WO2007149724A3 - Substrates for performing analytical reactions - Google Patents

Substrates for performing analytical reactions Download PDF

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Publication number
WO2007149724A3
WO2007149724A3 PCT/US2007/070901 US2007070901W WO2007149724A3 WO 2007149724 A3 WO2007149724 A3 WO 2007149724A3 US 2007070901 W US2007070901 W US 2007070901W WO 2007149724 A3 WO2007149724 A3 WO 2007149724A3
Authority
WO
WIPO (PCT)
Prior art keywords
substrates
analytical reactions
performing analytical
components
fυπclionai
Prior art date
Application number
PCT/US2007/070901
Other languages
French (fr)
Other versions
WO2007149724A2 (en
Inventor
Mathieu Foquet
Paul Peluso
Stephen Turner
Daniel Bernardo Roitman
Geoffrey Otto
Original Assignee
Pacific Biosciences California
Mathieu Foquet
Paul Peluso
Stephen Turner
Daniel Bernardo Roitman
Geoffrey Otto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences California, Mathieu Foquet, Paul Peluso, Stephen Turner, Daniel Bernardo Roitman, Geoffrey Otto filed Critical Pacific Biosciences California
Priority to AU2007261114A priority Critical patent/AU2007261114B2/en
Priority to CN2007800218264A priority patent/CN101467082B/en
Priority to JP2009515592A priority patent/JP2009539411A/en
Priority to EP07845184.6A priority patent/EP2027253A4/en
Priority to CA2654470A priority patent/CA2654470C/en
Publication of WO2007149724A2 publication Critical patent/WO2007149724A2/en
Publication of WO2007149724A3 publication Critical patent/WO2007149724A3/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7709—Distributed reagent, e.g. over length of guide
    • G01N2021/7713—Distributed reagent, e.g. over length of guide in core

Abstract

Substrates, including zero mode waveguide substrates that have been fabricated to provide additional fυπclionai elements and/or components including increased volumes for positioning of active surfaces and or components for the mitigation of negative electrochemical properties of the underlying substrates.
PCT/US2007/070901 2006-06-12 2007-06-11 Substrates for performing analytical reactions WO2007149724A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2007261114A AU2007261114B2 (en) 2006-06-12 2007-06-11 Substrates for performing analytical reactions
CN2007800218264A CN101467082B (en) 2006-06-12 2007-06-11 Substrates for performing analytical reactions
JP2009515592A JP2009539411A (en) 2006-06-12 2007-06-11 Substrates for performing analytical reactions
EP07845184.6A EP2027253A4 (en) 2006-06-12 2007-06-11 Substrates for performing analytical reactions
CA2654470A CA2654470C (en) 2006-06-12 2007-06-11 Substrates for performing analytical reactions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81286306P 2006-06-12 2006-06-12
US60/812,863 2006-06-12

Publications (2)

Publication Number Publication Date
WO2007149724A2 WO2007149724A2 (en) 2007-12-27
WO2007149724A3 true WO2007149724A3 (en) 2008-07-31

Family

ID=38834243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/070901 WO2007149724A2 (en) 2006-06-12 2007-06-11 Substrates for performing analytical reactions

Country Status (7)

Country Link
US (2) US7486865B2 (en)
EP (2) EP2857829B1 (en)
JP (1) JP2009539411A (en)
CN (2) CN101915957B (en)
AU (1) AU2007261114B2 (en)
CA (1) CA2654470C (en)
WO (1) WO2007149724A2 (en)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc Microfluidic devices
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US7486865B2 (en) * 2006-06-12 2009-02-03 Pacific Biosciences Of California, Inc. Substrates for performing analytical reactions
EP2097738B1 (en) 2006-12-21 2013-11-20 Koninklijke Philips N.V. Aperture biosensor with trenches
DE102007016699A1 (en) * 2007-04-04 2008-10-09 Synentec Gmbh Biochip for the fluorescence analysis of individual transporters
US20110250402A1 (en) * 2008-06-02 2011-10-13 Applied Biosystems, Llc Localization of near-field resonances in bowtie antennae: influence of adhesion layers
EP2362947B1 (en) 2008-09-30 2017-05-10 Pacific Biosciences of California, Inc. Ultra-high multiplex analytical systems and methods
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
JP5798926B2 (en) 2008-11-07 2015-10-21 シーケンタ インコーポレイテッド How to monitor disease states by sequence analysis
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
EP2387627B1 (en) 2009-01-15 2016-03-30 Adaptive Biotechnologies Corporation Adaptive immunity profiling and methods for generation of monoclonal antibodies
US9778188B2 (en) 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
CA2765949C (en) 2009-06-25 2016-03-29 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
WO2011031313A2 (en) 2009-09-11 2011-03-17 Pacific Biosciences Of California, Inc. Zero-mode waveguides with non-reflecting walls
US8367159B2 (en) 2009-09-11 2013-02-05 Pacific Biosciences Of California, Inc. Methods for producing ZMWs with islands of functionality
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
AU2011217862B9 (en) 2010-02-19 2014-07-10 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US9482615B2 (en) * 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
US9670243B2 (en) 2010-06-02 2017-06-06 Industrial Technology Research Institute Compositions and methods for sequencing nucleic acids
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
EP2658988B1 (en) 2010-12-27 2018-01-24 Ibis Biosciences, Inc. Nucleic acid sample preparation methods and compositions
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US9670538B2 (en) 2011-08-05 2017-06-06 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
CA2853088C (en) 2011-10-21 2018-03-13 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US9267917B2 (en) 2011-11-04 2016-02-23 Pacific Biosciences Of California, Inc. Nanopores in zero mode waveguides
EP3904536A1 (en) 2011-12-09 2021-11-03 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
WO2013096819A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Macromolecule positioning by electrical potential
WO2013102081A2 (en) 2011-12-29 2013-07-04 Ibis Biosciences, Inc. Macromolecule delivery to nanowells
US9222115B2 (en) 2011-12-30 2015-12-29 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
CN104334739A (en) 2012-01-13 2015-02-04 Data生物有限公司 Genotyping by next-generation sequencing
US9238836B2 (en) 2012-03-30 2016-01-19 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing modified nucleic acids
EP3222627B1 (en) 2012-02-15 2019-08-07 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
EP3372694A1 (en) 2012-03-05 2018-09-12 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
WO2013166304A1 (en) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Dna sequencing
ES2840456T3 (en) 2012-05-02 2021-07-06 Ibis Biosciences Inc DNA sequencing
ES2683707T3 (en) 2012-05-02 2018-09-27 Ibis Biosciences, Inc. DNA sequencing
CN107586832B (en) 2012-05-08 2021-03-30 适应生物技术公司 Compositions and methods for measuring and calibrating amplification bias in multiplex PCR reactions
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
US9551030B2 (en) 2012-06-17 2017-01-24 Pacific Biosciences Of California, Inc. Filter architecture for analytical devices
ES2660027T3 (en) 2012-10-01 2018-03-20 Adaptive Biotechnologies Corporation Evaluation of immunocompetence by the diversity of adaptive immunity receptors and clonal characterization
WO2014062835A1 (en) 2012-10-16 2014-04-24 Abbott Molecular Inc. Methods and apparatus to sequence a nucleic acid
EP4123294A1 (en) 2012-12-18 2023-01-25 Pacific Biosciences Of California, Inc. An optical analytical device
US9624540B2 (en) 2013-02-22 2017-04-18 Pacific Biosciences Of California, Inc. Integrated illumination of optical analytical devices
WO2014150851A1 (en) 2013-03-15 2014-09-25 Ibis Biosciences, Inc. Nucleotide analogs for sequencing
US9581550B2 (en) 2013-05-31 2017-02-28 Pacific Biosciences Of California Analytical devices having compact lens train arrays
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
ES2873850T3 (en) 2013-08-19 2021-11-04 Abbott Molecular Inc Next Generation Sequencing Libraries
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
WO2015095355A2 (en) 2013-12-17 2015-06-25 The Brigham And Women's Hospital, Inc. Detection of an antibody against a pathogen
US9540688B2 (en) 2014-02-19 2017-01-10 Personal Genomics, Inc. Real-time sequencing method for single molecule
US20170292149A1 (en) 2014-03-05 2017-10-12 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
ES2777529T3 (en) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Quantification of adaptive immune cell genomes in a complex mixture of cells
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US11155809B2 (en) 2014-06-24 2021-10-26 Bio-Rad Laboratories, Inc. Digital PCR barcoding
CN107209188A (en) 2014-06-27 2017-09-26 雅培制药有限公司 Composition and method for detecting people Pegivirus 2 (HPgV 2)
CN114280023A (en) 2014-08-27 2022-04-05 加利福尼亚太平洋生物科学股份有限公司 Integrated analytical device array
CN107002293B (en) 2014-09-17 2020-12-08 艾比斯生物科学公司 Sequencing by synthesis using pulsed readout optics
EP3209410A4 (en) 2014-10-22 2018-05-02 IntegenX Inc. Systems and methods for sample preparation, processing and analysis
EP3212790B1 (en) 2014-10-29 2020-03-25 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
US11066705B2 (en) 2014-11-25 2021-07-20 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
CN106148969A (en) * 2014-12-29 2016-11-23 厦门火炬特种金属材料有限公司 A kind of sacrificial magnesium alloy anode current efficiency device for fast detecting and method
US10302972B2 (en) 2015-01-23 2019-05-28 Pacific Biosciences Of California, Inc. Waveguide transmission
AU2016222788B2 (en) 2015-02-24 2022-03-31 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
EP3271762B1 (en) 2015-03-16 2023-01-04 Pacific Biosciences of California, Inc. Analytical system comprising integrated devices and systems for free-space optical coupling
EP3277294A4 (en) 2015-04-01 2018-11-14 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
CN107615283B (en) 2015-05-26 2022-07-05 加利福尼亚太平洋生物科学股份有限公司 Methods, software and systems for diploid genome assembly and haplotype sequence reconstruction
CN107924027B (en) 2015-06-12 2024-01-23 加利福尼亚太平洋生物科学股份有限公司 Integrated target waveguide device and system for optical coupling
US10280411B2 (en) 2015-10-27 2019-05-07 Pacific Biosciences of California, In.c Methods, systems, and reagents for direct RNA sequencing
TWI794145B (en) 2015-10-28 2023-03-01 美商加州太平洋生物科學公司 Arrays of optical devices comprising integrated bandpass filters
CN108350491A (en) 2015-11-18 2018-07-31 加利福尼亚太平洋生物科学股份有限公司 Nucleic acid is loaded on base material
WO2017087696A1 (en) 2015-11-18 2017-05-26 Pacific Biosciences Of California, Inc. Methods and compositions for loading of polymerase complexes
EP3400298B1 (en) 2016-01-08 2024-03-06 Bio-Rad Laboratories, Inc. Multiple beads per droplet resolution
US10544457B2 (en) 2016-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Methods and compositions for enriching compositions for polymerase enzyme complexes
US10711300B2 (en) 2016-07-22 2020-07-14 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
US11543417B2 (en) 2016-08-29 2023-01-03 Oslo Universitetssykehus Hf ChIP-seq assays
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
WO2018118971A1 (en) 2016-12-19 2018-06-28 Bio-Rad Laboratories, Inc. Droplet tagging contiguity preserved tagmented dna
US10468736B2 (en) 2017-02-08 2019-11-05 Aptiv Technologies Limited Radar assembly with ultra wide band waveguide to substrate integrated waveguide transition
US11186862B2 (en) 2017-06-20 2021-11-30 Bio-Rad Laboratories, Inc. MDA using bead oligonucleotide
CN111295443B (en) 2017-11-02 2024-04-16 生物辐射实验室股份有限公司 Transposase-based genomic analysis
EP3704521A4 (en) 2017-11-03 2021-07-07 Pacific Biosciences of California, Inc. Systems, devices, and methods for improved optical waveguide transmission and alignment
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
US10655168B2 (en) 2017-12-22 2020-05-19 Pacific Biosciences Of California, Inc. Modified biotin-binding proteins for immobilization
EP3746552B1 (en) 2018-01-31 2023-12-27 Bio-Rad Laboratories, Inc. Methods and compositions for deconvoluting partition barcodes
CN108375672B (en) * 2018-02-14 2022-06-24 京东方科技集团股份有限公司 Biological detection chip and detection method thereof
US11512002B2 (en) 2018-04-18 2022-11-29 University Of Virginia Patent Foundation Silica materials and methods of making thereof
US11332787B2 (en) 2018-06-29 2022-05-17 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
US11479816B2 (en) 2018-08-20 2022-10-25 Bio-Rad Laboratories, Inc. Nucleotide sequence generation by barcode bead-colocalization in partitions
US11527808B2 (en) 2019-04-29 2022-12-13 Aptiv Technologies Limited Waveguide launcher
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
WO2021214766A1 (en) 2020-04-21 2021-10-28 Yeda Research And Development Co. Ltd. Methods of diagnosing viral infections and vaccines thereto
EP3951352B1 (en) * 2020-08-06 2023-10-04 Cellular Highways Ltd. Apparatus for transmission optical measurements with a window in an opaque substrate
US11362436B2 (en) * 2020-10-02 2022-06-14 Aptiv Technologies Limited Plastic air-waveguide antenna with conductive particles
US11757166B2 (en) 2020-11-10 2023-09-12 Aptiv Technologies Limited Surface-mount waveguide for vertical transitions of a printed circuit board
US11681015B2 (en) 2020-12-18 2023-06-20 Aptiv Technologies Limited Waveguide with squint alteration
US11502420B2 (en) 2020-12-18 2022-11-15 Aptiv Technologies Limited Twin line fed dipole array antenna
US11901601B2 (en) 2020-12-18 2024-02-13 Aptiv Technologies Limited Waveguide with a zigzag for suppressing grating lobes
US11749883B2 (en) 2020-12-18 2023-09-05 Aptiv Technologies Limited Waveguide with radiation slots and parasitic elements for asymmetrical coverage
US11626668B2 (en) 2020-12-18 2023-04-11 Aptiv Technologies Limited Waveguide end array antenna to reduce grating lobes and cross-polarization
US11444364B2 (en) 2020-12-22 2022-09-13 Aptiv Technologies Limited Folded waveguide for antenna
US11668787B2 (en) 2021-01-29 2023-06-06 Aptiv Technologies Limited Waveguide with lobe suppression
US11721905B2 (en) 2021-03-16 2023-08-08 Aptiv Technologies Limited Waveguide with a beam-forming feature with radiation slots
US11616306B2 (en) 2021-03-22 2023-03-28 Aptiv Technologies Limited Apparatus, method and system comprising an air waveguide antenna having a single layer material with air channels therein which is interfaced with a circuit board
US11962085B2 (en) 2021-05-13 2024-04-16 Aptiv Technologies AG Two-part folded waveguide having a sinusoidal shape channel including horn shape radiating slots formed therein which are spaced apart by one-half wavelength
US11616282B2 (en) 2021-08-03 2023-03-28 Aptiv Technologies Limited Transition between a single-ended port and differential ports having stubs that match with input impedances of the single-ended and differential ports

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
CA2281205A1 (en) * 1997-02-12 1998-08-13 Eugene Y. Chan Methods and products for analyzing polymers
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
NO315342B1 (en) * 2001-12-27 2003-08-18 Optoplan As Fiber optic sensor
GB2423819B (en) * 2004-09-17 2008-02-06 Pacific Biosciences California Apparatus and method for analysis of molecules
JP2006115742A (en) * 2004-10-20 2006-05-11 Sumitomo Precision Prod Co Ltd Method and device for amplifying nucleic acid, and system for detecting nucleic acid
US7486865B2 (en) * 2006-06-12 2009-02-03 Pacific Biosciences Of California, Inc. Substrates for performing analytical reactions
EP2097738B1 (en) * 2006-12-21 2013-11-20 Koninklijke Philips N.V. Aperture biosensor with trenches

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US7013054B2 (en) * 2001-09-27 2006-03-14 Cornell Research Foundation, Inc. Waveguides for performing spectroscopy with confined effective observation volumes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2027253A4 *

Also Published As

Publication number Publication date
CN101915957B (en) 2012-12-12
WO2007149724A2 (en) 2007-12-27
US7907800B2 (en) 2011-03-15
AU2007261114B2 (en) 2012-07-12
AU2007261114A1 (en) 2007-12-27
US20080095488A1 (en) 2008-04-24
EP2857829A1 (en) 2015-04-08
CN101915957A (en) 2010-12-15
EP2027253A2 (en) 2009-02-25
US7486865B2 (en) 2009-02-03
CN101467082B (en) 2011-12-14
EP2857829B1 (en) 2017-08-09
US20090325166A1 (en) 2009-12-31
CN101467082A (en) 2009-06-24
EP2027253A4 (en) 2014-04-30
CA2654470C (en) 2015-02-03
JP2009539411A (en) 2009-11-19
CA2654470A1 (en) 2007-12-27

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