WO2007089335A3 - Multicyclic amino acid derivatives and methods of their use - Google Patents

Multicyclic amino acid derivatives and methods of their use Download PDF

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Publication number
WO2007089335A3
WO2007089335A3 PCT/US2006/047579 US2006047579W WO2007089335A3 WO 2007089335 A3 WO2007089335 A3 WO 2007089335A3 US 2006047579 W US2006047579 W US 2006047579W WO 2007089335 A3 WO2007089335 A3 WO 2007089335A3
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WO
WIPO (PCT)
Prior art keywords
methods
amino acid
acid derivatives
multicyclic
multicyclic amino
Prior art date
Application number
PCT/US2006/047579
Other languages
French (fr)
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WO2007089335A2 (en
Inventor
Arokiasamy Devasagayaraj
Haihong Jin
Qingyun Liu
Brent Marinelli
Lakshama Samala
Zhi-Cai Shi
Ashok Tunoori
Ying Wang
Wenxue Wu
Chengmin Zhang
Haiming Zhang
Original Assignee
Lexicon Genetics Inc
Arokiasamy Devasagayaraj
Haihong Jin
Qingyun Liu
Brent Marinelli
Lakshama Samala
Zhi-Cai Shi
Ashok Tunoori
Ying Wang
Wenxue Wu
Chengmin Zhang
Haiming Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP06849951A priority Critical patent/EP1984344B1/en
Priority to CA2635531A priority patent/CA2635531C/en
Priority to DK06849951.6T priority patent/DK1984344T3/en
Priority to EA200870127A priority patent/EA019879B1/en
Priority to KR1020087015697A priority patent/KR101360621B1/en
Priority to JP2008548561A priority patent/JP5483883B2/en
Priority to NZ568946A priority patent/NZ568946A/en
Priority to ES06849951T priority patent/ES2395392T3/en
Application filed by Lexicon Genetics Inc, Arokiasamy Devasagayaraj, Haihong Jin, Qingyun Liu, Brent Marinelli, Lakshama Samala, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Wenxue Wu, Chengmin Zhang, Haiming Zhang filed Critical Lexicon Genetics Inc
Priority to BRPI0620756-1A priority patent/BRPI0620756B1/en
Priority to PL06849951T priority patent/PL1984344T3/en
Priority to CN2006800499070A priority patent/CN101351451B/en
Priority to AU2006337137A priority patent/AU2006337137B2/en
Publication of WO2007089335A2 publication Critical patent/WO2007089335A2/en
Publication of WO2007089335A3 publication Critical patent/WO2007089335A3/en
Priority to IL191998A priority patent/IL191998A/en
Priority to NO20083324A priority patent/NO344848B1/en
Priority to HK09102308.4A priority patent/HK1124841A1/en

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    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Abstract

Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders.
PCT/US2006/047579 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use WO2007089335A2 (en)

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BRPI0620756-1A BRPI0620756B1 (en) 2005-12-29 2006-12-12 MULTICYCLIC AMINO ACID DERIVATIVES, PHARMACEUTICAL FORMULATION INCLUDING THE SAME AND THEIR USES TO INHIBIT THE ACTIVITY OF TRYPTOPHAN HYDROXYLASE 1 (TPH1)
CA2635531A CA2635531C (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use
PL06849951T PL1984344T3 (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use
KR1020087015697A KR101360621B1 (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use
JP2008548561A JP5483883B2 (en) 2005-12-29 2006-12-12 Polycyclic amino acid derivatives and methods of use thereof
NZ568946A NZ568946A (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use
ES06849951T ES2395392T3 (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use
EP06849951A EP1984344B1 (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use
DK06849951.6T DK1984344T3 (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods for their use
EA200870127A EA019879B1 (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives, pharmaceutical composition containing them and method of treatment using these derivatives
CN2006800499070A CN101351451B (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use
AU2006337137A AU2006337137B2 (en) 2005-12-29 2006-12-12 Multicyclic amino acid derivatives and methods of their use
IL191998A IL191998A (en) 2005-12-29 2008-06-05 Compounds and pharmaceutical formulations of multicyclic amino acid derivatives and their use
NO20083324A NO344848B1 (en) 2005-12-29 2008-07-28 Multicyclic amino acid derivatives and methods for their use
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