WO2007053869A3 - Novel 2,2-dithiosubstituted furanose derivatives, method for the production and use thereof - Google Patents
Novel 2,2-dithiosubstituted furanose derivatives, method for the production and use thereof Download PDFInfo
- Publication number
- WO2007053869A3 WO2007053869A3 PCT/AT2006/000458 AT2006000458W WO2007053869A3 WO 2007053869 A3 WO2007053869 A3 WO 2007053869A3 AT 2006000458 W AT2006000458 W AT 2006000458W WO 2007053869 A3 WO2007053869 A3 WO 2007053869A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- production
- general formula
- geminal
- radical
- dithiosubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
The invention relates to compounds of general formula (1), in which R1, R2, R3 and R4 are defined as cited in the description and R5 is either the radical of a base of general formula (3), in which R8 and R9 independently of one another represent hydrogen or an amino protecting group, preferably an optionally substituted alkanoyl or aroyl group or the radical of a base of general formula (4), in which R10 represents hydrogen, a saturated or unsaturated 1-3 C alkyl group with between 1 and 3 carbon atoms, bromine, fluorine, chlorine or iodine. The compounds can be used as valuable and appropriate intermediates for the production of geminal difluoronucleosides, which are in turn used in anti-viral and anti-carcinogenic treatments. The fluorination is achieved by means of oxidative desulphofluorination, which permits the economic production of geminal fluoronucleosides.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT94452006A AT509773B1 (en) | 2005-11-09 | 2006-11-08 | NEW 2,2-DITHIOSUBSTITUTED FURANOSE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ATA1837/2005 | 2005-11-09 | ||
AT0183705A AT502635A1 (en) | 2005-11-09 | 2005-11-09 | NEW 1,3-DITHIUM COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007053869A2 WO2007053869A2 (en) | 2007-05-18 |
WO2007053869A3 true WO2007053869A3 (en) | 2007-07-26 |
Family
ID=37807990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AT2006/000458 WO2007053869A2 (en) | 2005-11-09 | 2006-11-08 | Novel 2,2-dithiosubstituted furanose derivatives, method for the production and use thereof |
Country Status (2)
Country | Link |
---|---|
AT (2) | AT502635A1 (en) |
WO (1) | WO2007053869A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009058800A2 (en) * | 2007-10-29 | 2009-05-07 | President And Fellows Of Harvard College | Synthesis of nucleosides |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082911A (en) * | 1975-02-24 | 1978-04-04 | Schering Aktiengesellschaft | Process for the preparation of nucleosides |
EP0544010A1 (en) * | 1991-06-14 | 1993-06-02 | Japan Tobacco Inc. | Process for producing 2',3'-dideoxy-beta-nucleoside |
EP0576230A1 (en) * | 1992-06-22 | 1993-12-29 | Eli Lilly And Company | 2'-deoxy-2', 2'-difluoro(4-substituted pyrimidine) nucleosides having antiviral and anti-cancer activity and intermediates |
EP0576227A2 (en) * | 1992-06-22 | 1993-12-29 | Eli Lilly And Company | 2'-Deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates |
JPH07278178A (en) * | 1994-04-01 | 1995-10-24 | Japan Tobacco Inc | 2'-substituted-2',3'-didehydro-2',3'-dideoxynucleoside and its production |
-
2005
- 2005-11-09 AT AT0183705A patent/AT502635A1/en not_active Application Discontinuation
-
2006
- 2006-11-08 AT AT94452006A patent/AT509773B1/en not_active IP Right Cessation
- 2006-11-08 WO PCT/AT2006/000458 patent/WO2007053869A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082911A (en) * | 1975-02-24 | 1978-04-04 | Schering Aktiengesellschaft | Process for the preparation of nucleosides |
EP0544010A1 (en) * | 1991-06-14 | 1993-06-02 | Japan Tobacco Inc. | Process for producing 2',3'-dideoxy-beta-nucleoside |
EP0576230A1 (en) * | 1992-06-22 | 1993-12-29 | Eli Lilly And Company | 2'-deoxy-2', 2'-difluoro(4-substituted pyrimidine) nucleosides having antiviral and anti-cancer activity and intermediates |
EP0576227A2 (en) * | 1992-06-22 | 1993-12-29 | Eli Lilly And Company | 2'-Deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates |
JPH07278178A (en) * | 1994-04-01 | 1995-10-24 | Japan Tobacco Inc | 2'-substituted-2',3'-didehydro-2',3'-dideoxynucleoside and its production |
Non-Patent Citations (2)
Title |
---|
HERTEL L W: "SYNTHESIS OF 2-DEOXY-2,2-DIFLUORO-D-RIBOSE AND 2-DEOXY-2,2-DIFLUORO-D-RIBOFURANOSYL NUCLEOSIDES", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 53, no. 11, 27 May 1988 (1988-05-27), pages 2406 - 2409, XP000572745, ISSN: 0022-3263 * |
REINER M ET AL: "Synthesis of 3-deoxy-d-manno-2-octulosonic acid (Kdo) and d-glycero-d-talo-2-octulosonic acid (Ko) and their alpha-glycosides", TETRAHEDRON: ASYMMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 11, no. 1, January 2000 (2000-01-01), pages 319 - 335, XP004202388, ISSN: 0957-4166 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007053869A2 (en) | 2007-05-18 |
AT509773B1 (en) | 2011-11-15 |
AT502635A1 (en) | 2007-05-15 |
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