WO2007149438A3 - Pharmaceutical compositions - Google Patents

Pharmaceutical compositions Download PDF

Info

Publication number
WO2007149438A3
WO2007149438A3 PCT/US2007/014282 US2007014282W WO2007149438A3 WO 2007149438 A3 WO2007149438 A3 WO 2007149438A3 US 2007014282 W US2007014282 W US 2007014282W WO 2007149438 A3 WO2007149438 A3 WO 2007149438A3
Authority
WO
WIPO (PCT)
Prior art keywords
agonist
antagonist
pharmaceutical compositions
seal coat
pharmaceutical composition
Prior art date
Application number
PCT/US2007/014282
Other languages
French (fr)
Other versions
WO2007149438A2 (en
Inventor
Frank Matthews
Garth Boehm
Lijuan Tang
Alfred Liang
Original Assignee
Alpharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38834070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007149438(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP07809672A priority Critical patent/EP2034975B8/en
Priority to CN2007800303040A priority patent/CN101677963B/en
Priority to BRPI0714039A priority patent/BRPI0714039A8/en
Priority to JP2009516543A priority patent/JP5566102B2/en
Priority to SI200730929T priority patent/SI2034975T1/en
Priority to CA2655835A priority patent/CA2655835C/en
Priority to PL07809672T priority patent/PL2034975T3/en
Priority to KR20157004494A priority patent/KR20150029762A/en
Priority to AU2007261451A priority patent/AU2007261451A1/en
Application filed by Alpharma, Inc. filed Critical Alpharma, Inc.
Priority to ES07809672T priority patent/ES2385612T3/en
Priority to MX2008016372A priority patent/MX2008016372A/en
Priority to AT07809672T priority patent/ATE552829T1/en
Priority to DK07809672.4T priority patent/DK2034975T3/en
Priority to NZ573757A priority patent/NZ573757A/en
Priority to KR1020097000449A priority patent/KR101486228B1/en
Priority to KR1020147011462A priority patent/KR20140079441A/en
Publication of WO2007149438A2 publication Critical patent/WO2007149438A2/en
Priority to IL195834A priority patent/IL195834A/en
Priority to ZA2008/10501A priority patent/ZA200810501B/en
Publication of WO2007149438A3 publication Critical patent/WO2007149438A3/en
Priority to IL235150A priority patent/IL235150A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility

Abstract

Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing. such a pharmaceutical composition are also provided.
PCT/US2007/014282 2006-06-19 2007-06-19 Pharmaceutical compositions WO2007149438A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
ES07809672T ES2385612T3 (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
MX2008016372A MX2008016372A (en) 2006-06-19 2007-06-19 Pharmaceutical compositions.
CN2007800303040A CN101677963B (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
JP2009516543A JP5566102B2 (en) 2006-06-19 2007-06-19 Pharmaceutical composition
SI200730929T SI2034975T1 (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
CA2655835A CA2655835C (en) 2006-06-19 2007-06-19 Abuse-resistant pharmaceutical compositions of opioid agonists
PL07809672T PL2034975T3 (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
KR20157004494A KR20150029762A (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
AT07809672T ATE552829T1 (en) 2006-06-19 2007-06-19 PHARMACEUTICAL COMPOSITIONS
EP07809672A EP2034975B8 (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
KR1020147011462A KR20140079441A (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
BRPI0714039A BRPI0714039A8 (en) 2006-06-19 2007-06-19 PHARMACEUTICAL COMPOSITION
AU2007261451A AU2007261451A1 (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
DK07809672.4T DK2034975T3 (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
NZ573757A NZ573757A (en) 2006-06-19 2007-06-19 Coated multilayer oral dosage forms of naltrexone hydrochloride
KR1020097000449A KR101486228B1 (en) 2006-06-19 2007-06-19 Pharmaceutical compositions
IL195834A IL195834A (en) 2006-06-19 2008-12-10 Compositions comprising a plurality of multi-layer pellets and use thereof
ZA2008/10501A ZA200810501B (en) 2006-06-19 2008-12-11 Pharmaceutical compositions
IL235150A IL235150A (en) 2006-06-19 2014-10-19 Pharmaceutical compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81494906P 2006-06-19 2006-06-19
US60/814,949 2006-06-19

Publications (2)

Publication Number Publication Date
WO2007149438A2 WO2007149438A2 (en) 2007-12-27
WO2007149438A3 true WO2007149438A3 (en) 2009-09-24

Family

ID=38834070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/014282 WO2007149438A2 (en) 2006-06-19 2007-06-19 Pharmaceutical compositions

Country Status (23)

Country Link
US (9) US8158156B2 (en)
EP (4) EP2484346B1 (en)
JP (1) JP5566102B2 (en)
KR (3) KR101486228B1 (en)
CN (1) CN101677963B (en)
AT (1) ATE552829T1 (en)
AU (4) AU2007261451A1 (en)
BR (1) BRPI0714039A8 (en)
CA (1) CA2655835C (en)
CY (4) CY1112868T1 (en)
DK (4) DK2526932T3 (en)
ES (4) ES2622576T3 (en)
HK (1) HK1173980A1 (en)
HU (3) HUE033058T2 (en)
IL (2) IL195834A (en)
MX (1) MX2008016372A (en)
NZ (1) NZ573757A (en)
PL (4) PL2526932T3 (en)
PT (4) PT2526932T (en)
RU (1) RU2445077C2 (en)
SI (4) SI2484346T1 (en)
WO (1) WO2007149438A2 (en)
ZA (1) ZA200810501B (en)

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