WO2008020748A1 - Analgesic aromatic product - Google Patents

Analgesic aromatic product Download PDF

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Publication number
WO2008020748A1
WO2008020748A1 PCT/MX2007/000091 MX2007000091W WO2008020748A1 WO 2008020748 A1 WO2008020748 A1 WO 2008020748A1 MX 2007000091 W MX2007000091 W MX 2007000091W WO 2008020748 A1 WO2008020748 A1 WO 2008020748A1
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WO
WIPO (PCT)
Prior art keywords
essences
aromatic
composition
mixture
cushion
Prior art date
Application number
PCT/MX2007/000091
Other languages
Spanish (es)
French (fr)
Inventor
Martha Elena Cathy Correa Robles
Original Assignee
Correa Robles Martha Elena Cat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Correa Robles Martha Elena Cat filed Critical Correa Robles Martha Elena Cat
Publication of WO2008020748A1 publication Critical patent/WO2008020748A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives

Definitions

  • This invention presents an aromatic product, useful in the therapeutic field of alternative medicine
  • patent JP 11137232 presents a product that contains the following components: nail; garlic, licorice liquor, beet chard beet, ginkgo nut, chamomile, sage (Artemis), thyme, rosemary, black acacia, jasmine, liquid amber, lettuce, ginseng tea, cinnamon, mint, lavender and eucalyptus
  • This formula is registered to replace the use of nicotine Ia which contains tranquilizer products and a very light analgesic product.
  • Oral They can irritate the stomach or liver. Cutaneous: May cause rash or produce allergy.
  • the aromatic or volatile product with analgesic function presented by this invention is a product made with the purpose of treating acute and chronic pain present as a manifestation of a pathological state or disease.
  • ESSENCE DEAZAHAR 1. The lemon, lime or orange fruit are selected.
  • the method for carrying out the formula of the analgesic aromatic composition is to mix the components of the active ingredients in the exact amounts, as follows:
  • the aromatic or volatile composition object of this invention accesses the nerve terminals of the nose, and has essences in oil of four different fruits and flowers, two with relaxing properties so that together with the other two they take away the pain
  • this is applied in a synthetic fiber cushion that replaces the cotton, because the cotton dries in a short time and does not give off the aroma, instead the synthetic fiber remains impregnated for approximately 4 to 5 weeks, that is, it continues to give off the aroma for that time.
  • the cushion can have the following dimensions from 2 x 2 cm to 5 x 7 cm with the same amount of the mixture of the essence, that is, it apply 0.002g. This cushion can be used in both children and adults without any restrictions.
  • the aromatic composition with analgesic effect can be used with any vehicle that allows its permanence in the environment.
  • a calming composition can be produced, making a 1: 2 dilution with 70% ethanol or 96% ethanol, once applied as a flavoring agent, it remains active for approximately 6 hours. Requirements of the formula to be optimal

Abstract

The invention relates to a volatile or aromatic product having analgesic properties in humans and animals and formed by essence of lavender, lime, lemon and orange blossom. The invention also relates to an aromatic tranquiliser composition using a mixture of the same essential oils diluted 1:2 in 70% ethanol or 96% ethanol.

Description

PRODUCTO AROMÁTICO CON FUNCIÓN ANALGÉSICA AROMATIC PRODUCT WITH ANALGESIC FUNCTION
DESCRIPCIÓNDESCRIPTION
CAMPO DE LA INVENCIÓNFIELD OF THE INVENTION
Esta invención presenta un producto aromático, útil en el campo terapéutico de Ia medicina alternativaThis invention presents an aromatic product, useful in the therapeutic field of alternative medicine
ANTECEDENTES Existen en Ia naturaleza varias esencias que por sí solas actúan como analgésicos naturales, muy ligeramente; como el eucalipto, el pino, entre otrasBACKGROUND There are several essences in nature that by themselves act as natural analgesics, very slightly; such as eucalyptus, pine, among others
Por ejemplo Ia patente JP 11137232 presenta un producto que contiene los siguientes componentes: clavo; ajo, licor de regaliz, remolacha acelga betabel, nuez ginkgo, manzanilla, salvia (Artemisa), tomillo, romero, acacia negra, jazmín, ámbar líquido, lechuga, té ginseng, canela, menta, lavanda y eucaliptoFor example, patent JP 11137232 presents a product that contains the following components: nail; garlic, licorice liquor, beet chard beet, ginkgo nut, chamomile, sage (Artemis), thyme, rosemary, black acacia, jasmine, liquid amber, lettuce, ginseng tea, cinnamon, mint, lavender and eucalyptus
Esta fórmula está registrada para sustituir el uso de Ia nicotina Ia cual contiene productos tranquilizantes y un producto analgésico muy ligero.This formula is registered to replace the use of nicotine Ia which contains tranquilizer products and a very light analgesic product.
Las vías de administración más comunes de los analgésicos y sus efectos colaterales principales son:The most common routes of administration of analgesics and their main side effects are:
Oral: Pueden llegar a irritar el estómago o el hígado. Cutánea: Puede llegar a producir salpullido o producir alergia.Oral: They can irritate the stomach or liver. Cutaneous: May cause rash or produce allergy.
Intravenosa: Puede llegar a provocar adicción.Intravenous: May cause addiction.
Por absorción: Parches de drogas muy fuertes como opio y morfinaBy absorption: Very strong drug patches such as opium and morphine
El uso de este analgésico, por ser de aromaterapia, es muy bueno porque no produce ni tiene efectos colaterales o secundarios, ni produce adicción.The use of this analgesic, being aromatherapy, is very good because it does not produce or have side or side effects, nor does it cause addiction.
El problema técnico más importante que tuve que resolver fue el encontrar las cantidades exactas para que funcionara Ia fórmula en óptimas condiciones, para quitar el dolor. DESCRIPCIÓN DETALLADA DE LA INVENCIÓNThe most important technical problem that I had to solve was finding the exact amounts for the formula to work in optimal conditions, to remove the pain. DETAILED DESCRIPTION OF THE INVENTION
El producto aromático o volátil con función analgésica que presenta esta invención, es un producto elaborado con Ia finalidad de tratar el dolor agudo y crónico presente como manifestación de un estado patológico o enfermedad.The aromatic or volatile product with analgesic function presented by this invention is a product made with the purpose of treating acute and chronic pain present as a manifestation of a pathological state or disease.
Este producto está compuesto por las siguientes esencias:This product is composed of the following essences:
Lavanda,Lavender,
Lima,Lime,
LimónLemon
Azahar Para obtener 30 mi. de Ia fórmula se necesitan:Orange blossom To get 30 mi. of the formula you need:
Un kilo de limones, que hayan alcanzado casi su punto de madurez recientemente.A kilo of lemons, which have reached almost their point of maturity recently.
Medio kilo de limas que hayan alcanzado casi su punto de madurez recientemente. 20 flores de azahar.Half a kilo of files that have reached almost their point of maturity recently. 20 orange blossom flowers.
150 flores de lavanda.150 lavender flowers
Las cuales se obtienen de Ia siguiente manera.Which are obtained as follows.
ESENCIA DE LIMÓN 1- Se seleccionan las frutas, tiene que ser limón con semilla que esté casi en su punto de madurez.ESSENCE OF LEMON 1- The fruits are selected, it must be lemon with seed that is almost at its point of maturity.
2.- Se enjuagan perfectamente con agua esterilizada, para que no haya residuos de ningún químico.2.- They rinse perfectly with sterilized water, so that there are no residues of any chemical.
3.- La fruta se pela para usar Ia cascara. 4.- Se humedece, pero sin que quede empapada una esponja de aproximadamente 30 x 15 cm en etanol, al 70°.3.- The fruit is peeled to use the peel. 4.- It is moistened, but without soaking a sponge of approximately 30 x 15 cm in ethanol, at 70 °.
5.- La esponja se prensa contra las cascaras de Ia fruta, Ia cual se está perforando para que suelte el sumo. 6.- La solución obtenida se coloca en un alambique, para su obtención a través de un calentamiento para llegar al punto de ebullición, el cual es aproximadamente a C 95°, para que Ia solución volátil se evapore. Para al enfriarse y condensarse poder obtener Ia esencia requerida5.- The sponge is pressed against the peels of the fruit, which is being drilled to release the sumo. 6.- The solution obtained is placed in a still, to obtain it through a heating to reach the boiling point, which is approximately at 95 ° C, so that the volatile solution evaporates. To cool and condense to obtain the required essence
ESENCIA DE LIMAESSENCE OF LIMA
1- Se seleccionan las frutas, casi en el punto de madurez..1- The fruits are selected, almost at the point of maturity ..
2.- Se enjuagan perfectamente con agua esterilizada, para que no haya residuos de ningún químico. 3.- La fruta se pela para usar Ia cascara.2.- They rinse perfectly with sterilized water, so that there are no residues of any chemical. 3.- The fruit is peeled to use the peel.
4.- Se humedece, pero sin que quede empapada una esponja de aproximadamente 30 x 15 cm. en etanol, al 70°.4.- It moistens, but without soaking a sponge of approximately 30 x 15 cm. in ethanol, at 70 °.
5.- La esponja se prensa contra las cascaras de Ia fruta, Ia cual se está perforando para que suelte el sumo. 6.- La solución obtenida se coloca en un alambique, para su obtención a través de un calentamiento para llegar al punto de ebullición, el cual es aproximadamente a C 95°, para que Ia solución volátil se evapore. Para al enfriarse y condensarse poder obtener Ia esencia requerida5.- The sponge is pressed against the peels of the fruit, which is being drilled to release the sumo. 6.- The solution obtained is placed in a still, to obtain it through a heating to reach the boiling point, which is approximately at 95 ° C, so that the volatile solution evaporates. To cool and condense to obtain the required essence
ESENCIA DE LAVANDA -LAVENDER ESSENCE -
1- Se seleccionan las flores de lavanda.1- Lavender flowers are selected.
2.- Se enjuagan perfectamente con agua esterilizada, para que no haya residuos de ningún químico2.- They rinse perfectly with sterilized water, so that there is no residue of any chemical
3.- Lo único que se usa es Ia flor de Ia planta. 4.- Se humedece, pero sin que quede empapada una esponja de aproximadamente 30 x 15 cm. en etanol, al 70°.3.- The only thing that is used is the flower of the plant. 4.- It moistens, but without soaking a sponge of approximately 30 x 15 cm. in ethanol, at 70 °.
5.- La esponja se prensa contra las flores, las cuales se machacan para que suelten Ia sustancia requerida.5.- The sponge is pressed against the flowers, which are crushed to release the required substance.
6.- La solución obtenida se coloca en un alambique, para su obtención a través de un calentamiento para llegar al punto de ebullición, el cual es aproximadamente a C 95°, para que Ia solución volátil se evapore. Para al enfriarse y condensarse poder obtener Ia esencia requerida6.- The solution obtained is placed in a still, to obtain it through a heating to reach the boiling point, which is approximately at 95 ° C, so that the volatile solution evaporates. To cool and condense to obtain the required essence
ESENCIA DEAZAHAR 1.- Se seleccionan la fruta de limón, lima o naranjo.ESSENCE DEAZAHAR 1.- The lemon, lime or orange fruit are selected.
2.- Se enjuagan perfectamente con agua esterilizada, para que no haya residuos de ningún químico. 3.- Lo único que se usa es Ia flor de Ia planta. 4.- Se humedece, pero sin que quede empapada una esponja de aproximadamente 30 x 15 cm. en etanol, al 70°.2.- They rinse perfectly with sterilized water, so that there are no residues of any chemical. 3.- The only thing that is used is the flower of the plant. 4.- It moistens, but without soaking a sponge of approximately 30 x 15 cm. in ethanol, at 70 °.
5.- La esponja se prensa contra las flores, las cuales ya tienen que estar ligeramente machacadas para que suelten Ia sustancia requerida. 6.- La solución obtenida se coloca en un alambique, para su obtención a través de un calentamiento para llegar al punto de ebullición, el cual es aproximadamente a C 95°, para que Ia solución volátil se evapore. Para al enfriarse y condensarse poder obtener Ia esencia requerida5.- The sponge is pressed against the flowers, which already have to be slightly crushed to release the required substance. 6.- The solution obtained is placed in a still, to obtain it through a heating to reach the boiling point, which is approximately at 95 ° C, so that the volatile solution evaporates. To cool and condense to obtain the required essence
El método para realizar Ia fórmula de Ia composición aromática analgésica es mezclar en las cantidades exactas los componentes de los ingredientes activos, de Ia siguiente manera:The method for carrying out the formula of the analgesic aromatic composition is to mix the components of the active ingredients in the exact amounts, as follows:
Fórmula:Formula:
Lavanda 45%Lavender 45%
Lima 25% Limón 25%Lime 25% Lemon 25%
Azahar 5%Orange blossom 5%
Total 1'OO%Total 1 ' OO%
La composición aromática o volátil objeto de esta invención, accesa a las terminales nerviosas de Ia nariz, y posee esencias en aceite de cuatro diferentes frutas y flores, dos con propiedades relajantes para que en conjunto con las otras dos quitan los doloresThe aromatic or volatile composition object of this invention, accesses the nerve terminals of the nose, and has essences in oil of four different fruits and flowers, two with relaxing properties so that together with the other two they take away the pain
Para usar Ia mezcla de las esencias, ésta se aplica en un cojín de fibra sintética que sustituye al algodón, porque el algodón se seca en poco tiempo y no despide el aroma, en cambio Ia fibra sintética permanece impregnada aproximadamente de 4 a 5 semanas, es decir, sigue despidiendo el aroma por ese tiempo. El cojín puede tener las siguientes dimensiones desde 2 x 2 cm hasta 5 x 7 cm con Ia misma cantidad de Ia mezcla de Ia esencia, es decir, se aplican 0.002g. este cojín puede utilizarse tanto en niños como adultos sin restricción alguna.To use the mixture of the essences, this is applied in a synthetic fiber cushion that replaces the cotton, because the cotton dries in a short time and does not give off the aroma, instead the synthetic fiber remains impregnated for approximately 4 to 5 weeks, that is, it continues to give off the aroma for that time. The cushion can have the following dimensions from 2 x 2 cm to 5 x 7 cm with the same amount of the mixture of the essence, that is, it apply 0.002g. This cushion can be used in both children and adults without any restrictions.
La composición aromática con efecto analgésico puede ser utilizada con cualquier vehículo que permita su permanencia en el ambiente.The aromatic composition with analgesic effect can be used with any vehicle that allows its permanence in the environment.
Con Ia mezcla de estos aceites esenciales se puede producir una composición tranquilizante, realizando una dilución 1 :2 con etanol al 70% o etanol al 96%, una vez aplicada como aromatizante permanece activa aproximadamente 6 horas. Requerimientos de Ia fórmula para que sea óptimaWith the mixture of these essential oils, a calming composition can be produced, making a 1: 2 dilution with 70% ethanol or 96% ethanol, once applied as a flavoring agent, it remains active for approximately 6 hours. Requirements of the formula to be optimal
Se hace destacar que si se usa un porcentaje mayor de Ia lavanda, o el azahar, esta fórmula producirá mucho sueño y puede llegar a producir dolor de cabeza. Si se usa un porcentaje mayor de Ia de lima, limón, esta funcionará como aromatizante únicamente. It is noted that if a higher percentage of lavender, or orange blossom, is used, this formula will produce a lot of sleep and may lead to headache. If a higher percentage of lime, lemon, is used, this will work as a flavoring only.

Claims

REIVINDICACIONES
Habiendo descrito suficientemente mi invención reclamo como de mi exclusiva propiedad, Io establecido en las siguientes cláusulas:Having sufficiently described my invention claim as my exclusive property, as established in the following clauses:
1- Composición aromática analgésica que comprende Ia mezcla de las siguientes esencias: lima (25%), limón (25%), lavanda (45%) y azahar (5%), útil para el tratamiento contra el dolor agudo.1- Aromatic analgesic composition comprising the mixture of the following essences: lime (25%), lemon (25%), lavender (45%) and orange blossom (5%), useful for the treatment of acute pain.
2.- Método para producir Ia composición aromática analgésica como se reivindica en el número 1 , caracterizado por efectuarse mediante las siguientes etapas:2.- Method to produce the aromatic analgesic composition as claimed in No. 1, characterized by being carried out by the following steps:
a) Obtención de las esencias.a) Obtaining the essences.
b).- Se pesan las esencias líquidas en una balanza granataría,b) .- The liquid essences are weighed on a garnet scale,
c) Mezcla de las esencias. El orden de estos elementos no tiene relevancia. Es importante agitar Ia mezcla para que se revuelvan dichos elementos y se debe esperar son aproximadamente 15 minutos para que dicha fórmula llegue a estar en óptimas condiciones para su uso. Se debe guardar Ia mezcla en lugares o recipientes oscuros, de preferencia para evitar su volatilidad.c) Mixture of essences. The order of these elements has no relevance. It is important to stir the mixture so that these elements are stirred and it should be expected approximately 15 minutes for said formula to be in optimal conditions for use. The mixture should be stored in dark places or containers, preferably to avoid volatility.
3.- Método para producir las esencias, separadamente, presente en Ia composición aromática analgésica que se reivindica en el número 1 , el cual comprende las siguientes etapas: a.- Se seleccionan las frutas como limón o lima, o las flores, como lavanda y azahar.3.- Method to produce the essences, separately, present in the aromatic analgesic composition that is claimed in number 1, which comprises the following steps: a.- Fruits are selected as lemon or lime, or flowers, such as lavender and orange blossom.
b.- Se enjuagan perfectamente con agua esterilizada, para que no haya residuos de ningún químico.b.- They rinse perfectly with sterilized water, so that there is no residue of any chemical.
c- La fruta se pela para usar Ia cascara. Cuando se trate de Ia flor se utiliza Ia misma.c- The fruit is peeled to use the peel. In the case of the flower, the same is used.
d.- Se humedece, pero sin que quede empapada una esponja de aproximadamente 30 x 15 cm en etanol al 70°d.- It is moistened, but without soaking a sponge of approximately 30 x 15 cm in 70 ° ethanol
e.- La esponja se prensa contra las cascaras de Ia fruta perforada previamente para que suelte el sumo; en el caso de las flores, estas se machacan para que suelten Ia sustancia requeridae.- The sponge is pressed against the peels of the previously perforated fruit so that it releases the sumo; in the case of flowers, these are crushed to release the required substance
f.- Cada una de las esencias obtenidas, separadamente, se coloca en un alambique, para su obtención a través de un calentamiento a 950C, para eliminar las substancias cuyo punto de ebullición sea mayor a dicha temperatura. Se deja enfriar y queda condensada Ia esencia requerida.It f.- Each essences obtained separately, is placed in a still, for obtaining by heating at 95 0 C, to remove substances whose boiling point is higher than that temperature. It is allowed to cool and the required essence is condensed.
4.- Composición aromática tranquilizante que comprende Ia mezcla de las siguientes esencias: lima (25%), lavanda (45%), limón (25%) y azahar (5%), Ia cual se diluye 1 :2 en etanol al 70% o etanol al 96%, cuya eficacia es de al menos 6 horas una vez que se ha aplicado.4.- Aromatic tranquilizer composition comprising the mixture of the following essences: lime (25%), lavender (45%), lemon (25%) and orange blossom (5%), which is diluted 1: 2 in 70% ethanol % or 96% ethanol, whose effectiveness is at least 6 hours once it has been applied.
5.- Cojín para Ia aplicación de Ia composición aromática reivindicada en 1 , que comprende un cojín de fibra sintética que permite Ia permanencia del aroma durante 4 a 5 semanas; una cantidad efectiva de Ia composición de aceites esenciales de 0.002g. Dicho cojín se almacena en un empaque primario sellado que permita Ia percepción del aroma y posteriormente en uno secundario, el cual impide que se volatilice anticipadamente el aroma. Este cojín puede utilizarse tanto en niños como en adultos sin restricción alguna5.- Cushion for the application of the aromatic composition claimed in 1, which comprises a synthetic fiber cushion that allows the permanence of the aroma for 4 to 5 weeks; an effective amount of the composition of essential oils of 0.002g. Said cushion is stored in a sealed primary package that allows the perception of aroma and subsequently in one secondary, which prevents the aroma from volatilizing in advance. This cushion can be used in both children and adults without any restrictions
6.- Cojín para Ia aplicación de Ia composición aromática reivindicada en 5, que puede tener las siguientes dimensiones desde 2 x 2 cm hasta 5 x 7 cm 6.- Cushion for the application of the aromatic composition claimed in 5, which can have the following dimensions from 2 x 2 cm to 5 x 7 cm
PCT/MX2007/000091 2006-08-10 2007-08-08 Analgesic aromatic product WO2008020748A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXGT06000014A MXGT06000014A (en) 2006-08-10 2006-08-10 Aromatic product having an analgesic function.
MXGT/A/2006/000014 2006-08-10

Publications (1)

Publication Number Publication Date
WO2008020748A1 true WO2008020748A1 (en) 2008-02-21

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WO (1) WO2008020748A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001139488A (en) * 1999-11-12 2001-05-22 Karita Takahisa Analgesic essential oil composition and analgesic
US6579543B1 (en) * 2002-02-22 2003-06-17 Jackie H. McClung Composition for topical application to skin
GB2385271A (en) * 2002-01-24 2003-08-20 David Arthur Plant Pillow or cushion comprising micro-encapsulated essential oils
WO2005074692A1 (en) * 2004-01-30 2005-08-18 4Mula, Inc. Table of botanical ingredients and method of preparing a table useful for blending combinations thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001139488A (en) * 1999-11-12 2001-05-22 Karita Takahisa Analgesic essential oil composition and analgesic
GB2385271A (en) * 2002-01-24 2003-08-20 David Arthur Plant Pillow or cushion comprising micro-encapsulated essential oils
US6579543B1 (en) * 2002-02-22 2003-06-17 Jackie H. McClung Composition for topical application to skin
WO2005074692A1 (en) * 2004-01-30 2005-08-18 4Mula, Inc. Table of botanical ingredients and method of preparing a table useful for blending combinations thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Essential Oil Mankind's First Medicine", AMAL HERBAL FORMULATIONS, 2003 - 2005, Retrieved from the Internet <URL:http://www.amalspa.com/amal_spa_essential_oil.html> *
BOWLES E.J. ET AL.: "A survey of aromatherapy practices in aged care facilities in northern NSW, Australia", THE INTERNATIONAL JOURNAL OF AROMATHERAPY, vol. 15, 2005, pages 42 - 50, XP004762537, DOI: doi:10.1016/j.ijat.2004.09.012 *

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