WO2007117651A3 - Passive electric field focus system for in vivo and in vitro applications - Google Patents

Passive electric field focus system for in vivo and in vitro applications Download PDF

Info

Publication number
WO2007117651A3
WO2007117651A3 PCT/US2007/008662 US2007008662W WO2007117651A3 WO 2007117651 A3 WO2007117651 A3 WO 2007117651A3 US 2007008662 W US2007008662 W US 2007008662W WO 2007117651 A3 WO2007117651 A3 WO 2007117651A3
Authority
WO
WIPO (PCT)
Prior art keywords
vivo
electric field
focus system
vitro applications
passive electric
Prior art date
Application number
PCT/US2007/008662
Other languages
French (fr)
Other versions
WO2007117651A2 (en
Inventor
Jose I Rey
Richard Gilbert
Mark J Jaroszeski
Richard Heller
Original Assignee
Univ South Florida
Jose I Rey
Richard Gilbert
Mark J Jaroszeski
Richard Heller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ South Florida, Jose I Rey, Richard Gilbert, Mark J Jaroszeski, Richard Heller filed Critical Univ South Florida
Publication of WO2007117651A2 publication Critical patent/WO2007117651A2/en
Publication of WO2007117651A3 publication Critical patent/WO2007117651A3/en
Priority to US12/246,958 priority Critical patent/US9014800B2/en
Priority to US14/680,739 priority patent/US9486626B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Abstract

The present invention provides a system and method of directing, focusing, or concentrating electrical charges within a defined electric field so that these charges can be used to exert forces on cells and tissues in vivo and/or cell cultures in vitro. The present invention reduces and/or eliminates the damage at a target site that would normally be caused by an electrode that acts as a current source or sink to accomplish the same task.
PCT/US2007/008662 2006-04-07 2007-04-09 Passive electric field focus system for in vivo and in vitro applications WO2007117651A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/246,958 US9014800B2 (en) 2006-04-07 2008-10-07 Passive electric field focus system for in vivo and in vitro applications
US14/680,739 US9486626B2 (en) 2006-04-07 2015-04-07 Passive electric field focus system for in vivo and in vitro applications

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74442406P 2006-04-07 2006-04-07
US60/744,424 2006-04-07
US74553006P 2006-04-25 2006-04-25
US60/745,530 2006-04-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/246,958 Continuation US9014800B2 (en) 2006-04-07 2008-10-07 Passive electric field focus system for in vivo and in vitro applications

Publications (2)

Publication Number Publication Date
WO2007117651A2 WO2007117651A2 (en) 2007-10-18
WO2007117651A3 true WO2007117651A3 (en) 2008-09-04

Family

ID=38581669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/008662 WO2007117651A2 (en) 2006-04-07 2007-04-09 Passive electric field focus system for in vivo and in vitro applications

Country Status (2)

Country Link
US (2) US9014800B2 (en)
WO (1) WO2007117651A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117651A2 (en) * 2006-04-07 2007-10-18 University Of South Florida Passive electric field focus system for in vivo and in vitro applications
PL2369775T3 (en) 2010-03-16 2019-08-30 Lg Electronics Inc. Method and base station for transmitting reference signals, and method and user equipment for receiving reference signals

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US6132683A (en) * 1998-12-23 2000-10-17 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
US20050054969A1 (en) * 2001-03-13 2005-03-10 University Of South Florida Electromanipulation Device and Method

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US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
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US6775569B2 (en) * 1997-11-05 2004-08-10 Hisamitsu Pharmaceutical Co., Inc. Electroporation device for in vivo delivery of therapeutic agents
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CA2395492A1 (en) * 1999-12-22 2001-07-05 Diana Wang Method and apparatus for targeting localised electroporation
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051422A (en) * 1997-05-30 2000-04-18 Board Of Trustees, Leland Stanford, Jr., University Hybrid biosensors
US6132683A (en) * 1998-12-23 2000-10-17 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
US20050054969A1 (en) * 2001-03-13 2005-03-10 University Of South Florida Electromanipulation Device and Method

Also Published As

Publication number Publication date
US9486626B2 (en) 2016-11-08
WO2007117651A2 (en) 2007-10-18
US20150209582A1 (en) 2015-07-30
US20090131994A1 (en) 2009-05-21
US9014800B2 (en) 2015-04-21

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