WO2007097818A2 - Antimicrobial cellulosic sheet - Google Patents
Antimicrobial cellulosic sheet Download PDFInfo
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- WO2007097818A2 WO2007097818A2 PCT/US2006/060718 US2006060718W WO2007097818A2 WO 2007097818 A2 WO2007097818 A2 WO 2007097818A2 US 2006060718 W US2006060718 W US 2006060718W WO 2007097818 A2 WO2007097818 A2 WO 2007097818A2
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- Prior art keywords
- microbial
- sheet according
- cellulosic
- lotion
- web
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the present invention relates to paper towels used as hand towels.
- An anti-microbial lotion on the towel increases water absorbency times (WAR) to further promote lotion transfer to the skin and increase transfer effectiveness.
- WAR water absorbency times
- Frequent hand washing is a simple and effective means to ensure proper hygiene and prevent contamination of food and the spread of disease.
- Complex systems have been proposed to encourage food service and health care workers to adequately cleanse their hands frequently, in view of the relatively high potential for undesirable contamination associated with their activities.
- 6,832,916 discloses a hand-washing device containing a display panel that encourages the user to wash their hands for about 15 seconds to remove germs.
- Gorra, United States Patent No. 5,945,910 discloses method and apparatus for monitoring and reporting hand washing, which includes a sensor for signaling the dispensation of a cleaning agent from a dispenser, and a reporting and monitoring module.
- Allen et al., United States Patent No. 5,781,942 discloses wash stations and method of operation, which monitors hand washing and assists in hand washing. These systems are relatively expensive and difficult to implement; oftentimes involving training and monitoring personnel. Even when such steps have been taken, there is little certainty that all personnel have followed proper washing procedures.
- Frequent hand washing has the drawback that harsh soaps and cleansing agents can irritate the skin and damage the acid mantle of the skin.
- Cellulosic substrates coated with lotions are well known in the art.
- United States Patent No. 5,665,426 to Krzysik et al. is directed towards a lotion formula that can be applied to a tissue, which transfers the lotion to the user's skin in order to reduce irritation and redness.
- United States Patent No. 5,871,763 to Luu et al. is directed towards a lotion formula that is applied to a substrate for skin care treatment.
- the lotion composition of '763 is melted by the heat produced by the hands of a user of the cellulosic substrate to enable the lotion's transfer to the user's skin.
- Another lotion-treated substrate is described in United States Patent No. 5,525,345 to Warner et al.
- the lotion composition of '345 comprises a plastic or fluid emollient that is solid or semi solid at room temperature and an immobilizing agent with a melting point above room temperature, which stabilizes the lotion composition on the surface of the substrate.
- a plastic or fluid emollient that is solid or semi solid at room temperature and an immobilizing agent with a melting point above room temperature, which stabilizes the lotion composition on the surface of the substrate.
- an immobilizing agent with a melting point above room temperature
- a salient aspect of the invention involves application of a suitable anti-microbial lotion to a substrate in amounts that will actually increase WAR times of the cellulosic sheet.
- This feature while usually undesirable in a towel product, promotes anti-microbial lotion transfer to the skin, since a user will rub the towel longer when drying his or her hands. Lotion transfer is extremely important for both skin care and anti-microbial effectiveness as will be appreciated by one of the skill in the art.
- an anti-microbial cellulosic sheet for paper towel including: a) a cellulosic web; b) a transferable lotion composition comprising an emollient and anti-microbial agent, the lotion composition being immobilized on the cellolosic web in a solid or semi-solid form, wherein the transferable lotion composition is selected from lotion compositions which are transferable upon contact with water or lotion compositions which are transferable upon application of heat; and c) the transferable lotion composition disposed on the web is selected and applied in amounts such that it imparts a water absorption rate delay of at least about 25% to the cellulosic web.
- the transferable lotion composition disposed on the web is selected and applied in amounts such that it imparts a water absorption rate delay to the cellulosic web of at least about 50%, 75%, 100%, or more.
- the unlotioned cellulosic web preferably has substantially the same SAT value as the lotioned cellulosic web.
- the cellulosic sheet may have SAT values of at least about 3 g/g, at least about 3.5 g/g, at least about 4 g/g or at least about 4.5 g/g.
- the cellulosic sheet has a SAT value of from about 3 g/g to about 5 g/g-
- the lotioned cellulosic sheet typically has a WAR value of at least about 40 or 50 seconds, with WAR values of from about 55 seconds to about 75 seconds being generally suitable.
- the transferable lotion is suitably applied to the cellulosic web in an amount of from about 3 weight percent to about 20 weight percent such as in an amount of from about 5 percent by weight to about 15 percent by weight or in an amount of from about 8 percent by weight to about 10 percent by weight (based on the combined weight of towel and lotion).
- the unlotioned cellulosic web may have a basis weight of from about 15 g/m 2 to about 65 g/m 2 such as from about 25 g/m 2 to about 50 g/m 2 .
- a basis weight of from about 30 g/m 2 to about 40 g/m 2 is typical and the cellulosic web consists predominantly of softwood fiber.
- the web may include at least about 65 or 70 percent by weight softwood fiber and typically from about 70 percent by weight softwood fiber to about 90 percent by weight softwood fiber.
- a preferred softwood fiber is Douglas fir fiber especially for electronic (motion sensored) dispensers.
- the sheet suitably has an eight sheet caliper of from about 35 to about 90 mils, consists predominantly of softwood fiber and is in the form of a single ply towel.
- the lotion composition comprises from about 0.01% to about 10% by weight anti-microbial agent; preferably from about 0.05% to about 5% by weight antimicrobial agent.
- the anti-microbial agent may be selected from: 2,4,4'-trichloro-2'- hydroxydiphenyl ether; 3,4,4'-trichlorocarbanilide; 3,4,4'-trifluoromethyl-4,4'-d- ichlorocarbanilide; 5-chloro-2-methyl-4-isothiazolin-3-one; iodopropynlbutylcarbamate; 8-hydroxyquinoline; 8-hydroxyquinoline citrate; 8-hydroxyquinoline sulfate; 4-chloro-3,5- xylenol; 2-bromo-2-nitropropane-l,3-diol; diazolidinyl urea; butoconazole; nystatin; terconazole; nitrofurantoin; phenazopyridine; acyclovir
- the web optionally includes a wet strength agent selected from aldehyde-containing polyols, aldehyde-containing cationic starch, glyoxal, glutaraldehyde, dialdehydes, boric acid carbonate, zirconium ammonium carbonate, glyoxalated polyacrylamide, polyamide- epichlorohydrin, polyamine-epichlorohydrin, urea-formaldehyde, melamine-formaldehyde, polyethyleneimine, and latex emulsions.
- a wet strength agent selected from aldehyde-containing polyols, aldehyde-containing cationic starch, glyoxal, glutaraldehyde, dialdehydes, boric acid carbonate, zirconium ammonium carbonate, glyoxalated polyacrylamide, polyamide- epichlorohydrin, polyamine-epichlorohydrin, urea-formalde
- an anti-microbial cellulosic sheet for paper towel including: a) a cellulosic towel web; b) a lotion emulsion including an anti-microbial agent disposed on the web, the lotion emulsion including a polar emollient and a non-polar emollient as well as a surfactant composition comprising a nonionic surfactant, wherein the lotion emulsion is substantially liquid at room temperature, the emollients and surfactant composition are selected such that the lotion emulsion is immobilized on the web in a semisolid or solid state and wherein further the lotion emulsion is capable of forming an aqueous gel upon contact with water; and c) the lotion emulsion disposed on the web is selected and applied in amounts such that it imparts a water absorption rate delay of at least 25% to the cellulosic web.
- the lotion emulsion typically comprises polar emollient in an amount of from about 2% to about 40% by weight of the lotion emulsion and the lotion emulsion may include a polar polyhydroxy emollient selected from propylene glycol, glycol, glycerol, diethylene glycol, methylene glycol, polypropylene glycol, polyethylene glycol and sorbitol.
- polar polyhydroxy emollient selected from propylene glycol, glycol, glycerol, diethylene glycol, methylene glycol, polypropylene glycol, polyethylene glycol and sorbitol.
- the lotion emulsion also preferably includes a non- polar emollient in the amount of from about 10% to about 40% by weight of the lotion emulsion, which non-polar emollient may be selected from aromatic or linear esters, Guerbet ester, mineral oil, squalane, liquid paraffin, and mixtures thereof.
- Suitable non-polar emollients thus include: isopropyl myristate; C12-C15 alkyl benzoate esters; tri-octyldodecyl- citratc; mixtures of Q 2 -C 15 alkyl benzoate esters; and carnation oil.
- the surfactant composition may include non-ionic surfactant including a fatty alcohol in the amount of from about 40% to about 70% by weight of the lotion emulsion.
- Suitable non-ionic surfactants may be selected from PEG-20 methyl glucose sesquistearate, PPG-20 methyl glucose ether, PPG-20 methyl glucose ether distearate, PEG-20 methyl glucose distearate, PEG- 120 methyl glucose dioleate, ethoxylated methyl glucose having from about 10 to about 20 repeating ethoxy units, a mixture thereof and the like.
- the surfactant composition most preferably includes a co-surfactant in an amount of from about 0.1% to about 20% by weight of the lotion emulsion.
- the co-surfactant is suitably selected from C12 -Cig fatty alcohols, behenyl alcohol, cetyl alcohol, stearyl alcohol, iso-cetyl alcohol, and iso-stearyl alcohol, myristyl alcohol, and mixtures of cetyl alcohol (C 1 O) and stearyl alcohol (C 1 S).
- the lotion emulsion is substantially waterless.
- an anti-microbial cellulosic sheet comprising: a) a cellulosic web; b) a waterless micro-emulsion which is substantially liquid at room temperature immobilized on the web in a semi-solid or solid state; wherein the waterless micro-emulsion comprises an anti-microbial agent, a polar emollient, a non-polar emollient and a surfactant composition including a nonionic surfactant; and wherein further the waterless micro-emulsion is capable of forming an aqueous micro-emulsion upon contact with water; and c) the waterless micro-emulsion disposed on the web is selected and applied in amounts such that it imparts a water absorption rate delay of at least 25% to the cellulosic web.
- Still another aspect of the invention is an anti-microbial cellulosic sheet for paper towel comprising: a) a cellulosic web; b) a transferable lotion composition disposed on the web comprising an emollient, an anti-microbial agent, and a retention/release agent such that the lotion has a ⁇ H above about 37°C of more than about 10 calories/gram, a total heat of melting of above about 25 calories/gram, and an onset of melting temperature of at least about 30 0 C; and c) the transferable lotion composition disposed on the web is selected and applied in amounts such that it imparts a water absorption rate delay of at least about 25% to the cellulosic web.
- the lotion composition on this sheet optionally further comprises a surfactant composition in the amount of from about 10% to about 15% by weight of the lotion composition.
- the surfactants may be selected from methyl glucoside sesquistearate, cthoxylatcd methyl glucoside sesquistearate containing 20 moles of oxycthylcnc units, mixtures of PEG-20 methyl glucose sesquistearate and methyl glucose sesquistearate, or combinations of the foregoing.
- the lotion composition comprises an emollient in the amount of from about 5% to about 75% by weight of the lotion composition.
- the emollient may be an aromatic ester emollient, a fatty alcohol ester of a non-fatty organic acid emollient, or mixtures thereof.
- Typical aromatic ester emollients may be benzoate ester emollients selected from C 12 - C 1S alkyl benzoate, stearyl benzoate, octyl dodecyl benzoate, isostearyl benzoate, methyl gluceth-20 benzoate, stearyl ether benzoate, poloxamer 182 dibenzoate, poloxamer 105 benzoate, or mixtures thereof.
- a suitable fatty alcohol ester of a non-fatty organic acid emollient comprises C 12 - C 1 S octanoate.
- the heat-sensitive lotion composition typically includes a retention/release agent in the amount of from about 25% to about 95% by weight of the lotion composition, wherein the retention/release agent may be a C 12 - C 18 fatty alcohol.
- Suitable fatty alcohols are selected from dodecanol, tridecanol, tetradecanol, pentadecanol, hexadecanol, heptadecanol, octadecanol, mixtures of cetyl alcohol and stearyl alcohol and combinations of the foregoing.
- Figure 1 is a partial phase diagram of the composition of Example 1 showing the phase characteristics of a waterless micro-emulsion
- Figure 2 is a partial phase diagram of the composition of Example 1 with water showing the phase behavior of a mixture of the composition of Example 1 with water.
- the simple absorbency tester is a particularly useful apparatus for measuring the hydrophilicity and absorbency properties of a sample of tissue, napkins, or towel.
- a sample of tissue, napkins, or towel 2.0 inches in diameter is mounted between a top flat plastic cover and a bottom grooved sample plate.
- the tissue, napkin, or towel sample disc is held in place by a 1/8 inch wide circumference flange area.
- the sample is not compressed by the holder.
- De-ionized water at 73°F is introduced to the sample at the center of the bottom sample plate through a 1 mm. diameter conduit. This water is at a hydrostatic head of minus 5 mm.
- Flow is initiated by a pulse introduced at the start of the measurement by the instrument mechanism. Water is thus imbibed by the tissue, napkin, or towel sample from this central entrance point radially outward by capillary action. When the rate of water imbibation decreases below 0.005 gm water per 5 seconds, the test is terminated. The amount of water removed from the reservoir and absorbed by the sample is weighed and reported as grams of water per square meter of sample or grams of water per gram of sheet. In practice, an M/K Systems Inc. Gravimetric Absorbency Testing System is used. This is a commercial system obtainable from M/K Systems Inc., 12 Garden Street, Danvcrs, Mass., 01923.
- WAC or water absorbent capacity also referred to as SAT is actually determined by the instrument itself.
- WAC is defined as the point where the weight versus time graph has a "zero" slope, i.e., the sample has stopped absorbing.
- the termination criteria for a test are expressed in maximum change in water weight absorbed over a fixed time period. This is basically an estimate of zero slope on the weight versus time graph.
- the program uses a change of 0.005g over a 5 second time interval as termination criteria; unless "Slow SAT" is specified in which case the cut off criteria is 1 mg in 20 seconds.
- Water absorbency rate or WAR is measured in seconds and is the time it takes for a sample to absorb a 0.1 gram droplet of water disposed on its surface by way of an automated syringe.
- the test specimens are preferably conditioned at 23° C ⁇ 1° C (73.4 ⁇ 1.8°F) at 50 % relative humidity.
- 4 3x3 inch test specimens are prepared. Each specimen is placed in a sample holder such that a high intensity lamp is directed toward the specimen. 0.1 ml of water is deposited on the specimen surface and a stop watch is started. When the water is absorbed, as indicated by lack of further reflection of light from the drop, the stopwatch is stopped and the time recorded to the nearest 0.1 seconds. The procedure is repeated for each specimen and the results averaged for the sample.
- WAR is measured in accordance with TAPPI method T-432 om-99.
- the water absorption rate delay in percent is calculated from the WAR values of the unlotioned cellulosic web and lotioned sheet product of the invention as follows:
- Aqueous gel refers to viscous lotion/water compositions typically having a room temperature viscosity of above about 500 cps at room temperature and typically above about 1000 cps at room temperature. Preferred lotion compositions form gels of more than 1500 cps at room temperature as is seen in Table 2 below.
- Basis weight BWT, bwt and so forth is expressed in grams per square meter or pounds per 3000 square foot ream of product as is indicated.
- cellulosic cellulosic sheet and the like is meant to include any product incorporating papermaking fiber having cellulose as a major constituent.
- Papermaking fibers include virgin pulps or recycle (secondary) cellulosic fibers or fiber mixes comprising cellulosic fibers.
- Fibers suitable for making the webs of this invention include fibers such as those obtained from deciduous and coniferous trees, including softwood fibers, such as northern and southern softwood kraft fibers; hardwood fibers, such as eucalyptus, maple, birch, aspen, or the like as well as nonwood cellulosic fibers.
- Papermaking fibers can be liberated from their source material by any one of a number of chemical pulping processes familiar to one experienced in the art including sulfate, sulfite, polysulfide, soda pulping, etc.
- the pulp can be bleached if desired by chemical means including the use of chlorine, chlorine dioxide, oxygen, alkaline peroxide and so forth.
- the products of the present invention may comprise a blend of conventional fibers (whether derived from virgin pulp or recycle sources) and high coarseness lignin-rich tubular fibers, such as bleached chemical thcrmomcchanical pulp (BCTMP).
- BCTMP bleached chemical thcrmomcchanical pulp
- "Furnishes" and like terminology refers to aqueous compositions including papermaking fibers, optionally wet strength resins, debonders and the like for making paper products.
- the fiber in the towel products of the invention consists predominantly (more than 50% by weight of fiber based on fiber content) of softwood (SW) fiber such as Douglas fir.
- SW softwood
- SSWK Southern Softwood Kraft
- Softwood fibers provide strength to the product; Southern softwoods are generally preferred for towel of the invention; however thin and flexible Northern softwood may be used in some fiber mixtures.
- Weight percent means weight percent unless otherwise indicated and refers to weight percent without water unless the inclusion of the water weight is expressly indicated.
- Weight percent softwood fiber and like terminology or expressions refer to the weight percent of softwood fiber based on fiber content of a product or composition only, exclusive of other ingredients.
- Room temperature is refers to a temperature of from about 20 0 C to about 25°C.
- Dry tensile strengths (MD and CD), stretch, ratios thereof, modulus, break modulus, stress and strain are measured with a standard Instron test device or other suitable elongation tensile tester which may be configured in various ways, typically using 3 or 1 inch wide strips of tissue or towel, conditioned in an atmosphere of 23° ⁇ 1°C (73.4° ⁇ 1°F) at 50% relative humidity for 2 hours. The tensile test is run at a crosshead speed of 2 in/min. Break modulus is expressed in grams/3 inches/ %strain. % strain is dimensionless and need not be specified.
- Tensile ratios are simply ratios of the values determined by way of the foregoing methods.
- a tensile property is a dry sheet property.
- the wet tensile of the tissue of the present invention is measured using a three-inch wide strip of tissue that is folded into a loop, clamped in a special fixture termed a Finch Cup, then immersed in a water.
- the Finch Cup which is available from the Thwing-Albert Instrument Company of Philadelphia, Pa., is mounted onto a tensile tester equipped with a 2.0 pound load cell with the flange of the Finch Cup clamped by the tester's lower jaw and the ends of tissue loop clamped into the upper jaw of the tensile tester.
- the sample is immersed in water that has been adjusted to a pH of 7.0+- 0.1 and the tensile is tested after a 5 second immersion time.
- Waterless substantially waterless and like terminology refers to compositions which include generally less than about 10% by weight water. Tn cases where water is present at all, water is preferably not added as such, but is contained in other ingredients. - ⁇ v-
- the lotion composition is a "cold” lotion such as the lotions described in United States Application Serial No. 10/141,442 (United States Publication No. 2003/0211124) filed on May 7, 2002 and incorporated herein by reference in its entirety.
- Cold” lotions refer to lotions that are substantially liquid at room temperature and can be applied as such to substrates. Due to the liquid state of the "cold" lotions at room temperature, they do not require heating or melting equipment and can be applied to the substrates by several available technologies such as spraying, printing, coating, extrusion or other techniques.
- the cold lotion used in the present invention contains a micro-emulsion composition containing predominantly an emollient composition and a surfactant composition.
- the small particle size of the micro-emulsion increases the surface area of its constituents so it contributes to the utility of the present composition in increasing the interaction between the emollient and the skin surface; a desirable property for restoring the oil layer of the skin.
- the micro-emulsion composition contains an external continuous non-polar or polar emollient, an internal discontinuous polar or non-polar emollient, a surfactant and a mixture of fatty alcohol co-surfactants.
- the lotion composition may also contain optional ingredients, including typical cosmetic additives, preservatives, plant extracts, fragrances, and medicinal agents.
- any suitable combination or proportion of ingredients which produces a micro-emulsion can be used.
- An important aspect of the cold lotion employed is when the liquid lotion contacts the fibers or non- woven substrate, it undergoes an in-situ phase change from liquid to immobilized semi-solid or solid form. This phase change of the lotion results when the substrate web surface fibers absorb the continuous outer phase of the micro-emulsion, which may be a non-polar or polar-cmollicnt.
- the immobilized antimicrobial lotion is restorable to transferable form upon contact with water and is capable of forming an aqueous gel.
- the compositions of the present invention are preferably chosen to lie within the micro-emulsion region of a given formulation.
- micro-emulsion region of a ternary phase diagram of the polar emollient/non-polar emollient/co-surfactant/non-ionic surfactant formulations (PE/NPE/COS/NIS).
- PE/NPE/COS/NIS polar emollient/non-polar emollient/co-surfactant/non-ionic surfactant formulations
- a semi-solid or solid region is preferably present.
- a micro-emulsion is thermodynamically stable and is essentially transparent in the visible region of the spectrum, which typically indicates that particle size diameter is preferably less than about 0.1 micron, or so.
- the liquid When the particle size diameter is greater than about 3,200 A (about 0.32 micron), the liquid is no longer considered a micro-emulsion but is an emulsion which can often appear turbid and be thermodynamically unstable.
- the micelle structure of a micro-emulsion is cither a "direct" type (head out/tail in) or an "inverse” type (head in/tail out).
- the liquid micro-emulsion increases the surface area of the lipophilic constituent so it contributes significantly to the utility of the present composition in neat form. Fluidity on the skin surface, small particle size, high surface area and high hydrophilic character, are highly desirable properties for cleansing purposes either when the substrate is used by itself or when lotioned products are rewet with water. Any combination or proportion of these ingredients which produces a micro-emulsion can be used.
- a hot lotion composition used in connection with the present invention is chosen such that its ⁇ H of above about 37°C is above about 10 calories/gram, ⁇ H of below about 37°C is above about 15 calories/gram, ⁇ H total (total energy to melt) of above about 37°C is above about 25 calories/gram.
- the retention/release agent is preferably selected to have a melting point substantially higher than about room temperature but lower than about 65°C, such that the lotion onset of melting temperature is within the range of from about 30°C to about 45°C. This enables the lotion composition to maintain a substantially solid state at about room temperature and partially melted state at human skin temperature.
- the temperature of human skin is between about 30 0 C to about 37°C and room temperature is between about 20 0 C to about 25°C.
- An important aspect of a hot lotion used is that it is partially melted by body heat to enable transfer to the skin of partially liquefied and partially solid emollient(s), particles of retention/release agent and other ingredients.
- the partial melting of the lotion is important, because when the lotion is completely melted to liquid by body heat it is perceived as too greasy, and when a lotion is not sufficiently melted by body heat, it would not spread easily on the skin. At least a portion of the partially melted lotion resolidifies on the skin to form a smooth and moisturizing layer. Further details as to suitable hot lotion compositions are found in United States Patent No. 5,871,763, the disclosure of which is incorporated herein in its entirety.
- anti-viral agents including those effective against, or at least retardant toward Corona virus, Picorna virus, Rhino virus, Herpes simplex, Herpes genitalis, Herpes labialis, Respiratory Syncytial Virus (RSV), Para influenza, Cytomegalovirus, Adenovirus, Condyloma and certain synergistic disease states that can involve a virus and a protozoa or a virus and any unfriendly enzymes, e.g., protease, lipase and amylase, that cause a compromised skin as a precursor state for a viral infection to occur.
- RSV Respiratory Syncytial Virus
- anti-viral agents suitable for use in the lotions include bioflavonoids such as hesperitin, naringin, catechin and certain selected amino acids of leguminous origin such as L-canavanine and an analog of L-arginine; dicarboxylic acids such as malonic, glutaric, citric, succinic, and diglycolic acids; alpha hydroxy carboxylic acid such as D-galacturonic acid from Sterculia urens; neem seed oil (Azadirachta indica) in its un- denatured form; sandalwood oil (Santalum album L.) in its un-denatured form.
- the anti-viral agent could be admixed with at most about 50% by weight of the anti-viral agent of a protease inhibitor such as zinc oxide or other suitable zinc salt.
- the cold or hot lotion composition can include other optional components typically present in lotions of this type.
- These optional components include a botanical extract, such as aloe extract, avocado oil, basil extract, sesame oil, olive oil, jojoba oil, chamomile extract, eucalyptus extract, peppermint extract, as well as animal oils such as emu oil, cod liver oil, orange roughy oil, mink oil, and the like.
- the lotion of the present invention can also optionally include a humectant.
- Humectants are hygroscopic materials with a two-fold moisturizing action including water retention and water absorption. Humectants prevent the loss of moisture from skin and help to attract moisture from the environment.
- Preferred humectants include glycerol, hydrolyzed silk, ammonium lactate, hydroxypropyltrimonium hydrolyzed silk, hydroxypropyl chitosan, hydroxypropyltrimonium hydrolyzed wheat protein, lactamidopropyltrimonium chloride, and ethyl ester of hydrolyzed silk.
- the botanical extract, animal oil or humectant is preferably present in an amount of less than about 3% when used in the base formulation of the lotion.
- Further optional components include a skin refreshing agent such as encapsulated water in oil, eucalyptus oil, and menthol oil. All of these optional materials are well known in the art as additives for such formulations and can be employed in appropriate amounts in the lotion compositions of the present invention by those skilled in the art.
- a skin refreshing agent such as encapsulated water in oil, eucalyptus oil, and menthol oil. All of these optional materials are well known in the art as additives for such formulations and can be employed in appropriate amounts in the lotion compositions of the present invention by those skilled in the art.
- the lotion can optionally include a fragrance.
- the fragrance can be present in an amount of from 0.01% to about 2%.
- Suitable fragrance includes volatile aromatic esters, non- aromatic esters, aromatic aldehydes, non-aromatic aldehydes, aromatic alcohols, non-aromatic alcohols, heterocyclic aroma chemicals, and natural floral fragrances, such as blossom, carnation, gardenia, geranium, iris, hawthorne, hyacinth and jasmine.
- the lotion can also optionally include natural or synthetic powder like talc, mica, boron nitride, silicone, or mixtures thereof.
- the towel web of the present invention can be any suitable cellulosic substrate web, optionally wet-strengthened, and optionally including synthetic fibrous material such as melt- blown polyethylene, polypropylene, copolymers of polyethylene.
- the substrate also may be embossed.
- wet strength agents which may be added include temporary as well as permanent wet strength agents.
- Suitable wet strength agents include glyoxal; glutaraldehyde; uncharged chemical moieties selected from a group consisting of dialdchydcs, aldehyde-containing polyols, uncharged aldehyde-containing polymers, and cyclic ureas and mixtures thereof, and aldehyde-containing cationic starch; mixtures of polyvinyl alcohol and salts of multivalent anions, such as boric acid or zirconium ammonium carbonates; glyoxalated polyacrylamide; polyamide-epichlorohydrin; polyamine-epichlorohydrin; urea-formaldehyde; melamine- formaldehyde; polyethyleneimine; and latex emulsions.
- the present invention includes a web of cellulosic fibers treated on at least one side thereof, preferably in an amount of from about 0.1% to about 25%, more preferably from about 0.5% to about 20%, by weight of the dried fiber web with an anti-rnicrobial lotion.
- the cellulosic substrate can be prepared according to conventional processes (including TAD, CWP and variants thereof) known to those skilled in the art.
- a preferred towel web is a fabric-creped towel web as is used in Example 18. Lotion can be applied to the substrate according to conventional application methods known to those skilled in the art.
- Formulations of the waterless lotion were prepared in which, the components, their ratios and the conditions selected to provide micro-emulsion subject to in-situ phase change upon contact with a cellulosic substrate were varied as shown in the following Examples.
- the lotion of the present invention is characterized as having a good hand-fccl perception and non-greasy hand-feel, which is thought to be due to the particle size of the micro-emulsion being too small to be detected in the oil phase by the fingertips.
- Finsolv TN C12-C15 alkyl benzoate ester from Finetex Inc.
- Carnation Mineral oil from Witco Corp.
- Lambert CT 2000 tri-octyldodecyl-citrate (Guerbet ester) from Lambert Technologies.
- Kalcol 1618 Mixture 50/50 of cetyl alcohol (C 16) and stearyl alcohol (C 18) from Kao Corp. (5> 'Glucan P-20 Distearate: PEG-20 methyl glucose distearate from Amer-chol.
- Glucamate SSE-20 PEG-20 methyl glucose sesquistearate from Amer-chol.
- Example 1 The lotion prepared in Example 1 was applied to a tissue basesheet at a 5% add-on level, then converted to a two ply tissue product. The product was tested for the amount of lotion transferred to the skin. The results were compared with commercially available lotioned tissues by comparing the light reflection of cold lotion residual on glass relative to that from two other products. The scattering of light caused by lotion smeared onto the glass microscope slide was measured by using the UV/visible spectrophotometer in the wavelength region from 700 nm to 400 nm. Lotion was transferred to the slide by holding it between two layers of lotioned tissue for 30 seconds and then rubbing the tissue over the slide 20 times in
- the lotion smeared glass slide was placed in the sample beam of a double beam UV/Visible spectrometer to measure the light scattering.
- the results show that scattering of light caused by lotion smeared onto the slide rubbed with the tissue treated with the lotion in Example 1, looked identical to the control (untreated tissue).
- the two commercially available lotioned facial tissue products tested produced a significant amount of light scattering compared to the lotioned tissue of the present invention.
- the containers for these commercial products specifically state "not recommended for cleaning eyeglasses.”
- the amount of lotion transferred by the lotioned substrate of the present invention to the skin was measured to be about 4.2 mg/cm 2 .
- the lotioned substrate product of the present invention was able to transfer lotion to the skin for enhancing skin care benefits, while also being able to "wipe eyeglasses and still maintain clear vision.” These properties of the present invention represent significant advantages over the lotioned facial tissues of the prior art.
- the waterless emulsion compositions of the present invention have numerous attributes which make them particularly suitable for paper towels.
- the waterless micro-emulsions form low viscosity aqueous micro-emulsions with relatively small amounts of water such that an immobilized lotion on the substrate is restorable to readily transferable form when wetted or mixed with water.
- the lotion is readily transferred from the towel to the skin of a user.
- the lotion emulsions are capable of forming viscous gels with water as the amount of water mixed with the lotion is increased. Gels are generally more glutinous than liquids, thus being more desirable as hand lotions.
- Example 1 The composition of Example 1 was mixed with water and tested for viscosity using a Brookfield Digital Viscometer at 73°F. Examples 9, 10, 11 and 16 were tested with a No. 2 spindle, while Examples, 12, 13, 14 and 15 were tested with aNo. 5 spindle. Details as to composition and test conditions appear in Table 2 below. Table 2 - Aqueous Phasing Properties
- Example 2 It is seen in Table 2 that the water/emulsion mixtures remained a micro-emulsion up to a water concentration of between 10% and 15% by weight of the composition (Examples 9- 12). At 15% water, the lotion emulsion turned into a viscous gel, which became even more viscous as additional water was added. At 20% water, the composition was an elastic gel having a viscosity of 22,000 cps, making viscosity measurement difficult. At 30% water (Example 14), the gel exhibited some opacity and appeared to have some crystalline structure appearing almost brittle. Due to the difficulty of viscosity measurement as well as the elastic and adhesive properties of the elastic gel of Example 13, the actual difference in viscosity between Examples 13, 14 may be less than indicated in Table 2.
- Example 9 The phase behaviors of the mixtures of Table 2 are illustrated in the partial phase diagram of Figure 2, where it is seen that Examples 9, 10 and 11 arc within the micro- emulsion region of the phase diagram.
- Examples 12, 13, 14 and 15 are in "semi solid" form, while Example 16 is a two-phase liquid.
- WAR delay which promotes lotion transfer to the skin and anti -microbial action of paper towel.
- Towel basesheet was prepared using 100% Douglas Fir Kraft fiber by way of a fabric crepe/Yankee dry process of the class disclosed in co-pending United States Patent Application Serial No. 11/451,111, entitled “Fabric-Creped Sheet for Dispensers", filed June 12, 2006 (Attorney Docket No. 20079; GP-05-10), the relevant disclosure of which is incorporated herein by reference in its entirety.
- lotion was applied in 1 " bands along the machine direction (alternating with 1" bands of unlotioned towel) using a DynatecTM applicator of the class seen in United States Patent Nos.: 5,904,298; 5,902,540; and 5,882,573, the disclosures of which are incorporated herein by reference.
- the lotion formulation of Example 1 was used, containing additionally 2% by weight lotion triclosan anti-microbial compound, 2, 4,4'-trichloro-2'-hydroxy diphenyl ether. Further details appear in Table 3 below.
- the towel was treated for anti-microbial properties by placing a wetted specimen disk of towel in a Petri dish on inoculated agar.
- the anti-microbial properties are termed "negative” if microbe contamination is observed on or at the towel after incubation and "positive” if a "ring” around the test specimen is observed, indicating that microbe growth was inhibited by the towel. Results of anti-microbial testing also appear in Table 3.
- the lotion compositions in the following examples comprise a base lotion with and without a pH balancing agent.
- Suitable pH balancing agents include glycolic acid, alpha- acetyl glycolic acid, lactic acid, tartaric acid, alpha-acetyl lactic acid, alpha-hydroxy isobutyric acid, salicylic acid, mandelic acid, ortho-acetyl mandelic acid, benzilic acid, ortho- acetyl benzilic acid, malic acid, citric acid, gluconic acid, pyruvic acid, sorbic acid and combinations thereof.
- Examples 18 and 19 are comparative and contain no pH balancing agent
- Examples 20-22 relate to lotions compositions combined with a pH balancing agent. Further detail is seen in United States Patent No. 6,352,700, the disclosure of which is incorporated herein in its entirety.
- the lotions in Examples 20-22 were prepared according to the following procedure: the base lotion ingredients, i.e., emollient(s), release and retention agent and surfactants were mixed together and heated to 75°C until the mixture was completely melted.
- the lotion composition mixture was maintained at 75 0 C for about 15 minutes with moderate agitation.
- the pH balancing compound was then added, using high agitation, until the compound was completely melted and blended.
- the emulsion was shaken for 5 minutes before measuring pH using a standard calibrated pH meter.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008544592A JP2009519055A (en) | 2005-12-08 | 2006-11-09 | Antibacterial cellulose sheet |
CA002630112A CA2630112A1 (en) | 2005-12-08 | 2006-11-09 | Antimicrobial cellulosic sheet |
EP06850130A EP1962752A4 (en) | 2005-12-08 | 2006-11-09 | Antimicrobial cellulosic sheet |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74849905P | 2005-12-08 | 2005-12-08 | |
US60/748,499 | 2005-12-08 | ||
US11/557,782 | 2006-11-08 | ||
US11/557,782 US20080107698A1 (en) | 2006-11-08 | 2006-11-08 | Antimicrobial Cellulosic Sheet |
Publications (2)
Publication Number | Publication Date |
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WO2007097818A2 true WO2007097818A2 (en) | 2007-08-30 |
WO2007097818A3 WO2007097818A3 (en) | 2008-02-28 |
Family
ID=38437828
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Application Number | Title | Priority Date | Filing Date |
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PCT/US2006/060718 WO2007097818A2 (en) | 2005-12-08 | 2006-11-09 | Antimicrobial cellulosic sheet |
Country Status (5)
Country | Link |
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EP (1) | EP1962752A4 (en) |
JP (1) | JP2009519055A (en) |
CA (1) | CA2630112A1 (en) |
RU (2) | RU2414213C2 (en) |
WO (1) | WO2007097818A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9587328B2 (en) | 2011-09-21 | 2017-03-07 | Donaldson Company, Inc. | Fine fibers made from polymer crosslinked with resinous aldehyde composition |
US10300415B2 (en) | 2013-03-09 | 2019-05-28 | Donaldson Company, Inc. | Fine fibers made from reactive additives |
US20210171488A1 (en) * | 2012-08-24 | 2021-06-10 | Citrox Biosciences Limited | Bioflavonoid impregnated materials |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102008045290A1 (en) * | 2008-09-02 | 2010-03-04 | Thüringisches Institut für Textil- und Kunststoff-Forschung e.V. | Functional Cellulosic Moldings |
CA2784922C (en) | 2010-01-18 | 2018-05-01 | Cascades Canada Ulc | Antimicrobial tissue paper and process to manufacture same |
US20170027392A1 (en) * | 2014-04-08 | 2017-02-02 | Sca Hygiene Products Ab | Flushable hydroentangled moist wipe or hygiene tissue |
US11252960B2 (en) * | 2017-01-31 | 2022-02-22 | Kimberly-Clark Worldwide, Inc. | Antibacterial composition including benzoic acid ester and methods of inhibiting bacterial growth utilizing the same |
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US4144122A (en) * | 1976-10-22 | 1979-03-13 | Berol Kemi Ab | Quaternary ammonium compounds and treatment of cellulose pulp and paper therewith |
US5044324A (en) * | 1989-04-24 | 1991-09-03 | Mountain Cat, Inc. | Wood fiber crumbles |
JP3786686B2 (en) * | 1993-12-13 | 2006-06-14 | ザ プロクター アンド ギャンブル カンパニー | Lotion composition for imparting a soft, smooth feel to tissue paper |
US6238682B1 (en) * | 1993-12-13 | 2001-05-29 | The Procter & Gamble Company | Anhydrous skin lotions having antimicrobial components for application to tissue paper products which mitigate the potential for skin irritation |
CA2177682C (en) * | 1993-12-23 | 1999-12-28 | Sekhar Mitra | Antimicrobial wipe compositions |
MX9606376A (en) * | 1994-06-17 | 1997-04-30 | Procter & Gamble | Lotioned tissue paper. |
US5960508A (en) * | 1996-11-26 | 1999-10-05 | The Proctor & Gamble Company | Cleaning implement having controlled fluid absorbency |
US5871763A (en) * | 1997-04-24 | 1999-02-16 | Fort James Corporation | Substrate treated with lotion |
CO5111023A1 (en) * | 1998-12-31 | 2001-12-26 | Kimberly Clark Co | COMPOSITION OF ABSORBENT ARTICLE AND METHOD FOR USE TO SEQUEST SKIN IRRITANTS |
US6274232B1 (en) * | 1999-06-18 | 2001-08-14 | The Procter & Gamble Company | Absorbent sheet material having cut-resistant layer and method for making the same |
US6733773B1 (en) * | 2000-11-21 | 2004-05-11 | Kimberly-Clark Worldwide, Inc. | Paper products treated with oil-in-water emulsions |
US7169400B2 (en) * | 2002-05-07 | 2007-01-30 | Fort James Corporation | Waterless lotion and lotion-treated substrate |
-
2006
- 2006-11-09 EP EP06850130A patent/EP1962752A4/en not_active Withdrawn
- 2006-11-09 RU RU2008127494/15A patent/RU2414213C2/en not_active IP Right Cessation
- 2006-11-09 JP JP2008544592A patent/JP2009519055A/en active Pending
- 2006-11-09 WO PCT/US2006/060718 patent/WO2007097818A2/en active Application Filing
- 2006-11-09 CA CA002630112A patent/CA2630112A1/en not_active Abandoned
-
2010
- 2010-11-09 RU RU2010145602/15A patent/RU2462238C2/en not_active IP Right Cessation
Non-Patent Citations (1)
Title |
---|
See references of EP1962752A4 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9587328B2 (en) | 2011-09-21 | 2017-03-07 | Donaldson Company, Inc. | Fine fibers made from polymer crosslinked with resinous aldehyde composition |
US20210171488A1 (en) * | 2012-08-24 | 2021-06-10 | Citrox Biosciences Limited | Bioflavonoid impregnated materials |
US10300415B2 (en) | 2013-03-09 | 2019-05-28 | Donaldson Company, Inc. | Fine fibers made from reactive additives |
Also Published As
Publication number | Publication date |
---|---|
RU2010145602A (en) | 2012-05-20 |
EP1962752A2 (en) | 2008-09-03 |
WO2007097818A3 (en) | 2008-02-28 |
CA2630112A1 (en) | 2007-08-30 |
JP2009519055A (en) | 2009-05-14 |
EP1962752A4 (en) | 2011-11-16 |
RU2008127494A (en) | 2010-01-20 |
RU2462238C2 (en) | 2012-09-27 |
RU2414213C2 (en) | 2011-03-20 |
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