WO2007139748A3 - Extra-capillary fluid cycling system and method for a cell culture device - Google Patents

Extra-capillary fluid cycling system and method for a cell culture device Download PDF

Info

Publication number
WO2007139748A3
WO2007139748A3 PCT/US2007/012053 US2007012053W WO2007139748A3 WO 2007139748 A3 WO2007139748 A3 WO 2007139748A3 US 2007012053 W US2007012053 W US 2007012053W WO 2007139748 A3 WO2007139748 A3 WO 2007139748A3
Authority
WO
WIPO (PCT)
Prior art keywords
extra
reservoir
fluid
capillary
cell culture
Prior art date
Application number
PCT/US2007/012053
Other languages
French (fr)
Other versions
WO2007139748A2 (en
Inventor
Darrell Paul Page
Robert J Wojciechowski
Martin Peder Crep
Original Assignee
Biovest Internat Inc
Darrell Paul Page
Robert J Wojciechowski
Martin Peder Crep
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovest Internat Inc, Darrell Paul Page, Robert J Wojciechowski, Martin Peder Crep filed Critical Biovest Internat Inc
Priority to AT07777189T priority Critical patent/ATE496987T1/en
Priority to EP07777189A priority patent/EP2027247B1/en
Priority to DE602007012238T priority patent/DE602007012238D1/en
Publication of WO2007139748A2 publication Critical patent/WO2007139748A2/en
Publication of WO2007139748A3 publication Critical patent/WO2007139748A3/en
Priority to US12/274,993 priority patent/US8383397B2/en
Priority to US12/274,971 priority patent/US8540499B2/en
Priority to US13/664,048 priority patent/US9441195B2/en
Priority to US14/033,807 priority patent/US9534198B2/en
Priority to US15/245,601 priority patent/US10723993B2/en
Priority to US15/245,524 priority patent/US11345882B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/20—Heat exchange systems, e.g. heat jackets or outer envelopes the heat transfer medium being a gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/38—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of metabolites or enzymes in the cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/20—Heating or cooling
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00—Condition responsive control processes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/0009—Special features
    • F04B43/0054—Special features particularities of the flexible members
    • F04B43/0072—Special features particularities of the flexible members of tubular flexible members
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F04B43/09—Pumps having electric drive
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
    • F04B43/1292—Pumps specially adapted for several tubular flexible members

Abstract

An extra-capillary fluid cycling unit (40) for maintaining and cycling fluid volumes in a cell culture chamber includes a housing (50) and a first flexible extra-capillary fluid reservoir (42) disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir (44) is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate (46) is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
PCT/US2007/012053 2006-05-22 2007-05-21 Extra-capillary fluid cycling system and method for a cell culture device WO2007139748A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AT07777189T ATE496987T1 (en) 2006-05-22 2007-05-21 EXTRA-CAPILLARY FLUID CIRCULATION SYSTEM AND METHOD
EP07777189A EP2027247B1 (en) 2006-05-22 2007-05-21 Extra-capillary fluid cycling system and method
DE602007012238T DE602007012238D1 (en) 2006-05-22 2007-05-21 YEARS
US12/274,993 US8383397B2 (en) 2006-05-22 2008-11-20 Method and system for the production of cells and cell products and applications thereof
US12/274,971 US8540499B2 (en) 2006-05-22 2008-11-20 Extra-capillary fluid cycling system and method for a cell culture device
US13/664,048 US9441195B2 (en) 2006-05-22 2012-10-30 Method and system for the production of cells and cell products and applications thereof
US14/033,807 US9534198B2 (en) 2006-05-22 2013-09-23 Extra-capillary fluid cycling system and method for a cell culture device
US15/245,601 US10723993B2 (en) 2006-05-22 2016-08-24 Method and system for the production of cells and cell products and applications thereof
US15/245,524 US11345882B2 (en) 2006-05-22 2016-08-24 Extra-capillary fluid cycling system and method for a cell culture device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80237606P 2006-05-22 2006-05-22
US60/802,376 2006-05-22

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2007/012052 Continuation-In-Part WO2007139747A1 (en) 2006-05-22 2007-05-21 Interface of a cultureware module in a cell culture system and installation method thereof
PCT/US2007/012051 Continuation-In-Part WO2007139746A1 (en) 2006-05-22 2007-05-21 Rotary actuator valve for a cell culture system
PCT/US2007/012054 Continuation-In-Part WO2007136821A1 (en) 2006-05-22 2007-05-21 Media circulation system for a cell cultureware module

Related Child Applications (5)

Application Number Title Priority Date Filing Date
PCT/US2007/012052 Continuation-In-Part WO2007139747A1 (en) 2006-05-22 2007-05-21 Interface of a cultureware module in a cell culture system and installation method thereof
PCT/US2007/012051 Continuation-In-Part WO2007139746A1 (en) 2006-05-22 2007-05-21 Rotary actuator valve for a cell culture system
USPCT/US2007/102052 Continuation-In-Part 2007-05-21
US12/274,993 Continuation-In-Part US8383397B2 (en) 2006-05-22 2008-11-20 Method and system for the production of cells and cell products and applications thereof
US12/274,971 Continuation-In-Part US8540499B2 (en) 2006-05-22 2008-11-20 Extra-capillary fluid cycling system and method for a cell culture device

Publications (2)

Publication Number Publication Date
WO2007139748A2 WO2007139748A2 (en) 2007-12-06
WO2007139748A3 true WO2007139748A3 (en) 2008-03-13

Family

ID=38473943

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/US2007/012053 WO2007139748A2 (en) 2006-05-22 2007-05-21 Extra-capillary fluid cycling system and method for a cell culture device
PCT/US2007/012054 WO2007136821A1 (en) 2006-05-22 2007-05-21 Media circulation system for a cell cultureware module
PCT/US2007/012042 WO2007139742A1 (en) 2006-05-22 2007-05-21 Method and system for the production of cells and cell products and applications thereof
PCT/US2007/012052 WO2007139747A1 (en) 2006-05-22 2007-05-21 Interface of a cultureware module in a cell culture system and installation method thereof
PCT/US2007/012051 WO2007139746A1 (en) 2006-05-22 2007-05-21 Rotary actuator valve for a cell culture system

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/US2007/012054 WO2007136821A1 (en) 2006-05-22 2007-05-21 Media circulation system for a cell cultureware module
PCT/US2007/012042 WO2007139742A1 (en) 2006-05-22 2007-05-21 Method and system for the production of cells and cell products and applications thereof
PCT/US2007/012052 WO2007139747A1 (en) 2006-05-22 2007-05-21 Interface of a cultureware module in a cell culture system and installation method thereof
PCT/US2007/012051 WO2007139746A1 (en) 2006-05-22 2007-05-21 Rotary actuator valve for a cell culture system

Country Status (7)

Country Link
US (6) US8383397B2 (en)
EP (3) EP2029722B1 (en)
AT (1) ATE496987T1 (en)
DE (1) DE602007012238D1 (en)
DK (1) DK2029722T3 (en)
ES (1) ES2761938T3 (en)
WO (5) WO2007139748A2 (en)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US7651835B2 (en) 2004-10-07 2010-01-26 Transmedics, Inc. Method of timing pulsatile flow of normothermic perfusate to the heart
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
DK1942726T3 (en) 2006-04-19 2017-04-10 Transmedics Inc METHODS FOR EX VIVO ORGANIC CARE
WO2007139748A2 (en) 2006-05-22 2007-12-06 Biovest International Inc. Extra-capillary fluid cycling system and method for a cell culture device
JP2010519937A (en) 2007-03-05 2010-06-10 カリディアンビーシーティー、インコーポレーテッド Cell proliferation system and method of use
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US10750738B2 (en) 2008-01-31 2020-08-25 Transmedics, Inc. Systems and methods for ex vivo lung care
GB0808373D0 (en) * 2008-05-09 2008-06-18 Synexa Life Sciences Pty Ltd Scalable cell culture bioreactor and cell culture process
JP5416772B2 (en) 2008-08-12 2014-02-12 カリディアンビーシーティ、インコーポレイテッド Predictor for collecting cells grown in a bioreactor
CA2741481A1 (en) * 2008-10-22 2010-04-29 Biovest International, Inc. Perfusion bioreactors, cell culture systems, and methods for production of cells and cell-derived products
US8211692B2 (en) * 2008-10-24 2012-07-03 Coskata, Inc. Bioconversion process using liquid phase having to enhance gas phase conversion
US9284523B2 (en) 2008-10-27 2016-03-15 Terumo Bct, Inc. Premounted fluid conveyance assembly for cell expansion system and method of use associated therewith
FR2941385B1 (en) 2009-01-23 2011-04-01 Millipore Corp METHOD FOR PROVIDING A CIRCUIT FOR BIOLOGICAL LIQUID AND CIRCUIT OBTAINED
DE102009019868B4 (en) * 2009-05-06 2015-10-22 Hosokawa Alpine Ag Process engineering plant for laboratory use
US9247729B2 (en) * 2009-05-29 2016-02-02 Institut Georges Lopez Systems and methods for preserving a human organ for transplantation
US9206383B2 (en) * 2009-12-07 2015-12-08 The Trustees Of Columbia University In The City Of New York Bioreactor, devices, systems and methods
WO2011072039A1 (en) * 2009-12-08 2011-06-16 The Trustees Of Columbia University In The City Of New York Peristaltic pump devices, methods, and systems
US20120258441A1 (en) * 2009-12-22 2012-10-11 Ge Healthcare Bio-Sciences Ab Method for controlling culture parameters in a bioreactor
WO2011090605A2 (en) 2009-12-29 2011-07-28 Caridianbct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
FR2955119B1 (en) 2010-01-13 2012-12-28 Millipore Corp CIRCUIT FOR BIOLOGICAL LIQUID
EP2539426B1 (en) 2010-02-23 2016-11-09 Luminex Corporation Apparatus for integrated sample preparation, reaction and detection
WO2011126650A1 (en) 2010-04-09 2011-10-13 Caridianbct, Inc. Air removal chamber for a cell expansion system and method of use associated therewith
US20110265897A1 (en) * 2010-04-30 2011-11-03 Developmental Technologies, Llc Fertigation Efficacy Enhancement System And Associated Methods
EP2566951B1 (en) 2010-05-05 2020-03-04 Terumo BCT, Inc. Method of reseeding adherent cells grown in a hollow fiber bioreactor system
FR2960794B1 (en) 2010-06-08 2012-07-27 Millipore Corp DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID
FR2960795B1 (en) 2010-06-08 2012-07-27 Millipore Corp DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID
FR2960796B1 (en) 2010-06-08 2014-01-24 Millipore Corp DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID
FR2961713B1 (en) 2010-06-23 2012-08-10 Millipore Corp POCKET FOR CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT FACILITY
FR2961711B1 (en) 2010-06-23 2012-08-17 Millipore Corp POCKET FOR CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT FACILITY
FR2963573B1 (en) * 2010-08-03 2012-08-31 Millipore Corp PUMPING TROLLEY FOR A BIOLOGICAL LIQUID TREATMENT FACILITY
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
FR2973396B1 (en) 2011-03-28 2013-05-10 Millipore Corp FACILITY FOR TREATING BIOLOGICAL LIQUID
EP2698427B1 (en) * 2011-04-13 2018-09-12 Hitachi, Ltd. Cell culture device and transport device
JP6029650B2 (en) 2011-04-14 2016-11-24 トランスメディクス，インコーポレイテッド Organ protection solution for mechanical perfusion in ex-vivo of donor lung
CA2834790C (en) 2011-05-04 2019-04-09 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
WO2012171030A2 (en) 2011-06-10 2012-12-13 Biovest International, Inc. Method and apparatus for antibody production and purification
WO2012171026A2 (en) * 2011-06-10 2012-12-13 Biovest International, Inc. Methods for high yield virus production
SG11201401135XA (en) 2011-10-07 2014-10-30 Pall Technology Uk Ltd Fluid processing control system and related methods
US10087422B2 (en) * 2011-12-09 2018-10-02 President And Fellows Of Harvard College Organ chips and uses thereof
US9683207B2 (en) * 2012-05-01 2017-06-20 FiberCell Production Solutions LLC Method for growing cells in hollow fibers
ES2435092B1 (en) 2012-06-14 2014-09-09 Aglaris Cell S.L. Method and cell culture system
FR2993572B1 (en) 2012-07-23 2016-04-15 Emd Millipore Corp CIRCUIT FOR BIOLOGICAL LIQUID COMPRISING A PINCH VALVE
US9175259B2 (en) 2012-08-20 2015-11-03 Terumo Bct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
EP2909302A4 (en) * 2012-08-28 2016-07-27 Biovest Int Inc Biomanufacturing suite and methods for large-scale production of cells, viruses, and biomolecules
WO2014036488A1 (en) 2012-08-31 2014-03-06 Biovest International, Inc. Methods for producing high-fidelity autologous idiotype vaccines
US10407657B2 (en) 2012-09-05 2019-09-10 Hitachi, Ltd. Valve mechanism, cell cultivation apparatus using same, and cell cultivation method
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
USD727327S1 (en) * 2013-11-22 2015-04-21 Compliance Software, Inc. Compact stand with mobile scanner
KR102296181B1 (en) * 2013-12-06 2021-08-31 인제대학교 산학협력단 Cell culture system using complex stimulus
USD735883S1 (en) * 2013-12-30 2015-08-04 Illumina, Inc. Sample preparation instrument
EP3105311A1 (en) 2014-02-10 2016-12-21 Univercells NV System, apparatus and method for biomolecules production
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
WO2015164808A1 (en) 2014-04-24 2015-10-29 Terumo Bct, Inc. Measuring flow rate
EP3137590A1 (en) 2014-04-28 2017-03-08 VivaBioCell SpA Automated cell culturing and harvesting device
CA2950759C (en) 2014-06-02 2023-02-21 Transmedics, Inc. Ex vivo organ care system
CN106715676A (en) 2014-09-26 2017-05-24 泰尔茂比司特公司 Scheduled feed
AU364136S (en) * 2015-02-05 2015-09-14 Gen Electric Compact bioreactor for cell cultivation
AU364138S (en) * 2015-02-05 2015-09-14 Gen Electric Stackable bioreactor for cell cultivation
US10611991B2 (en) * 2015-04-07 2020-04-07 University Of South Carolina Pulsatile perfusion bioreactor for mimicking, controlling, and optimizing blood vessel mechanics
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
DE102015112343A1 (en) * 2015-07-29 2017-02-02 Westfälische Wilhelms-Universität Münster Apparatus and method for processing body fluids
USD776825S1 (en) * 2015-08-25 2017-01-17 General Electric Company Bioreactor housing
WO2017044465A1 (en) 2015-09-09 2017-03-16 Transmedics, Inc Aortic cannula for ex vivo organ care system
US10323225B2 (en) 2015-10-20 2019-06-18 Locus Solutions Apparatus, systems and methods for growing microorganisms
KR102116338B1 (en) * 2016-02-03 2020-06-05 밀워키 일렉트릭 툴 코포레이션 Systems and methods for constructing reciprocating saws
USD810084S1 (en) 2016-03-23 2018-02-13 Formfox, Inc. Mobile scanner
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
FR3053051B1 (en) * 2016-06-24 2022-11-11 Cellprothera CELL CULTURE CASSETTE AND AUTOMATA
CN106244453B (en) * 2016-08-22 2018-08-24 杭州荣泽生物科技有限公司 A kind of cell culture device for cultivating, measuring and analyzing
CN106190843B (en) * 2016-08-22 2018-06-15 刘力伟 A kind of multisample culture apparatus
CN106282017B (en) * 2016-08-22 2018-09-21 王铁苗 A kind of integrated form sample culture apparatus
CN106047703B (en) * 2016-08-22 2018-08-10 青岛爱博生物科技有限公司 A kind of test sample culture apparatus
CN106222089B (en) * 2016-08-22 2018-09-21 王铁苗 A kind of experiment auxiliary culture apparatus
CN106222090B (en) * 2016-08-22 2018-07-24 王铁苗 A kind of experiment assistant carrier
CN106244457B (en) * 2016-08-22 2018-08-03 日照安维信生物科技有限公司 A kind of experiment culture carrier structure
CN106222087B (en) * 2016-08-22 2018-07-24 王铁苗 A kind of sample culture carrier
CN106190839B (en) * 2016-08-22 2018-08-24 杭州荣泽生物科技有限公司 A kind of cell culture apparatus can be used for Comparability test
CN106119110A (en) * 2016-08-22 2016-11-16 诸葛洁婧 A kind of culture carrier structure
CN106467893B (en) * 2016-08-22 2018-07-24 王铁苗 A kind of experiment auxiliary device
WO2018044699A1 (en) 2016-08-27 2018-03-08 3D Biotek, Llc Bioreactor
EP3530727A4 (en) * 2017-02-27 2020-07-08 Koji Tanabe Somatic cell production system
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11518972B2 (en) * 2017-05-25 2022-12-06 Lun-Kuang Liu Movable cell incubator
US10987636B2 (en) 2017-08-31 2021-04-27 Massachusetts Institute Of Technology Filtration systems and methods for manufacturing biologically-produced products
US10247724B1 (en) 2017-09-28 2019-04-02 Autobiologic Inc. Optically clear sealable petri dish bioreactor
GB201717652D0 (en) * 2017-10-26 2017-12-13 Ge Healthcare Bio Sciences Ab Bioprocess System
CN107904170A (en) * 2017-12-18 2018-04-13 上海白泽医疗器械有限公司 Media to cell culture modules and cell culture system
WO2019191685A1 (en) * 2018-03-30 2019-10-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Workstation for automated control of an in vitro system
IL258738B (en) * 2018-04-16 2020-04-30 Pluristem Ltd Methods and compositions for formulating and dispensing pharmaceutical formulations
EP3790983B1 (en) * 2018-05-11 2023-07-05 Exothera SA Use of flexible or compressible liners in a system and method for clarifying a cell culture harvest solution
US20190352589A1 (en) * 2018-05-18 2019-11-21 Huacells Corporation Automated Cell Culturing
EP3584305B1 (en) * 2018-06-19 2021-07-28 Lun-Kuang Liu Movable cell incubator
EP4069824A1 (en) * 2019-12-02 2022-10-12 Avant Meats Company Limited Methods of meat production by in vitro cell cultivation
CN115551989A (en) * 2020-02-14 2022-12-30 艾克斯赛尔生物科学公司 Gas and liquid flow regulation system for cell culture
USD937266S1 (en) * 2020-02-25 2021-11-30 Amazon Technologies, Inc. Pedestal scanner
KR20220152304A (en) 2020-03-10 2022-11-15 셀라레스 코포레이션 Cell processing systems, devices and methods
USD962239S1 (en) 2020-08-20 2022-08-30 Amazon Technologies, Inc. Pedestal scanner
US20220135921A1 (en) * 2020-10-29 2022-05-05 Applied Materials, Inc. Methods and apparatus for cell development
CN112553072B (en) * 2020-12-10 2022-04-08 上海艾众生物科技有限公司 Micro-channel power equipment for external circulation of bioreactor tank
EP4301842A1 (en) * 2021-03-26 2024-01-10 TERUMO Kabushiki Kaisha Cell culturing system
EP4301841A1 (en) * 2021-03-26 2024-01-10 TERUMO Kabushiki Kaisha Cell culturing system
GB202105923D0 (en) 2021-04-26 2021-06-09 Cytiva Sweden Ab Reconfigurable bioprocessing systems
WO2023288314A1 (en) * 2021-07-15 2023-01-19 Georgia Tech Research Corporation Methods of determining viable cell count and impedance-based biosensors for the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3148624A (en) * 1961-06-21 1964-09-15 Alan W Baldwin Hydraulic pump
US4417861A (en) * 1981-08-10 1983-11-29 Monsanto Company Cell culture pumping system
US4804628A (en) * 1984-10-09 1989-02-14 Endotronics, Inc. Hollow fiber cell culture device and method of operation

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4047844A (en) 1975-12-08 1977-09-13 Searle Cardio-Pulmonary Systems Inc. Blood pumping system
US4167046A (en) * 1977-12-12 1979-09-11 Andros, Inc. Blood pumping device
US4282902A (en) * 1979-05-04 1981-08-11 Becton Dickinson & Company Valve apparatus for simultaneous control of a plurality of fluid paths
EP0164020B1 (en) * 1984-05-25 1989-08-16 ISCO, Inc. Peristaltic pump
US4604038A (en) * 1985-03-08 1986-08-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Remotely operable peristaltic pump
DE3782736T2 (en) 1986-04-28 1993-06-09 Endotronics Inc BREEDING PROCESS FOR LEUKOCYTEN.
US4973558A (en) 1988-04-28 1990-11-27 Endotronics, Inc. Method of culturing cells using highly gas saturated media
US5416022A (en) 1988-08-10 1995-05-16 Cellex Biosciences, Inc. Cell culture apparatus
WO1991002049A1 (en) 1989-08-04 1991-02-21 Peter Grandics An integrated cell culture-protein purification system for the automated production and purification of cell culture products
AR244863A1 (en) * 1989-09-07 1993-11-30 Marcelo Alberto Hoegner A multi-valve and the sterilising equipment that contains it.
US5656421A (en) 1990-02-15 1997-08-12 Unisyn Technologies, Inc. Multi-bioreactor hollow fiber cell propagation system and method
US5098261A (en) * 1990-05-04 1992-03-24 Brandel Corporation Peristaltic pump and method for adjustable flow regulation
US5330915A (en) 1991-10-18 1994-07-19 Endotronics, Inc. Pressure control system for a bioreactor
US5622857A (en) * 1995-08-08 1997-04-22 Genespan Corporation High performance cell culture bioreactor and method
US5882918A (en) * 1995-08-08 1999-03-16 Genespan Corporation Cell culture incubator
EP0775196B1 (en) * 1994-08-16 1999-03-24 Powell Biological Machines Ltd. Cell culture apparatus
US5554123A (en) * 1994-10-31 1996-09-10 Glenn Herskowitz Portable infusion pump
US5688687A (en) * 1995-06-07 1997-11-18 Aastrom Biosciences, Inc. Bioreactor for mammalian cell growth and maintenance
US5998184A (en) 1997-10-08 1999-12-07 Unisyn Technologies, Inc. Basket-type bioreactor
US6001585A (en) 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US6780617B2 (en) * 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
JP3461725B2 (en) * 1998-06-26 2003-10-27 東京エレクトロン株式会社 Treatment liquid supply device and treatment liquid supply method
NO20002828D0 (en) 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinaceous vaccine against Neisseria meningtidis serogroup and method of preparation thereof
WO2002087662A1 (en) * 2001-04-27 2002-11-07 Nexell Therapeutics Inc. Cell processing and fluid transfer apparatus and method of use
US6673595B2 (en) * 2001-08-27 2004-01-06 Biocrystal, Ltd Automated cell management system for growth and manipulation of cultured cells
US8492140B2 (en) 2002-04-08 2013-07-23 Octane Biotech Inc. Automated tissue engineering system
US6733252B2 (en) * 2002-05-10 2004-05-11 Fqubed Fluid-handling systems and components comprising a bladder pump, a methods therefor
US20030217957A1 (en) * 2002-05-24 2003-11-27 Bowman Joseph H. Heat seal interface for a disposable medical fluid unit
DE10244090A1 (en) 2002-09-23 2004-04-01 Ismatec S.A. Hose cassette for a peristaltic pump
US7377686B2 (en) * 2003-09-04 2008-05-27 Millipore Corporation Disposable mixing system
DE502004006604D1 (en) * 2003-09-26 2008-04-30 Ismatec Sa Laboratoriumstechni PERISTALTIC PUMP
WO2005087915A2 (en) 2004-03-08 2005-09-22 Biovest International, Inc. Use of ethanolamine for enhancing cell growth in membrane systems
WO2005090403A2 (en) 2004-03-12 2005-09-29 Biovest International, Inc. Method and apparatus for antibody purification
US9499780B2 (en) * 2004-05-26 2016-11-22 Octane Biotech Inc. Advanced tissue engineering system
US7143777B2 (en) * 2004-07-20 2006-12-05 Ing Tzon Co., Ltd. Control valve having pressure balance effect
AU2006246263A1 (en) 2005-05-09 2006-11-16 Saxonia Biotec Gmbh. Apparatus for providing media to cell culture modules
US7875184B2 (en) * 2005-09-22 2011-01-25 Eastman Chemical Company Crystallized pellet/liquid separator
WO2007106232A2 (en) * 2006-02-27 2007-09-20 Fluidnet Corporation Volume measurement using gas laws
EP2495327B1 (en) 2006-03-03 2016-09-28 ProMIS Neurosciences Inc. Methods and compositions to treat and detect misfolded-SOD1 mediated diseases
DK1942726T3 (en) 2006-04-19 2017-04-10 Transmedics Inc METHODS FOR EX VIVO ORGANIC CARE
SG10201503987WA (en) 2006-05-13 2015-06-29 Pall Life Sciences Belgium Disposable Bioreactor
WO2007139748A2 (en) * 2006-05-22 2007-12-06 Biovest International Inc. Extra-capillary fluid cycling system and method for a cell culture device
JP4585563B2 (en) * 2007-12-03 2010-11-24 株式会社コガネイ Chemical supply device and pump assembly
EP2344184A4 (en) 2008-10-07 2012-08-29 Biovest Int Inc Methods for inducing a sustained immune response againts a b-cell idiotype using autologous anti-idiotypic vaccines
CA2741481A1 (en) 2008-10-22 2010-04-29 Biovest International, Inc. Perfusion bioreactors, cell culture systems, and methods for production of cells and cell-derived products
US9284523B2 (en) 2008-10-27 2016-03-15 Terumo Bct, Inc. Premounted fluid conveyance assembly for cell expansion system and method of use associated therewith
US20140037615A1 (en) 2010-08-13 2014-02-06 Biovest International, Inc. Materials and methods for designing autologous idiotype vaccines and treatment of b-cell malignancies
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
EP2637691A4 (en) 2010-11-08 2015-09-02 Biovest Int Inc Materials and methods for directing an immune response to an epitope
WO2012171030A2 (en) 2011-06-10 2012-12-13 Biovest International, Inc. Method and apparatus for antibody production and purification
WO2012171026A2 (en) 2011-06-10 2012-12-13 Biovest International, Inc. Methods for high yield virus production
US20140363456A1 (en) 2011-12-09 2014-12-11 Biovest International, Inc. Tumor-specific gm-csf cytokine response as predictor of cancer vaccine effectiveness
EP2909302A4 (en) 2012-08-28 2016-07-27 Biovest Int Inc Biomanufacturing suite and methods for large-scale production of cells, viruses, and biomolecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3148624A (en) * 1961-06-21 1964-09-15 Alan W Baldwin Hydraulic pump
US4417861A (en) * 1981-08-10 1983-11-29 Monsanto Company Cell culture pumping system
US4804628A (en) * 1984-10-09 1989-02-14 Endotronics, Inc. Hollow fiber cell culture device and method of operation

Also Published As

Publication number Publication date
EP2404991A3 (en) 2013-05-22
EP2027247B1 (en) 2011-01-26
US9441195B2 (en) 2016-09-13
WO2007139746A1 (en) 2007-12-06
ATE496987T1 (en) 2011-02-15
ES2761938T3 (en) 2020-05-21
EP2029722A1 (en) 2009-03-04
US10723993B2 (en) 2020-07-28
US20090215022A1 (en) 2009-08-27
EP2404991A2 (en) 2012-01-11
EP2027247A2 (en) 2009-02-25
US20090269841A1 (en) 2009-10-29
US8383397B2 (en) 2013-02-26
WO2007139747A1 (en) 2007-12-06
WO2007139748A2 (en) 2007-12-06
WO2007136821A1 (en) 2007-11-29
US20160362650A1 (en) 2016-12-15
US11345882B2 (en) 2022-05-31
US9534198B2 (en) 2017-01-03
US20140024012A1 (en) 2014-01-23
US8540499B2 (en) 2013-09-24
DK2029722T3 (en) 2020-01-02
DE602007012238D1 (en) 2011-03-10
EP2029722B1 (en) 2019-10-16
US20160362652A1 (en) 2016-12-15
US20130058907A1 (en) 2013-03-07
WO2007139742A1 (en) 2007-12-06

Similar Documents

Publication Publication Date Title
WO2007139748A3 (en) Extra-capillary fluid cycling system and method for a cell culture device
CA2633984A1 (en) System and method for applying reduced pressure to cell culture
WO2003041964A1 (en) Liquid injector
NZ614023A (en) Modular, portable dialysis system
WO2005037706A3 (en) Fluid injection system
WO2005120605A3 (en) Flow regulator
MX2009001119A (en) Cannula and delivery device.
WO2007044425A3 (en) Fuel cartridge for fuel cells
UA100747C2 (en) Normal;heading 1;heading 2;heading 3;AUTO-INJECTOR, METHOD FOR INTRODUCING A FLUID THERETO AND INJECTION SYSTEM
WO2007016054A3 (en) System and method of controlling an air mattress
DK1720441T3 (en) Connector with pressure sensor designed for an endoscopy system
WO2004065618A3 (en) Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
WO2009006497A3 (en) Dialysis system having disposable cassette
EP1843705A4 (en) Quick cycle biopsy system
CA2552353A1 (en) Compression treatment system
MX2011008313A (en) Magnetically driven micropump.
WO2007038793A3 (en) System, method and apparatus for applying air pressure on a portion of the body of an individual
AU2003249601A1 (en) Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method
WO2006098869A3 (en) Fuel cell systems and related method
WO2010099264A3 (en) Cell culture system with manifold
DK2012633T3 (en) Beverage preparation system, holder and apparatus
MY142374A (en) Polishing apparatus.
WO2010058216A3 (en) Fluid supplier for ocular surgery
EP2326935A4 (en) Finger swipe fluid-transfer collection assembly and method of using the same
ATE551594T1 (en) PRESSURE SENSOR

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07777189

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007777189

Country of ref document: EP