WO2007127366A3 - Kinase inhibitors and methods of use thereof - Google Patents

Kinase inhibitors and methods of use thereof Download PDF

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Publication number
WO2007127366A3
WO2007127366A3 PCT/US2007/010233 US2007010233W WO2007127366A3 WO 2007127366 A3 WO2007127366 A3 WO 2007127366A3 US 2007010233 W US2007010233 W US 2007010233W WO 2007127366 A3 WO2007127366 A3 WO 2007127366A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
methods
compositions
edema
treating
Prior art date
Application number
PCT/US2007/010233
Other languages
French (fr)
Other versions
WO2007127366A2 (en
Inventor
John Doukas
Chi Ching Mak
Elena Dneprovskaia
Glenn Noronha
Original Assignee
Targegen Inc
John Doukas
Chi Ching Mak
Elena Dneprovskaia
Glenn Noronha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targegen Inc, John Doukas, Chi Ching Mak, Elena Dneprovskaia, Glenn Noronha filed Critical Targegen Inc
Publication of WO2007127366A2 publication Critical patent/WO2007127366A2/en
Publication of WO2007127366A3 publication Critical patent/WO2007127366A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Abstract

Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as uveitis, retinopathies or macular degeneration, macular edema or other vitreoretinal diseases, inflammatory diseases such as automimmune diseases, vascular leakage syndrome, edema, or diseases involving leukocyte activation, transplant rejection, respiratory diseases such as asthma, adult or acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, and the like.
PCT/US2007/010233 2006-04-25 2007-04-25 Kinase inhibitors and methods of use thereof WO2007127366A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79521806P 2006-04-25 2006-04-25
US60/795,218 2006-04-25

Publications (2)

Publication Number Publication Date
WO2007127366A2 WO2007127366A2 (en) 2007-11-08
WO2007127366A3 true WO2007127366A3 (en) 2008-11-27

Family

ID=38656213

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/010233 WO2007127366A2 (en) 2006-04-25 2007-04-25 Kinase inhibitors and methods of use thereof

Country Status (2)

Country Link
US (1) US7691858B2 (en)
WO (1) WO2007127366A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8372971B2 (en) 2004-08-25 2013-02-12 Targegen, Inc. Heterocyclic compounds and methods of use
US8481536B2 (en) 2004-04-08 2013-07-09 Targegen, Inc. Benzotriazine inhibitors of kinases

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120032574A (en) * 2002-10-03 2012-04-05 탈자진 인코포레이티드 Vasculostatic agents and methods of use thereof
US20050282814A1 (en) * 2002-10-03 2005-12-22 Targegen, Inc. Vasculostatic agents and methods of use thereof
NZ563984A (en) * 2005-06-08 2011-11-25 Targegen Inc Methods and compositions for the treatment of ocular disorders
EP1951684B1 (en) 2005-11-01 2016-07-13 TargeGen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
WO2007056075A2 (en) * 2005-11-02 2007-05-18 Targegen, Inc. Six membered heteroaromatic inhibitors targeting resistant kinase mutations
WO2007127366A2 (en) 2006-04-25 2007-11-08 Targegen, Inc. Kinase inhibitors and methods of use thereof
WO2009137052A1 (en) * 2008-05-05 2009-11-12 Winthrop University Hospital Method for improving cardiovascular risk profile of cox inhibitors
US20100233733A1 (en) * 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
CA2816957A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
JP6348904B2 (en) 2012-09-20 2018-06-27 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションＴｅｍｐｌｅ Ｕｎｉｖｅｒｓｉｔｙ−Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ Substituted alkyldiaryl derivatives, their production and use
CN113831347B (en) * 2021-10-22 2022-10-04 广东海洋大学 6, 7-disubstituted 2- (ethylthio) -pteridine-4-amine derivative and preparation method and application thereof

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EP1799656A4 (en) * 2004-08-25 2009-09-02 Targegen Inc Heterocyclic compounds and methods of use
EP1863794A2 (en) * 2005-03-16 2007-12-12 Targegen, Inc. Pyrimidine compounds and methods of use
NZ563984A (en) * 2005-06-08 2011-11-25 Targegen Inc Methods and compositions for the treatment of ocular disorders
EP1951684B1 (en) * 2005-11-01 2016-07-13 TargeGen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
WO2007056075A2 (en) * 2005-11-02 2007-05-18 Targegen, Inc. Six membered heteroaromatic inhibitors targeting resistant kinase mutations
WO2007127366A2 (en) 2006-04-25 2007-11-08 Targegen, Inc. Kinase inhibitors and methods of use thereof
WO2008008234A1 (en) * 2006-07-07 2008-01-17 Targegen, Inc. 2-amino-5-substituted pyrimidine inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2667486A (en) * 1951-05-24 1954-01-26 Research Corp 2,4-diamino pteridine and derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481536B2 (en) 2004-04-08 2013-07-09 Targegen, Inc. Benzotriazine inhibitors of kinases
US8372971B2 (en) 2004-08-25 2013-02-12 Targegen, Inc. Heterocyclic compounds and methods of use

Also Published As

Publication number Publication date
WO2007127366A2 (en) 2007-11-08
US7691858B2 (en) 2010-04-06
US20070259876A1 (en) 2007-11-08

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