WO2007047644A3 - Method for microchannel surface modification - Google Patents

Method for microchannel surface modification Download PDF

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Publication number
WO2007047644A3
WO2007047644A3 PCT/US2006/040505 US2006040505W WO2007047644A3 WO 2007047644 A3 WO2007047644 A3 WO 2007047644A3 US 2006040505 W US2006040505 W US 2006040505W WO 2007047644 A3 WO2007047644 A3 WO 2007047644A3
Authority
WO
WIPO (PCT)
Prior art keywords
channel
channel surfaces
molecules
surface modification
dewetting
Prior art date
Application number
PCT/US2006/040505
Other languages
French (fr)
Other versions
WO2007047644A2 (en
Inventor
Hsian-Rong Tseng
Guodong Sui
Jinji Wang
Original Assignee
Univ California
Hsian-Rong Tseng
Guodong Sui
Jinji Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Hsian-Rong Tseng, Guodong Sui, Jinji Wang filed Critical Univ California
Publication of WO2007047644A2 publication Critical patent/WO2007047644A2/en
Publication of WO2007047644A3 publication Critical patent/WO2007047644A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00206—Processes for functionalising a surface, e.g. provide the surface with specific mechanical, chemical or biological properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Landscapes

  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Silicon Polymers (AREA)

Abstract

A method (10) for functionalizing microfluidic channels with specific characteristics by the introduction of hydroxyl groups onto the surface area of the channel using a solution of an acid and a peroxide (30) followed by a reaction of an essentially pure siloxane-based reagent (60) and a funtional group (70). Chemically modified channel surfaces can be designed to prevent non-specific binding or interaction of biological samples with the channel surfaces; surface wetting or dewetting with the control of the hydrophobicity and hydrophilicity of the channel surfaces; confer solvent resistance by attaching inert molecules to the interior channel; and tethering molecules that have available amine, thiol, isocyanato and isothiocyanato or similar groups to permit the attachment of biomolecules to channel surfaces.
PCT/US2006/040505 2005-10-14 2006-10-13 Method for microchannel surface modification WO2007047644A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72721805P 2005-10-14 2005-10-14
US60/727,218 2005-10-14

Publications (2)

Publication Number Publication Date
WO2007047644A2 WO2007047644A2 (en) 2007-04-26
WO2007047644A3 true WO2007047644A3 (en) 2007-06-21

Family

ID=37963199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/040505 WO2007047644A2 (en) 2005-10-14 2006-10-13 Method for microchannel surface modification

Country Status (1)

Country Link
WO (1) WO2007047644A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL218755B1 (en) * 2010-09-16 2015-01-30 Inst Chemii Fizycznej Polskiej Akademii Nauk Method for modification of micro-channel surfaces performed in the polycarbonate object and polycarbonate object containing a microchannel modified with this method
GB201415804D0 (en) 2014-09-08 2014-10-22 Univ Singapore Assay Device
CN110433881B (en) * 2019-09-02 2021-10-22 丹娜(天津)生物科技股份有限公司 Hydrophilic modification method for micro-fluidic chip micro-channel material

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466631A (en) * 1991-10-11 1995-11-14 Canon Kabushiki Kaisha Method for producing semiconductor articles
US20030068657A1 (en) * 2000-10-30 2003-04-10 Sru Biosystems Llc Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466631A (en) * 1991-10-11 1995-11-14 Canon Kabushiki Kaisha Method for producing semiconductor articles
US20030068657A1 (en) * 2000-10-30 2003-04-10 Sru Biosystems Llc Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor

Also Published As

Publication number Publication date
WO2007047644A2 (en) 2007-04-26

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