WO2007146227A3 - Flow-induced delivery from a drug mass - Google Patents

Flow-induced delivery from a drug mass Download PDF

Info

Publication number
WO2007146227A3
WO2007146227A3 PCT/US2007/013686 US2007013686W WO2007146227A3 WO 2007146227 A3 WO2007146227 A3 WO 2007146227A3 US 2007013686 W US2007013686 W US 2007013686W WO 2007146227 A3 WO2007146227 A3 WO 2007146227A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
flow
drug mass
induced delivery
delivery
Prior art date
Application number
PCT/US2007/013686
Other languages
French (fr)
Other versions
WO2007146227A2 (en
Inventor
Thomas J Lobl
Anna Imola Nagy
Jacob E Pananen
John V Schloss
Original Assignee
Neurosystec Corp
Thomas J Lobl
Anna Imola Nagy
Jacob E Pananen
John V Schloss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosystec Corp, Thomas J Lobl, Anna Imola Nagy, Jacob E Pananen, John V Schloss filed Critical Neurosystec Corp
Priority to EP07795973A priority Critical patent/EP2026709A4/en
Priority to JP2009514423A priority patent/JP2009539485A/en
Priority to CA002654223A priority patent/CA2654223A1/en
Publication of WO2007146227A2 publication Critical patent/WO2007146227A2/en
Publication of WO2007146227A3 publication Critical patent/WO2007146227A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407Infusion of two or more substances
    • A61M5/1409Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02Access sites
    • A61M39/0208Subcutaneous access sites for injecting or removing fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02Access sites
    • A61M39/04Access sites having pierceable self-sealing members

Abstract

Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.
PCT/US2007/013686 2006-06-09 2007-06-08 Flow-induced delivery from a drug mass WO2007146227A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07795973A EP2026709A4 (en) 2006-06-09 2007-06-08 Flow-induced delivery from a drug mass
JP2009514423A JP2009539485A (en) 2006-06-09 2007-06-08 Flow-induced delivery from drug mass
CA002654223A CA2654223A1 (en) 2006-06-09 2007-06-08 Flow-induced delivery from a drug mass

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80439406P 2006-06-09 2006-06-09
US60/804,394 2006-06-09

Publications (2)

Publication Number Publication Date
WO2007146227A2 WO2007146227A2 (en) 2007-12-21
WO2007146227A3 true WO2007146227A3 (en) 2008-10-09

Family

ID=38832454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/013686 WO2007146227A2 (en) 2006-06-09 2007-06-08 Flow-induced delivery from a drug mass

Country Status (5)

Country Link
US (2) US7803148B2 (en)
EP (1) EP2026709A4 (en)
JP (1) JP2009539485A (en)
CA (1) CA2654223A1 (en)
WO (1) WO2007146227A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006079055A2 (en) * 2005-01-24 2006-07-27 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
US20060205789A1 (en) * 2005-03-04 2006-09-14 Neurosystec Corporation Gacyclidine formulations
US20060280655A1 (en) * 2005-06-08 2006-12-14 California Institute Of Technology Intravascular diagnostic and therapeutic sampling device
US8267905B2 (en) * 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US7803148B2 (en) 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
US20080145439A1 (en) * 2006-07-31 2008-06-19 Neurosystec Corporation Nanoparticle drug formulations
US8211134B2 (en) * 2007-09-29 2012-07-03 Restoration Robotics, Inc. Systems and methods for harvesting, storing, and implanting hair grafts
US8152827B2 (en) * 2008-01-11 2012-04-10 Restoration Robotics, Inc. Systems and methods for harvesting, storing, and implanting hair grafts
US20090209945A1 (en) * 2008-01-18 2009-08-20 Neurosystec Corporation Valveless impedance pump drug delivery systems
GB2459101A (en) * 2008-04-08 2009-10-14 Epsom And St Helier University Subcutaneous port and catheter
US20110288500A1 (en) * 2010-05-24 2011-11-24 Fysh Dadd Drug-delivery element for an elongate implantable medical device component
US8617097B2 (en) 2010-05-24 2013-12-31 Cochlear Limited Drug-delivery accessory for an implantable medical device
SG185774A1 (en) * 2010-05-28 2013-01-30 Twin Star Medical Inc Tissue infusion apparatus and method
JP6162047B2 (en) * 2011-02-02 2017-07-12 ザ チャールズ スターク ドレイパー ラボラトリー インク Drug delivery device
WO2012170732A2 (en) * 2011-06-07 2012-12-13 California Institute Of Technology Medicament delivery systems
CN104203220A (en) * 2011-10-24 2014-12-10 得克萨斯大学体系董事会 Device and method for sustained release of therapeutic agent
US8685106B2 (en) 2011-11-15 2014-04-01 Abraham Lin Method of a pharmaceutical delivery system for use within a joint replacement
US9610398B2 (en) * 2011-11-22 2017-04-04 Incube Labs, Llc Implantable solid-liquid drug delivery apparatus, formulations, and methods of use
US20150044271A1 (en) 2012-02-27 2015-02-12 O-Ray Pharma, Inc. Solid drug implants for intracochlear delivery of therapeutics for the treatment of otic disorders
CN104582782B (en) * 2012-08-20 2018-11-27 奥雷制药有限公司 The method for being used to prepare drug delivery preparation
WO2014204957A1 (en) * 2013-06-17 2014-12-24 Replenish, Inc. Vented implantable drug-delivery device
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
KR101928297B1 (en) * 2016-09-08 2018-12-12 이오플로우(주) Medical fluid delivery device
US11273295B2 (en) 2018-04-19 2022-03-15 Spiral Therapeutics, Inc. Inner ear drug delivery devices and methods of use
KR102157623B1 (en) * 2018-10-19 2020-09-18 김용현 Air filter device and chemical fluid injection device comprising the same
WO2020080883A1 (en) * 2018-10-19 2020-04-23 Yong Hyun Kim Medicine transfer device and medicinal liquid injection apparatus including the same
KR102581122B1 (en) * 2021-04-22 2023-09-21 재단법인대구경북과학기술원 injection device of Microstructure and the injection method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5971953A (en) * 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus

Family Cites Families (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034756A (en) * 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
CH557178A (en) * 1972-08-10 1974-12-31 Siemens Ag DEVICE FOR DISPENSING DRUGS.
US3850161A (en) * 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US3881495A (en) * 1973-08-08 1975-05-06 Anthony N Pannozzo Method of nerve therapy using trapezoidal pulses
US4073999A (en) * 1975-05-09 1978-02-14 Minnesota Mining And Manufacturing Company Porous ceramic or metallic coatings and articles
US4232679A (en) * 1977-01-26 1980-11-11 Pacesetter Systems, Inc. Programmable human tissue stimulator
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4481950A (en) * 1979-04-27 1984-11-13 Medtronic, Inc. Acoustic signalling apparatus for implantable devices
US4692147A (en) * 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US4408608A (en) * 1981-04-09 1983-10-11 Telectronics Pty. Ltd. Implantable tissue-stimulating prosthesis
US4496349A (en) * 1981-05-08 1985-01-29 Renal Systems, Inc. Percutaneous implant
DE3138320A1 (en) * 1981-09-25 1983-04-14 Siemens AG, 1000 Berlin und 8000 München INFUSION DEVICE PROVIDED FOR IMPLANTATION IN A LIVING BODY
US4484921A (en) * 1982-02-01 1984-11-27 Alza Corporation Theophylline therapy utilizing osmotic delivery
US4487603A (en) * 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4702254A (en) * 1983-09-14 1987-10-27 Jacob Zabara Neurocybernetic prosthesis
US4819647A (en) * 1984-05-03 1989-04-11 The Regents Of The University Of California Intracochlear electrode array
US4590946A (en) * 1984-06-14 1986-05-27 Biomed Concepts, Inc. Surgically implantable electrode for nerve bundles
CA1245931A (en) * 1984-09-21 1988-12-06 Sophia Pesotchinsky Positionable tissue interfacing device for the management of percutaneous conduits
US4649936A (en) * 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4608985A (en) * 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking
US4628942A (en) * 1984-10-11 1986-12-16 Case Western Reserve University Asymmetric shielded two electrode cuff
US4756710A (en) * 1985-04-05 1988-07-12 Merck & Co., Inc. pH-Mediated drug delivery system
US4725852A (en) * 1985-05-09 1988-02-16 Burlington Industries, Inc. Random artificially perturbed liquid apparatus and method
DE3713061A1 (en) * 1986-05-02 1987-11-05 Siemens Ag Medicament metering device implantable into the body of a patient
US4731076A (en) 1986-12-22 1988-03-15 Baylor College Of Medicine Piezoelectric fluid pumping system for use in the human body
GB8701731D0 (en) * 1987-01-27 1987-03-04 Patcentre Benelux Nv Sa Pumps
US4929236A (en) * 1988-05-26 1990-05-29 Shiley Infusaid, Inc. Snap-lock fitting catheter for an implantable device
CA1327838C (en) * 1988-06-13 1994-03-15 Fred Zacouto Implantable device to prevent blood clotting disorders
JPH02121042A (en) * 1988-10-31 1990-05-08 Toshiba Corp Memory system
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5314458A (en) * 1990-06-01 1994-05-24 University Of Michigan Single channel microstimulator
US5188104A (en) * 1991-02-01 1993-02-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5207640A (en) * 1991-03-27 1993-05-04 Hattler Brack G Method of anesthetizing a patient
US5299569A (en) * 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5215086A (en) * 1991-05-03 1993-06-01 Cyberonics, Inc. Therapeutic treatment of migraine symptoms by stimulation
ATE135203T1 (en) 1991-10-16 1996-03-15 Arto Olavi Urtti PERORAL DRUG DELIVERY SYSTEM
DE69227088T2 (en) * 1991-11-15 1999-06-02 Phafag Ag Use of 1- (aminoalkyl) -3-quinoxalin-2-one derivatives for the production of neuroprotective agents
US5358514A (en) * 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5330515A (en) * 1992-06-17 1994-07-19 Cyberonics, Inc. Treatment of pain by vagal afferent stimulation
DE4235506A1 (en) * 1992-10-21 1994-04-28 Bavaria Med Tech Drug injection catheter
US5468253A (en) * 1993-01-21 1995-11-21 Ethicon, Inc. Elastomeric medical device
US5538735A (en) * 1993-02-19 1996-07-23 Ahn; Sam S. Method of making a drug delivery system using hollow fibers
US5871478A (en) * 1993-08-11 1999-02-16 Berrigan; Thomas John Implantable drug delivery means
US5421818A (en) * 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
DE4402380A1 (en) * 1994-01-27 1995-08-03 Hans Peter Prof Dr Med Zenner Implantable dosing system
SE9400821D0 (en) * 1994-03-10 1994-03-10 Siemens Elema Ab Implantable infusion system with pressure neutral drug container
US5441481A (en) * 1994-05-27 1995-08-15 Mishra; Pravin Microdialysis probes and methods of use
DE4423881C1 (en) * 1994-07-07 1995-10-26 Karlsruhe Forschzent Surgical sewing device
AU8071894A (en) * 1994-09-22 1996-04-09 Jonathan M Licht Compositions useful for the preparation of medicines for treating a variety of intractable disorders
US5545152A (en) * 1994-10-28 1996-08-13 Minimed Inc. Quick-connect coupling for a medication infusion system
DE69529572T2 (en) * 1994-11-10 2003-06-18 Univ Kentucky Res Foundation L IMPLANTABLE REFILLABLE DEVICE WITH CONTROLLED RELEASE FOR ADMINISTERING MEDICINAL SUBSTANCES DIRECTLY ON AN INNER PART OF THE BODY
US5876187A (en) 1995-03-09 1999-03-02 University Of Washington Micropumps with fixed valves
US5716318A (en) * 1995-04-14 1998-02-10 The University Of North Carolina At Chapel Hill Method of treating cardiac arrest and apparatus for same
US6219580B1 (en) 1995-04-26 2001-04-17 Advanced Bionics Corporation Multichannel cochlear prosthesis with flexible control of stimulus waveforms
US5643207A (en) * 1995-04-28 1997-07-01 Medtronic, Inc. Implantable techniques for infusing a therapeutic agent with endogenous bodily fluid
US5843464A (en) * 1995-06-02 1998-12-01 The Ohio State University Synthetic chimeric fimbrin peptides
DE19528388A1 (en) * 1995-08-02 1997-02-06 Hans Peter Prof Dr Med Zenner Use of adamantane derivatives for the treatment of diseases of the inner ear
US5945052A (en) * 1995-09-18 1999-08-31 Specialty Silicone Fabricators Unitary "Y" tubing and method for manufacturing same
US5700282A (en) * 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
US5755750A (en) * 1995-11-13 1998-05-26 University Of Florida Method and apparatus for selectively inhibiting activity in nerve fibers
FR2742357B1 (en) 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa STABILIZED AND FILTRABLE NANOPARTICLES UNDER STERILE CONDITIONS
US5995868A (en) 1996-01-23 1999-11-30 University Of Kansas System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject
RU2189221C2 (en) * 1996-02-02 2002-09-20 Элзэ Копэрейшн Method and device for administering active substance and method for treating prostate carcinoma patients
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
AU3304997A (en) 1996-05-31 1998-01-05 Southern Illinois University Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
FR2751652B1 (en) 1996-07-24 1998-09-04 Expansia Sa THIENYLCYCLOHEXANE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS NEW INDUSTRIAL PRODUCTS FOR THE SYNTHESIS OF THIENYLCYCLOHEXYL DERIVATIVES
US5905000A (en) 1996-09-03 1999-05-18 Nanomaterials Research Corporation Nanostructured ion conducting solid electrolytes
US5752979A (en) * 1996-11-01 1998-05-19 Medtronic, Inc. Method of controlling epilepsy by brain stimulation
US5895416A (en) 1997-03-12 1999-04-20 Medtronic, Inc. Method and apparatus for controlling and steering an electric field
US20020039594A1 (en) 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6129753A (en) 1998-03-27 2000-10-10 Advanced Bionics Corporation Cochlear electrode array with electrode contacts on medial side
US6045528A (en) * 1997-06-13 2000-04-04 Intraear, Inc. Inner ear fluid transfer and diagnostic system
DE69818049T2 (en) * 1997-06-23 2004-07-15 Tanabe Seiyaku Co., Ltd. INHIBITORS OF ALPHA4-BETA1 MEDIATED CELL ADHESION
US5865789A (en) * 1997-07-23 1999-02-02 Hattler; Brack G. Percutaneous oxygenator for inducing a retrograde perfusion of oxygenated blood
US5980928A (en) * 1997-07-29 1999-11-09 Terry; Paul B. Implant for preventing conjunctivitis in cattle
AU753694B2 (en) 1997-08-01 2002-10-24 Advanced Bionics Corporation Implantable device with improved battery recharging and powering configuration
US5849015A (en) 1997-09-11 1998-12-15 Bristol-Myers Squibb Company Orthopaedic stem inserter with quick release lever and ratchet
US6012902A (en) * 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
US6597954B1 (en) 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6354299B1 (en) 1997-10-27 2002-03-12 Neuropace, Inc. Implantable device for patient communication
US6974590B2 (en) 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
AU3973599A (en) 1998-05-08 1999-11-29 Genetronics, Inc. Electrically induced vessel vasodilation
WO2000000251A1 (en) 1998-06-26 2000-01-06 Advanced Bionics Corporation Programmable current output stimulus stage for implantable device
US6440102B1 (en) 1998-07-23 2002-08-27 Durect Corporation Fluid transfer and diagnostic system for treating the inner ear
US6309410B1 (en) * 1998-08-26 2001-10-30 Advanced Bionics Corporation Cochlear electrode with drug delivery channel and method of making same
US6013051A (en) 1998-10-22 2000-01-11 Medtronic, Inc. Filtered access port with filter bypass for accessing body fluid samples
US6205359B1 (en) 1998-10-26 2001-03-20 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US6356788B2 (en) 1998-10-26 2002-03-12 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy for depression, migraine, neuropsychiatric disorders, partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US20040141925A1 (en) * 1998-11-12 2004-07-22 Elan Pharma International Ltd. Novel triamcinolone compositions
DE19853299C2 (en) * 1998-11-19 2003-04-03 Thomas Lenarz Catheter for the application of medication in fluid spaces of the human inner ear
US8197461B1 (en) * 1998-12-04 2012-06-12 Durect Corporation Controlled release system for delivering therapeutic agents into the inner ear
US6670321B1 (en) * 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
US6393325B1 (en) 1999-01-07 2002-05-21 Advanced Bionics Corporation Directional programming for implantable electrode arrays
US6120484A (en) 1999-02-17 2000-09-19 Silverstein; Herbert Otological implant for delivery of medicament and method of using same
US6112116A (en) 1999-02-22 2000-08-29 Cathco, Inc. Implantable responsive system for sensing and treating acute myocardial infarction
US6464687B1 (en) * 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
US20010041870A1 (en) * 1999-03-09 2001-11-15 Edward M. Gillis Implantable device for access to a treatment site
US6178349B1 (en) 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6254355B1 (en) 1999-04-19 2001-07-03 California Institute Of Technology Hydro elastic pump which pumps using non-rotary bladeless and valveless operations
MXPA01010832A (en) * 1999-04-26 2003-06-30 Gmp Vision Solutions Inc Shunt device and method for treating glaucoma.
US6341236B1 (en) 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
US6368315B1 (en) 1999-06-23 2002-04-09 Durect Corporation Composite drug delivery catheter
US6585703B1 (en) 1999-07-28 2003-07-01 Span-America Medical Systems, Inc. Dividable introducer catheter and positive-lock needle guard combination
US7060284B1 (en) * 1999-08-03 2006-06-13 The Ohio State University Polypeptides and polynucleotides for enhancing immune reactivity to HER-2 protein
WO2001012157A1 (en) * 1999-08-18 2001-02-22 Microchips, Inc. Thermally-activated microchip chemical delivery devices
WO2001020999A1 (en) 1999-09-23 2001-03-29 Trimedyne, Inc. Materials and methods for inducing angiogenesis and the repair of mammalian tissue
US6491666B1 (en) * 1999-11-17 2002-12-10 Microchips, Inc. Microfabricated devices for the delivery of molecules into a carrier fluid
US6613026B1 (en) 1999-12-08 2003-09-02 Scimed Life Systems, Inc. Lateral needle-less injection apparatus and method
US8002700B2 (en) 1999-12-30 2011-08-23 Medtronic, Inc. Communications system for an implantable medical device and a delivery device
US6967023B1 (en) 2000-01-10 2005-11-22 Foamix, Ltd. Pharmaceutical and cosmetic carrier or composition for topical application
US6764472B1 (en) 2000-01-11 2004-07-20 Bard Access Systems, Inc. Implantable refillable infusion device
US6458118B1 (en) * 2000-02-23 2002-10-01 Medtronic, Inc. Drug delivery through microencapsulation
US6826428B1 (en) 2000-04-11 2004-11-30 The Board Of Regents Of The University Of Texas System Gastrointestinal electrical stimulation
US20050049578A1 (en) 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20030215425A1 (en) 2001-12-07 2003-11-20 Simard John J. L. Epitope synchronization in antigen presenting cells
AU5543801A (en) * 2000-05-16 2001-11-26 Ortho Mcneil Pharm Inc Process for coating medical devices using super-critical carbon dioxide
US6526318B1 (en) 2000-06-16 2003-02-25 Mehdi M. Ansarinia Stimulation method for the sphenopalatine ganglia, sphenopalatine nerve, or vidian nerve for treatment of medical conditions
AU2001268473A1 (en) 2000-06-20 2002-01-02 Advanced Bionics Corporation Apparatus for treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion
US6895283B2 (en) 2000-08-10 2005-05-17 Advanced Neuromodulation Systems, Inc. Stimulation/sensing lead adapted for percutaneous insertion
US6560490B2 (en) 2000-09-26 2003-05-06 Case Western Reserve University Waveforms for selective stimulation of central nervous system neurons
CA2390591A1 (en) 2000-10-04 2002-04-11 Peter Gibson Cochlear implant electrode array
US6712753B2 (en) 2000-11-14 2004-03-30 Joseph Manne Electromagnetically induced anesthesia and sensory stimulation
US6409698B1 (en) * 2000-11-27 2002-06-25 John N. Robinson Perforate electrodiffusion pump
DE10101143A1 (en) 2001-01-08 2002-07-18 Ulrich Speck Sterile tissue access system
US6788975B1 (en) 2001-01-30 2004-09-07 Advanced Bionics Corporation Fully implantable miniature neurostimulator for stimulation as a therapy for epilepsy
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6726678B1 (en) 2001-02-22 2004-04-27 Isurgical, Llc Implantable reservoir and system for delivery of a therapeutic agent
US6858220B2 (en) * 2001-02-28 2005-02-22 Second Sight Medical Products, Inc. Implantable microfluidic delivery system using ultra-nanocrystalline diamond coating
US6743204B2 (en) * 2001-04-13 2004-06-01 Medtronic, Inc. Implantable drug delivery device with peristaltic pump having retracting roller
EP1385417B1 (en) 2001-04-18 2016-04-06 Cochlear Limited System for measurement of evoked neural response
US6632217B2 (en) 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
US6907295B2 (en) 2001-08-31 2005-06-14 Biocontrol Medical Ltd. Electrode assembly for nerve control
US7678065B2 (en) * 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US6928320B2 (en) 2001-05-17 2005-08-09 Medtronic, Inc. Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated
US20020175772A1 (en) 2001-05-25 2002-11-28 Infineon Technologies North America Corp. Power efficient delay stage for a voltage-controlled oscillator
EP1404325A2 (en) 2001-05-29 2004-04-07 Guilford Pharmaceuticals Inc. Method for treating nerve injury caused by surgery
US7048680B2 (en) 2001-06-06 2006-05-23 Orqis Medical Corporation Multilumen catheter for minimizing limb ischemia
US20040091995A1 (en) 2001-06-15 2004-05-13 Jeffrey Schlom Recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses
DE60215373T2 (en) * 2001-06-18 2007-08-23 Durect Corp., Cupertino DEVICE FOR DISTRIBUTING MICRO-DOSES OF A MEDICAMENT IN THE EAR
US6607504B2 (en) 2001-06-29 2003-08-19 Scimed Life Systems, Inc. Percutaneous access
US6796957B2 (en) 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Sterile aspiration/reinjection systems
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
US6855426B2 (en) 2001-08-08 2005-02-15 Nanoproducts Corporation Methods for producing composite nanoparticles
US7734355B2 (en) 2001-08-31 2010-06-08 Bio Control Medical (B.C.M.) Ltd. Treatment of disorders by unidirectional nerve stimulation
US6648873B2 (en) 2001-09-21 2003-11-18 Durect Corp. Aural catheter system including anchor balloon and balloon inflation device
US7044942B2 (en) 2001-10-24 2006-05-16 Med-El Elektromedizinische Geraete Gmbh Implantable fluid delivery apparatuses and implantable electrode
US20070088335A1 (en) 2001-10-24 2007-04-19 Med-El Elektromedizinische Geraete Gmbh Implantable neuro-stimulation electrode with fluid reservoir
US7308303B2 (en) 2001-11-01 2007-12-11 Advanced Bionics Corporation Thrombolysis and chronic anticoagulation therapy
US6894456B2 (en) * 2001-11-07 2005-05-17 Quallion Llc Implantable medical power module
WO2003053337A2 (en) 2001-11-09 2003-07-03 Advanced Therapeutics & Diagnostics, Lc Therapeutic compositions
US6692481B2 (en) * 2001-12-13 2004-02-17 John M. Guerrero Method and apparatus for treatment of amblyopia
EP1458365A1 (en) * 2001-12-21 2004-09-22 Celator Technologies Inc. Improved polymer-lipid delivery vehicles
US6718209B2 (en) * 2002-02-05 2004-04-06 Second Sight Medical Products, Inc. Retinal prosthesis with remote return electrode
JP2005517625A (en) 2002-02-15 2005-06-16 ナノフェイズ テクノロジーズ コーポレイション Composite nanoparticle material and method for producing the same
AUPS081502A0 (en) 2002-02-28 2002-03-21 Cochlear Limited Connector for drug delivery system
US20030171738A1 (en) * 2002-03-06 2003-09-11 Konieczynski David D. Convection-enhanced drug delivery device and method of use
US7206639B2 (en) * 2002-03-15 2007-04-17 Sarcos Investments Lc Cochlear drug delivery system and method
EP1509256B1 (en) 2002-05-24 2009-07-22 Angiotech International Ag Compositions and methods for coating medical implants
US20040015205A1 (en) 2002-06-20 2004-01-22 Whitehurst Todd K. Implantable microstimulators with programmable multielectrode configuration and uses thereof
US7292890B2 (en) 2002-06-20 2007-11-06 Advanced Bionics Corporation Vagus nerve stimulation via unidirectional propagation of action potentials
US7203548B2 (en) 2002-06-20 2007-04-10 Advanced Bionics Corporation Cavernous nerve stimulation via unidirectional propagation of action potentials
US7860570B2 (en) 2002-06-20 2010-12-28 Boston Scientific Neuromodulation Corporation Implantable microstimulators and methods for unidirectional propagation of action potentials
US20050238506A1 (en) 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
US7867193B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US6827559B2 (en) * 2002-07-01 2004-12-07 Ventaira Pharmaceuticals, Inc. Piezoelectric micropump with diaphragm and valves
US7142926B2 (en) 2002-08-30 2006-11-28 Advanced Bionics Corporation Quick connect earhook system for BTE devices
US7589110B2 (en) 2002-09-06 2009-09-15 Durect Corporation Delivery of modulators of glutamate-mediated neurotransmission to the inner ear
CA2497867A1 (en) 2002-09-06 2004-03-18 Durect Corporation Delivery of modulators of glutamate-mediated neurotransmission to the inner ear
US6962580B2 (en) * 2002-09-17 2005-11-08 Transoma Medical, Inc. Vascular access port with needle detector
US7150741B2 (en) 2002-09-20 2006-12-19 Advanced Neuromodulation Systems, Inc. Programmable dose control module
US6656172B1 (en) * 2002-09-27 2003-12-02 Medtronic, Inc. Method for treating severe tinnitus
WO2004037284A1 (en) 2002-10-22 2004-05-06 Sanofi Pasteur Limited Anti-cancer vaccines and high-dose cytokines as adjuvants
AU2003213756A1 (en) 2002-11-21 2004-06-18 California Institue Of Technology Hydroimpedance pump
US7923032B2 (en) * 2002-11-26 2011-04-12 Seacoast Neuroscience, Inc. Buoyant polymer particles for delivery of therapeutic agents to the central nervous system
US7285255B2 (en) 2002-12-10 2007-10-23 Ecolab Inc. Deodorizing and sanitizing employing a wicking device
CN104147597A (en) 2002-12-16 2014-11-19 全球免疫股份有限公司 Yeast-based vaccines as immunotherapy
WO2004073641A2 (en) 2003-02-18 2004-09-02 Kevin Slawin Induced activation in dendritic cells
DE602004023021D1 (en) 2003-03-03 2009-10-22 Greatbatch Ltd Low polarization coatings for implantable electrodes
US20060041182A1 (en) * 2003-04-16 2006-02-23 Forbes Zachary G Magnetically-controllable delivery system for therapeutic agents
US20050013812A1 (en) 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US20050055014A1 (en) * 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US7896865B2 (en) * 2003-09-30 2011-03-01 Codman & Shurtleff, Inc. Two-compartment reduced volume infusion pump
US7284966B2 (en) 2003-10-01 2007-10-23 Agency For Science, Technology & Research Micro-pump
US7351233B2 (en) 2003-10-14 2008-04-01 Parks Robert A Subcutaneous vascular access port, needle and kit, and methods of using same
AU2004293463A1 (en) 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US7702396B2 (en) 2003-11-21 2010-04-20 Advanced Bionics, Llc Optimizing pitch allocation in a cochlear implant
US7867194B2 (en) * 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
AU2005213457A1 (en) * 2004-02-05 2005-08-25 The Ohio State University Research Foundation Chimeric VEGF peptides
US7384550B2 (en) * 2004-02-24 2008-06-10 Becton, Dickinson And Company Glaucoma implant having MEMS filter module
ATE451099T1 (en) 2004-03-02 2009-12-15 Infusion Systems Llc DEVICE FOR AUTOMATICALLY MODIFYING THE DELIVERY PROFILE OF A MEDICATION DELIVERY SYSTEM
US8268866B2 (en) 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US20060063802A1 (en) 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US7361168B2 (en) * 2004-04-21 2008-04-22 Acclarent, Inc. Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US20060009805A1 (en) * 2004-04-26 2006-01-12 Ralph Jensen Neural stimulation device employing renewable chemical stimulation
CA2564122A1 (en) 2004-04-28 2005-11-10 Transoma Medical, Inc. Implantable medical devices and related methods
US20050267422A1 (en) 2004-05-26 2005-12-01 Kriesel Marshall S Fluid delivery apparatus
CA2569375A1 (en) * 2004-06-01 2006-08-17 Microchips, Inc. Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
KR100644271B1 (en) 2004-07-16 2006-11-10 한국전자통신연구원 Realization Method of Self-Equalized Multiple Passband Filter
US20060047270A1 (en) * 2004-08-27 2006-03-02 Shelton Brian M Drug delivery apparatus and method for automatically reducing drug dosage
US20060100672A1 (en) 2004-11-05 2006-05-11 Litvak Leonid M Method and system of matching information from cochlear implants in two ears
US7277760B1 (en) 2004-11-05 2007-10-02 Advanced Bionics Corporation Encoding fine time structure in presence of substantial interaction across an electrode array
US7522961B2 (en) 2004-11-17 2009-04-21 Advanced Bionics, Llc Inner hair cell stimulation model for the use by an intra-cochlear implant
US7242985B1 (en) 2004-12-03 2007-07-10 Advanced Bionics Corporation Outer hair cell stimulation model for the use by an intra—cochlear implant
US7749152B2 (en) 2005-01-10 2010-07-06 California Institute Of Technology Impedance pump used in bypass grafts
WO2006079055A2 (en) 2005-01-24 2006-07-27 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
US20060205789A1 (en) 2005-03-04 2006-09-14 Neurosystec Corporation Gacyclidine formulations
US20090110633A1 (en) 2005-03-14 2009-04-30 Shiladitya Sengupta Nanocells for Diagnosis and Treatment of Diseases and Disorders
US7801602B2 (en) 2005-04-08 2010-09-21 Boston Scientific Neuromodulation Corporation Controlling stimulation parameters of implanted tissue stimulators
US7200504B1 (en) 2005-05-16 2007-04-03 Advanced Bionics Corporation Measuring temperature change in an electronic biomedical implant
US8175717B2 (en) 2005-09-06 2012-05-08 Boston Scientific Neuromodulation Corporation Ultracapacitor powered implantable pulse generator with dedicated power supply
US20070085449A1 (en) 2005-10-13 2007-04-19 Nanyang Technological University Electro-active valveless pump
US20070122299A1 (en) 2005-11-29 2007-05-31 Chih-Yung Wen Valveless micro impedance pump
US7729758B2 (en) 2005-11-30 2010-06-01 Boston Scientific Neuromodulation Corporation Magnetically coupled microstimulators
JP5147720B2 (en) 2006-01-06 2013-02-20 カリフォルニア インスティテュート オブ テクノロジー Resonant multilayer impedance pump
GB0601179D0 (en) 2006-01-20 2006-03-01 Univ Cambridge Tech Therapies for psychotic disorders
US8267905B2 (en) 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US8818517B2 (en) 2006-05-05 2014-08-26 Advanced Bionics Ag Information processing and storage in a cochlear stimulation system
US7803148B2 (en) 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
JP2009544355A (en) 2006-07-20 2009-12-17 ニューロシステック コーポレイション Devices, systems, and methods for ophthalmic drug delivery
US20080145439A1 (en) * 2006-07-31 2008-06-19 Neurosystec Corporation Nanoparticle drug formulations
US20080065002A1 (en) 2006-09-07 2008-03-13 Neurosystec Corporation Catheter for Localized Drug Delivery and/or Electrical Stimulation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5971953A (en) * 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus

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