WO2007051081B1 - Methods and compounds for preparing cc-1065 analogs - Google Patents
Methods and compounds for preparing cc-1065 analogsInfo
- Publication number
- WO2007051081B1 WO2007051081B1 PCT/US2006/060050 US2006060050W WO2007051081B1 WO 2007051081 B1 WO2007051081 B1 WO 2007051081B1 US 2006060050 W US2006060050 W US 2006060050W WO 2007051081 B1 WO2007051081 B1 WO 2007051081B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substituted
- unsubstituted
- compound
- alkyl
- iii
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 19
- 150000001875 compounds Chemical class 0.000 title claims 17
- 125000000217 alkyl group Chemical group 0.000 claims abstract 17
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 4
- 125000006239 protecting group Chemical group 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000026045 iodination Effects 0.000 claims 2
- 238000006192 iodination reaction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 239000001177 diphosphate Substances 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000001151 peptidyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 claims 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 0 *c1cc2cc(*)cc(O*)c2cc1 Chemical compound *c1cc2cc(*)cc(O*)c2cc1 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006305842A AU2006305842B2 (en) | 2005-10-26 | 2006-10-18 | Methods and compounds for preparing CC-1065 analogs |
CA2627046A CA2627046C (en) | 2005-10-26 | 2006-10-18 | Methods and compounds for preparing cc-1065 analogs |
BRPI0619331-5A BRPI0619331A2 (en) | 2005-10-26 | 2006-10-18 | method for making a compound to prepare a cbi cc-1065 analog, method for making a cbi cc-1065 analog and compound |
CN2006800491755A CN101365679B (en) | 2005-10-26 | 2006-10-18 | Methods and compounds for preparing cc-1065 analogs |
US12/090,445 US7847105B2 (en) | 2005-10-26 | 2006-10-18 | Methods and compounds for preparing CC-1065 analogs |
JP2008538132A JP5116686B2 (en) | 2005-10-26 | 2006-10-18 | Methods for preparing CC-1065 analogs and compounds for preparation |
PL06839458T PL1940789T3 (en) | 2005-10-26 | 2006-10-18 | Methods and compounds for preparing cc-1065 analogs |
EA200801176A EA015324B1 (en) | 2005-10-26 | 2006-10-18 | Methods and compounds for preparing cc-1065 analogs |
ES06839458T ES2375843T3 (en) | 2005-10-26 | 2006-10-18 | PROCEDURES AND COMPOUNDS FOR THE PREPARATION OF ANC? LOGOS OF CC-1065. |
EP06839458A EP1940789B1 (en) | 2005-10-26 | 2006-10-18 | Methods and compounds for preparing cc-1065 analogs |
DK06839458.4T DK1940789T3 (en) | 2005-10-26 | 2006-10-18 | Methods and Compounds for the Preparation of CC-1065 Analogs |
AT06839458T ATE534629T1 (en) | 2005-10-26 | 2006-10-18 | METHOD AND COMPOUNDS FOR PRODUCING CC-1065 ANALOGUE |
IL190971A IL190971A (en) | 2005-10-26 | 2008-04-17 | Method of making a tricyclic compound and a method of making a cbi cc-1065 analog |
NO20082243A NO20082243L (en) | 2005-10-26 | 2008-05-15 | Methods and Compounds for Preparation of CC-1065 Analogs |
HK08110088.4A HK1118549A1 (en) | 2005-10-26 | 2008-09-11 | Methods and compounds for preparing cc-1065 analogs |
HR20120058T HRP20120058T1 (en) | 2005-10-26 | 2012-01-19 | Methods and compounds for preparing cc-1065 analogs |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73080405P | 2005-10-26 | 2005-10-26 | |
US60/730,804 | 2005-10-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2007051081A1 WO2007051081A1 (en) | 2007-05-03 |
WO2007051081B1 true WO2007051081B1 (en) | 2007-07-19 |
WO2007051081A8 WO2007051081A8 (en) | 2010-12-16 |
Family
ID=37766648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/060050 WO2007051081A1 (en) | 2005-10-26 | 2006-10-18 | Methods and compounds for preparing cc-1065 analogs |
Country Status (23)
Country | Link |
---|---|
US (1) | US7847105B2 (en) |
EP (1) | EP1940789B1 (en) |
JP (1) | JP5116686B2 (en) |
KR (1) | KR20080068084A (en) |
CN (1) | CN101365679B (en) |
AT (1) | ATE534629T1 (en) |
AU (1) | AU2006305842B2 (en) |
BR (1) | BRPI0619331A2 (en) |
CA (1) | CA2627046C (en) |
CY (1) | CY1112533T1 (en) |
DK (1) | DK1940789T3 (en) |
EA (1) | EA015324B1 (en) |
ES (1) | ES2375843T3 (en) |
HK (1) | HK1118549A1 (en) |
HR (1) | HRP20120058T1 (en) |
IL (1) | IL190971A (en) |
NO (1) | NO20082243L (en) |
PL (1) | PL1940789T3 (en) |
PT (1) | PT1940789E (en) |
RS (1) | RS52100B (en) |
SI (1) | SI1940789T1 (en) |
WO (1) | WO2007051081A1 (en) |
ZA (1) | ZA200804521B (en) |
Cited By (1)
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US11884729B2 (en) | 2018-06-29 | 2024-01-30 | ApitBio, Inc | Anti-L1CAM antibodies and uses thereof |
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HRP20120058T1 (en) | 2012-02-29 |
DK1940789T3 (en) | 2012-03-19 |
CN101365679B (en) | 2012-11-14 |
IL190971A (en) | 2013-02-28 |
NO20082243L (en) | 2008-07-21 |
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CY1112533T1 (en) | 2015-12-09 |
EA200801176A1 (en) | 2009-02-27 |
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PL1940789T3 (en) | 2012-04-30 |
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EA015324B1 (en) | 2011-06-30 |
JP5116686B2 (en) | 2013-01-09 |
ES2375843T3 (en) | 2012-03-06 |
CA2627046C (en) | 2015-09-15 |
EP1940789B1 (en) | 2011-11-23 |
WO2007051081A8 (en) | 2010-12-16 |
KR20080068084A (en) | 2008-07-22 |
CA2627046A1 (en) | 2007-05-03 |
AU2006305842B2 (en) | 2011-11-03 |
ZA200804521B (en) | 2009-04-29 |
RS52100B (en) | 2012-06-30 |
AU2006305842A1 (en) | 2007-05-03 |
EP1940789A1 (en) | 2008-07-09 |
BRPI0619331A2 (en) | 2011-09-27 |
SI1940789T1 (en) | 2012-03-30 |
CN101365679A (en) | 2009-02-11 |
PT1940789E (en) | 2012-02-01 |
IL190971A0 (en) | 2008-12-29 |
US7847105B2 (en) | 2010-12-07 |
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