WO2007047908A3 - Apparatus and method for performing counts within a biologic fluid sample - Google Patents

Apparatus and method for performing counts within a biologic fluid sample Download PDF

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Publication number
WO2007047908A3
WO2007047908A3 PCT/US2006/041011 US2006041011W WO2007047908A3 WO 2007047908 A3 WO2007047908 A3 WO 2007047908A3 US 2006041011 W US2006041011 W US 2006041011W WO 2007047908 A3 WO2007047908 A3 WO 2007047908A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
chamber
specific elements
fluid sample
biologic fluid
Prior art date
Application number
PCT/US2006/041011
Other languages
French (fr)
Other versions
WO2007047908A2 (en
Inventor
Stephen C Wardlaw
Original Assignee
Wardlaw Partners Lp
Levine Robert A
Stephen C Wardlaw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wardlaw Partners Lp, Levine Robert A, Stephen C Wardlaw filed Critical Wardlaw Partners Lp
Priority to CA2626271A priority Critical patent/CA2626271C/en
Priority to ES06817200T priority patent/ES2716944T3/en
Priority to EP06817200.6A priority patent/EP1949310B1/en
Priority to JP2008536820A priority patent/JP4977711B2/en
Priority to AU2006304717A priority patent/AU2006304717B2/en
Priority to CN2006800452036A priority patent/CN101322145B/en
Publication of WO2007047908A2 publication Critical patent/WO2007047908A2/en
Publication of WO2007047908A3 publication Critical patent/WO2007047908A3/en
Priority to HK09103694.4A priority patent/HK1123873A1/en

Links

Classifications

    • G01N15/1433—
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G01N2015/012—
    • G01N2015/016—
    • G01N2015/018—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1486—Counting the particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]

Abstract

A method and an apparatus for enumerating one or more specific elements within a biologic fluid sample are provided. An embodiment of the method includes the steps of: a) providing a chamber formed between a first planar member that is transparent and a second planar member, which members are separated from one another by a substantially uniform height; b) introducing the biologic fluid sample into the chamber, wherein the chamber height is sized such that the sample extends between the first and second members, and sized relative to the specific elements within the sample such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber; c) examining substantially all of the sample within the chamber and enumerating all of at least one of the specific elements; d) determining the volume of sample contained within the chamber; and e) determining the number of the at least one of the specific elements per unit volume.
PCT/US2006/041011 2005-10-19 2006-10-17 Apparatus and method for performing counts within a biologic fluid sample WO2007047908A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2626271A CA2626271C (en) 2005-10-19 2006-10-17 Apparatus and method for performing counts within a biologic fluid sample
ES06817200T ES2716944T3 (en) 2005-10-19 2006-10-17 Method for carrying out counts on a sample of biological fluid
EP06817200.6A EP1949310B1 (en) 2005-10-19 2006-10-17 Method for performing counts within a biologic fluid sample
JP2008536820A JP4977711B2 (en) 2005-10-19 2006-10-17 Apparatus and method for performing counting in a biological fluid sample
AU2006304717A AU2006304717B2 (en) 2005-10-19 2006-10-17 Apparatus and method for performing counts within a biologic fluid sample
CN2006800452036A CN101322145B (en) 2005-10-19 2006-10-17 Apparatus and method for performing counts within a biologicfluid sample
HK09103694.4A HK1123873A1 (en) 2005-10-19 2009-04-22 Apparatus and method for performing counts within a biologic fluid sample

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72805805P 2005-10-19 2005-10-19
US60/728,058 2005-10-19
US11/257,757 US7731901B2 (en) 2005-10-19 2005-10-25 Apparatus and method for performing counts within a biologic fluid sample
US11/257,757 2005-10-25

Publications (2)

Publication Number Publication Date
WO2007047908A2 WO2007047908A2 (en) 2007-04-26
WO2007047908A3 true WO2007047908A3 (en) 2007-06-14

Family

ID=37948604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/041011 WO2007047908A2 (en) 2005-10-19 2006-10-17 Apparatus and method for performing counts within a biologic fluid sample

Country Status (9)

Country Link
US (4) US7731901B2 (en)
EP (1) EP1949310B1 (en)
JP (2) JP4977711B2 (en)
CN (1) CN101322145B (en)
AU (1) AU2006304717B2 (en)
CA (1) CA2626271C (en)
ES (1) ES2716944T3 (en)
HK (1) HK1123873A1 (en)
WO (1) WO2007047908A2 (en)

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