WO2008008430A3 - Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases - Google Patents

Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases Download PDF

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Publication number
WO2008008430A3
WO2008008430A3 PCT/US2007/015892 US2007015892W WO2008008430A3 WO 2008008430 A3 WO2008008430 A3 WO 2008008430A3 US 2007015892 W US2007015892 W US 2007015892W WO 2008008430 A3 WO2008008430 A3 WO 2008008430A3
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WO
WIPO (PCT)
Prior art keywords
diagnosis
compositions
treatment
rna
micro
Prior art date
Application number
PCT/US2007/015892
Other languages
French (fr)
Other versions
WO2008008430A2 (en
Inventor
Carlo M Croce
Curtis C Harris
Aaron J Schetter
Original Assignee
Univ Ohio State Res Found
Carlo M Croce
Curtis C Harris
Aaron J Schetter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ohio State Res Found, Carlo M Croce, Curtis C Harris, Aaron J Schetter filed Critical Univ Ohio State Res Found
Priority to JP2009519525A priority Critical patent/JP5230619B2/en
Priority to CN200780033066.9A priority patent/CN101657547B/en
Priority to EP07810382A priority patent/EP2041317A4/en
Priority to CA002657030A priority patent/CA2657030A1/en
Priority to US12/373,358 priority patent/US8084199B2/en
Priority to AU2007272947A priority patent/AU2007272947B2/en
Publication of WO2008008430A2 publication Critical patent/WO2008008430A2/en
Publication of WO2008008430A3 publication Critical patent/WO2008008430A3/en
Priority to US13/295,440 priority patent/US8518647B2/en
Priority to US13/295,692 priority patent/US8338103B2/en
Priority to US13/295,209 priority patent/US8338102B2/en
Priority to US13/295,280 priority patent/US8349568B2/en
Priority to US13/296,371 priority patent/US8338105B2/en
Priority to US13/296,291 priority patent/US8338104B2/en
Priority to US13/296,448 priority patent/US8338106B2/en
Priority to US13/296,500 priority patent/US8343725B2/en
Priority to US13/296,545 priority patent/US20120065098A1/en
Priority to US15/057,308 priority patent/US20160177305A1/en
Priority to US15/484,446 priority patent/US20170275625A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Abstract

The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
PCT/US2007/015892 2006-07-13 2007-07-12 Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases WO2008008430A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP2009519525A JP5230619B2 (en) 2006-07-13 2007-07-12 MicroRNA-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
CN200780033066.9A CN101657547B (en) 2006-07-13 2007-07-12 For the diagnosis and treatment of the method and composition based on Microrna of colon cancer-related diseases
EP07810382A EP2041317A4 (en) 2006-07-13 2007-07-12 Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
CA002657030A CA2657030A1 (en) 2006-07-13 2007-07-12 Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
US12/373,358 US8084199B2 (en) 2006-07-13 2007-07-12 Method of diagnosing poor survival prognosis colon cancer using microRNA-21
AU2007272947A AU2007272947B2 (en) 2006-07-13 2007-07-12 Micro-RNA-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
US13/295,280 US8349568B2 (en) 2006-07-13 2011-11-14 Method of diagnosing poor survival prognosis colon cancer using let-7g
US13/295,209 US8338102B2 (en) 2006-07-13 2011-11-14 Method of diagnosing poor survival prognosis colon cancer using miR-181b
US13/295,692 US8338103B2 (en) 2006-07-13 2011-11-14 Method of diagnosing poor survival prognosis colon cancer using miR-106a
US13/295,440 US8518647B2 (en) 2006-07-13 2011-11-14 Method of diagnosing poor survival prognosis colon cancer using miR-16b
US13/296,371 US8338105B2 (en) 2006-07-13 2011-11-15 Method of diagnosing poor survival prognosis colon cancer using miR-203
US13/296,291 US8338104B2 (en) 2006-07-13 2011-11-15 Method of diagnosing poor survival prognosis colon cancer using miR-103-2
US13/296,448 US8338106B2 (en) 2006-07-13 2011-11-15 Method of diagnosing poor survival prognosis colon cancer using miR-29a
US13/296,500 US8343725B2 (en) 2006-07-13 2011-11-15 Method of diagnosing poor survival prognosis colon cancer using miR-10a
US13/296,545 US20120065098A1 (en) 2006-07-13 2011-11-15 Method of predicting chemotherapy effectiveness in colon adenocarcinoma patients, using mir-21
US15/057,308 US20160177305A1 (en) 2006-07-13 2016-03-01 Methods of Inhibiting Tumorigenesis in Colon Adenocarcinoma and Compositions Therefor
US15/484,446 US20170275625A1 (en) 2006-07-13 2017-04-11 Methods Of Inhibiting Tumorigenesis In Colon Adenocarcinoma And Compositions Therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80730406P 2006-07-13 2006-07-13
US60/807,304 2006-07-13
US93273607P 2007-06-01 2007-06-01
US60/932,736 2007-06-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US80730406P Substitution 2006-07-13 2006-07-13

Related Child Applications (10)

Application Number Title Priority Date Filing Date
US12/373,358 A-371-Of-International US8084199B2 (en) 2006-07-13 2007-07-12 Method of diagnosing poor survival prognosis colon cancer using microRNA-21
US13/295,280 Division US8349568B2 (en) 2006-07-13 2011-11-14 Method of diagnosing poor survival prognosis colon cancer using let-7g
US13/295,692 Division US8338103B2 (en) 2006-07-13 2011-11-14 Method of diagnosing poor survival prognosis colon cancer using miR-106a
US13/295,209 Division US8338102B2 (en) 2006-07-13 2011-11-14 Method of diagnosing poor survival prognosis colon cancer using miR-181b
US13/295,440 Division US8518647B2 (en) 2006-07-13 2011-11-14 Method of diagnosing poor survival prognosis colon cancer using miR-16b
US13/296,500 Division US8343725B2 (en) 2006-07-13 2011-11-15 Method of diagnosing poor survival prognosis colon cancer using miR-10a
US13/296,545 Division US20120065098A1 (en) 2006-07-13 2011-11-15 Method of predicting chemotherapy effectiveness in colon adenocarcinoma patients, using mir-21
US13/296,448 Division US8338106B2 (en) 2006-07-13 2011-11-15 Method of diagnosing poor survival prognosis colon cancer using miR-29a
US13/296,371 Division US8338105B2 (en) 2006-07-13 2011-11-15 Method of diagnosing poor survival prognosis colon cancer using miR-203
US13/296,291 Division US8338104B2 (en) 2006-07-13 2011-11-15 Method of diagnosing poor survival prognosis colon cancer using miR-103-2

Publications (2)

Publication Number Publication Date
WO2008008430A2 WO2008008430A2 (en) 2008-01-17
WO2008008430A3 true WO2008008430A3 (en) 2008-12-11

Family

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PCT/US2007/015892 WO2008008430A2 (en) 2006-07-13 2007-07-12 Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases

Country Status (8)

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US (12) US8084199B2 (en)
EP (11) EP2436787B1 (en)
JP (3) JP5230619B2 (en)
CN (2) CN101657547B (en)
AU (1) AU2007272947B2 (en)
CA (1) CA2657030A1 (en)
ES (9) ES2451695T3 (en)
WO (1) WO2008008430A2 (en)

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US8367632B2 (en) 2007-07-31 2013-02-05 Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
US8389210B2 (en) 2006-01-05 2013-03-05 The Ohio State University Research Foundation MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors
US8658370B2 (en) 2005-08-01 2014-02-25 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer

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