WO2007092416A3 - Melanin concentrating hormone receptor-1 antagonists - Google Patents
Melanin concentrating hormone receptor-1 antagonists Download PDFInfo
- Publication number
- WO2007092416A3 WO2007092416A3 PCT/US2007/003099 US2007003099W WO2007092416A3 WO 2007092416 A3 WO2007092416 A3 WO 2007092416A3 US 2007003099 W US2007003099 W US 2007003099W WO 2007092416 A3 WO2007092416 A3 WO 2007092416A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- present application
- application provides
- antagonists
- hormone receptor
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Abstract
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula (I) wherein R1a, R1b, R1c, Q, A, R3, W, D and R2 are defined herein. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07763593A EP1987039A2 (en) | 2006-02-06 | 2007-02-06 | Melanin concentrating hormone receptor-1 antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76553006P | 2006-02-06 | 2006-02-06 | |
US60/765,530 | 2006-02-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007092416A2 WO2007092416A2 (en) | 2007-08-16 |
WO2007092416A3 true WO2007092416A3 (en) | 2007-11-01 |
Family
ID=38284021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/003099 WO2007092416A2 (en) | 2006-02-06 | 2007-02-06 | Melanin concentrating hormone receptor-1 antagonists |
Country Status (3)
Country | Link |
---|---|
US (2) | US7553836B2 (en) |
EP (1) | EP1987039A2 (en) |
WO (1) | WO2007092416A2 (en) |
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AR056155A1 (en) | 2005-10-26 | 2007-09-19 | Bristol Myers Squibb Co | ANTAGONISTS OF NON-BASIC MELANINE CONCENTRATION HORMONE RECEIVER 1 |
WO2008039863A2 (en) * | 2006-09-27 | 2008-04-03 | Braincells, Inc. | Composition comprising a melanocortin receptor (mcr) modulating agent alone or in combination with a second neurogenic agent for treating nervous system disorders |
PE20091928A1 (en) * | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | HAVE HYDROXYSUSTITUTED PYRIMIDINES AS NON-BASIC MELANIN-CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS |
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CN102272135A (en) * | 2008-10-08 | 2011-12-07 | 百时美施贵宝公司 | Azolopyrrolone melanin concentrating hormone receptor-1 antagonists |
US8344160B2 (en) | 2008-10-08 | 2013-01-01 | Bristol-Myers Squibb Company | Pyrrolone melanin concentrating hormone receptor-1 antagonists |
AU2010232729A1 (en) * | 2009-03-31 | 2011-10-20 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
CN102781942B (en) | 2009-10-23 | 2015-09-23 | 詹森药业有限公司 | Octahydro pyrrolo-[3,4-c] pyrroles is replaced as two of orexin receptor modulators |
US8598156B2 (en) | 2010-03-25 | 2013-12-03 | Glaxosmithkline Llc | Chemical compounds |
WO2012036233A1 (en) * | 2010-09-17 | 2012-03-22 | 塩野義製薬株式会社 | Condensed heterocyclic derivative having melanine-concentrating hormone receptor antagonistic activity |
KR101273643B1 (en) | 2010-10-12 | 2013-06-11 | 한국화학연구원 | 5,6-Dihydro-pyrrolo[3,4-b]pyridine-7-one derivatives, or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition |
EP2683699B1 (en) | 2011-03-08 | 2015-06-24 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
EP2683704B1 (en) | 2011-03-08 | 2014-12-17 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120054A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
JO3368B1 (en) * | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JOP20150177B1 (en) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
US10967078B2 (en) | 2014-12-03 | 2021-04-06 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2 PET ligands |
US11045562B2 (en) | 2015-12-18 | 2021-06-29 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2/3 PET ligands |
US11033641B2 (en) | 2015-12-18 | 2021-06-15 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2/3 pet ligands |
CN108883110B (en) | 2016-03-10 | 2022-05-27 | 詹森药业有限公司 | Methods of treating depression using orexin-2 receptor antagonists |
TWI776812B (en) * | 2016-06-02 | 2022-09-11 | 荷蘭商菲林公司 | Angiotensin-1-receptor antagonists |
WO2024015425A1 (en) | 2022-07-14 | 2024-01-18 | Fmc Corporation | Herbicidal benzoxazines |
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-
2007
- 2007-02-05 US US11/671,150 patent/US7553836B2/en active Active
- 2007-02-06 WO PCT/US2007/003099 patent/WO2007092416A2/en active Application Filing
- 2007-02-06 EP EP07763593A patent/EP1987039A2/en not_active Withdrawn
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2009
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Also Published As
Publication number | Publication date |
---|---|
US20070185097A1 (en) | 2007-08-09 |
US7956049B2 (en) | 2011-06-07 |
EP1987039A2 (en) | 2008-11-05 |
US7553836B2 (en) | 2009-06-30 |
US20090221548A1 (en) | 2009-09-03 |
WO2007092416A2 (en) | 2007-08-16 |
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