WO2007051081A8 - Methods and compounds for preparing cc-1065 analogs - Google Patents

Methods and compounds for preparing cc-1065 analogs Download PDF

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Publication number
WO2007051081A8
WO2007051081A8 PCT/US2006/060050 US2006060050W WO2007051081A8 WO 2007051081 A8 WO2007051081 A8 WO 2007051081A8 US 2006060050 W US2006060050 W US 2006060050W WO 2007051081 A8 WO2007051081 A8 WO 2007051081A8
Authority
WO
WIPO (PCT)
Prior art keywords
analogs
preparing
compounds
methods
alkyl
Prior art date
Application number
PCT/US2006/060050
Other languages
French (fr)
Other versions
WO2007051081A1 (en
WO2007051081B1 (en
Inventor
Sanjeev Gangwar
Qian Zhang
Original Assignee
Medarex, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT06839458T priority Critical patent/ATE534629T1/en
Priority to DK06839458.4T priority patent/DK1940789T3/en
Priority to CN2006800491755A priority patent/CN101365679B/en
Priority to AU2006305842A priority patent/AU2006305842B2/en
Priority to ES06839458T priority patent/ES2375843T3/en
Priority to CA2627046A priority patent/CA2627046C/en
Priority to BRPI0619331-5A priority patent/BRPI0619331A2/en
Application filed by Medarex, Inc. filed Critical Medarex, Inc.
Priority to US12/090,445 priority patent/US7847105B2/en
Priority to JP2008538132A priority patent/JP5116686B2/en
Priority to PL06839458T priority patent/PL1940789T3/en
Priority to EP06839458A priority patent/EP1940789B1/en
Priority to EA200801176A priority patent/EA015324B1/en
Publication of WO2007051081A1 publication Critical patent/WO2007051081A1/en
Publication of WO2007051081B1 publication Critical patent/WO2007051081B1/en
Priority to IL190971A priority patent/IL190971A/en
Priority to NO20082243A priority patent/NO20082243L/en
Priority to HK08110088.4A priority patent/HK1118549A1/en
Publication of WO2007051081A8 publication Critical patent/WO2007051081A8/en
Priority to HR20120058T priority patent/HRP20120058T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A method of forming a CBI CC- 1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.
PCT/US2006/060050 2005-10-26 2006-10-18 Methods and compounds for preparing cc-1065 analogs WO2007051081A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
JP2008538132A JP5116686B2 (en) 2005-10-26 2006-10-18 Methods for preparing CC-1065 analogs and compounds for preparation
CN2006800491755A CN101365679B (en) 2005-10-26 2006-10-18 Methods and compounds for preparing cc-1065 analogs
AU2006305842A AU2006305842B2 (en) 2005-10-26 2006-10-18 Methods and compounds for preparing CC-1065 analogs
ES06839458T ES2375843T3 (en) 2005-10-26 2006-10-18 PROCEDURES AND COMPOUNDS FOR THE PREPARATION OF ANC? LOGOS OF CC-1065.
CA2627046A CA2627046C (en) 2005-10-26 2006-10-18 Methods and compounds for preparing cc-1065 analogs
BRPI0619331-5A BRPI0619331A2 (en) 2005-10-26 2006-10-18 method for making a compound to prepare a cbi cc-1065 analog, method for making a cbi cc-1065 analog and compound
PL06839458T PL1940789T3 (en) 2005-10-26 2006-10-18 Methods and compounds for preparing cc-1065 analogs
US12/090,445 US7847105B2 (en) 2005-10-26 2006-10-18 Methods and compounds for preparing CC-1065 analogs
DK06839458.4T DK1940789T3 (en) 2005-10-26 2006-10-18 Methods and Compounds for the Preparation of CC-1065 Analogs
AT06839458T ATE534629T1 (en) 2005-10-26 2006-10-18 METHOD AND COMPOUNDS FOR PRODUCING CC-1065 ANALOGUE
EP06839458A EP1940789B1 (en) 2005-10-26 2006-10-18 Methods and compounds for preparing cc-1065 analogs
EA200801176A EA015324B1 (en) 2005-10-26 2006-10-18 Methods and compounds for preparing cc-1065 analogs
IL190971A IL190971A (en) 2005-10-26 2008-04-17 Method of making a tricyclic compound and a method of making a cbi cc-1065 analog
NO20082243A NO20082243L (en) 2005-10-26 2008-05-15 Methods and Compounds for Preparation of CC-1065 Analogs
HK08110088.4A HK1118549A1 (en) 2005-10-26 2008-09-11 Methods and compounds for preparing cc-1065 analogs
HR20120058T HRP20120058T1 (en) 2005-10-26 2012-01-19 Methods and compounds for preparing cc-1065 analogs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73080405P 2005-10-26 2005-10-26
US60/730,804 2005-10-26

Publications (3)

Publication Number Publication Date
WO2007051081A1 WO2007051081A1 (en) 2007-05-03
WO2007051081B1 WO2007051081B1 (en) 2007-07-19
WO2007051081A8 true WO2007051081A8 (en) 2010-12-16

Family

ID=37766648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/060050 WO2007051081A1 (en) 2005-10-26 2006-10-18 Methods and compounds for preparing cc-1065 analogs

Country Status (23)

Country Link
US (1) US7847105B2 (en)
EP (1) EP1940789B1 (en)
JP (1) JP5116686B2 (en)
KR (1) KR20080068084A (en)
CN (1) CN101365679B (en)
AT (1) ATE534629T1 (en)
AU (1) AU2006305842B2 (en)
BR (1) BRPI0619331A2 (en)
CA (1) CA2627046C (en)
CY (1) CY1112533T1 (en)
DK (1) DK1940789T3 (en)
EA (1) EA015324B1 (en)
ES (1) ES2375843T3 (en)
HK (1) HK1118549A1 (en)
HR (1) HRP20120058T1 (en)
IL (1) IL190971A (en)
NO (1) NO20082243L (en)
PL (1) PL1940789T3 (en)
PT (1) PT1940789E (en)
RS (1) RS52100B (en)
SI (1) SI1940789T1 (en)
WO (1) WO2007051081A1 (en)
ZA (1) ZA200804521B (en)

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