WO2007056905A1

WO2007056905A1 - Hifu tumor ablating system

Info

Publication number: WO2007056905A1
Application number: PCT/CN2006/000322
Authority: WO
Inventors: Jiwei Jiang; Jiaxian Dong; Haijin Ma; Yisheng Chen; Yong Zhou
Original assignee: Shanghai A & S Science Technology Development Co., Ltd.
Priority date: 2005-11-16
Filing date: 2006-03-03
Publication date: 2007-05-24
Also published as: CN1966108A

Abstract

A HIFU tumor ablating system comprises at least a HIFU treatment means and an open-type MRI system. The magnetic material of the open-type MRI system is arranged vertical to the ground, and the HIFU treatment means is arranged between the magnetic materials. The MRI technology is combined with the HIFU technology; the common ground-parallel arrangement of the magnetic materials is changed to be a vertical arrangement.

Description

HIFU tumor ablation system

The invention relates to the field of tumor treatment, in particular to a HIFU tumor ablation system. technical background

The MRI (Magnetic Resonance Imaging) system is an imaging technique that reconstructs an image by collecting signals generated by magnetic resonance phenomena. The nucleus in the human tissue (including the base proton or neutron, generally referred to as the proton of hydrogen) is magnetized in a strong magnetic field. After the gradient field gives spatial localization, the RF pulse excites the hydrogen proton at a specific precession frequency, and the hydrogen proton that receives the excitation is in motion. The energy released during the process of helium is the magnetic resonance signal. The magnetic resonance signals are collected by a computer and converted into black and white gray scales according to the intensity of the signal. The two-dimensional or three-dimensional form is formed by position, and the magnetic resonance image (MRI) is finally formed. It has the advantages of no radiation damage, boneless artifacts, multi-faceted, multi-parametric imaging, and soft tissue resolution. In addition, non-invasive real-time temperature measurement for patients can be achieved by using temperature-dependent parameter changes such as changes in hydrogen proton resonance frequency and spin lattice relaxation time in MRI.

The basic components of the MRI system are magnets, spectrometers, patient carriers, computer analysis software, and more. In the MRI system currently used, the magnet has two basic structures, one is an open structure, and one magnetic material is placed on the upper and lower sides, and the main constant magnetic field generated is perpendicular to the ground, which is called an open MRI system; The MRI system is a ring-shaped structure that produces a main constant magnetic field in a closed annulus, in which the patient is placed in the annulus.

The basic components of the HIFU (High Intensity Focused Ultrasound) tumor ablation system are: HIFU treatment devices (also known as ultrasound transducers, transducer groups, wave sources, treatment heads, etc.), patient carriers for carrying patients , computer control software, power generators, etc.

The basic treatment principle is that a single or multiple ultrasonic transducers emit an ultrasound beam, and the patient's external body is focused by the medium to the target region of the body, so that the ultrasonic intensity at the focus of the target region reaches several thousand or even tens of thousands of W/cm 2 . The biological tissue at the focus of the target area produces intense mechanical vibration (relaxation) under the action of energy superposition, and continuously converts the ordered molecular vibration energy into disordered molecular thermal motion energy, that is, the mechanical energy is converted into thermal energy in the medium. The temperature of the biological tissue at the focus of the target region rises to above 65 °C in an instant (0.1-ls), and the irreversible coagulative necrosis of the protein is rapidly caused. Because in such a short period of time, the non-target tissue is hardly damaged by HIFU, so the purpose of non-invasive "ablation" of the tumor can be achieved. HIFU tumor ablation therapy is a non-invasive, non-toxic and side-effect tumor treatment method. In recent years, it has become a research hotspot in the international academic community, and has been widely used in the medical field. HIFU treatment technology has been promoted by certain clinical applications. It has been confirmed that China is the earliest and largest number of clinically applied HIFU treatment technologies in the world, and is also the country with the largest number of products manufacturing systems.

At present, the HIFU treatment system on the market adopts B-mode image guidance to implement positioning, and the system has fatal defects such as unclear imaging effect, inaccurate tumor positioning accuracy, and relatively poor safety and reliability. In addition, the inability to perform non-invasive temperature measurement and real-time evaluation of imaging has become a problem for its clinical application.

The EXABLTE 2000 ultrasound treatment system produced by Israel INSIGHTEC company uses US 1.5 GE magnetic resonance imaging system to guide the positioning, and the imaging effect is clear and the tumor positioning is accurate. However, due to the use of a high-field MRI system, the magnets are made of superconducting materials, and a circulating cooling device using liquid nitrogen is required, which makes the entire system too bulky, relatively cumbersome to operate, and expensive to manufacture. And the MRI system part of the HIFU system they use uses a traditional ring structure. Summary of the invention

It is an object of the present invention to overcome the above-discussed deficiencies of the prior art and to provide a novel HIFU tumor ablation system.

The object of the invention is achieved by the following technical solutions:

A HIFU tumor ablation system comprising at least one HIFU treatment device, further comprising an open MRI system, the magnetic material of the open MRI system being disposed perpendicular to the ground, the HIFU treatment device being disposed between the magnetic materials.

Wherein, the direction of the main constant magnetic field of the MRI system is parallel to the ground.

Wherein, the HIFU treatment device is an upper HIFU treatment device disposed between the magnetic materials of the open MRI system.

Alternatively, the HIFU treatment device can be an underlying HIFU treatment device disposed between the magnetic materials of the open M I system.

Alternatively, the HIFU tumor ablation system includes an upper HIFU treatment device disposed between the magnetic materials of the open MRI system and an underlying HIFU treatment device disposed between the magnetic materials of the open MRI system. .

Wherein, the upper HIFU treatment device is disposed on the upper portion between the magnetic materials by suspension or support.

The underlying HIFU treatment device is carried on the base of the HIFU tumor ablation system.

Additionally, the system further includes a patient carrying device coupled to the base by a lifting device, and The sealing device is connected to the underlying HIFU treatment device.

And, the patient carrying device is provided with an opening corresponding to the underlying HIFU treatment device.

The positive progress of the invention is as follows: The invention combines the MRI technology and the HIFU technology into one body, and creatively changes the magnetic material of the MRI system from the traditional horizontal up and down to the vertical plane setting, so that the magnetic material is more convenient to install HIFU. The treatment device solves the fundamental problems of precise positioning, non-invasive temperature measurement and therapeutic evaluation in the development and application of the B-type HIFU system by utilizing the MRI system precise positioning technology, real-time temperature change detection technology, and high-definition real-time image technology. It breaks through the development bottleneck of HIFU tumor ablation technology, makes HIFU treatment technology more secure, reliable, practical and credible, and it also has the advantages of low manufacturing cost and convenient use. DRAWINGS

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a front elevational view showing a first embodiment of the present invention.

Fig. 2 is a side view showing the first embodiment of the present invention. detailed description

Example 1

As shown in Figure 1-2, a HIFU tumor ablation system includes an open MRI system in which the magnetic materials 5, 6 are placed perpendicular to the ground, and the direction of the main constant magnetic field of the MRI system is parallel to the ground. Further comprising an upper HIFU treatment device 1 disposed between the magnetic materials of the open MRI system and an underlying HIFU treatment device 2 disposed between the magnetic materials of the open MRI system, further comprising a A patient carrying device 3 for carrying a patient.

The magnetic material 5, 6 is placed vertically on a horizontally placed base 4, and the MRI magnetic resonance imaging system has an open structure with an upward opening and a HIFU high intensity focused ultrasound system placed at the opening of the MRI magnetic resonance imaging system.

The upper HIFU treatment device 1 is suspended or supported in an upper portion between the magnetic materials 5, 6 above the patient carrying device 3, that is, above the patient.

In the present embodiment, the upper HIFU treatment device 1 is connected to the two magnetic materials 5, 6 via a bracket 8 and suspended above the patient carrying device 3. The upper HIFU treatment device 1 is controlled to perform a positioning sway of <90° along the axial and radial directions of the patient carrier 3.

The underlying HIFU treatment device 2 is located below the patient carrier device 3 and is disposed on the base 4 and connected to the patient carrier device 3 by a sealing material (not shown). The patient carrier 3 is carried on a lifting device 9 connected to the base 4 of the HIFU tumor ablation system. The lifting device 9 is disposed on the base 4, and the patient carrying device 3 is provided with an opening corresponding to the underlying HIFU treatment device 2 for use in the treatment of the lower HIFU treatment device 2.

In the specific application, by controlling the up, down, left and right, and front and rear movements of the patient carrying device 3, the patient 7 is placed in the center of the magnetic field formed by the magnetic materials 5 and 6 of the MRI magnetic resonance imaging system to form an integrated MRI-guided HIFU tumor. Ablation system to achieve the purpose of treating tumors.

Example 2

Embodiment 2 differs from Embodiment 1 in that: the HIFU treatment device is an upper-mounted HIFU treatment device located above the patient carrier device, not shown, and the other structures of Embodiment 2 are the same as Embodiment 1, and Make a statement.

Example 3

Embodiment 3 differs from Embodiment 1 in that: the HIFU treatment device is an underlying HIFU treatment device located below the patient carrier device, and is not shown. The other structures of Embodiment 3 are the same as in Embodiment 1, and Make a statement.

Claims

Rights request

What is claimed is: 1. A HIFU tumor ablation system comprising at least one HIFU treatment device, further comprising: an open MRI system, the magnetic material of the open MRI system being disposed perpendicular to the ground, the HIFU treatment device being disposed at Between the magnetic materials.

2. A HIFU tumor ablation system according to claim 1 wherein the direction of the main constant magnetic field of the MRI system is parallel to the ground.

3. The HIFU tumor ablation system according to claim 1, wherein: the HIFU treatment device is an upper HIFU treatment device disposed between the magnetic materials of the open MRI system.

4. The HIFU tumor ablation system according to claim 1, wherein: the HIFU treatment device is an underlying HIFU treatment device disposed between the magnetic materials of the open MRI system.

5. The HIFU tumor ablation system according to claim 1, comprising: an upper HIFU treatment device disposed between the magnetic materials of the open MRI system; and an upper MRI system disposed in the open MRI system A lower-mounted HIFU treatment device between the magnetic materials.

6. The HIFU tumor ablation system according to claim 3 or 5, wherein the upper HIFU treatment device is suspended or supported in an upper portion between the magnetic materials.

7. The HIFU tumor ablation system of claim 4 or 5, wherein: the underlying HIFU treatment device is carried on a base of the HIFU tumor ablation system.

8. The HIFU tumor ablation system of claim 7, further comprising a patient carrying device coupled to the base by a lifting device and coupled to the underlying HIFU therapy device by a sealing material.

9. The HIFU tumor ablation system according to claim 8, wherein the patient carrying device is provided with an opening corresponding to the underlying HIFU treatment device.