WO2008012828A3 - Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use - Google Patents

Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use Download PDF

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Publication number
WO2008012828A3
WO2008012828A3 PCT/IL2007/000946 IL2007000946W WO2008012828A3 WO 2008012828 A3 WO2008012828 A3 WO 2008012828A3 IL 2007000946 W IL2007000946 W IL 2007000946W WO 2008012828 A3 WO2008012828 A3 WO 2008012828A3
Authority
WO
WIPO (PCT)
Prior art keywords
collagen
matrices
scaffolds
cross
implants
Prior art date
Application number
PCT/IL2007/000946
Other languages
French (fr)
Other versions
WO2008012828A2 (en
Inventor
Yuval Zubery
Arie Goldlust
Thomas Bayer
Eran Nir
Original Assignee
Colbar Lifescience Ltd
Yuval Zubery
Arie Goldlust
Thomas Bayer
Eran Nir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colbar Lifescience Ltd, Yuval Zubery, Arie Goldlust, Thomas Bayer, Eran Nir filed Critical Colbar Lifescience Ltd
Priority to AU2007278024A priority Critical patent/AU2007278024A1/en
Priority to EP07790001A priority patent/EP2051658A4/en
Priority to JP2009521418A priority patent/JP2009544400A/en
Publication of WO2008012828A2 publication Critical patent/WO2008012828A2/en
Publication of WO2008012828A3 publication Critical patent/WO2008012828A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Abstract

Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.
PCT/IL2007/000946 2006-07-27 2007-07-29 Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use WO2008012828A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2007278024A AU2007278024A1 (en) 2006-07-27 2007-07-29 Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use
EP07790001A EP2051658A4 (en) 2006-07-27 2007-07-29 Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use
JP2009521418A JP2009544400A (en) 2006-07-27 2007-07-29 Complex embedded plants for promoting bone regeneration and growth and methods for their production and use.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83347606P 2006-07-27 2006-07-27
US60/833,476 2006-07-27

Publications (2)

Publication Number Publication Date
WO2008012828A2 WO2008012828A2 (en) 2008-01-31
WO2008012828A3 true WO2008012828A3 (en) 2009-05-07

Family

ID=38981889

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/000946 WO2008012828A2 (en) 2006-07-27 2007-07-29 Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use

Country Status (5)

Country Link
US (4) US20080026032A1 (en)
EP (1) EP2051658A4 (en)
JP (1) JP2009544400A (en)
AU (1) AU2007278024A1 (en)
WO (1) WO2008012828A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2389204B1 (en) 2009-01-23 2019-07-03 Royal College of Surgeons in Ireland Layered scaffold suitable for osteochondral repair
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
AU2013201872B2 (en) * 2009-07-22 2015-02-12 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US8329219B2 (en) 2009-12-22 2012-12-11 Cook Biotech Incorporated Methods for producing ECM-based biomaterials
US10226480B2 (en) * 2010-03-30 2019-03-12 Histocell, S.L. Biomaterial from Wharton's jelly umbilical cord
EP2529764A1 (en) * 2011-05-31 2012-12-05 Curasan AG Biodegradable composite material
DE102011082960A1 (en) * 2011-09-19 2013-03-21 Resorba Wundversorgung Gmbh & Co. Kg Shaped body with collagen-containing composite material for insertion into a bone defect site
US9878071B2 (en) * 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
US10314940B2 (en) 2014-08-27 2019-06-11 Purdue Research Foundation Collagen-based therapeutic delivery systems
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
US10537417B2 (en) 2016-07-07 2020-01-21 Collagen Matrix, Inc. Density gradient biopolymeric matrix implants
EP3615568A4 (en) 2017-04-25 2021-01-20 Purdue Research Foundation 3-dimensional (3d) tissue-engineered muscle for tissue restoration
CN111511900B (en) 2017-11-09 2021-12-31 南加利福尼亚大学阿尔弗雷德·E·曼恩生物医学工程研究所 Stem cells and devices for bone regeneration
KR20210132054A (en) * 2019-01-31 2021-11-03 셀 메디신 가부시키가이샤 Inorganic salt protein complex medical device
WO2020255113A1 (en) * 2019-06-20 2020-12-24 Datum Biotech Ltd. An implantable structure having a collagen membrane
JP6755052B1 (en) * 2019-07-10 2020-09-16 バイオチューブ株式会社 Connective tissue and its manufacturing method
CN113332497B (en) * 2021-04-30 2022-04-22 国家纳米科学中心 Double-sided bracket and preparation method and application thereof
WO2023137481A2 (en) * 2022-01-17 2023-07-20 Embody, Inc. Compressed implants for soft tissue repair
CN114618026B (en) * 2022-03-17 2023-09-12 西岭(镇江)医疗科技有限公司 Barrier membrane capable of promoting bone regeneration and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470911A (en) * 1988-11-21 1995-11-28 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
DE2929144A1 (en) * 1979-07-19 1981-02-12 Behringwerke Ag METHOD FOR PRODUCING COLLAGEN
US4582640A (en) * 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
IL76079A (en) * 1985-08-13 1991-03-10 Univ Ramot Collagen implants
US5108438A (en) * 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US5147514A (en) * 1987-08-02 1992-09-15 University Of North Carolina Process for cross-linking collagenous material and resulting product
US4772287A (en) * 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US4961707A (en) * 1987-12-22 1990-10-09 University Of Florida Guided periodontal tissue regeneration
AU624627B2 (en) * 1988-08-18 1992-06-18 Johnson & Johnson Orthopaedics, Inc. Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US4971954A (en) * 1988-11-23 1990-11-20 University Of Medicine And Dentistry Of New Jersey Collagen-based matrices ribose cross-linked
US5700479A (en) * 1988-12-23 1997-12-23 Guidor Ab Surgical element and method for selective tissue regeneration
DE69031483T2 (en) * 1989-08-02 1998-02-05 Univ North Carolina Process for the cross-linking of collagen and product produced thereby
EP0453393B1 (en) * 1990-04-20 1993-10-06 SULZER Medizinaltechnik AG Implant, particularly intervertebral prosthesis
US5292362A (en) * 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5192326A (en) * 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5047055A (en) * 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
JP3007903B2 (en) * 1991-03-29 2000-02-14 京セラ株式会社 Artificial disc
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5290763A (en) * 1991-04-22 1994-03-01 Intermedics Orthopedics/Denver, Inc. Osteoinductive protein mixtures and purification processes
FR2679778B1 (en) * 1991-08-02 1995-07-07 Coletica USE OF CROLAGEN CROSSLINKED BY A CROSSLINKING AGENT FOR THE MANUFACTURE OF A SLOW RESORPTIVE, BIOCOMPATIBLE, SUTURABLE MEMBRANE, AS WELL AS SUCH A MEMBRANE.
US6277112B1 (en) * 1996-07-16 2001-08-21 Arthrocare Corporation Methods for electrosurgical spine surgery
GB9206509D0 (en) * 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges containing active agents
GB9206504D0 (en) * 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges as wound implants
US5800537A (en) * 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5660857A (en) * 1993-03-22 1997-08-26 Johnson & Johnson Medical Inc. Biopolymer composites
US5534028A (en) * 1993-04-20 1996-07-09 Howmedica, Inc. Hydrogel intervertebral disc nucleus with diminished lateral bulging
GB9400163D0 (en) * 1994-01-06 1994-03-02 Geistlich Soehne Ag Membrane
US5514180A (en) * 1994-01-14 1996-05-07 Heggeness; Michael H. Prosthetic intervertebral devices
WO1996001641A1 (en) * 1994-07-08 1996-01-25 Sulzer Medizinaltechnik Ag Method of manufacturing implant materials
IL110367A (en) * 1994-07-19 2007-05-15 Colbar Lifescience Ltd Collagen-based matrix
ATE203885T1 (en) * 1994-09-08 2001-08-15 Stryker Technologies Corp HYDROGEL DISC CORE
US5824093A (en) * 1994-10-17 1998-10-20 Raymedica, Inc. Prosthetic spinal disc nucleus
JPH10507386A (en) * 1994-10-17 1998-07-21 レイメディカ， インコーポレイテッド Artificial spinal disc nucleus
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
GB9503492D0 (en) * 1995-02-22 1995-04-12 Ed Geistlich S Hne A G F R Che Chemical product
US7141072B2 (en) * 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
GB9721585D0 (en) * 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
EP0768332B1 (en) * 1995-10-11 2001-03-28 Sulzer Markets and Technology AG Process for photooxidative treatment of collagen-containing tissues
US5645597A (en) * 1995-12-29 1997-07-08 Krapiva; Pavel I. Disc replacement method and apparatus
US5788625A (en) * 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US5718012A (en) * 1996-05-28 1998-02-17 Organogenesis, Inc. Method of strength enhancement of collagen constructs
US5964807A (en) * 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US6126682A (en) * 1996-08-13 2000-10-03 Oratec Interventions, Inc. Method for treating annular fissures in intervertebral discs
TW501934B (en) * 1996-11-20 2002-09-11 Tapic Int Co Ltd Collagen material and process for making the same
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6309670B1 (en) * 1997-01-15 2001-10-30 Orquest, Inc. Collagen-polysaccharide matrix for treatment of bone tumors
US5800549A (en) * 1997-04-30 1998-09-01 Howmedica Inc. Method and apparatus for injecting an elastic spinal implant
US6022376A (en) * 1997-06-06 2000-02-08 Raymedica, Inc. Percutaneous prosthetic spinal disc nucleus and method of manufacture
US5997895A (en) * 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix
US8858981B2 (en) * 1997-10-10 2014-10-14 Ed. Geistlich Soehne Fuer Chemistrie Industrie Bone healing material comprising matrix carrying bone-forming cells
US5865833A (en) * 1997-11-24 1999-02-02 S.L.T. Japan Co., Ltd. Apparatus for laser treatment
US6156531A (en) * 1998-07-20 2000-12-05 Sulzer Carbomedics Inc. Cross-linking tissue with a compound having a C8 to C40 aliphatic chain
WO2000007527A1 (en) * 1998-08-03 2000-02-17 Synthes Ag Chur Intervertebral allograft spacer
JP3726280B2 (en) * 1998-09-18 2005-12-14 ニプロ株式会社 Medical collagen membrane
WO2000035510A1 (en) * 1998-12-14 2000-06-22 Osteotech, Inc. Bone graft and guided bone regeneration method
EP1022031B1 (en) * 1999-01-21 2005-03-23 Nipro Corporation Suturable adhesion-preventing membrane
US6585972B2 (en) * 1999-03-09 2003-07-01 Gholam A. Peyman Process for crosslinking of collagen in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina
US6177514B1 (en) * 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues
US6283966B1 (en) * 1999-07-07 2001-09-04 Sulzer Spine-Tech Inc. Spinal surgery tools and positioning method
US6264695B1 (en) * 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
US6283968B1 (en) * 2000-03-07 2001-09-04 Hamid M. Mehdizadeh Posterior laminectomy procedure
US6682760B2 (en) * 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
JP3747412B2 (en) * 2000-05-26 2006-02-22 エンゲルハード・リヨン Use of collagen from aquatic animals to produce carriers designed for tissue engineering and the carriers and biomaterials obtained thereby
US6790454B1 (en) * 2000-05-26 2004-09-14 Coletica Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained
US6500464B2 (en) * 2000-12-28 2002-12-31 Ortec International, Inc. Bilayered collagen construct
JP3871525B2 (en) * 2001-04-26 2007-01-24 ニプロ株式会社 Biological tissue or organ regeneration device
JP2003160506A (en) * 2001-08-10 2003-06-03 Ed Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material and method
JPWO2003090765A1 (en) * 2002-04-23 2005-08-25 株式会社ネーテック Medical composition containing photocrosslinkable chitosan derivative
US7166133B2 (en) * 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
WO2007082295A2 (en) * 2006-01-12 2007-07-19 Integra Lifesciences Corporation Suturable dural and meningeal repair product comprising collagen matrix

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470911A (en) * 1988-11-21 1995-11-28 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates

Also Published As

Publication number Publication date
JP2009544400A (en) 2009-12-17
AU2007278024A1 (en) 2008-01-31
US20080026032A1 (en) 2008-01-31
WO2008012828A2 (en) 2008-01-31
EP2051658A2 (en) 2009-04-29
US20090269387A1 (en) 2009-10-29
US20090269386A1 (en) 2009-10-29
US20090269385A1 (en) 2009-10-29
EP2051658A4 (en) 2012-05-30

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