WO2007145672A3 - Combinations of human proteins to enhance viability of stem cells and progenitor cells - Google Patents

Combinations of human proteins to enhance viability of stem cells and progenitor cells Download PDF

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Publication number
WO2007145672A3
WO2007145672A3 PCT/US2006/060956 US2006060956W WO2007145672A3 WO 2007145672 A3 WO2007145672 A3 WO 2007145672A3 US 2006060956 W US2006060956 W US 2006060956W WO 2007145672 A3 WO2007145672 A3 WO 2007145672A3
Authority
WO
WIPO (PCT)
Prior art keywords
combinations
cells
human proteins
stem cells
progenitor cells
Prior art date
Application number
PCT/US2006/060956
Other languages
French (fr)
Other versions
WO2007145672A2 (en
Inventor
Zoltan Kiss
Original Assignee
Zoltan Lab Llc
Zoltan Kiss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoltan Lab Llc, Zoltan Kiss filed Critical Zoltan Lab Llc
Priority to PCT/US2006/060956 priority Critical patent/WO2007145672A2/en
Priority to EP06848420.3A priority patent/EP2043677B1/en
Publication of WO2007145672A2 publication Critical patent/WO2007145672A2/en
Publication of WO2007145672A3 publication Critical patent/WO2007145672A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes

Abstract

Embodiments of the present invention include the use of placental alkaline phosphatase and other members of the alkaline phosphatase family alone or in combination with human transferrin and, optionally, human α1-antitrypsin to enhance the proliferation and survival of adult or embryonic stem cells and stem cell-derived progenitor cells in vitro and in vivo.
PCT/US2006/060956 2006-06-06 2006-11-16 Combinations of human proteins to enhance viability of stem cells and progenitor cells WO2007145672A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/US2006/060956 WO2007145672A2 (en) 2006-06-06 2006-11-16 Combinations of human proteins to enhance viability of stem cells and progenitor cells
EP06848420.3A EP2043677B1 (en) 2006-06-06 2006-11-16 Combinations of human proteins to enhance viability of stem cells and progenitor cells

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80406006P 2006-06-06 2006-06-06
US60/804,060 2006-06-06
US11/560,167 US20070280922A1 (en) 2006-06-06 2006-11-15 Combinations of human proteins to enhance viability of stem cells and progenitor cells
US11/160,167 2006-11-15
PCT/US2006/060956 WO2007145672A2 (en) 2006-06-06 2006-11-16 Combinations of human proteins to enhance viability of stem cells and progenitor cells

Publications (2)

Publication Number Publication Date
WO2007145672A2 WO2007145672A2 (en) 2007-12-21
WO2007145672A3 true WO2007145672A3 (en) 2008-04-03

Family

ID=38790473

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/060956 WO2007145672A2 (en) 2006-06-06 2006-11-16 Combinations of human proteins to enhance viability of stem cells and progenitor cells

Country Status (3)

Country Link
US (5) US20070280922A1 (en)
EP (1) EP2043677B1 (en)
WO (1) WO2007145672A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9457070B2 (en) 2005-06-07 2016-10-04 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses of alpha 1-antitrypsin for early intervention in bone marrow transplantation and treatment of graft versus host disease
ES2516690T5 (en) 2005-06-07 2017-11-21 The Regents Of The University Of Colorado, A Body Corporate Serine protease activity inhibitors and their use in methods and compositions for the treatment of graft rejection and graft survival promotion
US20070280922A1 (en) * 2006-06-06 2007-12-06 Zoltan Kiss Consulting Combinations of human proteins to enhance viability of stem cells and progenitor cells
WO2008137641A2 (en) * 2007-05-04 2008-11-13 Whitehead Institute For Biomedical Research Ex vivo expansion of human hematopoietic stem cells
CN103804484B (en) * 2014-01-24 2016-03-16 南京必优康生物技术有限公司 A kind of net erythrocyte growth factor and its preparation method and application
JP6713147B2 (en) 2014-01-24 2020-06-24 アーエム−ファルマ ベー．フェー．ＡＭ−Ｐｈａｒｍａ Ｂ．Ｖ． Downstream processing of alkaline phosphatase
EP3097189B1 (en) 2014-01-24 2018-07-11 AM-Pharma B.V. Chimeric alkaline phosphatase-like proteins
CA3057089A1 (en) 2017-03-21 2018-09-27 Synthetic Biologics, Inc. Alkaline phosphatase formulations
US11338020B2 (en) 2018-01-09 2022-05-24 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
CA3094174A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of radiation disorders
CA3094173A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Intestinal alkaline phosphatase formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US20050048046A1 (en) * 2003-09-02 2005-03-03 Zoltan Kiss Use of placental alkaline phosphatase to promote skin cell proliferation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544509B2 (en) * 2000-01-24 2009-06-09 Mcgill University Method for preparing stem cell preparations
US20030158132A1 (en) * 2002-01-22 2003-08-21 Genvec, Inc. Method for enhancing bone density or formation
US20060128014A1 (en) * 2002-08-26 2006-06-15 Johan Haggblad Compositions and methods for culturing stem cells
WO2006088867A2 (en) * 2005-02-15 2006-08-24 Medistem Laboratories, Incorporated Method for expansion of stem cells
US20070148140A1 (en) * 2005-12-28 2007-06-28 Zoltan Laboratories Llc Compositions and methods to enhance viability and function of islet cells
US20070280922A1 (en) 2006-06-06 2007-12-06 Zoltan Kiss Consulting Combinations of human proteins to enhance viability of stem cells and progenitor cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US20050048046A1 (en) * 2003-09-02 2005-03-03 Zoltan Kiss Use of placental alkaline phosphatase to promote skin cell proliferation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHE Q-B. ET AL.: "Alpha-1 antitrypsin can increase insulin-induced mitogenesis in various fibroblast and epithelial cell lines", FEBS LETTERS, vol. 473, 2000, pages 33 - 36, XP004337100 *

Also Published As

Publication number Publication date
US20130149779A1 (en) 2013-06-13
US20080299107A1 (en) 2008-12-04
US8372638B2 (en) 2013-02-12
US7786082B2 (en) 2010-08-31
US7790685B2 (en) 2010-09-07
US20080299106A1 (en) 2008-12-04
WO2007145672A2 (en) 2007-12-21
US20100279411A1 (en) 2010-11-04
US20070280922A1 (en) 2007-12-06
EP2043677A4 (en) 2009-08-12
EP2043677B1 (en) 2018-06-13
EP2043677A2 (en) 2009-04-08
US8778674B2 (en) 2014-07-15

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