WO2007044616A3 - Optimized anti-cd30 antibodies - Google Patents

Optimized anti-cd30 antibodies Download PDF

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Publication number
WO2007044616A3
WO2007044616A3 PCT/US2006/039306 US2006039306W WO2007044616A3 WO 2007044616 A3 WO2007044616 A3 WO 2007044616A3 US 2006039306 W US2006039306 W US 2006039306W WO 2007044616 A3 WO2007044616 A3 WO 2007044616A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
antibodies
optimized anti
parent
fcgr
Prior art date
Application number
PCT/US2006/039306
Other languages
French (fr)
Other versions
WO2007044616A2 (en
Inventor
Gregory Alan Lazar
John R Desjarlais
Philip W Hammond
David F Carmichael
Bao-Lu Chen
Seung Y Chu
Sher Bahadur Karki
Original Assignee
Xencor Inc
Gregory Alan Lazar
John R Desjarlais
Philip W Hammond
David F Carmichael
Bao-Lu Chen
Seung Y Chu
Sher Bahadur Karki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc, Gregory Alan Lazar, John R Desjarlais, Philip W Hammond, David F Carmichael, Bao-Lu Chen, Seung Y Chu, Sher Bahadur Karki filed Critical Xencor Inc
Priority to EP06825618.9A priority Critical patent/EP1951757B1/en
Priority to US12/089,384 priority patent/US7973136B2/en
Priority to AU2006302254A priority patent/AU2006302254B2/en
Priority to JP2008534748A priority patent/JP4860703B2/en
Priority to CA2625998A priority patent/CA2625998C/en
Publication of WO2007044616A2 publication Critical patent/WO2007044616A2/en
Publication of WO2007044616A3 publication Critical patent/WO2007044616A3/en
Priority to AU2011202115A priority patent/AU2011202115A1/en
Priority to US13/163,465 priority patent/US9574006B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Abstract

An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an FcgR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.
PCT/US2006/039306 2005-10-06 2006-10-06 Optimized anti-cd30 antibodies WO2007044616A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP06825618.9A EP1951757B1 (en) 2005-10-06 2006-10-06 Optimized anti-cd30 antibodies
US12/089,384 US7973136B2 (en) 2005-10-06 2006-10-06 Optimized anti-CD30 antibodies
AU2006302254A AU2006302254B2 (en) 2005-10-06 2006-10-06 Optimized anti-CD30 antibodies
JP2008534748A JP4860703B2 (en) 2005-10-06 2006-10-06 Optimized anti-CD30 antibody
CA2625998A CA2625998C (en) 2005-10-06 2006-10-06 Optimized anti-cd30 antibodies
AU2011202115A AU2011202115A1 (en) 2005-10-06 2011-05-09 Optimized Anti-CD30 Antibodies
US13/163,465 US9574006B2 (en) 2005-10-06 2011-06-17 Optimized anti-CD30 antibodies

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US72462405P 2005-10-06 2005-10-06
US60/724,624 2005-10-06
US73799805P 2005-11-18 2005-11-18
US60/737,998 2005-11-18
US75069705P 2005-12-15 2005-12-15
US60/750,697 2005-12-15
US77659806P 2006-02-24 2006-02-24
US60/776,598 2006-02-24
US74553606P 2006-04-25 2006-04-25
US60/745,536 2006-04-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/089,384 A-371-Of-International US7973136B2 (en) 2005-10-06 2006-10-06 Optimized anti-CD30 antibodies
US13/163,465 Division US9574006B2 (en) 2005-10-06 2011-06-17 Optimized anti-CD30 antibodies

Publications (2)

Publication Number Publication Date
WO2007044616A2 WO2007044616A2 (en) 2007-04-19
WO2007044616A3 true WO2007044616A3 (en) 2007-07-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/039306 WO2007044616A2 (en) 2005-10-06 2006-10-06 Optimized anti-cd30 antibodies

Country Status (6)

Country Link
US (2) US7973136B2 (en)
EP (1) EP1951757B1 (en)
JP (1) JP4860703B2 (en)
AU (2) AU2006302254B2 (en)
CA (1) CA2625998C (en)
WO (1) WO2007044616A2 (en)

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US9200079B2 (en) 2004-11-12 2015-12-01 Xencor, Inc. Fc variants with altered binding to FcRn

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