WO2007096874A3 - Blood oxygenation sensor - Google Patents

Blood oxygenation sensor Download PDF

Info

Publication number
WO2007096874A3
WO2007096874A3 PCT/IL2007/000232 IL2007000232W WO2007096874A3 WO 2007096874 A3 WO2007096874 A3 WO 2007096874A3 IL 2007000232 W IL2007000232 W IL 2007000232W WO 2007096874 A3 WO2007096874 A3 WO 2007096874A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
core
waveguide
planar
evanescent field
Prior art date
Application number
PCT/IL2007/000232
Other languages
French (fr)
Other versions
WO2007096874A2 (en
Inventor
Noel Axelrod
Eran Ofek
Original Assignee
Physical Logic Ag
Noel Axelrod
Eran Ofek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Physical Logic Ag, Noel Axelrod, Eran Ofek filed Critical Physical Logic Ag
Publication of WO2007096874A2 publication Critical patent/WO2007096874A2/en
Publication of WO2007096874A3 publication Critical patent/WO2007096874A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection

Abstract

A planar dielectric waveguide sensor is used to determine the concentrations of oxygenated and deoxygenated hemoglobin and other blood constituents such as pH, sugar. The planar waveguide core is in direct contact with the blood such that evanescent field of the light propagating within the core is selectively attenuated at specific wavelengths of interest. The planar waveguide has a construction that promotes strong interaction of the evanescent field with blood cells that contact it. In preferred embodiments, the waveguide is constructed of a low refractive index core to propagate an evanescent wave comparable in size to a red blood cell.
PCT/IL2007/000232 2006-02-21 2007-02-20 Blood oxygenation sensor WO2007096874A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77553106P 2006-02-21 2006-02-21
US60/775,531 2006-02-21
US11/676,301 2007-02-18
US11/676,301 US20070197888A1 (en) 2006-02-21 2007-02-18 Blood Oxygenation Sensor

Publications (2)

Publication Number Publication Date
WO2007096874A2 WO2007096874A2 (en) 2007-08-30
WO2007096874A3 true WO2007096874A3 (en) 2009-04-09

Family

ID=38429230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/000232 WO2007096874A2 (en) 2006-02-21 2007-02-20 Blood oxygenation sensor

Country Status (2)

Country Link
US (1) US20070197888A1 (en)
WO (1) WO2007096874A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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US10080499B2 (en) 2008-07-30 2018-09-25 Medtronic, Inc. Implantable medical system including multiple sensing modules
WO2010014059A1 (en) * 2008-07-30 2010-02-04 Medtronic, Inc. Implantable medical system including multiple sensing modules
US9737213B1 (en) 2009-03-24 2017-08-22 Vioptix, Inc. Using an oximeter probe to detect intestinal ischemia
US8750652B2 (en) * 2010-10-12 2014-06-10 The Board Of Trustees Of The Leland Stanford Junior University Microfluidic waveguide detector
DE102015119180A1 (en) 2015-11-06 2017-05-11 Infineon Technologies Ag Electromagnetic wave sensor to determine a hydration status of body tissue in vivo
US11835803B2 (en) 2019-12-11 2023-12-05 The Trustees Of Columbia University In The City Of New York Controlling evanescent waves on dielectric waveguides

Citations (9)

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US4818710A (en) * 1984-12-10 1989-04-04 Prutec Limited Method for optically ascertaining parameters of species in a liquid analyte
US5396350A (en) * 1993-11-05 1995-03-07 Alliedsignal Inc. Backlighting apparatus employing an array of microprisms
US5425115A (en) * 1994-07-18 1995-06-13 Martin Marietta Corporation Polarization insensitive optical switch
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5790727A (en) * 1997-02-05 1998-08-04 Brookhaven Science Associates Llc Laser illumination of multiple capillaries that form a waveguide
US6052220A (en) * 1997-01-21 2000-04-18 Molecular Optoelectronics Corporation Optical amplifier and process for amplifying an optical signal propagating in a fiber optic employing an overlay waveguide and stimulated emission
US6259841B1 (en) * 1996-12-20 2001-07-10 Corning Incorporated Reflective coupling array for optical waveguide
US6624061B2 (en) * 1998-05-28 2003-09-23 Nec Electronics Corporation Semiconductor device and method of manufacturing the same capable of reducing deterioration of low dielectric constant film
US6859658B1 (en) * 1998-11-18 2005-02-22 Lea Medizintechnik Gmbh Device for non-invasively detecting the oxygen metabolism in tissues

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US4344438A (en) * 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US4730622A (en) * 1986-07-01 1988-03-15 Cordis Corporation Pressure and oxygen saturation catheter
US4974929A (en) * 1987-09-22 1990-12-04 Baxter International, Inc. Fiber optical probe connector for physiologic measurement devices
EP0336984B1 (en) * 1988-04-09 1990-12-27 Hewlett-Packard GmbH Measuring probe
JPH0257239A (en) * 1988-08-23 1990-02-27 Terumo Corp Probe for optical sensor
US5048524A (en) * 1989-03-03 1991-09-17 Camino Laboratories, Inc. Blood parameter measurement
US5280786A (en) * 1992-01-21 1994-01-25 Fiberoptic Sensor Technologies, Inc. Fiberoptic blood pressure and oxygenation sensor
US5439000A (en) * 1992-11-18 1995-08-08 Spectrascience, Inc. Method of diagnosing tissue with guidewire
US7400918B2 (en) * 1998-07-04 2008-07-15 Edwards Lifesciences Measurement of blood oxygen saturation
US7164948B2 (en) * 2002-04-22 2007-01-16 Medtronic, Inc. Cardiac output measurement using dual oxygen sensors in right and left ventricles
KR100730567B1 (en) * 2002-07-09 2007-06-20 한라공조주식회사 Receiver-drier for an air-conditioning system and a method for making it
TW200510736A (en) * 2003-07-01 2005-03-16 Chrysalis Tech Inc Capacitive position sensor and sensing methodology

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818710A (en) * 1984-12-10 1989-04-04 Prutec Limited Method for optically ascertaining parameters of species in a liquid analyte
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5396350A (en) * 1993-11-05 1995-03-07 Alliedsignal Inc. Backlighting apparatus employing an array of microprisms
US5425115A (en) * 1994-07-18 1995-06-13 Martin Marietta Corporation Polarization insensitive optical switch
US6259841B1 (en) * 1996-12-20 2001-07-10 Corning Incorporated Reflective coupling array for optical waveguide
US6052220A (en) * 1997-01-21 2000-04-18 Molecular Optoelectronics Corporation Optical amplifier and process for amplifying an optical signal propagating in a fiber optic employing an overlay waveguide and stimulated emission
US5790727A (en) * 1997-02-05 1998-08-04 Brookhaven Science Associates Llc Laser illumination of multiple capillaries that form a waveguide
US6624061B2 (en) * 1998-05-28 2003-09-23 Nec Electronics Corporation Semiconductor device and method of manufacturing the same capable of reducing deterioration of low dielectric constant film
US6859658B1 (en) * 1998-11-18 2005-02-22 Lea Medizintechnik Gmbh Device for non-invasively detecting the oxygen metabolism in tissues

Also Published As

Publication number Publication date
US20070197888A1 (en) 2007-08-23
WO2007096874A2 (en) 2007-08-30

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