WO2007092416A3 - Melanin concentrating hormone receptor-1 antagonists - Google Patents

Melanin concentrating hormone receptor-1 antagonists Download PDF

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Publication number
WO2007092416A3
WO2007092416A3 PCT/US2007/003099 US2007003099W WO2007092416A3 WO 2007092416 A3 WO2007092416 A3 WO 2007092416A3 US 2007003099 W US2007003099 W US 2007003099W WO 2007092416 A3 WO2007092416 A3 WO 2007092416A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
present application
application provides
antagonists
hormone receptor
Prior art date
Application number
PCT/US2007/003099
Other languages
French (fr)
Other versions
WO2007092416A2 (en
Inventor
Guohua Zhao
Original Assignee
Bristol Myers Squibb Co
Guohua Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Guohua Zhao filed Critical Bristol Myers Squibb Co
Priority to EP07763593A priority Critical patent/EP1987039A2/en
Publication of WO2007092416A2 publication Critical patent/WO2007092416A2/en
Publication of WO2007092416A3 publication Critical patent/WO2007092416A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Abstract

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula (I) wherein R1a, R1b, R1c, Q, A, R3, W, D and R2 are defined herein. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.
PCT/US2007/003099 2006-02-06 2007-02-06 Melanin concentrating hormone receptor-1 antagonists WO2007092416A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07763593A EP1987039A2 (en) 2006-02-06 2007-02-06 Melanin concentrating hormone receptor-1 antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76553006P 2006-02-06 2006-02-06
US60/765,530 2006-02-06

Publications (2)

Publication Number Publication Date
WO2007092416A2 WO2007092416A2 (en) 2007-08-16
WO2007092416A3 true WO2007092416A3 (en) 2007-11-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/003099 WO2007092416A2 (en) 2006-02-06 2007-02-06 Melanin concentrating hormone receptor-1 antagonists

Country Status (3)

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US (2) US7553836B2 (en)
EP (1) EP1987039A2 (en)
WO (1) WO2007092416A2 (en)

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WO2012036233A1 (en) * 2010-09-17 2012-03-22 塩野義製薬株式会社 Condensed heterocyclic derivative having melanine-concentrating hormone receptor antagonistic activity
KR101273643B1 (en) 2010-10-12 2013-06-11 한국화학연구원 5,6-Dihydro-pyrrolo[3,4-b]pyridine-7-one derivatives, or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683704B1 (en) 2011-03-08 2014-12-17 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120055A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
JO3368B1 (en) * 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JOP20150177B1 (en) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JP6861154B2 (en) 2014-12-03 2021-04-21 ヤンセン ファーマシューティカ エヌ．ベー． Radiolabeled mGluR2 PET ligand
EP3389728B1 (en) 2015-12-18 2020-08-05 Janssen Pharmaceutica NV Radiolabelled mglur2/3 pet ligands
LT3389727T (en) 2015-12-18 2020-10-12 Janssen Pharmaceutica Nv Radiolabelled mglur2/3 pet ligands
JP7066622B2 (en) 2016-03-10 2022-05-13 ヤンセン ファーマシューティカ エヌ．ベー． How to treat depression with orexin-2 receptor antagonists
TWI776812B (en) * 2016-06-02 2022-09-11 荷蘭商菲林公司 Angiotensin-1-receptor antagonists
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US7956049B2 (en) 2011-06-07
US7553836B2 (en) 2009-06-30
US20070185097A1 (en) 2007-08-09
EP1987039A2 (en) 2008-11-05
US20090221548A1 (en) 2009-09-03
WO2007092416A2 (en) 2007-08-16

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