WO2008014223A3 - Assay particle concentration and imaging apparatus and method - Google Patents

Assay particle concentration and imaging apparatus and method Download PDF

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Publication number
WO2008014223A3
WO2008014223A3 PCT/US2007/074161 US2007074161W WO2008014223A3 WO 2008014223 A3 WO2008014223 A3 WO 2008014223A3 US 2007074161 W US2007074161 W US 2007074161W WO 2008014223 A3 WO2008014223 A3 WO 2008014223A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample vessel
holder
assay
imaging apparatus
particle concentration
Prior art date
Application number
PCT/US2007/074161
Other languages
French (fr)
Other versions
WO2008014223A2 (en
Inventor
Scott M Norton
Edward Robert Holland
Ian D Walton
Remy Cromer
Rebecca Louise Stoermer
Original Assignee
Oxonica Inc
Scott M Norton
Edward Robert Holland
Ian D Walton
Remy Cromer
Rebecca Louise Stoermer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38982246&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008014223(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oxonica Inc, Scott M Norton, Edward Robert Holland, Ian D Walton, Remy Cromer, Rebecca Louise Stoermer filed Critical Oxonica Inc
Priority to ES07799772.4T priority Critical patent/ES2422295T5/en
Priority to US12/375,096 priority patent/US20100060893A1/en
Priority to EP07799772.4A priority patent/EP2044402B2/en
Priority to JP2009521938A priority patent/JP5277165B2/en
Publication of WO2008014223A2 publication Critical patent/WO2008014223A2/en
Publication of WO2008014223A3 publication Critical patent/WO2008014223A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N21/658Raman scattering enhancement Raman, e.g. surface plasmons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082Test tubes per se
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N2015/0092Monitoring flocculation or agglomeration
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/651Cuvettes therefore
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00524Mixing by agitating sample carrier
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Abstract

An assay apparatus having a sample vessel within which an assay may be performed. The apparatus further includes a holder having a receptacle, socket or other device configured to operatively receive the sample vessel in a precise and easily repeated location with respect to the holder. A magnet may be operatively associated with the holder such that a magnetic field generated by the magnet intersects a portion of the sample vessel defining a magnetic concentration region within the sample vessel. A separate or integrated detection or interrogation instrument, typically a spectrometer, may be provided.
PCT/US2007/074161 2006-07-24 2007-07-24 Assay particle concentration and imaging apparatus and method WO2008014223A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES07799772.4T ES2422295T5 (en) 2006-07-24 2007-07-24 Apparatus and method for performing an assay using magnetic particles
US12/375,096 US20100060893A1 (en) 2006-07-24 2007-07-24 Assay particle concentration and imaging apparatus and method
EP07799772.4A EP2044402B2 (en) 2006-07-24 2007-07-24 Apparatus and method for performing an assay using magnetic particles
JP2009521938A JP5277165B2 (en) 2006-07-24 2007-07-24 Analytical particle agglomeration and imaging apparatus and method

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83292106P 2006-07-24 2006-07-24
US60/832,921 2006-07-24
US91025607P 2007-04-05 2007-04-05
US91024607P 2007-04-05 2007-04-05
US60/910,246 2007-04-05
US60/910,256 2007-04-05

Publications (2)

Publication Number Publication Date
WO2008014223A2 WO2008014223A2 (en) 2008-01-31
WO2008014223A3 true WO2008014223A3 (en) 2008-04-03

Family

ID=38982246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074161 WO2008014223A2 (en) 2006-07-24 2007-07-24 Assay particle concentration and imaging apparatus and method

Country Status (5)

Country Link
US (1) US20100060893A1 (en)
EP (2) EP2044402B2 (en)
JP (1) JP5277165B2 (en)
ES (2) ES2422295T5 (en)
WO (1) WO2008014223A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102224260B (en) * 2008-09-24 2015-11-25 施特劳斯控股公司 For test kit and the device of detect analytes
US8427641B2 (en) * 2008-12-18 2013-04-23 Azbil BioVigilant, Inc. Compact detector for simultaneous particle size and fluorescence detection
US8828729B1 (en) 2009-01-28 2014-09-09 Cabot Corporation Methods and apparatus for the detection of taggants by surface enhanced raman scattering
US20140106336A1 (en) * 2010-12-07 2014-04-17 Colorado School Of Mines Detection of Magnetic-Field-Concentrated Analytes in a Lateral Flow Capillary
US8624199B2 (en) 2011-10-28 2014-01-07 Fei Company Sample block holder
USD690826S1 (en) 2012-04-12 2013-10-01 Becton Dickinson And Company Vessel assembly
US9874555B2 (en) * 2012-04-12 2018-01-23 Becton, Dickinson And Company Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples
US8664595B2 (en) 2012-06-28 2014-03-04 Fei Company Cluster analysis of unknowns in SEM-EDS dataset
US9188555B2 (en) 2012-07-30 2015-11-17 Fei Company Automated EDS standards calibration
US9091635B2 (en) 2012-10-26 2015-07-28 Fei Company Mineral identification using mineral definitions having compositional ranges
US8937282B2 (en) 2012-10-26 2015-01-20 Fei Company Mineral identification using mineral definitions including variability
US9048067B2 (en) 2012-10-26 2015-06-02 Fei Company Mineral identification using sequential decomposition into elements from mineral definitions
US9778215B2 (en) 2012-10-26 2017-10-03 Fei Company Automated mineral classification
US9194829B2 (en) 2012-12-28 2015-11-24 Fei Company Process for performing automated mineralogy
WO2015121533A1 (en) 2014-02-11 2015-08-20 Wallac Oy A device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier
ITUB20154940A1 (en) * 2015-11-06 2017-05-06 Disa Raffaele E F Lli S A S Cell for analysis by Raman spectroscopy.
EP3429755A1 (en) 2016-03-18 2019-01-23 Andrew Alliance S.A Methods and apparatus for bead manipulation in a tip of a liquid handler
EP3642625A4 (en) * 2017-06-20 2021-06-09 Salus Discovery, LLC Lateral flow devices and methods
GB201818412D0 (en) * 2018-11-12 2018-12-26 Lumiradx Tech Ltd A magnetic assembly for use in a device for conducting assays
US11480565B2 (en) 2020-06-12 2022-10-25 Bio-Rad Laboratories, Inc. Automated immunoassay
WO2023198908A1 (en) * 2022-04-15 2023-10-19 Quantoom Biosciences S.A. Device and method for the separation and/or purification of a compound of interest
BE1030466B1 (en) * 2022-04-20 2023-11-21 Quantoom Biosciences S A DEVICE AND METHOD FOR THE SEPARATION AND/OR PURIFICATION OF A COMPOUND OF INTEREST

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040021073A1 (en) * 2002-04-12 2004-02-05 California Institute Of Technology Apparatus and method for magnetic-based manipulation of microscopic particles
US20060240572A1 (en) * 2004-08-24 2006-10-26 Carron Keith T System and method for Raman spectroscopy assay using paramagnetic particles

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4039297A (en) * 1971-12-25 1977-08-02 Japanese National Railways Heat insulating particles
GB1452271A (en) * 1972-10-23 1976-10-13 English Clays Lovering Pochin Apparatus for use in separating magnetic particles from a fluid in which they are suspended
US3975084A (en) * 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
NL7807532A (en) * 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
GB8415998D0 (en) * 1984-06-22 1984-07-25 Janssen Pharmaceutica Nv Staining method
US5059394A (en) * 1986-08-13 1991-10-22 Lifescan, Inc. Analytical device for the automated determination of analytes in fluids
JPS63106559A (en) * 1986-10-23 1988-05-11 Nippon Telegr & Teleph Corp <Ntt> Method and apparatus for laser magnetic immunoassay
US5238810A (en) 1986-09-22 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus thereof
US4802761A (en) * 1987-08-31 1989-02-07 Western Research Institute Optical-fiber raman spectroscopy used for remote in-situ environmental analysis
US4853335A (en) * 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US5238811A (en) * 1988-04-26 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus therefor and superparamagnetic material-labeled body and method for the manufacture of same
JP2551627B2 (en) * 1988-04-26 1996-11-06 日本電信電話株式会社 Laser magnetic immunoassay device
US5096809A (en) * 1988-07-25 1992-03-17 Pacific Biotech, Inc. Whole blood assays using porous membrane support devices
US5023139A (en) * 1989-04-04 1991-06-11 Research Corporation Technologies, Inc. Nonlinear optical materials
DE3934351A1 (en) * 1989-10-14 1991-04-18 Studiengesellschaft Kohle Mbh METHOD FOR PRODUCING MICROCRYSTALLINE TO AMORPHOUS METAL OR ALLOY POWDER AND WITHOUT PROTECTIVE COLLOID IN ORGANIC SOLVENTS SOLVED METALS OR. ALLOYS
US5112127A (en) * 1989-11-28 1992-05-12 Eic Laboratories, Inc. Apparatus for measuring Raman spectra over optical fibers
US5255067A (en) * 1990-11-30 1993-10-19 Eic Laboratories, Inc. Substrate and apparatus for surface enhanced Raman spectroscopy
JPH04348277A (en) * 1991-05-24 1992-12-03 Nippon Paint Co Ltd Method and apparatus for measuring in-vivo substance
US6200820B1 (en) * 1992-12-22 2001-03-13 Sienna Biotech, Inc. Light scatter-based immunoassay
US5384265A (en) * 1993-03-26 1995-01-24 Geo-Centers, Inc. Biomolecules bound to catalytic inorganic particles, immunoassays using the same
US5637508A (en) * 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
JPH06300762A (en) * 1993-04-14 1994-10-28 Nippon Telegr & Teleph Corp <Ntt> Non-separate type apparatus for fluorescent immunoassay
US5441894A (en) * 1993-04-30 1995-08-15 Abbott Laboratories Device containing a light absorbing element for automated chemiluminescent immunoassays
AU7170994A (en) * 1993-06-08 1995-01-03 Chronomed, Inc. Two-phase optical assay method and apparatus
US7141212B2 (en) * 1993-11-12 2006-11-28 Inverness Medical Switzerland Gmbh Reading devices and assay devices for use therewith
ZA948782B (en) * 1993-11-12 1996-05-07 Unipath Ltd Reading devices and assay devices for use therewith
JP3115501B2 (en) * 1994-06-15 2000-12-11 プレシジョン・システム・サイエンス株式会社 Method for controlling desorption of magnetic material using dispenser and various devices processed by this method
US6451619B1 (en) * 1994-06-29 2002-09-17 Inverness Medical Switzerland Gmbh Monitoring methods and devices for use therein
US5891738A (en) * 1995-01-16 1999-04-06 Erkki Soini Biospecific multiparameter assay method
EP0810905B1 (en) * 1995-02-21 1998-11-04 Iqbal W. Dr. Siddiqi Apparatus and method for mixing and separation employing magnetic particles
JPH09218201A (en) * 1995-12-07 1997-08-19 Seiko Instr Inc Method for separating magnetic particle
US5833924A (en) * 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay device and interface system
US6750031B1 (en) * 1996-01-11 2004-06-15 The United States Of America As Represented By The Secretary Of The Navy Displacement assay on a porous membrane
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
AUPN825796A0 (en) * 1996-02-26 1996-03-14 Ashdown, Martin The application of infrared (ir) spectrometry to the investigations of components of blood and other body fluids
US6103868A (en) * 1996-12-27 2000-08-15 The Regents Of The University Of California Organically-functionalized monodisperse nanocrystals of metals
US5958704A (en) * 1997-03-12 1999-09-28 Ddx, Inc. Sensing system for specific substance and molecule detection
US5998224A (en) * 1997-05-16 1999-12-07 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US6558956B1 (en) * 1997-06-24 2003-05-06 The University Of Wyoming Method and apparatus for detection of a controlled substance
US5864397A (en) * 1997-09-15 1999-01-26 Lockheed Martin Energy Research Corporation Surface-enhanced raman medical probes and system for disease diagnosis and drug testing
US6060256A (en) * 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
US6020207A (en) * 1998-06-17 2000-02-01 World Precision Instruments, Inc. Optical analysis technique and sensors for use therein
US6226082B1 (en) * 1998-06-25 2001-05-01 Amira Medical Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US6150182A (en) 1998-11-30 2000-11-21 Cassaday; Michael M. Method for separation of components in a biochemical reaction utilizing a combination of magnetic and centrifugal processes
US6743581B1 (en) * 1999-01-25 2004-06-01 Ut-Battelle, Lc Multifunctional and multispectral biosensor devices and methods of use
CA2371011C (en) * 1999-04-28 2009-12-22 Eidgenossisch Technische Hochschule Zurich Polyionic coatings in analytic and sensor devices
AU4701200A (en) * 1999-05-07 2000-11-21 Quantum Dot Corporation A method of detecting an analyte using semiconductor nanocrystals
US7123359B2 (en) * 1999-05-17 2006-10-17 Arrowhead Center, Inc. Optical devices and methods employing nanoparticles, microcavities, and semicontinuous metal films
US6730400B1 (en) * 1999-06-15 2004-05-04 Teruo Komatsu Ultrafine composite metal particles and method for manufacturing same
US7105310B1 (en) * 2000-07-19 2006-09-12 California Institute Of Technology Detection of biomolecules by sensitizer-linked substrates
EP1072887B1 (en) * 1999-07-30 2005-11-16 Mitsubishi Chemical Corporation Immunoassay
US6422998B1 (en) * 1999-09-20 2002-07-23 Ut-Battelle, Llc Fractal analysis of time varying data
US6254830B1 (en) * 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
US6645777B1 (en) * 1999-11-05 2003-11-11 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantation Tapered tubular optical waveguide probe for magnetic focusing immunosensors
US6587197B1 (en) * 1999-12-06 2003-07-01 Royce Technologies Llc Multiple microchannels chip for biomolecule imaging, and method of use thereof
EP2365096A1 (en) * 2000-03-22 2011-09-14 Life Technologies Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US6759235B2 (en) * 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
JP2003530568A (en) * 2000-04-11 2003-10-14 シェモメテック・アクティーゼルスカブ Method and apparatus for detecting fluorescence of a sample
US6610351B2 (en) * 2000-04-12 2003-08-26 Quantag Systems, Inc. Raman-active taggants and their recognition
US6838243B2 (en) * 2000-04-28 2005-01-04 Quantum Dot Corporation Methods and compositions for polynucleotide analysis using generic capture sequences
US6649138B2 (en) * 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US20020083888A1 (en) * 2000-12-28 2002-07-04 Zehnder Donald A. Flow synthesis of quantum dot nanocrystals
WO2003092043A2 (en) * 2001-07-20 2003-11-06 Quantum Dot Corporation Luminescent nanoparticles and methods for their preparation
US6972173B2 (en) * 2002-03-14 2005-12-06 Intel Corporation Methods to increase nucleotide signals by raman scattering
US6562403B2 (en) * 2001-10-15 2003-05-13 Kansas State University Research Foundation Synthesis of substantially monodispersed colloids
US6778316B2 (en) * 2001-10-24 2004-08-17 William Marsh Rice University Nanoparticle-based all-optical sensors
US7098041B2 (en) * 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US7102752B2 (en) * 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
JP3983593B2 (en) * 2002-04-26 2007-09-26 プレシジョン・システム・サイエンス株式会社 Magnetic particle suspension measuring device
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
EP1580555B1 (en) * 2002-11-07 2014-02-12 Mitsubishi Chemical Medience Corporation Magnetic material for collecting magnetic particles and utilization thereof
US7695738B2 (en) * 2003-02-19 2010-04-13 Academia Sinica Carbohydrate encapsulated nanoparticles
US7239394B2 (en) * 2003-06-04 2007-07-03 Inverness Medical Switzerland Gmbh Early determination of assay results
US7317532B2 (en) * 2003-06-04 2008-01-08 Inverness Medical Switzerland Gmbh Flow sensing for determination of assay results
US7315378B2 (en) * 2003-06-04 2008-01-01 Inverness Medical Switzerland Gmbh Optical arrangement for assay reading device
EP1651960A1 (en) * 2003-07-30 2006-05-03 Koninklijke Philips Electronics N.V. Use of magnetic particles for determining binding between bioactive molecules
NZ528323A (en) * 2003-09-18 2006-05-26 Horticulture & Food Res Inst Immunoassay
US20050112703A1 (en) * 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
WO2005069006A1 (en) * 2004-01-06 2005-07-28 Bwt Property Inc. Novel antibody mediated surface enhanced raman scattering (sers) immunoassay and multiplexing schemes
JP4728663B2 (en) * 2004-03-22 2011-07-20 シスメックス株式会社 Target substance detection probe set and target substance detection method
JP2005315726A (en) * 2004-04-28 2005-11-10 Canon Inc Detection reagent, detector, detection method and detection kit
US7102747B2 (en) * 2004-10-13 2006-09-05 Hewlett-Packard Development Company, L.P. In situ excitation for Surface Enhanced Raman Spectroscopy
US7518721B2 (en) * 2005-09-09 2009-04-14 Ge Homeland Protection, Inc. Raman-active lateral flow device and methods of detection
US7355703B2 (en) * 2005-09-09 2008-04-08 Ge Homeland Protection, Inc. Raman-active lateral flow device and methods of detection and making

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040021073A1 (en) * 2002-04-12 2004-02-05 California Institute Of Technology Apparatus and method for magnetic-based manipulation of microscopic particles
US20060240572A1 (en) * 2004-08-24 2006-10-26 Carron Keith T System and method for Raman spectroscopy assay using paramagnetic particles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2044402A4 *

Also Published As

Publication number Publication date
EP2044402B1 (en) 2013-04-24
JP5277165B2 (en) 2013-08-28
EP2620771A1 (en) 2013-07-31
EP2044402A4 (en) 2010-11-10
JP2009544975A (en) 2009-12-17
EP2044402B2 (en) 2016-11-30
EP2044402A2 (en) 2009-04-08
ES2422295T5 (en) 2017-06-15
US20100060893A1 (en) 2010-03-11
EP2620771B1 (en) 2017-08-30
ES2649986T3 (en) 2018-01-16
ES2422295T3 (en) 2013-09-10
WO2008014223A2 (en) 2008-01-31

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