WO2007070679A3 - Compositions and methods for dermally treating pain - Google Patents

Compositions and methods for dermally treating pain Download PDF

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Publication number
WO2007070679A3
WO2007070679A3 PCT/US2006/047926 US2006047926W WO2007070679A3 WO 2007070679 A3 WO2007070679 A3 WO 2007070679A3 US 2006047926 W US2006047926 W US 2006047926W WO 2007070679 A3 WO2007070679 A3 WO 2007070679A3
Authority
WO
WIPO (PCT)
Prior art keywords
volatile solvent
drug
pain
treating pain
compositions
Prior art date
Application number
PCT/US2006/047926
Other languages
French (fr)
Other versions
WO2007070679A2 (en
Inventor
Jie Zhang
Kevin S Warner
Sanjay Sharma
Original Assignee
Zars Inc
Jie Zhang
Kevin S Warner
Sanjay Sharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zars Inc, Jie Zhang, Kevin S Warner, Sanjay Sharma filed Critical Zars Inc
Priority to AU2006326018A priority Critical patent/AU2006326018B2/en
Priority to CN200680051992.4A priority patent/CN101494976B/en
Priority to CA2633515A priority patent/CA2633515C/en
Priority to JP2008545844A priority patent/JP2009524586A/en
Priority to EP06848632A priority patent/EP1959931A4/en
Publication of WO2007070679A2 publication Critical patent/WO2007070679A2/en
Publication of WO2007070679A3 publication Critical patent/WO2007070679A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

Abstract

The present invention is drawn to solidifying formulations for dermal delivery of a drug for treating pain, such as musculoskeletal pain, inflammation, joint pain, or neuropathic pain. The formulation can include a drug selected from certain drug classes, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein the evaporation of at least some of the volatile solvent converts the formulation on the skin into a solidified layer and the non-volatile solvent system is capable of facilitating the topical delivery of the drug(s) at therapeutically effective rates over a sustained period of time.
PCT/US2006/047926 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain WO2007070679A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2006326018A AU2006326018B2 (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain
CN200680051992.4A CN101494976B (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain
CA2633515A CA2633515C (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain
JP2008545844A JP2009524586A (en) 2005-12-14 2006-12-14 Compositions and methods for skin treatment of pain
EP06848632A EP1959931A4 (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US75068305P 2005-12-14 2005-12-14
US75063705P 2005-12-14 2005-12-14
US75051905P 2005-12-14 2005-12-14
US60/750,519 2005-12-14
US60/750,637 2005-12-14
US60/750,683 2005-12-14

Publications (2)

Publication Number Publication Date
WO2007070679A2 WO2007070679A2 (en) 2007-06-21
WO2007070679A3 true WO2007070679A3 (en) 2009-01-08

Family

ID=38163542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/047926 WO2007070679A2 (en) 2005-12-14 2006-12-14 Compositions and methods for dermally treating pain

Country Status (5)

Country Link
EP (1) EP1959931A4 (en)
JP (1) JP2009524586A (en)
AU (1) AU2006326018B2 (en)
CA (1) CA2633515C (en)
WO (1) WO2007070679A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
US8741333B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
US9283177B2 (en) * 2007-01-16 2016-03-15 Juventio, Llc Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
US8759391B2 (en) 2007-01-16 2014-06-24 Juventio, Llc Topical anesthetic for rapid local anesthesia
JP5723600B2 (en) 2008-02-29 2015-05-27 ブイエム ディスカバリー インコーポレイテッド Treatment of pain syndrome and other disorders
CA2730787A1 (en) 2008-07-16 2010-01-21 David M. Cohen Topical drug delivery system
US9012477B2 (en) * 2009-01-06 2015-04-21 Nuvo Research Inc. Method of treating neuropathic pain
CA2757302A1 (en) * 2009-04-01 2010-10-07 Andrew Crockett Methods for treating myofascial, muscle, and/or back pain
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia
CN102427792A (en) 2009-05-04 2012-04-25 扎斯制药公司 Methods of treating pains associated with neuroma, nerve entrapment, and other conditions
AU2011205730C1 (en) 2010-01-14 2014-10-09 Nuvo Research Inc. Solid-forming local anesthetic formulations for pain control
WO2012107575A1 (en) 2011-02-10 2012-08-16 Moberg Derma Ab Novel formulations for dermal, transdermal and mucosal use 2
ES2743524T3 (en) * 2011-05-10 2020-02-19 Itochu Chemical Frontier Corp Non-aqueous patch
US9925264B2 (en) 2011-05-10 2018-03-27 Itochu Chemical Frontier Corporation Non-aqueous patch
US11786455B2 (en) 2011-05-10 2023-10-17 Itochu Chemical Frontier Corporation Non-aqueous patch
JP2014515365A (en) * 2011-05-26 2014-06-30 ノバルティス アーゲー Composition for transdermal administration of physiologically active agents
CN102302418B (en) * 2011-09-21 2013-01-23 韩褆 Water-saving type multifunctional hand-washing disinfectant
PL2823815T3 (en) 2011-09-27 2018-10-31 Itochu Chemical Frontier Corporation Non-aqueous patch
CN103142458B (en) * 2013-01-22 2015-09-09 莱普德制药有限公司 Without prescription and the preparation method of additive analgesia sustained release drug delivery systems
GB201317718D0 (en) * 2013-10-07 2013-11-20 Buzzz Pharmaceuticals Ltd Novel formulation
JP6209749B2 (en) * 2015-12-10 2017-10-11 伊藤忠ケミカルフロンティア株式会社 Non-aqueous patch
US11141387B2 (en) 2017-01-05 2021-10-12 Medrx Co., Ltd. Memantine-containing transdermally absorbable liquid
US11452701B2 (en) 2017-12-04 2022-09-27 Johnson & Johnson Consumer Inc. Topical emulsion composition containing nonsteroidal anti-inflammatory drug
WO2022167359A1 (en) * 2021-02-02 2022-08-11 DuPont Nutrition USA, Inc. An aqueous gel composition comprising an ethylcellulose

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037890A1 (en) * 1999-11-23 2001-05-31 Ever Power Holding Inc A propellant free spray-on skin patch composition for improving wound healing and for drug administration
US6432415B1 (en) * 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
RU2234337C2 (en) * 1997-09-26 2004-08-20 Ноувен Фамэсьютикэлз, Инк. Bioadhesive composition (variants), method for its preparing, device for delivery of active agent through mucosa, method for prolonged topical administration of one or more active agents to patient (variants) and method for reducing time required for sticking composition to mucosa tissue
US20040018241A1 (en) * 1997-09-26 2004-01-29 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037890A1 (en) * 1999-11-23 2001-05-31 Ever Power Holding Inc A propellant free spray-on skin patch composition for improving wound healing and for drug administration
US6432415B1 (en) * 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FARBER ET AL.: "Serotonergic Agents That Activate 5HT2A Receptors Prevent NMDA Antagonist Neurotoxicity", NEUROPSYCHOPHARMACOLOGY, vol. 18, no. 1, 1998, pages 57 - 62, XP002396767 *
PADILLA ET AL.: "TOPICAL MEDICATIONS FOR OROFACIAL NEUROPATHIC PAIN: A REVIEW", J. AM. DENT. ASSOC., vol. 131, no. 2, 2000, pages 184 - 195, XP008131443 *
See also references of EP1959931A4 *

Also Published As

Publication number Publication date
CA2633515A1 (en) 2007-06-21
AU2006326018B2 (en) 2013-04-18
EP1959931A2 (en) 2008-08-27
JP2009524586A (en) 2009-07-02
CA2633515C (en) 2011-10-18
WO2007070679A2 (en) 2007-06-21
EP1959931A4 (en) 2012-08-22
AU2006326018A1 (en) 2007-06-21

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