WO2007095925A1

WO2007095925A1 - System for determining and regulating a psychophysiological condition of a biological system

Info

Publication number: WO2007095925A1
Application number: PCT/DE2007/000336
Authority: WO
Inventors: Hans-Ullrich Balzer
Original assignee: Brandes, Vera
Priority date: 2006-02-23
Filing date: 2007-02-22
Publication date: 2007-08-30
Also published as: DE112007001021A5; EP1988831A1

Abstract

The invention relates to a system for determining and regulating a psychophysiological condition of a biological system. Said system comprises at least one sensor unit which is configured to detect measuring values for at least one physiological parameter that is characteristic of a psychophysiological condition of the biological system, a data evaluation unit, connected to the at least one sensor unit so as to exchange data and configured to automatically derive from the detected at least one physiological parameter a psychophysiological starting condition of the biological system, and a selection unit, connected to the data evaluation unit so as to exchange data and configured to select a sound file for reproduction on a reproduction unit from a sound data memory in accordance with the psychophysiological starting condition. The data evaluation unit is also configured to determine a regulation condition of the biological system during or after reproduction of the selected sound file via the reproduction unit from the measuring values that are additionally acquired by the sensor units for the at least one physiological or at least one other physiological parameter.

Description

System for determining and regulating a psychophysiological state of a biological system

The invention is in the field of system for determining and regulating complex vegetative states of a biological system.

Background of the invention

In behavioral research, especially in behavioral psychology, the emotional states or reaction or behavior of biological systems in different life situations are usually described verbally with the aid of illustrations, be it graphic or photographic. In addition, there are a number of behavioral psycho-physiological examinations by means of the absorption of physiological bodily functions, for example electroencephalogram (EEG), electromyogram (EMG), electrocardiogram (ECG) or the like. In addition, there are biochemical studies to characterize certain behaviors, such as food intake or immune behavior under specific conditions, such as pathological behavior.

Vegetative-emotional investigations of humans are carried out by means of skin resistance measurements. In this case, various types of regulatory states such as arousal, relaxation, overload inhibition or the like can be detected.

Psychological tests, such as the Freiburg Personal Inven- tar (FPI), record and describe psychological behaviors. These were coined terms such as: choleric, melancholic, Sanquiniker and phlegmatic. There are a number of other typifications today. The typing of stress suppressors, stress relievers, stress compensators and stress relievers was introduced by means of a psycho-physiological stress diagnostic test (Balzer et al .: Chrono-Biological Regulation Diagnostics (RD): A New Path to the Objective Determination of Health and Illness In: Hecht et al (Ed): Stress Management Disaster Medicine Regulation Medicine Prevention, 1st Berlin Stress Research Days 2000 Pabst Science Publisher, p. 134 -

BESTATIGUNGSKOPIE 155). The basis of this test procedure is a measurement of skin resistance under defined test conditions.

From long-term investigations of skin resistance (Boucsein: Electrodermal Activity: Fundamentals, Methods and Applications, Springer-Verlag, Berlin, 1998; Balzer et al: Is Stress Noninvasive to Measure ?, Scientific Journal of the Humboldt University of Berlin, 38th ed.), 1989, H. 4, pp. 456-460; DE 42 21 526 A1; Stück et al .: Psychological and Psychophysiological Effects of a High-Montain Expedition to Tibet, Journal of Human Performance in Extreme Enviroments, 2005, Vol. 8, Nos. 1-2, 11-20, Stück et al .: Hypersensitivity states of electrodermal activity and stress experiences in the teaching profession, Psycho- med, 17 (2), 109-114, 2005) of chronobiological information about various periodic events (circadian, ultradian and infradial rhythms) are contained in the data structures. By means of the methods developed by Balzer / Hecht for the analysis of time series it could be shown that, among other things, convulsive reactions are expressed by rigid regulatory processes.

By means of psycho-diagnostic methods, psychological basic states such as well-being, happiness, sadness, anger or psychological mixed states such as anxious, pleasant, aggressive, nervous or the like are determined by questioning or by biofeedback methods.

Methods for the non-invasive determination of basic psycho-physiological and mixed states by means of non-invasive measurement of autonomic physiological parameters are not yet known.

The previously known literature and the experimental research results show the possibility of measuring emotional states in humans in five ways: measurement of heart rate variability and evaluation of sympathetic parts; Measurement of skin conductance or skin resistance as a result of sympathetically innervated sweat gland secretion; Biochemical determinations of the value of various stress hormones, such as epinephrine, norepinephrine, cortisol; Determination of the shift of the basic vocal frequency or determination of EEG behavioral patterns. From the literature and behavioral research is also known that it can come under certain states of excitement to erecting the body hair and to the formation of goose bumps. The straightening of the hair is sympathetically innervated via the hair muscle {pilo arrektoreή). In high states of excitement electrostatically charged hair is also known.

The vegetative state of a biological system (human or animal) can be described by measuring and analyzing the three basic vegetative parameters: electromyogram (EMG), skin resistance (HW) and skin potential (HP). The EMG reflects the muscular and motor activity of the system, the skin resistance reflects on the sympathetic activity and the associated sweat gland secretion the vegetative-emotional component, the skin potential reflected as the difference of summary cell potential differences on the skin surface parasympathisch innervierter reactions. The physiological basic states include the waking state, the sleep state and the sleep phases or sleep states (for example REM sleep).

Psycho-physiological states are determined in biological systems by means of time series analyzes, for example dynamics analysis, with the aid of logic programs or artificial neural networks (Balzer et al.: Chrono-Biological Regulation Diagnosis (RD): A New Path to Objective Determination of Health and Illness, In: Hecht et al. (Ed.): Stress Management Disaster Medicine Regulation Medicine Prevention, 1st Berlin Stress Research Days 2000 Pabst Science Publisher, pp 134-155, piece et al .: Psychological and Psychophysiological Effects of a High -Montain Expedition to Tibet, Journal of Human Performance in Extreme Enviroments, 2005, Vol. 8, Nos. 1-2, 11-20; Piece et al .: Hypersensitivity states of electrodermal activity and stress experience in the teaching profession, Psychomed, 17 (2) , 109-114, 2005. Fritz: Investigation of the Regulating of Biological and Musical Processes with the help of a Neural Network, Dissertation, University of Moza Salzburg, 2005).

Musical works are analyzed and fragmented using mathematical methods to determine elements of sentences, sequences of notes, repetitions, and other musical-analytical elements (Mazzola: Geometry of Sounds - Elements of Mathematical Music Theory, Basel: Birkhäuser, 1190). Musical works are analyzed by means of mathematical methods in order to establish correspondences or deviations from one another or to make references to the composer or for interpretation (Langner et al .: Visualizing expressive performance in tempo-loudness space, Computer Music Journal, 27, (4), 69-83, 2003).

On the basis of this there is a need for a system for determining the possible medical or psychological effect of the music on human beings on the basis of musical parameters.

Summary of the invention

The object of the invention is to provide a system for determining and regulating complex vegetative states of a biological system.

According to one aspect of the invention, there is provided a system for determining and regulating a psycho-physiological condition of a biological system having at least one sensor unit configured to provide measurements of at least one physiological parameter characterizing a psychophysiological state of the biological system to detect a data analysis unit coupled to the at least one sensor unit and configured to automatically derive a psycho-physiological initial state of the biological system from the acquired at least one physiological parameter, and to a selection unit that is connected and configured in data technology with the data evaluation unit an audio data memory corresponding to the psychophysiological initial state to select an audio file for playback via a playback unit, the data evaluation unit is further configured to a regulatory state of the b During or after the playback of the selected audio file via the playback unit, the iological system can then be used to determine measured values for the at least one physiological or at least one other physiological parameter which are additionally recorded by the sensor units.

As a result, a therapy system or treatment device is provided, which provides the possibility, by means of objective, ambulatory measurement of parameters such as electrical myogram (EMG), skin resistance (HW) or skin potential (HP) psycho-physiological states, including basic and mixed states, without verbal or other feedback on the condition to be determined by the biological system being studied or measured by automatic electronic data processing receive. By means of data analysis of physical parameters of music, sounds, sequences of sounds or noises such as amplitude, frequency spectrum and Tonfolgedichte psycho-physiological states of music, sounds, sequences or sounds are determined, so that a prediction of the possible medical or psychological effect of the music, the sounds , Sound sequences or sounds can be made. By using music, sounds, sound sequences or noises, based on the initial situation of the biological system, that hears the music, sounds, sound sequences or noises or the biological system that produces the music, sounds, sound sequences or noises, becomes psycho-physiological regulatory state.

A preferred embodiment of the invention provides that the at least one sensor unit is configured to record measured values for at least one physiological parameter selected from the following group of physiological parameters: muscular-motor reaction parameter (for example an electromyogram-EMG), vegetative-cognitive reaction parameter ( For example, a skin potential - HP) and vegetative-emotional reaction parameters (for example, a skin resistance - HW). Preferably, an embodiment is provided that all aforementioned reaction parameters for determining the psycho-physiological state of the biological system are recorded and evaluated. This can be provided both for the determination of the psycho-physiological initial state of the biological system and for the determination of the psycho-physiological regulatory state of the biological system. In this way the determination of the psychophysiological state of the biological system is optimized.

In an expedient embodiment of the invention, it may be provided that the at least one sensor unit is configured to detect the measured values for the at least one physiological parameter in a non-invasive (non-bloody) manner.

An advantageous embodiment of the invention provides that in the audio data memory to the selectable audio files each have an associated record is stored, which electronically evaluable information on at least one physical parameter of the audio data contained in the respective audio file selected from the following group of physical parameters: temporal change of the amplitude (LS), temporal change of the accumulated frequency spectrum (FS) and temporal change of the Tonfolgedichte (TD).

Preferably, a development of the invention provides that the data evaluation unit is configured to generate the respectively assigned data record for the analyzed audio data file by means of an analysis of the audio file and to transfer it to the audio data memory.

In an advantageous embodiment of the invention can be provided that in the audio data storage to the selectable audio files in each case an electronically evaluable information about an associated psycho-physiological ground state is stored. A psycho-physiological ground state in the sense of the present application is characterized by a group of psycho-physiological regulatory states which were determined or determinable simultaneously or chronologically successively. Additionally or alternatively, the electronically evaluable information about a psycho-physiological ground state characterizing, temporal course of one or more regulatory states may be stored to the selectable audio files, which are adjustable by means of the associated audio data file for the biological system. The electronically evaluable information is expediently stored in the form of a further associated data set.

A development of the invention can provide that the electronically evaluable information assigns to the respective audio data file a psycho-physiological ground state selected from the following group of psycho-physiological ground states: a basic state of well-being, a ground state of pleasure, a ground state of sadness, a ground state of anger and a mixed state of at least two of the ground states.

A preferred embodiment of the invention provides that the data evaluation unit is configured to evaluate in the respectively assigned data record for the selectable audio data files the electronically evaluable information about the at least one physical parameter of the audio data contained in the respective audio file, in order to provide for the respective To generate audio data file electronically evaluable information about the associated psychophysiological ground state. Additionally or alternatively, the data evaluation unit can be configured to evaluate the electronically evaluable information about the time profile of one or more regulatory states which can be set for the biological system by means of the associated audio data file.

In an expedient embodiment of the invention, it can be provided that the data evaluation unit is configured to use one or more evaluation methods for assigning the basic psychophysiological state to the respective audio data file, the same as those used to determine the psycho-physiological initial state and the incoming one Regulating state of the biological system used evaluation.

An advantageous embodiment of the invention provides that the selection unit is configured to select from the audio data memory an audio file for reproduction via the reproduction unit whose associated psycho-physiological ground state corresponds to the psycho-physiological initial state.

Preferably, a development of the invention provides that the selection unit is configured to select from the audio data memory an audio file for playback via the playback unit whose assigned psycho-physiological ground state deviates from the psychophysiological initial state.

In an advantageous embodiment of the invention it can be provided that an operating mode can be selected in which a plurality of regulatory states of the biological system are determined simultaneously or in a serial manner.

A development of the invention can provide that the data evaluation unit is configured to determine a time profile for the at least one physiological and / or the at least one other physiological parameter and / or the regulatory state of the biological system, including basic states and mixed states. A preferred embodiment of the invention provides that the data evaluation unit is configured to determine a regulation effect selected from the following group of regulatory effects when determining the temporal course of the regulatory state of the biological system: dragging effect, adaptation effect and synchronization effect. In this case, it can be provided that the data evaluation unit interacts with a control unit which can then optionally assume the function of determining the regulation effect. Data evaluation unit and control unit are connected by data technology, so that electronic data can be exchanged.

In an expedient embodiment of the invention, provision may be made for a preselection unit to be provided and configured to detect the preselection data influencing the selection of the audio file and optionally to be manually entered data, and to pass them on to the selection unit.

An advantageous embodiment of the invention provides that a control unit is provided and configured to modify the reproduction of the selected audio file via the playback unit by aborting the playback and optionally reproducing another audio data file if a preselectable regulation effect is not achieved.

Preferably, a development of the invention provides that an information unit is provided and configured to provide electronically evaluatable overview information about the determination and regulation of the psycho-physiological state of the biological system.

A data evaluation unit and a further data evaluation unit may be formed, to which various functions in the data processing in the context of the overall procedure are assigned by forming corresponding hardware and software equipment. Typically, a processor unit can be programmed as desired to provide functionality for data processing in at least one of the data evaluation units. In a preferred embodiment, the data evaluation unit assumes, in particular, a temporal course for the at least one physiological and / or the at least one other physiological parameter and / or the regulatory state of the biological system, including ground states and mixed states, and to determine a regulatory effect selected from the following group of regulatory effects when determining the time course of the regulatory state of the biological system: entrainment effect, adaptation effect and synchronization effect.

The further data evaluation unit is configured in this embodiment, in particular:

to generate the respectively assigned data record for the analyzed audio data file by means of an analysis of the audio file and to transfer it to the audio data memory,

in the respectively assigned data set for the selectable audio data files, evaluate the electronically evaluable information about the at least one physical parameter of the audio data contained in the respective audio file in order to generate for the respective audio data file the electronically evaluable information about the assigned basic psychophysiological state;

to use one or more evaluation methods for assigning the psycho-physiological ground state to the respective audio data file, which are equal to the evaluation methods used to determine the psycho-physiological initial state and the regulatory state of the biological system.

With the system described above in its various embodiments, it is possible to carry out a method for determining and regulating a psycho-physiological state of a biological system, the method comprising the following steps:

Acquiring measured values for at least one physiological parameter characterizing a psycho-physiological state of the biological system, automatically deriving a psycho-physiological initial state of the biological system from the acquired at least one physiological parameter, and

Selecting an audio field corresponding to the psycho-physiological initial state from an audio data memory for playback via a playback unit, wherein during or after the playback of the selected audio file via the playback unit further a regulatory state of the biological system from additionally acquired measured values for the at least one physiological or at least one other physiological parameter is determined. The acquisition of measured values for at least one physiological parameter characterizing a psychophysiological state of the biological system is expediently carried out by means of at least one sensor unit. For the automatic derivation of a psychophysiological initial state of the biological system from the detected at least one physiological parameter, a data analysis unit coupled to the at least one sensor unit is expediently used. The selection of an audio file corresponding to the psychophysiological initial state from an audio data memory for reproduction via a reproduction unit is expediently carried out by means of a selection unit which is connected to the data evaluation unit by data technology. The determination of a regulatory state of the biological system from additionally acquired measured values for the at least one physiological or at least one other physiological parameter during or after the reproduction of the selected audio file via the reproduction unit is advantageously carried out with the aid of the data evaluation unit.

The method may be developed according to the described embodiments of the system. For example, it may be provided that measured values for at least one physiological parameter selected from the following group of physiological parameters are detected: muscular-motor reaction parameters (for example an electromyogram-EMG), vegetative-cognitive reaction parameters (for example a skin potential-HP) and vegetative-emotional reaction parameter (for example a skin resistance - HW). Preferably, an embodiment is provided that all aforementioned reaction parameters for determining the psycho-physiological state of the biological system are detected and evaluated. This can be provided both for the determination of the psychophysiological initial state of the biological system and for the determination of the psycho-physiological regulatory state of the biological system.

A further embodiment can provide that a psycho-physiological ground state of well-being of the biological system is determined if regulation states of the physiological parameters are located in the upper left quadrant of the graphical representation in FIG. 2 below for a predetermined period of time. In the same way, a psycho-physiological basic state of well-being is determined for an audio data file. A psychophysiological ground state Delight of the biological system or of an audio data file is determined when the regulatory states of the biological system are over a given period of time or the psychophysiological parameters are located in the upper right quadrant of the graph in FIG. In an analogous manner, a psycho-physiological ground state of sadness of the biological system or of an audio data file is determined if the regulatory states of the psychophysiological parameter (s) are in the lower left quadrant of the graphical representation in FIG. 2 for the given period of time. If the regulatory states of the psycho-physiological parameter or parameters are located in the lower right quadrant of the graphical representation in FIG. 2 over the given period of time, a psycho-physiological basic condition of anger is determined for the biological system or an audio data file. A psycho-physiological mixed state is determined when the regulatory states of the psycho-physiological parameter (s) are distributed over the four quadrants of the graphical representation in FIG. 2 within the predetermined period of time.

Description of preferred embodiments of the invention

The invention is explained below with reference to preferred Ausfiüirungsbeispielen with reference to figures. Hereby show:

1 is a schematic representation of a system for determining and regulating a psycho-physiological state of a biological system; FIG. 2 is a graphic representation for assigning regulatory states of a physiological parameter to the psycho-physiological basic states of well-being, joy, sadness, anger,

3 shows a graph for a frequency of occurrence of regulation states of the physiological parameters EMG, HW, HP of a person at the beginning of listening to music (starting situation),

4 is a graph showing a waveform of an amplitude change (LS), a change of a summed frequency spectrum (FS), and a tone sequence density (TD) of an audio file;

5 shows a graphical representation for a course of regulatory states of an audio file,

6 shows a graph for a frequency distribution of regulation states of the parameters LS, FS and TD of an audio file, 7 is a graphical representation of a course of an activation portion of average regulation profiles of the parameters LS, FS and TD of an audio file,

FIG. 8 is a graph showing a course of a regulation quality of regularized regulation waveforms of the parameters LS, FS and TD of an audio file. FIG. 9 is a graph showing a fitting effect, entrainment effect and synchronization effect based on a regulatory quality trend of averaged regulatory states of the physiological FIG. 10 shows a graph of a model of a stimulation of a basic resting activity cycle of a person, EMG, HW, HP of a person caused by the change of the regulation quality of averaged parameters LS, FS and TD of an audio file;

11 shows a graph for a course of the regulatory quality of averaged regulation states of the physiological parameters EMG, HW, HP of a person and the regulation quality of the averaged parameters LS, FS and TD of an audio file,

12 shows a graph for a profile of an activation portion of averaged regulation states of the physiological parameters EMG, HW, HP of a person and the regulation quality of the averaged parameters LS, FS and TD of an audio file, and FIG. 13 shows a representation for a state graph of the regulation states LS, FIG. FS and TD of an audio file.

Fig. 1 shows a schematic block diagram of a system for determining and regulating a psycho-physiological state of a biological system. A plurality of sensor units 2.1,..., 2.n are connected to a data evaluation unit 1, with which physiological parameters of a measured object (person) can be respectively detected. One or more of the following parameters can be detected by means of the sensor units 2.1,..., 2.n: electromyogram (EMG), skin resistance (HW) and skin potential (HP). With the aid of the data evaluation unit 1, the values for the physiological parameters detected with the sensor units 2.1,..., 2.n can then be evaluated in terms of data technology. The results of the evaluation can be transferred from the data evaluation unit 1 to a selection unit 3 connected to it. The selection unit 3 is further connected to a preselection unit 4, a control unit 5, an amplifier unit 6 and a Information unit 7 and a further data evaluation unit 8. To the amplifier unit 6 are coupled a plurality of playback devices 9 for outputting audio signals. The audio files to be selected for reproduction are provided in an audio data memory 10, which is optionally implemented on an external server. In an alternative embodiment (not shown), the data evaluation unit 1 and the further data evaluation unit 8 are at least partially implemented in a common data evaluation unit.

Via the preselection unit 4, user inputs are recorded, which are explained in detail below.

The system shown schematically in FIG. 1 may be implemented involving multiple hardware and software components. The electronic exchange of information between the units of the system takes place by means of electronic data signals, for the transmission of which both wired and wireless transmission technologies can be used.

The preselection unit 4 in FIG. 1 collects as subjective data of the regulation process both subjective and objective data (by questionnaire) of the person to be regulated and the recommendation of a third person (for example trainer, doctor, therapist, psychologist or the like) for the regulation of regulatory states of the respective person to be regulated.

The subjective data of the person to be regulated include: preferred musical genre (order) and general information on the condition (good, bad, not to be assigned).

The objective data to be recorded for the person to be regulated include: determination of the type of day (morning type-evening type-indifferent type), mean lark eulenest (questionnaire) and sensitivity questionnaire.

Data to be collected from a third person include: type of regulation, timing of regulation and duration of regulation. By means of the measuring object (person) mounted sensors for detecting the physiological parameters EMG, HW and HP continuously data via the sensor units 2.1, ..., 2.n (Fig. 1) in the data evaluation 1. With the help of the data evaluation unit 1 who preferably according to a known method (Balzer et al.: Dynamic of Processes a possi- bility to analysis physiological parameters, Supplement to "The Physiologist", Vol.31, Number 1, Feb. 1988, Proceedings of the Ninth Annual Session of the IUPS Commission on Gravitational Physiology, 1988; Balzer et al .: Chrono-Biological Regulation Diagnostics (RD): A New Path to the Objective Determination of Health and Disease In: Hecht et al. (ed.): Stress Management Disaster Medicine Regulation Medicine Prevention, 1. Berlin Stress Research Days 2000 Pabst Science Publisher, pp. 134-155: Fritz: Investigation of the Control of Biological and Musical Processes Using a Neural Network, Dissertation, University Mozarteum Salzburg, 2005, which allows the determination of a regulatory state of a biological system, regulation states of the parameters EMG, HW, HP of the measurement object (person) in the form of time series determined before, during and after listening to an audio file.

The determination of the basic psychophysiological states of well-being, joy, sadness and anger takes place in accordance with FIG. 2 taking into account the following definitions.

A regulatory function represents the course of the most likely regulatory portion of a time series, which may also be periodic. For the purposes of the present application, a regulation state is understood to mean a quasi-stationary state of a regulation system which is characterized by characteristic regulatory processes for a specific time. A characteristic regulatory process is the distribution of a regulatory function over time, in which the distribution function contains mathematically definable characteristics such as gypsum, skewness or the like. Regulation processes are characterized, among other things, by multiplicative or demultiplicative leaps of regulation (Fritz: Examination of control processes of biological and musical processes with the help of a neural network, dissertation, University Mozarteum Salzburg, 2005).

It has been shown that significant changes in a regulatory state are coupled with psychophysiologically significant changes in the control state of a body function are and thus health or disease states and their transitions can be represented. In principle, a state function is a 3-dimensional function which contains information about the degree of activation in addition to the time axis and information about the regulation quality.

The degree of activation provides information on whether rapid regulation processes (short periods) = activation or slow regulation processes (slow periods) = deactivation prevail in the distribution function. In balanced states, distributed activation is represented by '0'.

The quality of the regulation or the quality of the regulation provides information about the form in which the periods are distributed. A single period corresponds to a rigid regulatory process and is rated, for example, with a poor regulatory quality. In a completely desynchronized state, like in a chaos of all periods, they are equally distributed.

For the purposes of the present application, a musical work is also understood to mean individual sounds, sequences of sounds or noises with periodic parts.

The psycho-physiological ground state Well-being of a person or an audio file is determined when the regulation states of the psychophysiological parameters EMG, HP and HW of the measured person or the physical parameters Course of the amplitude (LS), frequency spectrum (FS) over a defined time , Tonfolgedichte (TD) of the audio file mainly in the upper left quadrant (named wellbeing) in Fig. 2 are.

The psycho-physiological ground state Joy of a person or an audio file is determined, if over a defined time the regulation states of the psychophysiological parameters EMG, HP and HW of the measured person or the physical parameters LS, FS, TD of the audio file predominantly in the right upper quadrant (named joy) in Fig. 2 are located. The basic psychophysiological state of sadness of a person or of an audio file is determined if, over a defined time, the regulatory states of the psychophysiological parameters EMG, HP and HW of the measured person or of the physical parameters LS, FS, TD of the audiofile are predominantly in the lower left quadrant ( Term sadness) in Fig. 2 are located.

The basic psychophysiological state of annoyance of a person or an audiofile is determined when the regulatory states of the measured psychophysiological parameters EMG, HP and HW of the measured person or the physical parameters LS, FS, TD of the audio file are predominantly in the lower right for a defined time Quadrants (named sadness) in Fig. 2 are located.

Psycho-physiological mixed states of a person such as anxious, aggressive, unpleasant, melancholic, depressive or the like or psycho-physiological mixed states of an audio file are determined if, over a defined time, a distribution of the regulatory states of the psycho-physiological parameters EMG, HP and HW of the measured person or the physical parameter LS, FS, TD of the audio file on the four quadrants in Fig. 2 is present, namely, well-being, joy, anger, sadness.

From the measurement of the data EMG, HW and HP in the last minute before listening to an audio file, a musical work or an interpretation of the psycho-physiological initial state of each measurement object (person) via a frequency distribution (Fig. 3) of the known methods (Balzer et al .: Dynamic of processes-a possibility to analyze physiological parameters, Supplement to "The Physiologist", Vol. 31, Number 1, Feb. 1988, Proceedings of the Ninth Annual Session of the IUPS Commission on Gravitational Physiology , 1988; Balzer et al .: Chrono-Biological Regulation Diagnostics (RD): A New Path to the Objective Determination of Health and Illness In: Hecht et al. (Ed.): Stress Management Disaster Medicine Regulation Medicine Prevention, 1st Berlin Stress Research Days 2000 Pabst Science Publisher, pp. 134-155; Fritz: Investigation of the Rule Processes of Biological and Musical Processes with the Use of a Neural Network, Dissertation, U Mozarteum Salzburg) calculated regulatory states (Fig. 4), corresponding to FIG. 2, and evaluating the initial situation with respect to the psycho-physiological ground states illustrated in FIG. 2. Table 1 - Assessment of the psychophysiological ground states of the person (% data)

In the initial situation of this example, the psycho-physiological ground state predominates sadness.

The audio storage unit 10 contains audio files with detailed information on the composition and interpretation of the audio files. The audio storage unit 10 receives via the preselection unit 4 or generates the following additional information for each new recording of an audio file in the audio storage unit 10 in interaction with the data evaluation unit 2 for each audio file:

- assignment to genre (for example classical, jazz, rock pop, folk music ....)

- Determination of the musical initial state of the audio file for the first minute - Determination of the general psycho-physiological regulatory state of the audio file

- Type of regulation (see Table 3)

- Activation

- Quality - duration of regulation

All of the above information is referred to as characteristic data of an audio file and assigned to this.

Assignment to the genre: Classical (example: Music: Mozart - Piano Concerto No. 17, KV 453, 3rd movement)

Determining the initial musical state of the audio web for the first minute

The audio storage unit 10 contains a limited only by the memory amount of musical works, interpretations, sounds, sound sequences or sounds, which by a external server can be reloaded at any time. In the audio memory unit 10, additional information about the course of the amplitude (LS), the accumulated frequency spectrum (FS) and the tone sequence density (TD - number of tones per unit time) are stored for each audio file in the form of time series (FIG. 4). With the aid of the data evaluation unit 2 for analyzing physical parameters of musical information (LS, FS, TD), according to a known method (Balzer et al .: Dynamic of Processes - a possibility to analyze physiological parameters, Supplement to "The Physiologist", Vol , Number I ₅ February 1988, Proceedings of tlie Ninth Annual Session of the IUPS Commission on Gravitational Physiology, 1988; Balzer et al.: Chrono-biological Regulation Diagnostics (RD): A New Path to Objectively Identifying Health and Illness In: Hecht et al. (ed.): Stress Management Disaster Medicine Regulation Medicine Prevention, 1. Berlin Stress Research Days 2000 Pabst Science Publisher, pp. 134-155; Fritz: Investigation of Regulating Biological and Musical Processes Using a Neural Network, Dissertation, University of Mozarteum Salzburg , 2005) or other methods that determine a regulatory state of a biological system, regulatory states de r Parameters LS, FS and TD of the audio files in the form of time series (Fig. 5). All musical works or interpretations analyzed in this way receive an evaluation and assignment to the psychophysiological basic states according to the definition of psycho-physiological ground states.

From the time series of the physical parameters LS, FS and TD in the first minute of an audio file, the psycho-physiological initial state of the respective audio file is determined via a frequency distribution of the previously determined regulatory states, corresponding to FIG. 2, and the initial situation with respect to that in FIG evaluated psycho-physiological ground conditions.

Table 2 - Evaluation of psycho-physiological ground states of music (% data) - initial state

The piece of music used in this example (Mozart - Piano Concerto No. 17, KV 453, 3rd movement) shows a preponderance of the psycho-physiological ground state of well-being for the first minute (initial state).

Determination of the general psycho-physiological regulatory state of the audio web

Analogously to the determination of the musical initial state, from the time series of the physical parameters LS, FS and TD of the entire duration of an audio file, the psycho-physiological regulatory state of the respective audiofile is determined via a frequency distribution of the previously determined regulatory states (FIG. assigned according to Fig. 2 and evaluated the initial situation with respect to the psycho-physiological ground states shown in Fig. 2.

Table 3 - Assessment of general psycho-physiological ground state (% - data)

The piece of music used in this example (Mozart - Piano Concerto No. 17, KV 453, 3rd movement) shows a preponderance of the general psychophysiological state of well-being

Determination of the type of regulation

To determine the type of regulation by means of the data evaluation unit 1, data files are generated from the audio files using any desired method, corresponding to the temporal change of the physical parameters amplitude (LS), summed frequency spectrum (FS) and tone sequence density (TD) (number of tones per unit time) Fig. 4 included.

These data files are prepared according to known evaluation methods (see Balzer et al .: Dynamic of processes - a possibility to analysis physiological parameters, Supplement to "The Physiologist", Vol. 31, Number 1, February 1988, Proceedings of the Ninth Annual Session of the IUPS

Commission on Gravitational Physiology, 1988; Balzer et al .: Chrono-Biological Regula- Onsdiagnostik (RD): A New Way to Objectively Determine Health and Illness In: Hecht et al. (Eds): Stress Management Disaster Medicine Regulation Medicine Prevention, 1st Berlin Stress Research Days 2000 Pabst Science Publisher, pp. 134-155; Fritz: Examination of control processes of biological and musical processes with the help of a neural network, dissertation, University Mozarteum Salzburg, 2005) edited so that in each case for the parameters LS, FS, TD time series of regulatory states arise, Fig. 5.

From these time series of the individual parameters LS, FS and TD, the averaged regulation profile (arithmetic mean) is determined separately for the portions activation / deactivation (horizontal axis in FIG. 2) and regulation quality / regulation quality (vertical axis in FIG. 2). The averaged activation / deactivation control pattern is subjected to a trend analysis (FIG. 7), as is the course of the regulation quality (FIG. 8). By means of a least squares comparison algorithm, the closest approximation to one of the following types of regulation is determined and assigned:

Table 4 - Regulation Type Activation / Quality

For the piece of music (Mozart - Piano Concerto No. 17, KV 453, 3rd movement), Example 9 of the types of regulation is determined for the course of activation. For the regulation course of the regulation quality likewise.

Determination of the duration of regulation

The duration of the regulation is determined from the duration of the audio files in correspondence to chronobiological periodic operations on the basis of Table 5.

Table 5: Duration of Regulation in the Duration Groups:

* The fat-labeled time-duration groups correspond in their duration to proven chronobiological regulatory processes. In this case, multiplicative multiples of the chronobiological basic rhythms (marked in bold) are taken into account.

** REM - "rapid eye movement", BRAC - "base rest activity cycle" (Kleitmann 1970)

From the duration of the audiofile (example: piece of music: Mozart - Piano Concerto No. 17, KV 453, 3rd movement (7min 32s) the assignment to group 5 is adequate to the chronobiologically determined rhythm of about 7 - 8 minutes.

In the selection unit 3, the details of the manual input from the preselection unit 4

- Which musical genre (order) is preferred; - general information on well-being (good, bad, not to be assigned);

- Determination of the day type (morning type evening type-indifferent type) medium lark eulenest (questionnaire)

- feeling questionnaire (mood, psycho-physiological ground state, type of regulation) - information of a third person;

- type of regulation;

- timing of regulation;

- duration of regulation; as well as the psycho-physiological ground state of the respective measurement object (person) determined in the last minute before listening to an audio file, according to specified criteria (see Criteria and Specifications) and selecting the optimal audio file for the regulation process (tune, sounds, tone sequence, noise) ,

At the beginning of the regulation process, the preselection unit 4 acoustically informs the person to be regulated (measured object) of the playback devices 9 about the imminent start of the regulation process or requests the person to be regulated to start this regulation process via the respective manual start unit. While listening to an audio file, the changing psychophysiological state of the person to be regulated is continuously recorded via the sensor units 2.1,..., 2.n and made available to the selection unit 3 via the data evaluation unit 1. At the same time, the data evaluation unit 2 supplies the changing psycho-physiological state of the audio file.

The adaptation effect of one regulatory system to another external regulatory system is understood as a process in which the regulatory state of the first regulatory system adapts to the regulatory state of the external system. Here, it is assumed that the regulatory states of both systems at the beginning of the adaptation process are different or equal and the state of adaptation - same or similar regulatory state - occurs after a defined time.

The dragging effect of one regulatory system on another external regulatory system is understood to mean a process in which the regulatory state of the first regulatory system is not substantially different from that of the external and the regulatory state of the regulatory system is due to the effect of the external regulatory system first system moves in the same direction as that of the externally acting. In this case, a time delay with respect to the change of the first regulatory system from the outside acting occur (Fig. 9).

Synchronization of a regulatory system by another regulatory system operating externally is understood to be a process in which the regulatory state of the first regulatory system simultaneously changes synchronously in the same direction over a longer period of time as the regulatory state of the external system (FIG. 9). ,

An optimal regulatory effect, for example an increase in the performance of the person to be regulated, is achieved when the psycho-physiological state of the audioflex is equal to the psycho-physiological states of the audio film when the audio file first acts on the object to be measured (person) psycho-physiological states is achieved by changing the psychophysiological states of the audio file in the form that a so-called adaptation, entrainment or synchronization effect, as shown in Fig. 9, is ensured individually.

An optimal regulatory effect is achieved if, taking into account the information entered in the preselection unit 4 about the measured objects to be regulated (persons) and the respective audio files selected for regulation by the selection unit 3 by means of an adaptation, entrainment and / or synchronization effect desired regulatory effect (type of regulation according to Table 4) is achieved.

In the event that during the hearing of an audiophile by the person to be regulated in each case the desired regulatory effect, for example the adaptation or the dragging or the synchronization between the changing psychophysiological regulatory states of the person and the audio file does not occur, the control unit effects 5, that the process is either aborted or provided via the audio storage unit another to the currently existing state of the person to be regulated better corresponding Audiofi- Ie and the desired effect (regulation type). For this purpose, the previously presented audio file is ended via a fade-out effect.

To select another audio file, the selection unit 3 makes use of the possibility that the analysis of the physical parameters amplitude (LS), frequency spectrum (FS) and tone sequence density (TD) with the aid of the applied algorithms, a determination of the possible psycho-physiological effect on a Allow person such that the time course that reach the regulatory states of an audio file of Fig. 2, as a two-dimensional state graph corresponding to FIG. 13 against the background of the possible psycho-physiological regulatory states of FIG. 2 can be mapped. The state graph is associated with the audio file as additional information in the audio storage unit 10. It contains the information as to which time which basic psychophysiological status could be reached with the respective audio file. Should the desired regulatory effect, for example the adaptive or entraining effect, have not yet been achieved in order to achieve a regulatory effect on the individual, the selection unit 3 selects an audiofile with an adequate desired regulatory mode according to Table 4, but at least twice temporally Duration and informed the person to be regulated on the respective playback unit on the change to another audio file Notification of the nearest possible optimal date of application (see the following criteria and definitions - time of application) of a regulatory effect.

All characteristic data of the preselection unit 4 and of the audio storage unit 10, which were used as parameters in the course of a regulatory process, are made available for further use by the information unit 7.

Defined criteria and definitions

regulation time

The time of application for the regulation of a biological system is determined according to objective and subjective criteria. By means of the questionnaire test for the day type, the following objective types are determined:

Table 5 - Day types

The temporal shift of the deactivation maximum in the course of the day of the individual types of day compared to the deactivation maxima of the indifferent type is shown in Table 5. The deactivation maxima of the indifferent type are at the following chronobiologically determined times: 09:00, 13:00, 17:00, 21:00, 01:00, 05:00. The activation maxima of the indifferent type are at the following chronobiologically determined times: 10:00, 14:00, 18:00, 22:00, 02:00, 06:00. Depending on the chosen type of regulation - activating or deactivating - independent of the subgroup of these types of regulation, the actual onset of regulation is determined depending on the duration of the audio file used for regulation. It is stipulated that, depending on the type of regulation selected according to Table 4-activating or deactivating-the respective reference points are the activation maxima when the regulation type of activation is selected, the deactivation maxima when deactivated. The duration of effect of the selected audio file is distributed half to the time before and after the maxima. The beginning of regulation is rounded to the full minute.

Example 1: determined type of day: indifferently selected regulation: deactivating

Duration of the selected audio file: 30 minutes

Beginning of the regulation for example 08:45 o'clock (see also FIG. 10)

Example 2: determined day type: evening type selected regulation type: activating duration of the selected audio file: 8 minutes beginning of the regulation: for example 09:56 o'clock

Example 3: determined day type: morning type selected regulation type: deactivating duration of the selected audio file: 15 minutes beginning of the regulation: for example 16:52 o'clock

If the day type determined in the questionnaire for the determination of the day type differs with the time of the possible break time also determined in the questionnaire, the possible break time β is selected as a possible deactivation time. The corresponding activation time is shifted back by 1 hour. Regulationsart

The determination of the type of regulation is carried out with the help of the feeling questionnaire, the objective determination of the psycho-physiological ground state by recording physiological data in the last few minutes before listening to an audio file and / or according to criteria of a third person.

For this purpose, the general psycho-physiological ground state is used with the help of the questionnaire

Well-being (disabled, well regulated) pleasure (activated, well-regulated)

Sadness (disabled, poorly regulated) anger (activated, poorly regulated)

and the prevailing sentiment generally and presently prevails after "good" - appropriately well regulated and "bad" - appropriately ill-regulated.

It is selected according to the following criteria: - existing psychophysiological ground state should be stabilized

- existing psychophysiological ground state should be destabilized

- existing psychophysiological ground state should be changed

- existing psychophysiological ground state should be activated

- existing psycho-physiological ground state should be deactivated

Types of activation are types 1, 4, 5, 6 and 10 according to Table 4. Types of deactivation are types 2, 3, 7, 8 and 11 according to Table 4. For general stabilization type 9 according to Table 4 is used also type 12 according to table 4. The type of deactivation also includes type 13 according to table 4.

To destabilize an existing psycho-physiological ground state of the person to be regulated, the regulation mode 14 (random course) is selected according to Table 4. The selection from these types of the regulation used is made either by the person to be regulated (statement in the sensitivity questionnaire) or a third person.

Duration of regulation

The duration of the regulation is determined according to the chronobiologically determined durations according to Table 5 as follows:

For optimal deactivation procedures in persons who have no ability to relax: at least 15 - 16 minutes duration

For people who can relax normally: at least 7 - 8 minutes duration

For people who can relax well to very well: at least 3 - 4 minutes duration.

For persons who are in a hyperactive state, the duration of regulation should be doubled over the optimal time periods.

For people who are in a hypoactive or deactivated state activation processes must be triggered.

For persons who are difficult to activate or excitable: the duration of regulation is at least 15-16 minutes.

For normally activatable or excitable persons the duration of regulation is: at least 7 - 8 minutes duration.

For fast activatable or excitable persons, the duration of regulation is: at least 3 - 4 minutes duration.

Determination of adaptation effect, drag effect and synchronization

The adaptation effect of one regulatory system to another, external regulatory system is understood to mean a process in which the regulatory state of the first regulatory system is the regulatory state of the external system adapts. It is assumed that the regulatory states of both systems at the beginning of the adaptation process are different and the state of adaptation - same or similar regulatory state - occurs after a defined time.

When adapting the regulatory system to be regulated to an external regulatory system, a distinction is made between adaptation of the regulatory qualities or regulation type and activation or deactivation.

A regu- latory system to be regulated has then adapted to an external regulatory system, either

- The regulatory qualities of both systems after a period of at least 1.5 minutes are similar

(In this case, similarity exists when the averaged regulation patterns either intersect (Figure 11) or differ by no more than 25% at a point within the first 1.5 minutes of listening to an audio file) or

- the types of activation / deactivation are similar after a period of at least 5 minutes.

(In this case, similarity exists if the averaged trend curves of the Activation / Deactivation type of regulation either intersect (Figure 12) or differ by no more than 25% at a point within the first 5 minutes of listening to an audio file)

The drag-and-pull effect of one regulatory system on another external regulatory system is understood to mean a process in which the regulatory state of the first regulatory system is not significantly different from that of the external one, and by the effect of the external regulatory system Regulatory state of the first system moves in the same direction as that of the externally acting. In this case, a time delay with regard to the change of the first regulatory system compared to the external acting occur (FIG. 9).

Definition: The direction of a regulatory process is derived from the first derivation according to the time of the trend function of the change in the regulation quality or regulation quality (see 8) or the regulation course activation / deactivation (FIG. 7). The direction of the system to be regulated should not differ from the direction of the external system by more than 25%. Directional differences of up to 25% are referred to as a similar direction. The same or similar direction should last for at least 30 seconds. A time shift between the change in direction of the system to be regulated and the system operating from the outside of up to a maximum of 10 s is permissible.

Synchronization of a regulatory system with another external regulatory system is understood to mean a process in which the regulatory state of the first regulatory system simultaneously changes synchronously in the same or similar direction over a longer period of time as the regulatory state of the external system.

Definition: The duration of an identical or similar direction should be at least 60 s.

The features of the invention disclosed in the foregoing description, the claims and the figures may be of importance both individually and in any combination for the realization of the invention in its various embodiments.

Claims

claims

A system for determining and regulating a psychophysiological condition of a biological system, comprising: at least one sensor unit (2.1, ..., 2.n) configured to provide measurements for at least one of a psycho-physiological condition of the biological system to record physiological parameters,

a data evaluation unit (1, 8) which is coupled to the at least one sensor unit (2.1, ..., 2.n) and which is configured to automatically derive a psycho-physiological initial state of the biological system from the detected at least one physiological parameter, and

a selection unit (3) which is connected to the data evaluation unit (1; 8) and configured to select an audio file for reproduction via a reproduction unit (9) from an audio data memory (10) in accordance with the psychophysiological initial state; Datenauswerteeinheit (1; 8) is further configured, a regulatory state of the biological system during or after the playback of the selected audio file on the playback unit (9) from the sensor units (2.1, ..., 2.n) additionally detected measured values for the at least to determine a physiological or at least one other physiological parameter.

2. The system of claim 1, wherein the at least one sensor unit is configured to acquire measured values for at least one physiological parameter selected from the following group of physiological parameters: muscular-motor reaction parameters, vegetative-cognitive response parameter and vegetative emotional response parameter.

3. System according to claim 1 or 2, wherein the at least one sensor unit (2.1, ..., 2.n) is configured to non-invasively detect the measured values for the at least one physiological parameter.

4. System according to claim 1, wherein in the audio data memory (10) to the selectable audio files in each case an associated record is stored, which electronically evaluable information about at least one physical parameter of the audio data contained in the respective audio file selected from the following group of physical parameters: temporal change of the amplitude, temporal change of the summed frequency spectrum and temporal change of Tonfolgedich- te.

5. System according to claim 4, wherein the data evaluation unit (1; 8) is configured to generate, by means of an analysis of the audio file, the respectively assigned data record for the analyzed audio data file and to transfer it to the audio data memory (10).

6. System according to claim 1, wherein in the audio data memory (10) to the selectable audio files in each case an electronically evaluable information about an associated psycho-physiological ground state is stored.

The system of claim 6, wherein the electronically evaluable information assigns to the respective audio data file a psycho-physiological ground state selected from the following group of psycho-physiological ground states: a ground state of well-being, a ground state of pleasure, a ground state of sadness, a ground state of anger, and a mixed state from at least two of the basic states.

8. System according to claim 4 and claim 6 or 7, wherein the data evaluation unit (1; 8) is configured, in the respectively assigned record for the selectable audio data files, the electronically evaluable Infoπnation on the at least one physical parameter of the respective audio file evaluated audio data to generate for the respective audio data file electronically evaluable information about the associated psycho-physiological ground state.

9. System according to claim 8, wherein the data evaluation unit (1; 8) is configured to use one or more evaluation methods for assigning the psycho-physiological basic state to the respective audio data file, the same as those for determining the psycho-physiological initial state and the regulatory state of the biological system are used.

10. The system of claim 6, wherein the selection unit (3) is configured to select from the audio data memory (10) an audio file for playback via the playback unit (9) whose associated psycho-physiological ground state corresponds to the psychophysiological initial state.

11. The system of claim 6, wherein the selection unit (3) is configured to select from the audio data memory (10) an audio file for playback via the playback unit (9) whose associated psycho-physiological ground state differs from the psycho-physiological initial state.

12. The system of claim 1, wherein a mode is selectable in which a plurality of regulatory states of the biological system are determined simultaneously or in a serial manner.

The system of claim 12, wherein the data evaluation unit (1; 8) is configured to provide a time history for the at least one physiological and / or the at least one other physiological parameter and / or the regulatory state of the biological system, including ground states and mixed states. to determine.

14. The system of claim 13, wherein the data evaluation unit is configured to determine a regulatory effect selected from the following group of regulatory effects when determining the time course of the regulatory state of the biological system: entrainment effect, adaptation effect, and synchronization effect.

A system according to claim 1, wherein a preselection unit (4) is provided and configured to detect and forward to the selection unit (3) the selection of the audio file for playback influencing preselection data, which is optionally manual input data.

16. The system of claim 1, wherein a control unit (5) is provided and configured to enable the playback of the selected audio file via the playback unit (9) by aborting playback and optionally playing another audio data file if a preselectable regulatory effect is not achieved.

The system of claim 1, wherein an information unit (7) is provided and configured to provide electronically evaluable summary information about determining and regulating the psycho-physiological condition of the biological system.