WO2007053869A3 - Novel 2,2-dithiosubstituted furanose derivatives, method for the production and use thereof - Google Patents

Novel 2,2-dithiosubstituted furanose derivatives, method for the production and use thereof Download PDF

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Publication number
WO2007053869A3
WO2007053869A3 PCT/AT2006/000458 AT2006000458W WO2007053869A3 WO 2007053869 A3 WO2007053869 A3 WO 2007053869A3 AT 2006000458 W AT2006000458 W AT 2006000458W WO 2007053869 A3 WO2007053869 A3 WO 2007053869A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
general formula
geminal
radical
dithiosubstituted
Prior art date
Application number
PCT/AT2006/000458
Other languages
German (de)
French (fr)
Other versions
WO2007053869A2 (en
Inventor
Gerald Saischek
Ewald Saischek
Original Assignee
Saischek Und Partner Meg
Gerald Saischek
Ewald Saischek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saischek Und Partner Meg, Gerald Saischek, Ewald Saischek filed Critical Saischek Und Partner Meg
Priority to AT94452006A priority Critical patent/AT509773B1/en
Publication of WO2007053869A2 publication Critical patent/WO2007053869A2/en
Publication of WO2007053869A3 publication Critical patent/WO2007053869A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The invention relates to compounds of general formula (1), in which R1, R2, R3 and R4 are defined as cited in the description and R5 is either the radical of a base of general formula (3), in which R8 and R9 independently of one another represent hydrogen or an amino protecting group, preferably an optionally substituted alkanoyl or aroyl group or the radical of a base of general formula (4), in which R10 represents hydrogen, a saturated or unsaturated 1-3 C alkyl group with between 1 and 3 carbon atoms, bromine, fluorine, chlorine or iodine. The compounds can be used as valuable and appropriate intermediates for the production of geminal difluoronucleosides, which are in turn used in anti-viral and anti-carcinogenic treatments. The fluorination is achieved by means of oxidative desulphofluorination, which permits the economic production of geminal fluoronucleosides.
PCT/AT2006/000458 2005-11-09 2006-11-08 Novel 2,2-dithiosubstituted furanose derivatives, method for the production and use thereof WO2007053869A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT94452006A AT509773B1 (en) 2005-11-09 2006-11-08 NEW 2,2-DITHIOSUBSTITUTED FURANOSE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1837/2005 2005-11-09
AT0183705A AT502635A1 (en) 2005-11-09 2005-11-09 NEW 1,3-DITHIUM COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE

Publications (2)

Publication Number Publication Date
WO2007053869A2 WO2007053869A2 (en) 2007-05-18
WO2007053869A3 true WO2007053869A3 (en) 2007-07-26

Family

ID=37807990

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2006/000458 WO2007053869A2 (en) 2005-11-09 2006-11-08 Novel 2,2-dithiosubstituted furanose derivatives, method for the production and use thereof

Country Status (2)

Country Link
AT (2) AT502635A1 (en)
WO (1) WO2007053869A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009058800A2 (en) * 2007-10-29 2009-05-07 President And Fellows Of Harvard College Synthesis of nucleosides

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082911A (en) * 1975-02-24 1978-04-04 Schering Aktiengesellschaft Process for the preparation of nucleosides
EP0544010A1 (en) * 1991-06-14 1993-06-02 Japan Tobacco Inc. Process for producing 2',3'-dideoxy-beta-nucleoside
EP0576230A1 (en) * 1992-06-22 1993-12-29 Eli Lilly And Company 2'-deoxy-2', 2'-difluoro(4-substituted pyrimidine) nucleosides having antiviral and anti-cancer activity and intermediates
EP0576227A2 (en) * 1992-06-22 1993-12-29 Eli Lilly And Company 2'-Deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
JPH07278178A (en) * 1994-04-01 1995-10-24 Japan Tobacco Inc 2'-substituted-2',3'-didehydro-2',3'-dideoxynucleoside and its production

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082911A (en) * 1975-02-24 1978-04-04 Schering Aktiengesellschaft Process for the preparation of nucleosides
EP0544010A1 (en) * 1991-06-14 1993-06-02 Japan Tobacco Inc. Process for producing 2',3'-dideoxy-beta-nucleoside
EP0576230A1 (en) * 1992-06-22 1993-12-29 Eli Lilly And Company 2'-deoxy-2', 2'-difluoro(4-substituted pyrimidine) nucleosides having antiviral and anti-cancer activity and intermediates
EP0576227A2 (en) * 1992-06-22 1993-12-29 Eli Lilly And Company 2'-Deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
JPH07278178A (en) * 1994-04-01 1995-10-24 Japan Tobacco Inc 2'-substituted-2',3'-didehydro-2',3'-dideoxynucleoside and its production

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HERTEL L W: "SYNTHESIS OF 2-DEOXY-2,2-DIFLUORO-D-RIBOSE AND 2-DEOXY-2,2-DIFLUORO-D-RIBOFURANOSYL NUCLEOSIDES", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 53, no. 11, 27 May 1988 (1988-05-27), pages 2406 - 2409, XP000572745, ISSN: 0022-3263 *
REINER M ET AL: "Synthesis of 3-deoxy-d-manno-2-octulosonic acid (Kdo) and d-glycero-d-talo-2-octulosonic acid (Ko) and their alpha-glycosides", TETRAHEDRON: ASYMMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 11, no. 1, January 2000 (2000-01-01), pages 319 - 335, XP004202388, ISSN: 0957-4166 *

Also Published As

Publication number Publication date
WO2007053869A2 (en) 2007-05-18
AT509773B1 (en) 2011-11-15
AT502635A1 (en) 2007-05-15

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