WO2008007069A3 - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number
WO2008007069A3
WO2008007069A3 PCT/GB2007/002561 GB2007002561W WO2008007069A3 WO 2008007069 A3 WO2008007069 A3 WO 2008007069A3 GB 2007002561 W GB2007002561 W GB 2007002561W WO 2008007069 A3 WO2008007069 A3 WO 2008007069A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass
electrodes
ions
analyser
mass analyser
Prior art date
Application number
PCT/GB2007/002561
Other languages
French (fr)
Other versions
WO2008007069A2 (en
Inventor
John Brian Hoyes
Original Assignee
Micromass Ltd
John Brian Hoyes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/483,961 external-priority patent/US7405401B2/en
Priority claimed from PCT/GB2006/002728 external-priority patent/WO2007010272A2/en
Priority claimed from GB0704923A external-priority patent/GB0704923D0/en
Priority to US12/373,204 priority Critical patent/US7960694B2/en
Priority to CN2007800297586A priority patent/CN101536137B/en
Priority to EP07733500.8A priority patent/EP2038913B1/en
Priority to CA2656197A priority patent/CA2656197C/en
Priority to JP2009518951A priority patent/JP5341753B2/en
Application filed by Micromass Ltd, John Brian Hoyes filed Critical Micromass Ltd
Publication of WO2008007069A2 publication Critical patent/WO2008007069A2/en
Publication of WO2008007069A3 publication Critical patent/WO2008007069A3/en
Priority to HK10101506.3A priority patent/HK1134722A1/en
Priority to US13/157,021 priority patent/US8389933B2/en
Priority to US13/784,130 priority patent/US8742339B2/en
Priority to US14/291,274 priority patent/US9312118B2/en

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/36Radio frequency spectrometers, e.g. Bennett-type spectrometers, Redhead-type spectrometers
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/42Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205Device types
    • H01J49/422Two-dimensional RF ion traps
    • H01J49/4235Stacked rings or stacked plates
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0031Step by step routines describing the use of the apparatus

Abstract

A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass ((analyser 2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC' or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser (2).
PCT/GB2007/002561 2004-01-09 2007-07-09 Mass spectrometer WO2008007069A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US12/373,204 US7960694B2 (en) 2004-01-09 2007-07-09 Mass spectrometer
CN2007800297586A CN101536137B (en) 2006-07-10 2007-07-09 Mass spectrometer
EP07733500.8A EP2038913B1 (en) 2006-07-10 2007-07-09 Mass spectrometer
CA2656197A CA2656197C (en) 2006-07-10 2007-07-09 Mass spectrometer
JP2009518951A JP5341753B2 (en) 2006-07-10 2007-07-09 Mass spectrometer
HK10101506.3A HK1134722A1 (en) 2006-07-10 2010-02-10 Mass spectrometer
US13/157,021 US8389933B2 (en) 2005-01-10 2011-06-09 Mass analyzer utilizing a plurality of axial pseudo-potential wells
US13/784,130 US8742339B2 (en) 2004-01-09 2013-03-04 Mass spectrometer
US14/291,274 US9312118B2 (en) 2004-01-09 2014-05-30 Mass spectrometer

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11/483,961 2006-07-10
US11/483,961 US7405401B2 (en) 2004-01-09 2006-07-10 Ion extraction devices, mass spectrometer devices, and methods of selectively extracting ions and performing mass spectrometry
PCT/GB2006/002728 WO2007010272A2 (en) 2005-07-21 2006-07-21 Mass spectrometer
GBPCT/GB2006/002728 2006-07-21
GB0704923.2 2007-03-14
GB0704923A GB0704923D0 (en) 2007-03-14 2007-03-14 Mass spectrometer
US91389707P 2007-04-25 2007-04-25
US60/913,897 2007-04-25

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
PCT/GB2005/000050 Continuation-In-Part WO2005067000A2 (en) 2004-01-09 2005-01-10 Ion extraction devices and methods of selectively extracting ions
US11/483,961 Continuation-In-Part US7405401B2 (en) 2004-01-09 2006-07-10 Ion extraction devices, mass spectrometer devices, and methods of selectively extracting ions and performing mass spectrometry
PCT/GB2006/002728 Continuation-In-Part WO2007010272A2 (en) 2004-01-09 2006-07-21 Mass spectrometer

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/373,204 A-371-Of-International US7960694B2 (en) 2004-01-09 2007-07-09 Mass spectrometer
US13/157,021 Continuation US8389933B2 (en) 2004-01-09 2011-06-09 Mass analyzer utilizing a plurality of axial pseudo-potential wells

Publications (2)

Publication Number Publication Date
WO2008007069A2 WO2008007069A2 (en) 2008-01-17
WO2008007069A3 true WO2008007069A3 (en) 2008-10-02

Family

ID=38786866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002561 WO2008007069A2 (en) 2004-01-09 2007-07-09 Mass spectrometer

Country Status (5)

Country Link
US (4) US7960694B2 (en)
EP (1) EP2038913B1 (en)
JP (1) JP5341753B2 (en)
CA (1) CA2656197C (en)
WO (1) WO2008007069A2 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0514964D0 (en) 2005-07-21 2005-08-24 Ms Horizons Ltd Mass spectrometer devices & methods of performing mass spectrometry
GB0608470D0 (en) 2006-04-28 2006-06-07 Micromass Ltd Mass spectrometer
EP2038913B1 (en) * 2006-07-10 2015-07-08 Micromass UK Limited Mass spectrometer
GB0624535D0 (en) * 2006-12-08 2007-01-17 Micromass Ltd Mass spectrometer
US9673034B2 (en) 2006-12-08 2017-06-06 Micromass Uk Limited Mass spectrometer
EP2089895B1 (en) 2006-12-08 2017-10-04 Micromass UK Limited Mass spectrometer
GB0713590D0 (en) 2007-07-12 2007-08-22 Micromass Ltd Mass spectrometer
WO2009114932A1 (en) * 2008-03-20 2009-09-24 Mds Analytical Technologies, A Business Unit Of Mds Inc., Systems and methods for analyzing substances using a mass spectrometer
GB0817433D0 (en) * 2008-09-23 2008-10-29 Thermo Fisher Scient Bremen Ion trap for cooling ions
US8138472B2 (en) * 2009-04-29 2012-03-20 Academia Sinica Molecular ion accelerator
US20110149252A1 (en) * 2009-12-21 2011-06-23 Matthew Keith Schwiebert Electrohydrodynamic Air Mover Performance
GB201000852D0 (en) * 2010-01-19 2010-03-03 Micromass Ltd Mass spectrometer
EP2529388B1 (en) * 2010-01-29 2019-10-23 Micromass UK Limited Fragmentation reagents for mass spectrometry
WO2011125218A1 (en) * 2010-04-09 2011-10-13 株式会社島津製作所 Quadrupolar mass analysis device
US9048080B2 (en) * 2010-08-19 2015-06-02 Leco Corporation Time-of-flight mass spectrometer with accumulating electron impact ion source
WO2012035165A1 (en) * 2010-09-17 2012-03-22 Iee International Electronics & Engineering S.A. Dynamic trap ion mobility spectrometer
GB2484136B (en) * 2010-10-01 2015-09-16 Thermo Fisher Scient Bremen Method and apparatus for improving the throughput of a charged particle analysis system
GB201018184D0 (en) * 2010-10-27 2010-12-08 Micromass Ltd Asymmetric field ion mobility in a linear geometry ion trap
CN103718270B (en) * 2011-05-05 2017-10-03 岛津研究实验室(欧洲)有限公司 The device of electrified particle
US9318310B2 (en) 2011-07-11 2016-04-19 Dh Technologies Development Pte. Ltd. Method to control space charge in a mass spectrometer
GB201114735D0 (en) 2011-08-25 2011-10-12 Micromass Ltd Mass spectrometer
GB201114734D0 (en) 2011-08-25 2011-10-12 Micromass Ltd Mass spectrometer
GB201119059D0 (en) 2011-11-04 2011-12-21 Micromass Ltd Improvements to tof mass spectrometers using linear accelerator devices
US9812311B2 (en) 2013-04-08 2017-11-07 Battelle Memorial Institute Ion manipulation method and device
US8835839B1 (en) 2013-04-08 2014-09-16 Battelle Memorial Institute Ion manipulation device
GB201322515D0 (en) * 2013-12-19 2014-02-05 Micromass Ltd High pressure mass resolving ion guide with axial field
DE112014005915T5 (en) 2013-12-19 2016-09-08 Micromass Uk Limited Mass-dissolving high-pressure ion guide with axial field
US10497551B2 (en) * 2013-12-24 2019-12-03 Micromass Uk Limited Storage ring for fast processes
US9490115B2 (en) * 2014-12-18 2016-11-08 Thermo Finnigan Llc Varying frequency during a quadrupole scan for improved resolution and mass range
US9799503B2 (en) * 2015-01-20 2017-10-24 Agilent Technologies, Inc. Traveling-well ion guides and related systems and methods
GB201513472D0 (en) * 2015-07-30 2015-09-16 Smiths Detection Watford Ltd Apparatus and method
US9704701B2 (en) 2015-09-11 2017-07-11 Battelle Memorial Institute Method and device for ion mobility separations
AU2016335524B2 (en) 2015-10-07 2019-05-16 Battelle Memorial Institute Method and apparatus for ion mobility separations utilizing alternating current waveforms
US10692710B2 (en) 2017-08-16 2020-06-23 Battelle Memorial Institute Frequency modulated radio frequency electric field for ion manipulation
GB2579314A (en) 2017-08-16 2020-06-17 Battelle Memorial Institute Methods and systems for ion manipulation
EP3692564A1 (en) 2017-10-04 2020-08-12 Battelle Memorial Institute Methods and systems for integrating ion manipulation devices
WO2019158931A1 (en) * 2018-02-16 2019-08-22 Micromass Uk Limited Quadrupole devices
AU2019269449A1 (en) 2018-05-14 2020-12-10 MOBILion Systems, Inc. Coupling of ion mobility spectrometer with mass spectrometer
GB201808936D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808949D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808894D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
WO2019229463A1 (en) 2018-05-31 2019-12-05 Micromass Uk Limited Mass spectrometer having fragmentation region
GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808892D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
US11367607B2 (en) 2018-05-31 2022-06-21 Micromass Uk Limited Mass spectrometer
GB201808890D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
US10665441B2 (en) 2018-08-08 2020-05-26 Thermo Finnigan Llc Methods and apparatus for improved tandem mass spectrometry duty cycle
AU2020280042A1 (en) 2019-05-21 2021-12-23 MOBILion Systems, Inc. Voltage control for ion mobility separation
GB201912489D0 (en) 2019-08-30 2019-10-16 Shimadzu Corp Mass analysis apparatuses and methods
US11543384B2 (en) 2019-11-22 2023-01-03 MOBILion Systems, Inc. Mobility based filtering of ions
EP4133264A4 (en) 2020-04-06 2024-05-01 Mobilion Systems Inc Systems and methods for two-dimensional mobility based filtering of ions
CN115885176A (en) 2020-05-22 2023-03-31 莫比莱昂系统有限公司 Method and apparatus for trapping and accumulating ions
EP4161683A1 (en) 2020-06-05 2023-04-12 Mobilion Systems, Inc. Apparatus and methods for ion manipulation having improved duty cycle

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040046124A1 (en) * 2000-11-23 2004-03-11 Derrick Peter John Ion focussing and conveying device and a method of focussing the conveying ions
WO2005067000A2 (en) * 2004-01-09 2005-07-21 Ms Horizons Limited Ion extraction devices and methods of selectively extracting ions
US20050253064A1 (en) * 2004-05-05 2005-11-17 Sciex Division Of Mds Inc. Method and apparatus for selective axial ejection
WO2007052025A2 (en) * 2005-11-01 2007-05-10 Micromass Uk Limited Mass spectrometer

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206506A (en) * 1991-02-12 1993-04-27 Kirchner Nicholas J Ion processing: control and analysis
US6177668B1 (en) * 1996-06-06 2001-01-23 Mds Inc. Axial ejection in a multipole mass spectrometer
GB9612070D0 (en) * 1996-06-10 1996-08-14 Micromass Ltd Plasma mass spectrometer
US6525312B1 (en) * 2000-02-25 2003-02-25 Mds Inc. Mass spectrometer with method for real time removal of background signal
GB0025016D0 (en) * 2000-10-12 2000-11-29 Micromass Ltd Method nad apparatus for mass spectrometry
CA2364676C (en) * 2000-12-08 2010-07-27 Mds Inc., Doing Business As Mds Sciex Ion mobility spectrometer incorporating an ion guide in combination with an ms device
GB2375653B (en) * 2001-02-22 2004-11-10 Bruker Daltonik Gmbh Travelling field for packaging ion beams
US6956205B2 (en) * 2001-06-15 2005-10-18 Bruker Daltonics, Inc. Means and method for guiding ions in a mass spectrometer
US7586088B2 (en) * 2001-06-21 2009-09-08 Micromass Uk Limited Mass spectrometer and method of mass spectrometry
CA2391140C (en) * 2001-06-25 2008-10-07 Micromass Limited Mass spectrometer
US6906319B2 (en) * 2002-05-17 2005-06-14 Micromass Uk Limited Mass spectrometer
US6794641B2 (en) * 2002-05-30 2004-09-21 Micromass Uk Limited Mass spectrometer
US7095013B2 (en) * 2002-05-30 2006-08-22 Micromass Uk Limited Mass spectrometer
ATE339011T1 (en) * 2002-05-30 2006-09-15 Micromass Ltd MASS SPECTROMETRY
US6800846B2 (en) * 2002-05-30 2004-10-05 Micromass Uk Limited Mass spectrometer
US7034292B1 (en) * 2002-05-31 2006-04-25 Analytica Of Branford, Inc. Mass spectrometry with segmented RF multiple ion guides in various pressure regions
US6891157B2 (en) * 2002-05-31 2005-05-10 Micromass Uk Limited Mass spectrometer
US6770871B1 (en) * 2002-05-31 2004-08-03 Michrom Bioresources, Inc. Two-dimensional tandem mass spectrometry
US6791078B2 (en) * 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
US6884995B2 (en) * 2002-07-03 2005-04-26 Micromass Uk Limited Mass spectrometer
US7045797B2 (en) * 2002-08-05 2006-05-16 The University Of British Columbia Axial ejection with improved geometry for generating a two-dimensional substantially quadrupole field
US7071467B2 (en) * 2002-08-05 2006-07-04 Micromass Uk Limited Mass spectrometer
US7049583B2 (en) * 2002-08-08 2006-05-23 Micromass Uk Limited Mass spectrometer
US6875980B2 (en) * 2002-08-08 2005-04-05 Micromass Uk Limited Mass spectrometer
US6794642B2 (en) * 2002-08-08 2004-09-21 Micromass Uk Limited Mass spectrometer
US7102126B2 (en) * 2002-08-08 2006-09-05 Micromass Uk Limited Mass spectrometer
DE10392952B4 (en) * 2002-09-03 2012-04-19 Micromass Uk Ltd. Method for mass spectrometry
US6835928B2 (en) * 2002-09-04 2004-12-28 Micromass Uk Limited Mass spectrometer
US6838662B2 (en) * 2002-11-08 2005-01-04 Micromass Uk Limited Mass spectrometer
US7087897B2 (en) * 2003-03-11 2006-08-08 Waters Investments Limited Mass spectrometer
US6992283B2 (en) * 2003-06-06 2006-01-31 Micromass Uk Limited Mass spectrometer
CA2431603C (en) * 2003-06-10 2012-03-27 Micromass Uk Limited Mass spectrometer
GB0514964D0 (en) * 2005-07-21 2005-08-24 Ms Horizons Ltd Mass spectrometer devices & methods of performing mass spectrometry
US7405401B2 (en) * 2004-01-09 2008-07-29 Micromass Uk Limited Ion extraction devices, mass spectrometer devices, and methods of selectively extracting ions and performing mass spectrometry
US7026613B2 (en) * 2004-01-23 2006-04-11 Thermo Finnigan Llc Confining positive and negative ions with fast oscillating electric potentials
CA2565909A1 (en) * 2004-05-20 2005-12-01 Applera Corporation Method for providing barrier fields at the entrance and exit end of a mass spectrometer
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
US7642511B2 (en) * 2004-09-30 2010-01-05 Ut-Battelle, Llc Ultra high mass range mass spectrometer systems
GB0424426D0 (en) * 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
GB0425426D0 (en) * 2004-11-18 2004-12-22 Micromass Ltd Mass spectrometer
CA2587742C (en) * 2004-12-07 2014-03-11 Micromass Uk Limited Mass spectrometer
GB0426900D0 (en) * 2004-12-08 2005-01-12 Micromass Ltd Mass spectrometer
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
GB0511333D0 (en) * 2005-06-03 2005-07-13 Micromass Ltd Mass spectrometer
GB0608470D0 (en) * 2006-04-28 2006-06-07 Micromass Ltd Mass spectrometer
EP2013895B8 (en) * 2006-04-28 2019-07-17 Micromass UK Limited Mass spectrometer
EP2038913B1 (en) * 2006-07-10 2015-07-08 Micromass UK Limited Mass spectrometer
GB0620468D0 (en) * 2006-10-16 2006-11-22 Micromass Ltd Mass spectrometer
GB0624535D0 (en) * 2006-12-08 2007-01-17 Micromass Ltd Mass spectrometer
GB0713590D0 (en) * 2007-07-12 2007-08-22 Micromass Ltd Mass spectrometer
GB0723183D0 (en) * 2007-11-23 2008-01-09 Micromass Ltd Mass spectrometer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040046124A1 (en) * 2000-11-23 2004-03-11 Derrick Peter John Ion focussing and conveying device and a method of focussing the conveying ions
WO2005067000A2 (en) * 2004-01-09 2005-07-21 Ms Horizons Limited Ion extraction devices and methods of selectively extracting ions
US20050253064A1 (en) * 2004-05-05 2005-11-17 Sciex Division Of Mds Inc. Method and apparatus for selective axial ejection
WO2007052025A2 (en) * 2005-11-01 2007-05-10 Micromass Uk Limited Mass spectrometer

Also Published As

Publication number Publication date
EP2038913B1 (en) 2015-07-08
US20140264008A1 (en) 2014-09-18
EP2038913A2 (en) 2009-03-25
WO2008007069A2 (en) 2008-01-17
US20110233396A1 (en) 2011-09-29
CA2656197A1 (en) 2008-01-17
US8742339B2 (en) 2014-06-03
US8389933B2 (en) 2013-03-05
US20130175439A1 (en) 2013-07-11
CA2656197C (en) 2015-06-16
US20090314935A1 (en) 2009-12-24
US9312118B2 (en) 2016-04-12
US7960694B2 (en) 2011-06-14
JP5341753B2 (en) 2013-11-13
JP2009543311A (en) 2009-12-03

Similar Documents

Publication Publication Date Title
WO2008007069A3 (en) Mass spectrometer
WO2007052025A3 (en) Mass spectrometer
GB2455593B (en) Mass spectrometer
WO2007125354A3 (en) Mass spectrometer
WO2006075182A3 (en) Mass spectrometer
WO2010028081A3 (en) Two-dimensional radial-ejection trap operable as a quadrupole mass filter
WO2006085110A3 (en) Mass spectrometer
WO2005022113A3 (en) Ion channel assay methods
WO2008067331A3 (en) Quadrupole faims apparatus
WO2002069414A3 (en) Electrochemical cell with zigzag electrodes
WO2007060436A3 (en) Mass spectrometer
WO2007104992A3 (en) Mass spectrometer
WO2002008748A3 (en) Ion channel assay methods
EP2091305A3 (en) Plasma reactor and plasma reaction apparatus
EP1662592A4 (en) Current collecting structure and electrode structure
WO2005043115A3 (en) Ion mobility tof/maldi/ms using drift cell alternating high and low electrical field regions
EA200700395A1 (en) SPECTROMETER OF ION MOBILITY
JP2008530748A5 (en)
EA200501154A1 (en) POROUS ELECTRODE, SOLID OXIDE FUEL ELEMENT AND METHOD OF THEIR PRODUCTION
WO2009059052A3 (en) Bipolar electrosurgical probe having insulated overlapping conductive elements
WO2009064350A3 (en) Linear faims power supply
WO2008103492A3 (en) Coaxial hybrid radio frequency ion trap mass analyzer
WO2011089419A3 (en) Mass to charge ratio selective ejection from ion guide having supplemental rf voltage applied thereto
WO2007118047A3 (en) Multi-frequency static neutralization
EP1830610A3 (en) Plasma discharged static eliminator

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780029758.6

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07733500

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2656197

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2007733500

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 176/DELNP/2009

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2009518951

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: RU

WWE Wipo information: entry into national phase

Ref document number: 12373204

Country of ref document: US