WO2007043050A3 - Bioconjugates comprising sulfated polysaccharides and their uses - Google Patents
Bioconjugates comprising sulfated polysaccharides and their uses Download PDFInfo
- Publication number
- WO2007043050A3 WO2007043050A3 PCT/IL2006/001178 IL2006001178W WO2007043050A3 WO 2007043050 A3 WO2007043050 A3 WO 2007043050A3 IL 2006001178 W IL2006001178 W IL 2006001178W WO 2007043050 A3 WO2007043050 A3 WO 2007043050A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bioconjugates
- polypeptide
- bioactive
- sulfate
- sulfated polysaccharides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
Abstract
The present invention provides bioconjugates comprising a sulfated polysaccharide such as alginate sulfate and hyaluronan sulfate and at least one bioactive polypeptide capable of binding a sulfate group of said sulfated polysaccharide. The bioactive polypeptide can be a heparin-binding polypeptide or a positively-charged polypeptide and is preferably a peptide growth factor or a cytokine. The bioconjugates serve as delivery systems for sustained release of the bioactive polypeptides. Also provided are pharmaceutical compositions comprising the bioconjugates or comprising the sulfated polysaccharides.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06809754A EP1933879A2 (en) | 2005-10-11 | 2006-10-15 | Bioconjugates comprising sulfated polysaccharides and their uses |
EP14187527.8A EP2902040B1 (en) | 2005-10-11 | 2006-10-15 | Bioconjugates comprising sulfated polysaccharides and their use |
IL190719A IL190719A (en) | 2005-10-11 | 2008-04-08 | Bioconjugates comprising sulfated polysaccharides and their uses |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/374,279 US7517856B2 (en) | 2005-10-11 | 2005-10-11 | Bioconjugates comprising sulfated polysaccharides and their uses |
US11/374,279 | 2005-10-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007043050A2 WO2007043050A2 (en) | 2007-04-19 |
WO2007043050A3 true WO2007043050A3 (en) | 2008-07-24 |
Family
ID=37667182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IL2006/001178 WO2007043050A2 (en) | 2005-10-11 | 2006-10-15 | Bioconjugates comprising sulfated polysaccharides and their uses |
Country Status (3)
Country | Link |
---|---|
US (2) | US7517856B2 (en) |
EP (2) | EP2902040B1 (en) |
WO (1) | WO2007043050A2 (en) |
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US7517856B2 (en) * | 2005-10-11 | 2009-04-14 | Ben-Gurion University Of The Negev Research And Development Authority | Bioconjugates comprising sulfated polysaccharides and their uses |
EP2025687A1 (en) * | 2007-07-23 | 2009-02-18 | Istituto Scientifico di Chimica E Biochimica "G Ronzoni | Process for the preparation of heparanase-inhibiting sulfated hyaluronates and products obtained thereby |
IL187707A0 (en) * | 2007-11-27 | 2008-11-03 | Univ Ben Gurion | Alginate scaffold in hepatectomy |
US20110244006A1 (en) * | 2007-11-29 | 2011-10-06 | The Trustees Of Columbia University In The City Of New York | Microsphere skin treatment |
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EP2391217A4 (en) | 2009-01-28 | 2015-05-20 | Smartcells Inc | Synthetic conjugates and uses thereof |
CA2750269A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Crystalline insulin-conjugates |
JP5508438B2 (en) | 2009-01-28 | 2014-05-28 | スマートセルズ・インコーポレイテツド | Complex-based system for controlled drug delivery |
AU2010226243A1 (en) | 2009-03-20 | 2011-09-22 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
EP2408470A4 (en) | 2009-03-20 | 2012-08-29 | Smartcells Inc | Soluble non-depot insulin conjugates and uses thereof |
IT1397247B1 (en) * | 2009-05-14 | 2013-01-04 | Fidia Farmaceutici | NEW REGULATORY AGENTS OF CYTOKINIC ACTIVITY |
CN102781463A (en) * | 2009-10-07 | 2012-11-14 | 戈诺珍公司 | Methods and compositions for skin regeneration |
US8795727B2 (en) | 2009-11-09 | 2014-08-05 | Spotlight Technology Partners Llc | Fragmented hydrogels |
CN106913902A (en) | 2009-11-09 | 2017-07-04 | 聚光灯技术合伙有限责任公司 | Polysaccharide based aquagel |
WO2011078990A1 (en) * | 2009-12-14 | 2011-06-30 | Benaroya Research Institute At Virginia Mason | Hydrogels comprising hyaluronan and at least one t cell induction agent |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
CN102686235A (en) * | 2010-01-04 | 2012-09-19 | Mapi医药公司 | Depot systems comprising glatiramer or a pharmacologically acceptable salt thereof |
WO2011121036A2 (en) * | 2010-03-30 | 2011-10-06 | Vib Vzw | Induction of arteriogenesis using specific factors or by cell therapy with polarized myeloid cells |
CA2795360A1 (en) | 2010-04-16 | 2011-10-20 | Momenta Pharmaceuticals, Inc. | Tissue targeting |
EP2588594B1 (en) * | 2010-07-01 | 2022-11-30 | Regenerative Research Foundation | Methods for culturing undifferentiated cells using sustained release compositions |
JP2013535467A (en) | 2010-07-28 | 2013-09-12 | スマートセルズ・インコーポレイテツド | Recombinantly expressed insulin polypeptide and uses thereof |
US8933207B2 (en) | 2010-07-28 | 2015-01-13 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
US9068013B2 (en) | 2010-07-28 | 2015-06-30 | Smart Cells, Inc. | Recombinant lectins, binding-site modified lectins and uses thereof |
JP6062917B2 (en) | 2011-03-23 | 2017-01-18 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション | Method of treating and preventing urological inflammation |
ES2601892T3 (en) | 2011-04-21 | 2017-02-16 | Mapi Pharma Limited | Random Pentapolymer for the treatment of autoimmune diseases |
KR101388785B1 (en) * | 2011-07-25 | 2014-04-23 | 가톨릭대학교 산학협력단 | Drug Complex Consisting of Protein or Peptide Drug and Sulfate Groups-Containing Polysaccharides for Stable and Continuous drug delivery |
US9731046B2 (en) | 2012-02-21 | 2017-08-15 | Ben Gurion University Of The Negev Research And Development Authority | Hydrogel system comprising spatially separated bioactive polypeptides |
US10195252B2 (en) | 2012-08-03 | 2019-02-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Recruitment of mensenchymal cells using controlled release systems |
EP2916881B1 (en) * | 2012-11-07 | 2020-01-01 | ETH Zurich | Sulfated alginate hydrogels for cell culture and therapy |
US9931404B2 (en) * | 2013-06-10 | 2018-04-03 | Case Western Reserve University | Glycosaminoglycans for chemokine drug delivery |
AU2014300650B2 (en) | 2013-06-13 | 2019-11-21 | Orgenesis Ltd. | Cell populations, methods of transdifferention and methods of use thereof |
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WO2015070172A1 (en) * | 2013-11-08 | 2015-05-14 | The Regents Of The University Of Michigan | Efficient aqueous encapsulation and controlled release of bioactive agents |
EP3012269A1 (en) | 2014-10-20 | 2016-04-27 | Erhard Hofer | Cytokine-like 1 (CYTL1) protein and uses thereof |
MA41296A (en) | 2014-12-30 | 2017-11-07 | Orgenesis Ltd | TRANSDIFFERENTIATION PROCESSES AND METHODS FOR USING THE SAME |
EP3400074B1 (en) * | 2016-01-07 | 2021-10-20 | B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University | Compositions for generating immunotolerant responses |
WO2017175229A1 (en) * | 2016-04-07 | 2017-10-12 | B.G. Negev Technologies And Applications Ltd. | Polysaccharide compositions and uses thereof |
US11337994B2 (en) | 2016-09-15 | 2022-05-24 | University Of Utah Research Foundation | In situ gelling compositions for the treatment or prevention of inflammation and tissue damage |
CN106435831B (en) * | 2016-09-23 | 2018-07-06 | 青岛大学 | A kind of preparation method of the sodium alginate nano fiber based on self-assembly process |
EP3600553A4 (en) | 2017-03-26 | 2020-09-02 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
EP3635106A4 (en) | 2017-05-08 | 2021-01-06 | Orgenesis Ltd. | Transdifferentiated cell populations and methods of use thereof |
US11389545B2 (en) * | 2018-01-09 | 2022-07-19 | Aqua Regenerative Therapies Llc | Bioactive nanoparticles and methods for making same |
EP3768141A4 (en) * | 2018-03-23 | 2021-12-29 | Inscopix, Inc. | Reagent coated lenses |
CN109908359B (en) * | 2019-04-21 | 2022-04-29 | 西北工业大学 | Multi-drug staged continuous controlled release drug delivery system and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989012464A1 (en) * | 1988-06-14 | 1989-12-28 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
WO1999021588A1 (en) * | 1997-10-28 | 1999-05-06 | Cancer Research Campaign Technology Limited | Heparin-binding growth factor derivatives |
WO2000064481A1 (en) * | 1999-04-22 | 2000-11-02 | Eidgenössische Technische Hochschule (ETH) | Controlled release of growth factors from heparin containing matrices |
WO2001066164A1 (en) * | 1999-04-22 | 2001-09-13 | Eidgenossisch Technische Hochschule Zurich | Modified protein matrices |
EP1886696A1 (en) * | 2006-08-03 | 2008-02-13 | Endotis Pharma | Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4178361A (en) * | 1973-09-10 | 1979-12-11 | Union Corporation | Sustained release pharmaceutical composition |
US6388060B1 (en) * | 1998-11-06 | 2002-05-14 | Vascular Therapeutics Inc. | Process for the sulfation of uronic acid-containing polysaccharides |
US7517856B2 (en) * | 2005-10-11 | 2009-04-14 | Ben-Gurion University Of The Negev Research And Development Authority | Bioconjugates comprising sulfated polysaccharides and their uses |
-
2005
- 2005-10-11 US US11/374,279 patent/US7517856B2/en active Active
-
2006
- 2006-10-15 EP EP14187527.8A patent/EP2902040B1/en active Active
- 2006-10-15 WO PCT/IL2006/001178 patent/WO2007043050A2/en active Application Filing
- 2006-10-15 EP EP06809754A patent/EP1933879A2/en not_active Withdrawn
-
2007
- 2007-01-05 US US11/649,844 patent/US7642240B2/en active Active - Reinstated
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989012464A1 (en) * | 1988-06-14 | 1989-12-28 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
WO1999021588A1 (en) * | 1997-10-28 | 1999-05-06 | Cancer Research Campaign Technology Limited | Heparin-binding growth factor derivatives |
WO2000064481A1 (en) * | 1999-04-22 | 2000-11-02 | Eidgenössische Technische Hochschule (ETH) | Controlled release of growth factors from heparin containing matrices |
WO2001066164A1 (en) * | 1999-04-22 | 2001-09-13 | Eidgenossisch Technische Hochschule Zurich | Modified protein matrices |
EP1886696A1 (en) * | 2006-08-03 | 2008-02-13 | Endotis Pharma | Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins |
Non-Patent Citations (1)
Title |
---|
SCHROEDER-TEFFT J A ET AL: "Collagen and heparin matrices for growth factor delivery", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 1, 22 September 1997 (1997-09-22), pages 29 - 33, XP004125838, ISSN: 0168-3659 * |
Also Published As
Publication number | Publication date |
---|---|
EP2902040B1 (en) | 2022-03-23 |
EP1933879A2 (en) | 2008-06-25 |
WO2007043050A2 (en) | 2007-04-19 |
US20070110814A1 (en) | 2007-05-17 |
US7517856B2 (en) | 2009-04-14 |
US7642240B2 (en) | 2010-01-05 |
US20070081976A1 (en) | 2007-04-12 |
EP2902040A1 (en) | 2015-08-05 |
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