WO2007130960A3 - Stable ophthalmic oil-in-water emulsions with omega-3 fatty acids for alleviating dry eye - Google Patents

Stable ophthalmic oil-in-water emulsions with omega-3 fatty acids for alleviating dry eye Download PDF

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Publication number
WO2007130960A3
WO2007130960A3 PCT/US2007/067911 US2007067911W WO2007130960A3 WO 2007130960 A3 WO2007130960 A3 WO 2007130960A3 US 2007067911 W US2007067911 W US 2007067911W WO 2007130960 A3 WO2007130960 A3 WO 2007130960A3
Authority
WO
WIPO (PCT)
Prior art keywords
omega
dry eye
fatty acids
water emulsions
globules
Prior art date
Application number
PCT/US2007/067911
Other languages
French (fr)
Other versions
WO2007130960A2 (en
Inventor
Zhi-Jian Yu
Lauren Crawford
Original Assignee
Advanced Medical Optics Inc
Zhi-Jian Yu
Lauren Crawford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medical Optics Inc, Zhi-Jian Yu, Lauren Crawford filed Critical Advanced Medical Optics Inc
Publication of WO2007130960A2 publication Critical patent/WO2007130960A2/en
Publication of WO2007130960A3 publication Critical patent/WO2007130960A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/55—Linaceae (Flax family), e.g. Linum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Abstract

An ophthalmic composition includes oil globules dispersed in an aqueous phase. The globules include a surfactant component, a polar oil component that includes an Omega-3 fatty acid and a viscosity modifying agent. The surfactant to oil ratio produces an average size of globules of about 0.1 microns or less. The viscosity is at least as viscous as.25% 800K sodium hyaluronate. The composition can be used for treatment of dry eye. The compositions are stable and can have anti-microbial activity sufficient for use as contact lens disinfecting solutions.
PCT/US2007/067911 2006-05-03 2007-05-01 Stable ophthalmic oil-in-water emulsions with omega-3 fatty acids for alleviating dry eye WO2007130960A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/418,486 US20060251685A1 (en) 2003-03-18 2006-05-03 Stable ophthalmic oil-in-water emulsions with Omega-3 fatty acids for alleviating dry eye
US11/418,486 2006-05-03

Publications (2)

Publication Number Publication Date
WO2007130960A2 WO2007130960A2 (en) 2007-11-15
WO2007130960A3 true WO2007130960A3 (en) 2008-05-22

Family

ID=38668486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/067911 WO2007130960A2 (en) 2006-05-03 2007-05-01 Stable ophthalmic oil-in-water emulsions with omega-3 fatty acids for alleviating dry eye

Country Status (2)

Country Link
US (1) US20060251685A1 (en)
WO (1) WO2007130960A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101043884A (en) * 2004-07-01 2007-09-26 谢彭斯眼科研究公司 Compositions and methods for treating eye disorders and conditions
US20070293410A1 (en) * 2006-06-15 2007-12-20 Surowiak Richard J Contact lens and method for preventing contact lens intolerance
US8609634B2 (en) * 2007-05-16 2013-12-17 Mcneil-Ppc, Inc. Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods
US20110046033A1 (en) * 2008-01-31 2011-02-24 Jinzhong Zhang Multipurpose Lens Care Solution with Benefits to Corneal Epithelial Barrier Function
US20100234319A1 (en) * 2009-03-11 2010-09-16 Abbott Medical Optics Inc. Complex of Polymeric Quaternary Ammonium and Anionic Polymers as a New Antimicrobial Agent for Ophthalmic Compositions
CA2762939C (en) 2009-05-22 2017-07-18 Mochida Phamaceutical Co., Ltd. Self-emulsifying composition of .omega.3 fatty acid
US20100303915A1 (en) * 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Therapeutic opthalmic emulsions
US20100305046A1 (en) * 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Stable cyclosporine containing ophthalmic emulsion for treating dry eyes
US9480645B2 (en) 2009-06-02 2016-11-01 Abbott Medical Optics Inc. Omega-3 oil containing ophthalmic emulsions
EP2437762B1 (en) 2009-06-05 2017-08-09 Allergan, Inc. Artificial tears and therapeutic uses
JP2012531440A (en) * 2009-06-26 2012-12-10 エリック カーツ， Water soluble dietary fatty acids
WO2011047259A1 (en) 2009-10-16 2011-04-21 Glaxosmithkline Llc Compositions
EP2498602A4 (en) * 2009-11-10 2014-05-21 Mycell Technologies Llc Stabilized formulations of fatty acids
CN101816423A (en) * 2010-04-22 2010-09-01 王京南 Purple perilla seed oil lipid emulsion oral solution, beverage and manufacturing method thereof
DE102010050570A1 (en) 2010-11-05 2012-05-10 F. Holzer Gmbh Composition and medicaments containing ω-3 fatty acids and an inhibitor of NF-κB transcription factor
US20140005266A1 (en) * 2010-12-01 2014-01-02 Nostrum Laboratories, Inc. Topical formulations for administration of omega-3 fatty acids
ITMO20100369A1 (en) * 2010-12-30 2012-07-01 Enable Innovations Srl RANGE OF PRODUCTS FOR OPHTHALMIC USE.
US10383839B2 (en) 2011-06-30 2019-08-20 Johnson & Johnson Vision Care, Inc. Esters for treatment of ocular inflammatory conditions
WO2014035451A1 (en) * 2012-08-31 2014-03-06 Bausch & Lomb Incorporated Ophthalmic compositions with wax esters
EP2664330A1 (en) 2012-05-15 2013-11-20 F. Holzer GmbH Composition and medication containing Omega 3 fatty acids and a glucosaminoglucan
ES2748562T3 (en) * 2013-02-28 2020-03-17 Basf As A composition comprising a lipid compound, a triglyceride and a surfactant, and methods of using the same
CA3187647A1 (en) 2014-06-15 2015-12-23 Yeda Research And Development Co. Ltd. Surface treatment by water-soluble polymers and lipids/liposomes
NZ732058A (en) 2014-11-25 2023-06-30 Allergan Inc Stabilized omega-3 ophthalmic compositions
EP3280395B1 (en) * 2015-04-08 2019-03-27 For Health Pharma S.r.l. Ophthalmic compositions based on polyunsaturated fatty acids and triacylglycerols
ES2607715B1 (en) * 2015-10-01 2018-01-17 Solutex Na, Lcc PROCESS FOR THE PREPARATION AND STABILIZATION OF EMULSIONS WITH OMEGA-3 THROUGH ISOMETRIC CRYSTAL NETWORKS OF CELLULOSE DERIVATIVES
WO2018035469A1 (en) 2016-08-19 2018-02-22 Akrivista, LLC Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye
CN111295169A (en) 2017-08-18 2020-06-16 阿克里维斯塔有限责任公司 Methods of diagnosing and treating dry eye syndrome and compositions for treating human eyes
WO2020250252A1 (en) 2019-06-11 2020-12-17 Sifi S.P.A. Microemulsion compositions
MX2021003369A (en) * 2021-03-22 2022-09-23 Laboratorios Grin S A De C V Triple ocular tear.
US11951123B2 (en) 2022-01-12 2024-04-09 Platform Ophthalmic Innovations, LLC Fortified nutritional lubricating drops for dry eye disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004082625A2 (en) * 2003-03-18 2004-09-30 Advanced Medical Optics, Inc. Self-emulsifying compositions, methods of use and preparation
US20050196370A1 (en) * 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
WO2006007510A1 (en) * 2004-07-01 2006-01-19 Schepens Eye Research Compositions and methods for treating eye disorders and conditions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
AU728695B2 (en) * 1997-07-29 2001-01-18 Boehringer Ingelheim International Gmbh Self-emulsifying formulation for lipophilic compounds
FR2787027B1 (en) * 1998-12-14 2001-01-12 Oreal NANOEMULSION BASED ON SUGAR FATTY ESTERS OR SUGAR FATHER ETHERS AND ITS USE IN THE COSMETIC, DERMATOLOGICAL AND / OR OPHTHALMOLOGICAL FIELDS
US6506394B1 (en) * 1999-06-30 2003-01-14 Kimberly-Clark Worldwide, Inc. Delivery of a botanical extract to a treated substrate for transfer to skin
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
WO2001097784A1 (en) * 2000-06-23 2001-12-27 Takeda Chemical Industries, Ltd. Process for producing phospholipid-containing drugs
US7235230B2 (en) * 2001-10-24 2007-06-26 Clariant Finance (Bvi) Limited Leave-on compositions for personal care
US20040137079A1 (en) * 2003-01-08 2004-07-15 Cook James N. Contact lens and eye drop rewetter compositions and methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004082625A2 (en) * 2003-03-18 2004-09-30 Advanced Medical Optics, Inc. Self-emulsifying compositions, methods of use and preparation
US20050196370A1 (en) * 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
WO2006007510A1 (en) * 2004-07-01 2006-01-19 Schepens Eye Research Compositions and methods for treating eye disorders and conditions

Also Published As

Publication number Publication date
WO2007130960A2 (en) 2007-11-15
US20060251685A1 (en) 2006-11-09

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