WO2008014521A3 - Improved vaccines and methods for using the same - Google Patents

Improved vaccines and methods for using the same Download PDF

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Publication number
WO2008014521A3
WO2008014521A3 PCT/US2007/074769 US2007074769W WO2008014521A3 WO 2008014521 A3 WO2008014521 A3 WO 2008014521A3 US 2007074769 W US2007074769 W US 2007074769W WO 2008014521 A3 WO2008014521 A3 WO 2008014521A3
Authority
WO
WIPO (PCT)
Prior art keywords
those
consensus sequences
encode
nucleic acid
acid molecules
Prior art date
Application number
PCT/US2007/074769
Other languages
French (fr)
Other versions
WO2008014521A2 (en
WO2008014521A8 (en
Inventor
David B Weiner
Jian Yan
Original Assignee
Univ Pennsylvania
David B Weiner
Jian Yan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN200780036389.3A priority Critical patent/CN101679475B/en
Priority to KR1020217039157A priority patent/KR102511874B1/en
Priority to JP2009522035A priority patent/JP2009544333A/en
Priority to DK07840587.5T priority patent/DK2049559T3/en
Priority to KR1020197019662A priority patent/KR102173636B1/en
Priority to KR1020237009029A priority patent/KR20230042399A/en
Priority to MX2009001099A priority patent/MX2009001099A/en
Priority to AU2007278831A priority patent/AU2007278831B2/en
Priority to EP07840587A priority patent/EP2049559B1/en
Priority to US12/375,518 priority patent/US8168769B2/en
Priority to EP16156199.8A priority patent/EP3037429B1/en
Priority to KR1020147035344A priority patent/KR101609235B1/en
Priority to MX2015000975A priority patent/MX346862B/en
Priority to EP21163008.2A priority patent/EP3907232B1/en
Priority to KR1020177004941A priority patent/KR101848867B1/en
Priority to KR1020167007633A priority patent/KR101710981B1/en
Priority to KR1020187010028A priority patent/KR101999376B1/en
Priority to EP18196529.4A priority patent/EP3489251B1/en
Application filed by Univ Pennsylvania, David B Weiner, Jian Yan filed Critical Univ Pennsylvania
Priority to CA2659262A priority patent/CA2659262C/en
Priority to KR1020207031173A priority patent/KR102334637B1/en
Publication of WO2008014521A2 publication Critical patent/WO2008014521A2/en
Publication of WO2008014521A3 publication Critical patent/WO2008014521A3/en
Priority to HK09109663.8A priority patent/HK1130807A1/en
Priority to US13/458,013 priority patent/US8697084B2/en
Publication of WO2008014521A8 publication Critical patent/WO2008014521A8/en
Priority to US14/139,729 priority patent/US9376471B2/en
Priority to US14/139,660 priority patent/US9290546B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001157—Telomerase or TERT [telomerase reverse transcriptase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/12—Viral antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/24011—Poxviridae
    • C12N2710/24034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2740/10011—Retroviridae
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Abstract

Improved anti-HlV immυnogens and nucleic acid molecules that encode them are disclosed, lmmunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HlV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
PCT/US2007/074769 2006-07-28 2007-07-30 Improved vaccines and methods for using the same WO2008014521A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
CA2659262A CA2659262C (en) 2006-07-28 2007-07-30 Improved hpv vaccines and methods for using the same
JP2009522035A JP2009544333A (en) 2006-07-28 2007-07-30 Improved vaccine and method for using the same
DK07840587.5T DK2049559T3 (en) 2006-07-28 2007-07-30 Improved HPV vaccines
KR1020197019662A KR102173636B1 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
KR1020237009029A KR20230042399A (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
MX2009001099A MX2009001099A (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same.
AU2007278831A AU2007278831B2 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
EP07840587A EP2049559B1 (en) 2006-07-28 2007-07-30 Improved hpv vaccines
US12/375,518 US8168769B2 (en) 2006-07-28 2007-07-30 HPV vaccines and methods for using the same
EP16156199.8A EP3037429B1 (en) 2006-07-28 2007-07-30 Improved hiv vaccines
KR1020147035344A KR101609235B1 (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same
MX2015000975A MX346862B (en) 2006-07-28 2007-07-30 Improved vaccines and methods for using the same.
EP21163008.2A EP3907232B1 (en) 2006-07-28 2007-07-30 Improved hiv vaccines
CN200780036389.3A CN101679475B (en) 2006-07-28 2007-07-30 The vaccine improved and using method thereof
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