member.
- the attachment member may have a post configuration and the push member has a hole defined therein to receive the post.
- the attachment member may include a loop of material coupled to the push member and a pin, the loop extending through a hole formed in the attachment member and being secured to the attachment member by the pin, wherein removing the pin releases the attachment member.
- the attachment member may also include a tab while the push member includes a pin configured to retain the tab in contact with the push member.
- the tab may have a dog-leg shape.
- the push member may include a slot defined therein configured to receive a portion of the tab while the device further includes a release wire configured to retain the tab in the slot and to be withdrawn to release the tab from the slot.
- the pin and tab may be interlocking members held in engagement while retained within the push member and that are released when moved from the push member.
- the push member may be formed from a meltable material.
- the device may further include a coil of electrically conductive wire in which a portion of the push member extends at least partially through the coil. The device is configured to release the attachment member by heating the coil to melt a portion of the push member. Insulation may surround at least a portion of the coil.
- the device may also include a current source configured to provide a direct current and/or alternating current to the coil.
- the current source may be configured to provide an alternating current to the coil at a frequency up to radio frequencies.
- the coil may also be configured a resistive temperature device and may be formed from nickel, copper, and/or platinum or any other suitable material.
- the device includes bimetallic actuator configured to release the attachment member from the push member at a specified temperature range.
- the bimetallic actuator may include a bimetallic strip and a securing member operatively associated with both the attachment member and the push member.
- the securing member may be configured to couple movement of push member to the attachment member when engaged and to be disengaged at a specified temperature range to decouple the attachment member from the push member.
- the push member and the attachment member may each include a receiving portion, such as a loop, defined therein which allows the securing member to pass at least partially through each of the receiving portions.
- the bimetallic actuator may be secured directly to the securing member and/or a linkage may couple the bimetallic strip and the securing member.
- a pivot may also be coupled to the linkage member.
- Example 66. A device according to example 65, further including a pivot coupled to the linkage member.
- the linkage member may include a first portion proximate the bimetallic strip relative to the pivot and a second portion proximate the bimetallic strip relative to the pivot in which the first portion is shorter than the second portion.
- a medical device further includes a shape-memory actuator configured to move between an initial shape below a transition temperature and a preset shape above the transition temperature to secure the attachment member in the initial shape and release the attachment member when moved to the preset shape.
- the push member may include a receiving portion.
- the shape memory actuator may extend through the receiving portion in the initial shape to secure the push member to the attachment member and wherein the shape memory actuator is drawn from engagement with the receiving portion when moved to the initial state to release the push member from attachment member.
- the attachment member has a recess defined therein and the shape memory actuator engages the recess when in the initial state and is released from engagement with the recess when moved to the preset shape.
- the device may include a cutting feature secured to the shape memory actuator, the cutting feature being configured to cut a portion of the push member when the shape memory actuator is moved to the preset shape.
- cutting feature may have an opening defined therein and at least a portion of the push member may extend through the opening.
- the device may include a linkage and a securing member, the linkage coupling the shape memory actuator to the securing member. The securing member may couple the push member to the attachment member when the shape memory actuator is in the initial shape and release the push member from the attachment member when the shape memory actuator is in the preset shape.
- a pivot may also be operatively associated with the linkage.
- a device in another example, includes a cylinder and piston secured to the implant, a linkage, and a securing member.
- the securing member may be configured to release the push member in response to operation of the cylinder and piston, such as by expansion of the cylinder and piston.
- a phase change material may be expanded within an enclosed space of the cylinder to drive the piston.
- Phase change materials may include a hydro-carbon fluid as well as formulations of waxes such as those used in the thermostats of common automotive engine thermostats.
- a cross hole is defined in the push member and a hole is defined in the attachment member.
- the device may further include a flexible filament extending through the cross hole through the hole and into a distal end of the push member.
- the device may include a cutting feature. The cutting feature may engage the filament at the cross hole to cut the filament.
- a delivery device for delivering a closure device includes a handle body and a pusher handle operatively associated with the handle body, the pusher handle having a guide slot defined therein.
- the guide slot may be configured to allow the pusher handle to move linearly with respect to the handle body a first linear distance to deploy a first portion of the closure device.
- the guide slot may be further configured to allow the pusher handle to move linearly with respect to the handle body additional linear distances to deploy additional portions of the closure device, such as a second linear distance to deploy a second portion of the closure device.
- the guide slot may be configured to allow the pusher handle to rotate a rotational distance between the first linear distance and the second linear distance.
- First and second grooves may be defined in the handle body while first and second stops may be associated with the first and second grooves.
- the first and second stops may be associated with the guide slot.
- the first and second stops are configured to move between initial positions and rotated positions to constrain the movement of pusher handle. For example, rotating the first stop to the rotated position allows the pusher handle to move from the first position to the second position and rotating the second stop to the rotated position after rotating the first stop to the rotated position allows the pusher handle to move from the second position to the third position.
- the linear distance from the first position to the second position may correspond to the first linear distance and the distance between the second position and the third position may correspond to the second linear distance.
- the guide slot includes a first linear portion, a transverse portion transverse to the first linear portion and in communication with the first linear portion, and a second linear portion substantially parallel to the first linear portion, the second linear portion in communication with the transverse portion.
- the delivery device may also include a release assembly configured to release the closure device from the delivery device.
- the release assembly may include a release cap having a slot defined therein, the slot having a linear portion and a transverse portion transverse to the linear portion in which the linear portion extends proximally of the linear portion.
- the slot may also include a detent formed defined therein in communication with the transverse portion.
- a pin is coupled to the handle portion and is operatively associated with the pin.
- the delivery device may also include a drain lumen in fluid communication with the handle body.
- a medical device has a multi-cellular structure being configured to be moved from a collapsed state to an expanded state, the multi-cellular structure including a waist portion configured to engage a tunnel of an internal tissue opening in the expanded state to close the internal tissue opening, and in-growth media having an ingrowth configuration secured to the medical device.
- the in-growth configuration may include at least one filament secured to a central portion of the medical device, a filament coiled around the central portion of the medial device, and/or anchoring points configured to have the in-growth media secured thereto.
- the anchoring points may allow the filament to be secured to the medical device by sewing, fixing by adhesive, and/or knots.
- the in-growth media also include strips of in-growth media.
- the strips may be formed of a loosely woven gauze-like material that is woven into an interlocking structure. The strips may also be wrapped around a cellular portion of the closure device.
- the in-growth media may also include a membrane.
- the in-growth media may be located at least partially between the closure device and an adjacent closure device. The closure device and the adjacent closure device may be different or may be substantially similar.
- a medical device has multiple chambers configured to be inflated from a collapsed state to an expanded state, the multiple chambers having a waist portion configured to engage a tunnel of an internal tissue opening in the expanded state to close the internal tissue opening.
- the multiple chambers may a distal anchor portion and/or a proximal anchor portion.
- the distal anchor portion may be configured to be inflated first and the proximal anchor portion may be configured to be inflated subsequent to inflation of the proximal anchor portion, such as second.
- the multiple chambers may be interconnected, isolated or a mix of the two.
- the multiple chambers may also be formed of bioresorbable materials.
- a method for detaching a tether from an implant within a body lumen includes positioning an implant within a body lumen, a tether being coupled to the implant to aid with positioning the implant within the body lumen, and applying at least one of an electrical input or a thermal input to the tether to detach the tether from implant.
- Applying at least one of an electrical input or a thermal input may include applying electrical input to the tether to melt the tether and detach the tether from the implant, applying thermal input to a bimetallic actuator to remove a securing member from engagement with the tether and detach the tether from the implant, applying thermal input to a shape memory actuator releasably coupled to the implant to move a portion of the shape memory actuator relative to the implant to disengage from the tether and detach the tether from the implant, applying thermal input to a shape memory actuator, the shape memory actuator being mounted to a cutting structure that at least partially surrounds the tether, wherein the thermal input moves the shape memory actuator and the cutting structure to cut the tether and detach the tether from the implant, and/ or applying thermal input to a phase change assembly resulting detaching of the tether from the implant.
- the present invention can also include the following methods, systems and devices.
- a medical device comprising: a body portion comprising two or more cells, said body portion being movable between a deployed and non-deployed orientation; and at least one anchor linked to said body portion, said at least one anchor being adapted to reduce proximal movement of the medical device when the medical device is positioned in an internal tissue opening.
- a medical device comprising: a multi-cellular structure adapted to selectively expand and contract between a deployed and non-deployed orientation; a first anchor operatively associated with said multi-cellular structure, said first anchor being adapted to selectively engage at least a portion of a wall of an internal tissue opening; and a second anchor operatively associated with said multi-cellular structure, said second anchor being adapted to engage at least a portion of at least another portion of the wall of the tissue opening.
- a method for closing a Patent Foramen Ovale comprising the steps of: positioning at least a portion of a medical device into a left atrium of a heart, said medical device comprising a first anchor, a multi-cellular structure linked to said first anchor, and a second anchor linked to said multi-cellular structure, said first anchor, said multi-cellular structure and said second anchor being adapted to selectively move between a non-deployed and deployed orientation; locating at least a portion of said first anchor against at least a portion of a left atrial wall of the heart; and locating at least a portion of said second anchor against at least a portion of at least one of a tunnel of the Patent Foramen Ovale or a right atrial wall of the heart.
- a medical device for approximating tissue of an internal tissue opening together comprising: a body portion comprising two or more cells, said body portion being adapted to apply lateral force to tissue of an internal tissue opening; and at least one anchor operatively associated with said body portion.
- a medical device for approximating tissue of an internal tissue opening together comprising: a multi-cellular structure adapted to selectively expand and contract between a deployed and non-deployed orientation, said multi-cellular structure configured to preferentially expand; and at least one anchor operatively associated with said multi-cellular structure, said at least one anchor being adapted to move between a deployed and non-deployed orientation, at least a portion of said at least one anchor being adapted to apply lateral force to at least a portion of tissue of an internal tissue opening when said first anchor is deployed.
- a method for reducing the size of an internal tissue opening comprising the steps of: positioning at least a portion of a medical device through an internal tissue opening, said medical device comprising a multi-cellular structure and at least a first anchor associated with said multi-cellular structure, said at least one anchor and said multi-cellular structure being adapted to selectively move between a non-deployed and deployed orientation; and applying lateral force to tissue of the internal tissue opening by at least partially deploying said at least one anchor.
- a medical device comprising: two or more cells forming a body portion, said body portion being adapted to move between a collapsed and expanded orientation to apply lateral force to tissue of an internal tissue opening; and at least one anchor linked to said body portion, said at least one anchor being adapted to extend distally when said at least one anchor is collapsed and extend laterally when said at least one anchor is moved from a collapsed to an expanded orientation.
- a method for deploying a closure device comprising the steps of: deploying a left anchor of a closure device from a delivery device, said delivery device comprising an actuating assembly operatively associated with a handle body, said left anchor being adapted to deploy by linearly moving at least a portion of said actuating assembly with respect to said handle body; and deploying a second anchor of said closure device from said delivery device by rotating at least a portion of said actuating assembly with respect to said handle body.
- a delivery device for an internal tissue opening closure device comprising: a handle body including first and second guide members; a first member operatively associated with said handle body, at least a portion of said first member defining a guide, said first guide member cooperating with said guide to influence movement of said first member with respect to said handle body, said first member including a guide structure; and a second member operatively associated with said first member, at least a portion of said second member defining a second guide, said guide structure cooperating with said second guide to influence the movement of said second member with respect to said first member, and said second guide member cooperating with said second guide to influence the movement of said second member with respect to said handle body.
- a delivery device for an internal tissue opening closure device comprising: a handle body; a first pin coupled to said handle body; a second pin coupled to said handle body; a first cam adapted to be at least partially received into and movable with respect to at least a portion of said handle body, said first cam including a slot formed on an external surface of said first cam, said slot including a first portion and a second portion, said first portion of said slot extending along at least a portion of the length of said first cam, said second portion of said slot extending at least partially around said first cam, said first pin received in said slot; a third pin coupled to said first cam; and a second cam adapted to be at least partially received into and movable with respect to at least a portion of said first cam, said second cam including a first and second slot formed on an external surface of said second cam, said first slot of said second cam extending at least partially around said second cam and said second slot of said second cam extending along at least a portion of the length of said second cam, said third pin received in said
- a medical device for closing an internal tissue opening comprising: a multi-cellular structure configured to assume a substantially flat configuration; at least one anchor operatively associated with said multi-cellular structure, said at least one anchor comprising a plurality of segments at least partially defining a closed periphery.
- a medical device for closing an internal tissue opening comprising: a multi-cellular structure adapted to be moveable between a first orientation and a second orientation; at least one anchor operably associated with said multi-cellular structure; and a tissue growth member associated with said multicellular structure, said tissue growth member being adapted to enhance tissue growth in the internal tissue opening.
- An expandable medical device deployable at least partially within a tissue structure, the expandable medical device comprising: a non-tubular multi-cellular body portion configured to self expand from a non-deployed orientation, said body portion comprising a plurality of interconnecting body support segments defining at least two apertures; and at least one anchor linked to said multi-cellular body portion.
- An expandable medical device deployable at least partially within a tissue structure, the expandable medical device comprising: a frame configured to assume a substantially flat configuration, said frame comprising a central portion adapted to move between a first orientation and a second orientation, said central portion comprising a plurality of struts defining a multi-cellular structure.
- a medical device for reducing a size of a Patent Foramen Ovale comprising: a self-expanding frame configured to be constricted within a catheter and configured to assume a substantially flat configuration, said frame comprising a central portion with proximal and distal anchors extending from said central portion, said central portion comprising a multi-cellular structure configured to self-expand outwardly against a wall of the PFO.
- a medical device for reducing the size of an internal tissue opening comprising: a frame including a central portion having a plurality of struts defining a multi-cellular structure, said central portion having at least one anchor extending from said central portion, said central portion configured to assume a substantially flat configuration; and a member associated with said frame, said member adapted to induce tissue growth in the internal tissue opening.
- a medical device for closing an internal tissue opening comprising: a frame including a central portion with at least one anchor extending from said central portion, said central portion configured to assume a substantially flat configuration; and a tissue growth promoting member attached to said frame, said tissue growth promoting member configured to substantially extend out-of-plane from the substantially flat configuration and configured to enhance tissue growth in the internal tissue opening.
- a medical implant delivery system for delivering a medical device in a human body, the delivery system comprising: a handle; a catheter coupled to the handle with lines coupled to the medical device; and a tip portion coupled to a distal end of the catheter, the tip portion defining at least a first passageway and a second passageway extending at least partially along a length through the tip portion, the first passageway configured to move over a guide wire and the second passageway configured to communicate with the catheter and configured to facilitate delivery of the medical device, the first passageway and the second passageway being in a spaced apart arrangement.
- a delivery device configured to be coupled to a catheter for delivering a medical device in a human body, the delivery device comprising: a tip member configured to be coupled at a distal end of the catheter, the tip member defining at least a first passageway and a second passageway extending at least partially along a length through the tip member, the first passageway configured to move over a guide wire and the second passageway configured to communicate with the catheter and configured to facilitate delivery of the medical device, the first passageway and the second passageway being in a spaced apart arrangement.
- a medical implant delivery system for delivering a medical device in a human body, the delivery system comprising: a handle; a catheter coupled to the handle with lines coupled to the medical device; and a tip portion coupled to a distal end of the catheter, the tip portion defining at least a first passageway and a second passageway extending at least partially along a length through the tip portion, the first passageway configured to move over a guide wire and the second passageway configured to communicate with the catheter and configured to deliver the medical device, the second passageway and the first passageway being in a non-coaxial arrangement.
- a delivery device for delivering a medical device comprising: a handle body; and an actuating assembly operatively associated with said handle body, said actuating assembly being adapted to move linearly with respect to said handle body to deploy at least a portion of a medical device, and to rotate with respect to said handle body to deploy additional portions of the medical device.
- a delivery device for delivering a Patent Foramen Ovale closure device comprising: a handle body; a first member operatively associated with said handle body, said first member being adapted to move linearly with respect to said handle body; and a second member linked to said handle body and said first member, said second member being adapted to move linearly with respect to said handle body and adapted to rotate with respect to said handle body and said first member.
- a method for deploying an internal tissue opening closure device comprising the steps of: deploying a left anchor of a closure device from a delivery device, said delivery device comprising an actuating assembly linked to a handle body, said left anchor being adapted to deploy by a first movement of at least a portion of said actuating assembly with respect to said handle body; and deploying a right anchor of said closure device from said delivery device by a second movement of at least a portion of said actuating assembly with respect to said handle body.
- a method for closing an internal tissue opening wherein the internal tissue opening includes first and second opposing tissue walls and a tunnel therethrough defining the internal tissue opening
- the method comprising the steps of: deploying a first anchor of a closure device from a delivery device by moving at least a portion of an actuating assembly of said delivery device in a linear direction with respect to a handle body of said delivery device; positioning said first anchor against a first tissue wall of an internal tissue opening; and deploying a second anchor of said closure device from said delivery device to engage at least a portion of at least one of a tunnel or a second tissue wall of the internal tissue opening by rotating at least a portion of said actuating assembly.
- a method for closing a Patent Foramen Ovale comprising the steps of: translating at least a portion of an actuating assembly of a delivery device with respect to a handle body of said delivery device to deploy at least a first portion of a closure device from said delivery device, said closure device comprising a multicellular structure linked to said first portion and a second portion linked to said multicellular structure; and rotating at least a portion of said actuating assembly to deploy said second portion of said closure device from said delivery device.
- a medical system for treating an internal tissue opening comprising: a medical device comprising: a multi-cellular structure, and at least one anchor operatively associated with said multi-cellular structure; and a delivery device comprising: a handle body, and an actuating assembly operatively associated with said handle body, said actuating assembly being adapted to selectively deploy at least a first portion of said closure device by a first movement, and said actuating assembly being adapted to selectively deploy at least a second portion of said closure device by a second movement.
- a medical system for treating a tissue structure comprising: a medical device comprising a frame configured to assume a substantially flat configuration, said frame including a central portion and at least one anchor extending from the central portion, the central portion including a plurality of struts defining a multi-cellular structure; and a delivery device comprising: a handle body, and an actuating assembly, said actuating assembly adapted to enable deployment of said at least one anchor by movement of at least a portion of said actuating assembly.
Abstract
Description
Claims
Priority Applications (5)
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NZ574738A NZ574738A (en) | 2006-08-09 | 2007-08-09 | System for treating a hole in a tissue structure using a frame and wire loops |
CA002659365A CA2659365A1 (en) | 2006-08-09 | 2007-08-09 | Methods, systems and devices for reducing the size of an internal tissue opening |
JP2009524000A JP5334850B2 (en) | 2006-08-09 | 2007-08-09 | Method, system and apparatus for reducing internal tissue pore size |
EP07840825.9A EP2068759A4 (en) | 2006-08-09 | 2007-08-09 | Methods, systems and devices for reducing the size of an internal tissue opening |
AU2007286171A AU2007286171A1 (en) | 2006-08-09 | 2007-08-09 | Methods, systems and devices for reducing the size of an internal tissue opening |
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US11/836,016 US9220487B2 (en) | 2006-08-09 | 2007-08-08 | Devices for reducing the size of an internal tissue opening |
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NZ574737A (en) | 2012-05-25 |
WO2008021969A3 (en) | 2008-11-13 |
WO2008036478A2 (en) | 2008-03-27 |
EP2068759A2 (en) | 2009-06-17 |
JP2010500129A (en) | 2010-01-07 |
JP5334850B2 (en) | 2013-11-06 |
NZ574738A (en) | 2012-02-24 |
AU2007286171A1 (en) | 2008-02-21 |
CA2659365A1 (en) | 2008-02-21 |
EP2068759A4 (en) | 2013-04-10 |
EP2068777A4 (en) | 2013-05-15 |
AU2007297516A1 (en) | 2008-03-27 |
EP2068777A2 (en) | 2009-06-17 |
WO2008036478A3 (en) | 2008-12-18 |
JP2010500130A (en) | 2010-01-07 |
CA2659109A1 (en) | 2008-03-27 |
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