WO2007109104A3 - Modified release formulations containing drug-ion exchange resin complexes - Google Patents

Modified release formulations containing drug-ion exchange resin complexes Download PDF

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Publication number
WO2007109104A3
WO2007109104A3 PCT/US2007/006572 US2007006572W WO2007109104A3 WO 2007109104 A3 WO2007109104 A3 WO 2007109104A3 US 2007006572 W US2007006572 W US 2007006572W WO 2007109104 A3 WO2007109104 A3 WO 2007109104A3
Authority
WO
WIPO (PCT)
Prior art keywords
exchange resin
ion exchange
release formulations
formulations containing
modified release
Prior art date
Application number
PCT/US2007/006572
Other languages
French (fr)
Other versions
WO2007109104A2 (en
Inventor
Ketan Mehta
Yu-Hsing Tu
Original Assignee
Tris Pharma Inc
Ketan Mehta
Yu-Hsing Tu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38512117&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007109104(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2007227569A priority Critical patent/AU2007227569B9/en
Priority to JP2009500494A priority patent/JP5479086B2/en
Priority to ES07753217T priority patent/ES2378573T3/en
Priority to BRPI0709606A priority patent/BRPI0709606B8/en
Priority to AT07753217T priority patent/ATE536867T1/en
Application filed by Tris Pharma Inc, Ketan Mehta, Yu-Hsing Tu filed Critical Tris Pharma Inc
Priority to DK07753217.4T priority patent/DK2018160T3/en
Priority to EP07753217A priority patent/EP2018160B1/en
Priority to CN2007800092088A priority patent/CN101400343B/en
Priority to KR1020087024357A priority patent/KR101495146B1/en
Priority to CA2645855A priority patent/CA2645855C/en
Publication of WO2007109104A2 publication Critical patent/WO2007109104A2/en
Publication of WO2007109104A3 publication Critical patent/WO2007109104A3/en
Priority to IL194042A priority patent/IL194042A/en

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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

A coated drug - ion exchange resin complex comprising a core composed of a drug complexed with a pharmaceutically acceptable ion-exchange resin is provided. The drug - ion exchange resin complex is in admixture with a release retardant. The coating contains a polyvinyl acetate polymer and a plasticizer. Methods of making and products containing this coated complex are described.
PCT/US2007/006572 2006-03-16 2007-03-15 Modified release formulations containing drug-ion exchange resin complexes WO2007109104A2 (en)

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CA2645855A CA2645855C (en) 2006-03-16 2007-03-15 Modified release formulations containing drug-ion exchange resin complexes
EP07753217A EP2018160B1 (en) 2006-03-16 2007-03-15 Modified release formulations containing drug-ion exchange resin complexes
ES07753217T ES2378573T3 (en) 2006-03-16 2007-03-15 Modified release formulations containing ion exchange drug-resin complexes
BRPI0709606A BRPI0709606B8 (en) 2006-03-16 2007-03-15 orally administrable liquid suspension with modified release characteristics
AT07753217T ATE536867T1 (en) 2006-03-16 2007-03-15 MODIFIED RELEASE FORMULATIONS WITH DRUG ION EXCHANGE RESIN COMPLEXES
AU2007227569A AU2007227569B9 (en) 2006-03-16 2007-03-15 Modified release formulations containing drug-ion exchange resin complexes
DK07753217.4T DK2018160T3 (en) 2006-03-16 2007-03-15 Modified depot formulations containing drug-ion exchange resin complexes
JP2009500494A JP5479086B2 (en) 2006-03-16 2007-03-15 Controlled release formulation containing drug-ion exchange resin complex
CN2007800092088A CN101400343B (en) 2006-03-16 2007-03-15 Modified release formulations containing drug-ion exchange resin complexes
KR1020087024357A KR101495146B1 (en) 2006-03-16 2007-03-15 Modified release formulations containing drug - ion exchange resin complexes
IL194042A IL194042A (en) 2006-03-16 2008-09-11 Modified release formulations containing drug-ion exchange resin complexes

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US78318106P 2006-03-16 2006-03-16
US60/783,181 2006-03-16

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CN (2) CN101400343B (en)
AT (1) ATE536867T1 (en)
BR (1) BRPI0709606B8 (en)
CA (1) CA2645855C (en)
DK (2) DK2428205T3 (en)
ES (2) ES2396039T3 (en)
IL (1) IL194042A (en)
RU (1) RU2435569C2 (en)
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