WO2007050705A3 - Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof - Google Patents

Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof Download PDF

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Publication number
WO2007050705A3
WO2007050705A3 PCT/US2006/041669 US2006041669W WO2007050705A3 WO 2007050705 A3 WO2007050705 A3 WO 2007050705A3 US 2006041669 W US2006041669 W US 2006041669W WO 2007050705 A3 WO2007050705 A3 WO 2007050705A3
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WO
WIPO (PCT)
Prior art keywords
methods
alzheimer
disease
detection
genetic polymorphisms
Prior art date
Application number
PCT/US2006/041669
Other languages
French (fr)
Other versions
WO2007050705A2 (en
Inventor
Yonghong Li
Andrew Grupe
Original Assignee
Celera Diagnostics Llc
Yonghong Li
Andrew Grupe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celera Diagnostics Llc, Yonghong Li, Andrew Grupe filed Critical Celera Diagnostics Llc
Priority to JP2008537920A priority Critical patent/JP5268145B2/en
Priority to CA002626086A priority patent/CA2626086A1/en
Priority to EP06844222A priority patent/EP1948831A4/en
Publication of WO2007050705A2 publication Critical patent/WO2007050705A2/en
Publication of WO2007050705A3 publication Critical patent/WO2007050705A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
PCT/US2006/041669 2005-10-26 2006-10-26 Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof WO2007050705A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008537920A JP5268145B2 (en) 2005-10-26 2006-10-26 Genetic polymorphisms associated with Alzheimer's disease, detection methods and uses thereof
CA002626086A CA2626086A1 (en) 2005-10-26 2006-10-26 Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof
EP06844222A EP1948831A4 (en) 2005-10-26 2006-10-26 Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73091805P 2005-10-26 2005-10-26
US60/730,918 2005-10-26
US11/586,427 US7695911B2 (en) 2005-10-26 2006-10-24 Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
US11/586,427 2006-10-24

Publications (2)

Publication Number Publication Date
WO2007050705A2 WO2007050705A2 (en) 2007-05-03
WO2007050705A3 true WO2007050705A3 (en) 2009-05-07

Family

ID=37968529

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/041669 WO2007050705A2 (en) 2005-10-26 2006-10-26 Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof

Country Status (5)

Country Link
US (2) US7695911B2 (en)
EP (1) EP1948831A4 (en)
JP (1) JP5268145B2 (en)
CA (1) CA2626086A1 (en)
WO (1) WO2007050705A2 (en)

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WO2009067657A2 (en) * 2007-11-21 2009-05-28 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Methods of identifying molecular function
WO2009126678A2 (en) * 2008-04-08 2009-10-15 Cornell University Detection of target nucleic acid sequences using fluorescence resonance energy transfer
WO2010005939A1 (en) * 2008-07-07 2010-01-14 University Of Florida Research Foundation, Inc. Methods and kits for detecting risk factors for development of jaw osteonecrosis and methods of treatment thereof
EP2321753A1 (en) * 2008-08-08 2011-05-18 Navigenics INC. Methods and systems for personalized action plans
WO2010030929A1 (en) * 2008-09-12 2010-03-18 Navigenics, Inc. Methods and systems for incorporating multiple environmental and genetic risk factors
EP2342353A1 (en) * 2008-10-03 2011-07-13 Mars, Incorporated Genetic test for liver copper accumulation in dogs and low copper pet diet
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GB201120989D0 (en) 2011-12-06 2012-01-18 Mars Inc Genetic test
US9782075B2 (en) 2013-03-15 2017-10-10 I2Dx, Inc. Electronic delivery of information in personalized medicine
US10249389B2 (en) * 2017-05-12 2019-04-02 The Regents Of The University Of Michigan Individual and cohort pharmacological phenotype prediction platform
EP3764902A4 (en) * 2018-03-13 2021-12-08 I2Dx, Inc. Electronic delivery of information in personalized medicine
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. Data compression and communication using machine learning

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Also Published As

Publication number Publication date
EP1948831A2 (en) 2008-07-30
JP5268145B2 (en) 2013-08-21
US20100196400A1 (en) 2010-08-05
WO2007050705A2 (en) 2007-05-03
CA2626086A1 (en) 2007-05-03
US20070254289A1 (en) 2007-11-01
US7695911B2 (en) 2010-04-13
JP2009528023A (en) 2009-08-06
EP1948831A4 (en) 2009-11-18

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