WO2007059116A3 - Geldanamycin derivatives and pharmaceutical compositions thereof - Google Patents

Geldanamycin derivatives and pharmaceutical compositions thereof Download PDF

Info

Publication number
WO2007059116A3
WO2007059116A3 PCT/US2006/044165 US2006044165W WO2007059116A3 WO 2007059116 A3 WO2007059116 A3 WO 2007059116A3 US 2006044165 W US2006044165 W US 2006044165W WO 2007059116 A3 WO2007059116 A3 WO 2007059116A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
geldanamycin derivatives
derivatives
methods
geldanamycin
Prior art date
Application number
PCT/US2006/044165
Other languages
French (fr)
Other versions
WO2007059116A2 (en
Inventor
Chunlin Tao
Hongna Han
Xiaowen Sun
Tapas De
Neil P Desai
Patrick Soon-Shiong
Original Assignee
Abraxis Bioscience Inc
Chunlin Tao
Hongna Han
Xiaowen Sun
Tapas De
Neil P Desai
Patrick Soon-Shiong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abraxis Bioscience Inc, Chunlin Tao, Hongna Han, Xiaowen Sun, Tapas De, Neil P Desai, Patrick Soon-Shiong filed Critical Abraxis Bioscience Inc
Publication of WO2007059116A2 publication Critical patent/WO2007059116A2/en
Publication of WO2007059116A3 publication Critical patent/WO2007059116A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The invention provides novel geldanamycin derivatives and methods of their production. The invention also provides methods of treating a disease or condition associated with undesirable cellular proliferation using the same.
PCT/US2006/044165 2005-11-14 2006-11-14 Geldanamycin derivatives and pharmaceutical compositions thereof WO2007059116A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73656305P 2005-11-14 2005-11-14
US60/736,563 2005-11-14

Publications (2)

Publication Number Publication Date
WO2007059116A2 WO2007059116A2 (en) 2007-05-24
WO2007059116A3 true WO2007059116A3 (en) 2007-07-26

Family

ID=37983582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/044165 WO2007059116A2 (en) 2005-11-14 2006-11-14 Geldanamycin derivatives and pharmaceutical compositions thereof

Country Status (1)

Country Link
WO (1) WO2007059116A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034375B2 (en) 2005-02-18 2011-10-11 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
US9399071B2 (en) 2010-06-04 2016-07-26 Abraxis Bioscience, Llc Methods of treatment of pancreatic cancer

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
DE102006026464A1 (en) * 2006-06-01 2007-12-06 Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma Pharmaceutical composition for the treatment of viral infections and / or tumors by inhibiting protein folding and protein degradation
DE102006044472A1 (en) * 2006-09-21 2008-04-03 Discovery Partner International Gmbh Geldanamycin derivatives
PE20081506A1 (en) 2006-12-12 2008-12-09 Infinity Discovery Inc ANSAMYCIN FORMULATIONS
CN102115460B (en) * 2010-01-05 2014-08-20 杭州华东医药集团生物工程研究所有限公司 Geldanamycin derivative and preparation method and application thereof
KR20130028728A (en) 2010-03-29 2013-03-19 아브락시스 바이오사이언스, 엘엘씨 Methods of treating cancer
JP6242213B2 (en) 2010-03-29 2017-12-06 アブラクシス バイオサイエンス， エルエルシー Methods for improving the effectiveness of drug delivery and therapeutic agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002079167A1 (en) * 2001-03-30 2002-10-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Geldanamycin derivative and method of treating cancer using same
US6855705B1 (en) * 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
WO2005056531A1 (en) * 2003-11-12 2005-06-23 Kosan Biosciences, Inc. 11-o-methylgeldanamycin compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002079167A1 (en) * 2001-03-30 2002-10-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Geldanamycin derivative and method of treating cancer using same
US6855705B1 (en) * 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
WO2005056531A1 (en) * 2003-11-12 2005-06-23 Kosan Biosciences, Inc. 11-o-methylgeldanamycin compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SCHNUR ET AL: "erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 38, 1995, pages 3813 - 3820, XP002193280, ISSN: 0022-2623 *
SCHNUR ET AL: "Inhibition of the Oncogene Product p185erb-b2 in Vitro and in Vivo by Geldanamycin and Dihydrogeldanamycin Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 38, no. 19, 1995, pages 3806 - 3812, XP002202371, ISSN: 0022-2623 *
TIAN Z-Q ET AL: "Synthesis and biological activities of novel 17-aminogeldanamycin derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 12, no. 20, 15 October 2004 (2004-10-15), pages 5317 - 5329, XP004573353, ISSN: 0968-0896 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034375B2 (en) 2005-02-18 2011-10-11 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
US9399071B2 (en) 2010-06-04 2016-07-26 Abraxis Bioscience, Llc Methods of treatment of pancreatic cancer

Also Published As

Publication number Publication date
WO2007059116A2 (en) 2007-05-24

Similar Documents

Publication Publication Date Title
WO2007059116A3 (en) Geldanamycin derivatives and pharmaceutical compositions thereof
WO2006124713A3 (en) 4-biarylyl-1-phenylazetidin-2-ones
WO2006023627A8 (en) Rapamycin polymorph ii and uses thereof
WO2008034013A3 (en) Medical devices and methods of making the same
WO2006124748A3 (en) Multicyclic compounds and methods of their use
WO2007076423A3 (en) INHIBITORS OF Akt ACTIVITY
TW200720085A (en) Multilayer articles having acoustical absorbance properties and methods of making and using the same
MX2007002470A (en) Substituted phenylaminothiazoles and use thereof.
WO2006058201A3 (en) Heterocyclic and bicyclic compounds, compositions and methods
EP1908749A4 (en) Process for production of isocyanate, isocyanate produced by the process, and use of the isocyanate
WO2008115469A3 (en) Role of hedgehog signaling in atherosclerosis and cardiovascular disease
WO2005086656A3 (en) Heteroarylaminopyrazole derivatives useful for the treatment of diabetes
WO2006127757A3 (en) Interferon-igg fusion
WO2007137071A3 (en) Compositions of r(+) and s(-) pramipexole and methods of using the same
WO2006100082A3 (en) Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
WO2007059008A3 (en) N-substituted indenoisoquinolines and syntheses thereof
WO2007075870A3 (en) Processes for taxane derivatives and intermediates useful therein
WO2007059341A3 (en) Pyrazolothiazole protein kinase modulators
WO2008060795A3 (en) Antimicrobial articles and method of manufacture
HK1110025A1 (en) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives the treatment of infertility
EP1867623A4 (en) Terphenylene derivatives, tetrahaloterphenyl derivatives and processes for the production of both
WO2007006591A3 (en) Dihalogenation of n,o-disubstituted hydroxipyridones and uses thereof
WO2006078998A3 (en) Methods and compositions for decreasing saliva production
DE602005003246D1 (en) Polyalkylenimine derivative, its production process and uses
AU2006243194A8 (en) 4-phenyl-5-oxo-l,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06837547

Country of ref document: EP

Kind code of ref document: A2