WO2008014521A8 - Improved vaccines and methods for using the same - Google Patents

Improved vaccines and methods for using the same Download PDF

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Publication number
WO2008014521A8
WO2008014521A8 PCT/US2007/074769 US2007074769W WO2008014521A8 WO 2008014521 A8 WO2008014521 A8 WO 2008014521A8 US 2007074769 W US2007074769 W US 2007074769W WO 2008014521 A8 WO2008014521 A8 WO 2008014521A8
Authority
WO
WIPO (PCT)
Prior art keywords
those
consensus sequences
encode
nucleic acid
acid molecules
Prior art date
Application number
PCT/US2007/074769
Other languages
French (fr)
Other versions
WO2008014521A3 (en
WO2008014521A2 (en
Inventor
David B. Weiner
Jian Yan
Dominick Laddy
Original Assignee
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP07840587A priority Critical patent/EP2049559B1/en
Priority to KR1020197019662A priority patent/KR102173636B1/en
Priority to KR1020177004941A priority patent/KR101848867B1/en
Priority to KR1020167007633A priority patent/KR101710981B1/en
Priority to DK07840587.5T priority patent/DK2049559T3/en
Priority to KR1020237009029A priority patent/KR20230042399A/en
Priority to AU2007278831A priority patent/AU2007278831B2/en
Priority to MX2009001099A priority patent/MX2009001099A/en
Priority to EP16156199.8A priority patent/EP3037429B1/en
Priority to CN200780036389.3A priority patent/CN101679475B/en
Priority to KR1020147035344A priority patent/KR101609235B1/en
Priority to KR1020187010028A priority patent/KR101999376B1/en
Priority to MX2015000975A priority patent/MX346862B/en
Priority to KR1020207031173A priority patent/KR102334637B1/en
Priority to CA2659262A priority patent/CA2659262C/en
Priority to US12/375,518 priority patent/US8168769B2/en
Priority to JP2009522035A priority patent/JP2009544333A/en
Priority to EP21163008.2A priority patent/EP3907232B1/en
Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Priority to KR1020217039157A priority patent/KR102511874B1/en
Priority to EP18196529.4A priority patent/EP3489251B1/en
Publication of WO2008014521A2 publication Critical patent/WO2008014521A2/en
Publication of WO2008014521A3 publication Critical patent/WO2008014521A3/en
Priority to HK09109663.8A priority patent/HK1130807A1/en
Priority to US13/458,013 priority patent/US8697084B2/en
Publication of WO2008014521A8 publication Critical patent/WO2008014521A8/en
Priority to US14/139,660 priority patent/US9290546B2/en
Priority to US14/139,729 priority patent/US9376471B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001157—Telomerase or TERT [telomerase reverse transcriptase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/24011—Poxviridae
    • C12N2710/24034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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Abstract

Improved anti-HlV immυnogens and nucleic acid molecules that encode them are disclosed, lmmunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HlV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
PCT/US2007/074769 2006-07-28 2007-07-30 Improved vaccines and methods for using the same WO2008014521A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
KR1020217039157A KR102511874B1 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
KR1020177004941A KR101848867B1 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
KR1020167007633A KR101710981B1 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
DK07840587.5T DK2049559T3 (en) 2006-07-28 2007-07-30 Improved HPV vaccines
KR1020237009029A KR20230042399A (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
AU2007278831A AU2007278831B2 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
MX2009001099A MX2009001099A (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same.
EP16156199.8A EP3037429B1 (en) 2006-07-28 2007-07-30 Improved hiv vaccines
CN200780036389.3A CN101679475B (en) 2006-07-28 2007-07-30 The vaccine improved and using method thereof
KR1020147035344A KR101609235B1 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
KR1020187010028A KR101999376B1 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
MX2015000975A MX346862B (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same.
KR1020207031173A KR102334637B1 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
EP07840587A EP2049559B1 (en) 2006-07-28 2007-07-30 Improved hpv vaccines
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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101710981B1 (en) * 2006-07-28 2017-02-28 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Improved vaccines and methods for using the same
US8926961B2 (en) * 2007-10-03 2015-01-06 Board Of Trustees Of The University Of Arkansas HPV E6 protein T cell epitopes and uses thereof
EP2217064A4 (en) * 2007-11-12 2012-10-03 Univ Pennsylvania Novel vaccines against multiple subtypes of influenza virus
CA2653478A1 (en) * 2009-01-23 2010-07-23 Gregg Martin Automated wash system for industrial vehicles
EP2404312A4 (en) 2009-03-02 2013-10-02 Univ California DEVICES GROWN ON NONPOLAR OR SEMIPOLAR (Ga,Al,In,B)N SUBSTRATES
WO2011032179A1 (en) * 2009-09-14 2011-03-17 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
WO2011097640A1 (en) 2010-02-08 2011-08-11 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same
KR102035199B1 (en) 2010-02-16 2019-10-22 울티모백스 에이에스 Polypeptides
US8932575B2 (en) 2010-09-21 2015-01-13 University Of Miami Compositions and methods for inducing migration by dendritic cells and an immune response
WO2012040266A2 (en) * 2010-09-24 2012-03-29 University Of Miami Gene-based adjuvants and compositions thereof to increase antibody production in response to gene-based vaccines
BR112013008700B8 (en) * 2010-10-11 2022-10-04 Novartis Ag SELF-REPLICATING RNA MOLECULE, ALPHAVIRUS REPLICON PARTICLE, COMPOSITION, RECOMBINANT DNA MOLECULE, USE OF SELF-REPLICATING RNA MOLECULE
WO2013055326A2 (en) * 2011-10-12 2013-04-18 The Trustees Of The University Of Pennsylvania Vaccines for human papilloma virus and methods for using the same
JP6407028B2 (en) * 2011-12-12 2018-10-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Protein containing MRSA PBP2a and fragments thereof, nucleic acid encoding the same, composition for preventing and treating MRSA infection and use thereof
EP2892913A4 (en) * 2012-09-07 2017-01-18 Agency For Science, Technology And Research Peptides and their uses
CN103113458B (en) * 2013-02-27 2014-08-20 北京大学人民医院 Hepatitis c virus B-cell epitope peptide PUHI34 and application thereof
CN103172705B (en) * 2013-02-27 2014-08-20 北京大学人民医院 Hepatitis C virus (HCV) B cell epitope peptide PUHI16 and application thereof
CN103102394B (en) * 2013-02-27 2014-06-25 北京大学人民医院 B cell epitope peptide PUHI49 for hepatitis c virus (HCV) and application of B cell epitope peptide PUHI49
EP3586870A1 (en) * 2013-03-12 2020-01-01 The Trustees Of The University Of Pennsylvania Improved vaccines for human papilloma virus and methods for using the same
KR20150130284A (en) 2013-03-15 2015-11-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Cancer vaccines and methods of treatment using the same
US20160256539A1 (en) * 2013-11-14 2016-09-08 The Trustees Of The University Of Pennsylvania HIV-1 ENV DNA Vaccine Plus Protein Boost Delivered by EP Expands B- and T-Cell Response and Neutralizing
MA40783A (en) * 2014-10-03 2017-08-08 Los Alamos Nat Security Llc HIV VACCINES CONTAINING ONE OR MORE POPULATION EPISENSUS ANTIGENS
BR112018015893A2 (en) 2016-02-05 2019-03-06 Inovio Pharmaceuticals Inc cancer vaccines and treatment methods using the same
WO2017147160A1 (en) * 2016-02-23 2017-08-31 Maurizio Zanetti A universal cancer vaccine
CA3038889A1 (en) * 2016-09-30 2018-04-05 Jian Yan Tert immunogenic compositions and methods of treatment using the same
US20190076460A1 (en) * 2017-02-22 2019-03-14 Enyu Ding An mRNA cancer vaccine encoding human GM-CSF fused to multiple tandem epitopes
CN109142723B (en) * 2018-08-21 2021-07-13 苏州华益美生物科技有限公司 Human immunodeficiency virus rapid detection test card and application thereof
US11795210B2 (en) 2019-07-16 2023-10-24 Gilead Sciences, Inc. HIV vaccines and methods of making and using
US20230277645A1 (en) * 2020-04-02 2023-09-07 Inovio Pharmaceuticals, Inc. Compositions and methods for treating vulvar dysplasia

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US21579A (en) 1858-09-21 Rotary valve fob steam-engines
US2157994A (en) 1937-11-08 1939-05-09 Kelsey Hayes Wheel Co Brake mechanism
US5077044A (en) 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
US5110587A (en) 1981-12-24 1992-05-05 Health Research, Incorporated Immunogenic composition comprising synthetically modified vaccinia virus
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US5643579A (en) 1984-11-01 1997-07-01 American Home Products Corporation Oral vaccines
ZA858044B (en) 1984-11-01 1987-05-27 American Home Prod Oral vaccines
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5036006A (en) * 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
GB8508845D0 (en) 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
US5223424A (en) 1985-09-06 1993-06-29 Prutech Research And Development Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence
US4790987A (en) * 1985-11-15 1988-12-13 Research Corporation Viral glycoprotein subunit vaccine
US5310668A (en) * 1986-06-20 1994-05-10 Merck & Co., Inc. Varicella-zoster virus as a live recombinant vaccine
US5242829A (en) * 1986-09-23 1993-09-07 Therion Biologics Corporation Recombinant pseudorabies virus
IL86583A0 (en) 1987-06-04 1988-11-15 Molecular Eng Ass Vaccine containing a derivative of a microbe and method for the production thereof
US5387744A (en) 1987-06-04 1995-02-07 Washington University Avirulent microbes and uses therefor: Salmonella typhi
US5294441A (en) 1987-06-04 1994-03-15 Washington University Avirulent microbes and uses therefor: salmonella typhi
US5112749A (en) 1987-10-02 1992-05-12 Praxis Biologics, Inc. Vaccines for the malaria circumsporozoite protein
US5225336A (en) 1989-03-08 1993-07-06 Health Research Incorporated Recombinant poxvirus host range selection system
JP3044062B2 (en) 1989-03-08 2000-05-22 ヘルス・リサーチ・インク Recombinant poxvirus host selection system
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5591439A (en) 1989-03-24 1997-01-07 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
DK0465560T3 (en) 1989-03-31 1996-10-28 Univ Washington Vaccines containing avirulent phoP-type microorganisms
ES2070997T3 (en) 1989-12-04 1995-06-16 Akzo Nobel Nv RECOMBINANT HERPES VIRUSES OF TURKEYS AND LIVING VECTOR VACCINES DERIVED FROM THEM.
US5294548A (en) 1990-04-02 1994-03-15 American Biogenetic Sciences, Inc Recombianant Hepatitis a virus
WO1991018088A1 (en) 1990-05-23 1991-11-28 The United States Of America, Represented By The Secretary, United States Department Of Commerce Adeno-associated virus (aav)-based eucaryotic vectors
US5462734A (en) 1990-11-02 1995-10-31 Wisconsin Alumni Research Foundation Bovine herpesvirus vaccine and method of using same
US5240703A (en) 1991-03-01 1993-08-31 Syntro Corporation Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof
US6034298A (en) 1991-08-26 2000-03-07 Prodigene, Inc. Vaccines expressed in plants
US5955088A (en) * 1992-02-03 1999-09-21 Cedars-Sinai Medical Center Pharmaceutical compsition of herpes simplex virus type-1 (HSV-1), glycoproteins
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5981505A (en) 1993-01-26 1999-11-09 The Trustees Of The University Of Pennsylvania Compositions and methods for delivery of genetic material
DK0681483T3 (en) 1993-01-26 2005-11-21 Univ Pennsylvania Preparations and methods for administering genetic material
CA2164505A1 (en) 1993-06-07 1994-12-22 Phillip W. Berman Hiv envelope polypeptides
US5739118A (en) * 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
US6156319A (en) 1994-07-25 2000-12-05 The Trustees Of The University Of Pennsylvania Soluble herpesvirus glycoprotein complex vaccine
NL9401820A (en) 1994-11-02 1996-06-03 Meyn Maschf Device for processing poultry suspended from its legs.
AUPN015794A0 (en) * 1994-12-20 1995-01-19 Csl Limited Variants of human papilloma virus antigens
US5962428A (en) 1995-03-30 1999-10-05 Apollon, Inc. Compositions and methods for delivery of genetic material
US5650309A (en) 1995-05-16 1997-07-22 The Regents Of The University Of California Viral vectors
US5698202A (en) * 1995-06-05 1997-12-16 The Wistar Institute Of Anatomy & Biology Replication-defective adenovirus human type 5 recombinant as a rabies vaccine carrier
US7585622B1 (en) * 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
KR20000048820A (en) * 1996-10-01 2000-07-25 게론 코포레이션 Telomerase reverse transcriptase
CN1240480A (en) * 1996-10-18 2000-01-05 坎吉有限公司 Methods and compositions for delivery and expression of interferon-'alpha' nucleic acids
AUPO517897A0 (en) * 1997-02-19 1997-04-11 Csl Limited Chelating immunostimulating complexes
KR100581990B1 (en) * 1997-07-01 2006-05-23 캄비아 바이오시스템즈 엘엘씨 Vertebrate telomerase genes and proteins and uses thereof
GB9717953D0 (en) * 1997-08-22 1997-10-29 Smithkline Beecham Biolog Vaccine
ES2389519T3 (en) * 1997-09-18 2012-10-26 The Trustees Of The University Of Pennsylvania Attenuated vif DNA immunization cassettes for genetic vaccines
US6589529B1 (en) 1998-10-30 2003-07-08 Children's Hospital Medical Center Rotavirus subunit vaccine
CN1312171C (en) 2000-07-14 2007-04-25 宾夕法尼亚州立大学托管会 DNA vaccines encoding HIV accessory proteins
WO2002029088A2 (en) * 2000-10-04 2002-04-11 The Trustees Of The University Of Pennsylvania Highly expressible genes
EP1195438A1 (en) * 2000-10-06 2002-04-10 Rijksuniversiteit te Groningen Genetic immunisation against cervical carcinoma
US7245963B2 (en) 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
CN1468956A (en) * 2002-07-15 2004-01-21 杨 琴 Recombinant virus of antibody for high-efficiency expression to treat tumor and its use
CN1315536C (en) * 2002-09-13 2007-05-16 李进 Novel vaccine of tumor antigen, its preparation method and vaccine composition
ATE465753T1 (en) * 2002-10-21 2010-05-15 Eisai Inc COMPOSITIONS AND METHODS FOR TREATING DISEASES CAUSED BY THE HUMAN PAPILLOMA VIRUS
CN1453361A (en) * 2003-05-30 2003-11-05 中国科学院上海生命科学研究院 Construction method of virus as anticancer targeting adjustable gene
NZ570709A (en) * 2003-06-13 2010-04-30 Univ Pennsylvania Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
EP2371387A3 (en) * 2003-09-17 2012-01-25 Duke University HIV consensus sequence antigens and their use in vaccina
US20070275010A1 (en) * 2003-09-18 2007-11-29 Mark Feinberg Mva Vaccines
KR101710981B1 (en) * 2006-07-28 2017-02-28 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Improved vaccines and methods for using the same
NZ576134A (en) * 2006-10-12 2011-09-30 Angeletti P Ist Richerche Bio Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof
GB2504774A (en) 2012-08-10 2014-02-12 Munster Simms Eng Ltd Diaphragm pump with integral motor housing and rear pump housing
KR20140137679A (en) 2013-05-23 2014-12-03 삼성전자주식회사 Socket for card

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