WO2007061627A3 - Direct dna delivery to bone cells - Google Patents

Direct dna delivery to bone cells Download PDF

Info

Publication number
WO2007061627A3
WO2007061627A3 PCT/US2006/043375 US2006043375W WO2007061627A3 WO 2007061627 A3 WO2007061627 A3 WO 2007061627A3 US 2006043375 W US2006043375 W US 2006043375W WO 2007061627 A3 WO2007061627 A3 WO 2007061627A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone cells
direct dna
dna delivery
bone
polynucleotides
Prior art date
Application number
PCT/US2006/043375
Other languages
French (fr)
Other versions
WO2007061627A2 (en
Inventor
Vladimir Subbotin
Julia Hegge
Original Assignee
Mirus Bio Corp
Vladimir Subbotin
Julia Hegge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirus Bio Corp, Vladimir Subbotin, Julia Hegge filed Critical Mirus Bio Corp
Publication of WO2007061627A2 publication Critical patent/WO2007061627A2/en
Publication of WO2007061627A3 publication Critical patent/WO2007061627A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous

Abstract

An method is described that enables in vivo delivery of polynucleotides to cells of a mammalian bone limb. The method involves the injection of polynucleotides in a large volume into the lumen of the bone.
PCT/US2006/043375 2005-11-23 2006-11-07 Direct dna delivery to bone cells WO2007061627A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/286,719 2005-11-23
US11/286,719 US20060115462A1 (en) 2004-12-01 2005-11-23 Direct DNA delivery to bone cells

Publications (2)

Publication Number Publication Date
WO2007061627A2 WO2007061627A2 (en) 2007-05-31
WO2007061627A3 true WO2007061627A3 (en) 2007-08-02

Family

ID=38067713

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/043375 WO2007061627A2 (en) 2005-11-23 2006-11-07 Direct dna delivery to bone cells

Country Status (2)

Country Link
US (1) US20060115462A1 (en)
WO (1) WO2007061627A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7850382B2 (en) 2007-01-18 2010-12-14 Sanford, L.P. Valve made from two materials and writing utensil with retractable tip incorporating same
US7488130B2 (en) 2007-02-01 2009-02-10 Sanford, L.P. Seal assembly for retractable instrument
US8226312B2 (en) 2008-03-28 2012-07-24 Sanford, L.P. Valve door having a force directing component and retractable instruments comprising same
US8221012B2 (en) 2008-11-07 2012-07-17 Sanford, L.P. Retractable instruments comprising a one-piece valve door actuating assembly
US8393814B2 (en) 2009-01-30 2013-03-12 Sanford, L.P. Retractable instrument having a two stage protraction/retraction sequence

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002043759A2 (en) * 2000-12-01 2002-06-06 Wyeth Method and composition for modulating bone growth
US20040115195A1 (en) * 1999-09-13 2004-06-17 Peter Bodine Pharmaceutical compositions and methods of using secreted frizzled related protein

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673776B1 (en) * 1989-03-21 2004-01-06 Vical Incorporated Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5922687A (en) * 1995-05-04 1999-07-13 Board Of Trustees Of The Leland Stanford Junior University Intracellular delivery of nucleic acids using pressure
US6265387B1 (en) * 1995-10-11 2001-07-24 Mirus, Inc. Process of delivering naked DNA into a hepatocyte via bile duct
US6627616B2 (en) * 1995-12-13 2003-09-30 Mirus Corporation Intravascular delivery of non-viral nucleic acid
US7803782B2 (en) * 2003-05-28 2010-09-28 Roche Madison Inc. Intravenous delivery of polynucleotides to cells in mammalian limb
US6379966B2 (en) * 1999-02-26 2002-04-30 Mirus Corporation Intravascular delivery of non-viral nucleic acid
US5779708A (en) * 1996-08-15 1998-07-14 Cyberdent, Inc. Intraosseous drug delivery device and method
US6897068B2 (en) * 1999-02-26 2005-05-24 Mirus Bio Corporation Polynucleotide complex delivery
US6881576B2 (en) * 1999-12-31 2005-04-19 Mirus Bio Corporation Formation of polyampholytes in the presence of a polyion
CA2415389C (en) * 2000-07-14 2009-02-17 Kyphon Inc. Systems and methods for treating vertebral bodies
US6656155B2 (en) * 2001-12-17 2003-12-02 Scimed Life Systems, Inc. Catheter for endoluminal delivery of therapeutic agents that minimizes loss of therapeutic
US20040136960A1 (en) * 2003-01-10 2004-07-15 Wolff Jon A. Devices and processes for distribution of genetic material to mammalian limb
US20050020965A1 (en) * 2003-03-20 2005-01-27 Scimed Life Systems, Inc. Devices and methods for delivering agents to tissue region while preventing leakage

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040115195A1 (en) * 1999-09-13 2004-06-17 Peter Bodine Pharmaceutical compositions and methods of using secreted frizzled related protein
WO2002043759A2 (en) * 2000-12-01 2002-06-06 Wyeth Method and composition for modulating bone growth

Also Published As

Publication number Publication date
WO2007061627A2 (en) 2007-05-31
US20060115462A1 (en) 2006-06-01

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