WO2007084549A3 - Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation - Google Patents
Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation Download PDFInfo
- Publication number
- WO2007084549A3 WO2007084549A3 PCT/US2007/001214 US2007001214W WO2007084549A3 WO 2007084549 A3 WO2007084549 A3 WO 2007084549A3 US 2007001214 W US2007001214 W US 2007001214W WO 2007084549 A3 WO2007084549 A3 WO 2007084549A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plaque
- detergent
- angioplasty procedure
- eluting stent
- dissolving
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/422—Anti-atherosclerotic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
Abstract
A drug eluting stent for release over time of a detergent in loco at the site of an angioplasty procedure for the dissolution of the fatty component of the atherosclerotic plaque. The detergent has the capability of passing thru the fibrous cap and of targeting the fatty components of the plaque. The detergent is aimed at dissolving the cholesterol aggregates of the plaque post angioplasty procedure, plaque which is fractured, compressed, locally redistributed by the angioplasty procedure but that it is still present within the artery wall post angioplasty procedure. Numerous other pharmacological compounds with different targeted functions can be combined with the detergent in the stent including Antineoplastics, Immnunosuppressants, Migration inhibitors, Enhanced Healing Factors, Collagen and Proteoglycan degrading enzymes. The drug eluting stent by providing the dissolution of one of the major plaque components i.e. the fatty component is expected to greatly reduce the chance of restenosis.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/024,908 US8304383B2 (en) | 2005-11-22 | 2008-02-01 | Dissolution of arterial plaque |
US12/211,754 US20090035348A1 (en) | 2005-11-22 | 2008-09-16 | Dissolution of arterial plaque |
US13/633,704 US8697633B2 (en) | 2005-11-22 | 2012-10-02 | Dissolution of arterial plaque |
US13/871,904 US20140234398A1 (en) | 2005-11-22 | 2013-04-26 | Dissolution of Arterial Plaque |
US14/164,648 US20140142071A1 (en) | 2005-11-22 | 2014-01-27 | Regression of arterial plaque |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76047106P | 2006-01-20 | 2006-01-20 | |
US60/760,471 | 2006-01-20 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/044619 Continuation-In-Part WO2007061820A2 (en) | 2005-11-22 | 2006-11-16 | Dissolution of arterial cholesterol plaques by a class of pharmacological compounds |
US12/024,908 Continuation-In-Part US8304383B2 (en) | 2005-11-22 | 2008-02-01 | Dissolution of arterial plaque |
US12/211,754 Continuation-In-Part US20090035348A1 (en) | 2005-11-22 | 2008-09-16 | Dissolution of arterial plaque |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007084549A2 WO2007084549A2 (en) | 2007-07-26 |
WO2007084549A3 true WO2007084549A3 (en) | 2007-12-21 |
Family
ID=38288202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/001214 WO2007084549A2 (en) | 2005-11-22 | 2007-01-16 | Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007084549A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102727949A (en) * | 2011-10-25 | 2012-10-17 | 上海交通大学附属第一人民医院 | Drug eluting stone-dissolving bile duct stent and preparation method thereof |
CN102727943A (en) * | 2011-11-14 | 2012-10-17 | 上海市第一人民医院 | Biodegradable polymer braided stone-dissolving bile duct stent and preparation method thereof |
US10117761B2 (en) * | 2014-12-19 | 2018-11-06 | Boston Scientific Scimed, Inc. | Stent with anti-migration features |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020091111A1 (en) * | 1998-04-08 | 2002-07-11 | Galmed International Limited | Bile salt conjugates |
US20040143322A1 (en) * | 2002-11-08 | 2004-07-22 | Conor Medsystems, Inc. | Method and apparatus for treating vulnerable artherosclerotic plaque |
US6780849B2 (en) * | 2000-12-21 | 2004-08-24 | Scimed Life Systems, Inc. | Lipid-based nitric oxide donors |
US20040267354A1 (en) * | 1994-05-13 | 2004-12-30 | Ringeisen Timothy A. | Method for making a porous polymeric material |
US20050070997A1 (en) * | 2003-09-29 | 2005-03-31 | Ronan Thornton | Laminated drug-polymer coated stent with dipped and cured layers |
US20050163821A1 (en) * | 2002-08-02 | 2005-07-28 | Hsing-Wen Sung | Drug-eluting Biodegradable Stent and Delivery Means |
US20050177225A1 (en) * | 2003-11-10 | 2005-08-11 | Angiotech International Ag | Medical implants and anti-scarring agents |
US20050249770A1 (en) * | 1996-12-02 | 2005-11-10 | Angiotech International Ag | Compositions and methods for treating or preventing inflammatory diseases |
US20050267407A1 (en) * | 2002-02-01 | 2005-12-01 | Vascular Designs, Inc. | Multi-function catheter and use thereof |
-
2007
- 2007-01-16 WO PCT/US2007/001214 patent/WO2007084549A2/en active Application Filing
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040267354A1 (en) * | 1994-05-13 | 2004-12-30 | Ringeisen Timothy A. | Method for making a porous polymeric material |
US20050249770A1 (en) * | 1996-12-02 | 2005-11-10 | Angiotech International Ag | Compositions and methods for treating or preventing inflammatory diseases |
US20020091111A1 (en) * | 1998-04-08 | 2002-07-11 | Galmed International Limited | Bile salt conjugates |
US6780849B2 (en) * | 2000-12-21 | 2004-08-24 | Scimed Life Systems, Inc. | Lipid-based nitric oxide donors |
US20050267407A1 (en) * | 2002-02-01 | 2005-12-01 | Vascular Designs, Inc. | Multi-function catheter and use thereof |
US20050163821A1 (en) * | 2002-08-02 | 2005-07-28 | Hsing-Wen Sung | Drug-eluting Biodegradable Stent and Delivery Means |
US20040143322A1 (en) * | 2002-11-08 | 2004-07-22 | Conor Medsystems, Inc. | Method and apparatus for treating vulnerable artherosclerotic plaque |
US20050070997A1 (en) * | 2003-09-29 | 2005-03-31 | Ronan Thornton | Laminated drug-polymer coated stent with dipped and cured layers |
US20050177225A1 (en) * | 2003-11-10 | 2005-08-11 | Angiotech International Ag | Medical implants and anti-scarring agents |
Also Published As
Publication number | Publication date |
---|---|
WO2007084549A2 (en) | 2007-07-26 |
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