WO2007037849A3 - Compositions and methods for the intraocular transport of therapeutic agents - Google Patents
Compositions and methods for the intraocular transport of therapeutic agents Download PDFInfo
- Publication number
- WO2007037849A3 WO2007037849A3 PCT/US2006/032765 US2006032765W WO2007037849A3 WO 2007037849 A3 WO2007037849 A3 WO 2007037849A3 US 2006032765 W US2006032765 W US 2006032765W WO 2007037849 A3 WO2007037849 A3 WO 2007037849A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- therapeutic agents
- intraocular
- compositions
- transport
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006295305A AU2006295305B2 (en) | 2005-09-16 | 2006-08-23 | Compositions and methods for the intraocular transport of therapeutic agents |
BRPI0616041-7A BRPI0616041A2 (en) | 2005-09-16 | 2006-08-23 | compositions and methods for intraocular transport of therapeutic agents |
JP2008531128A JP5122460B2 (en) | 2005-09-16 | 2006-08-23 | Compositions and methods for intraocular delivery of therapeutic agents |
CA002602440A CA2602440A1 (en) | 2005-09-16 | 2006-08-23 | Compositions and methods for the intraocular transport of therapeutic agents |
EP06802088A EP1924292A2 (en) | 2005-09-16 | 2006-08-23 | Compositions and methods for the intraocular transport of therapeutic agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71794605P | 2005-09-16 | 2005-09-16 | |
US60/717,946 | 2005-09-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007037849A2 WO2007037849A2 (en) | 2007-04-05 |
WO2007037849A3 true WO2007037849A3 (en) | 2008-01-24 |
Family
ID=37668145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/032765 WO2007037849A2 (en) | 2005-09-16 | 2006-08-23 | Compositions and methods for the intraocular transport of therapeutic agents |
Country Status (7)
Country | Link |
---|---|
US (2) | US7714024B2 (en) |
EP (1) | EP1924292A2 (en) |
JP (2) | JP5122460B2 (en) |
AU (1) | AU2006295305B2 (en) |
BR (1) | BRPI0616041A2 (en) |
CA (2) | CA2602440A1 (en) |
WO (1) | WO2007037849A2 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
US20070160622A1 (en) * | 2005-12-07 | 2007-07-12 | Medivas, Llc | Method for assembling a polymer-biologic delivery composition |
BRPI0510485A (en) | 2004-04-30 | 2007-11-13 | Allergan Inc | biodegradable intravitreal tyrosine kinase inhibitor implants |
US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
US8455656B2 (en) * | 2004-04-30 | 2013-06-04 | Allergan, Inc. | Kinase inhibitors |
US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
ES2532912T3 (en) | 2005-06-01 | 2015-04-01 | Edison Pharmaceuticals, Inc. | Active redox therapeutic compounds for the treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
CA2602440A1 (en) * | 2005-09-16 | 2007-04-05 | Allergan, Inc. | Compositions and methods for the intraocular transport of therapeutic agents |
WO2007038246A2 (en) * | 2005-09-22 | 2007-04-05 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
WO2007035938A2 (en) | 2005-09-22 | 2007-03-29 | Medivas, Llc | BIS-(α-AMINO)-DIOL-DIESTER-CONTAINING POLY(ESTER AMIDE) AND POLY(ESTER URETHANE) COMPOSITIONS AND METHODS OF USE |
WO2007100652A2 (en) | 2006-02-22 | 2007-09-07 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
JP5445130B2 (en) * | 2006-05-02 | 2014-03-19 | メディバス エルエルシー | Delivery of ophthalmic drugs to the exterior or interior of the eye |
WO2007133616A2 (en) * | 2006-05-09 | 2007-11-22 | Medivas, Llc | Biodegradable water soluble polymers |
WO2008133021A1 (en) * | 2007-04-12 | 2008-11-06 | R-Tech Ueno, Ltd. | COMPOSITION FOR AMELIORATING OPTIC NERVE DISORDER COMPRISING PROSTAGLANDIN F2α COMPOUND AS ACTIVE INGREDIENT |
US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
CA2709412A1 (en) * | 2007-07-24 | 2009-01-29 | Medivas, Llc | Biodegradable cationic polymer gene transfer compositions and methods of use |
ES2600469T3 (en) * | 2008-05-23 | 2017-02-09 | National Jewish Health | A compound for use in the treatment of lesions associated with exposure to phosgene gas or chlorine gas |
JP2012500207A (en) * | 2008-08-13 | 2012-01-05 | メディバス エルエルシー | AABB-poly (depsipeptide) biodegradable polymer and method of use |
MX2011002318A (en) | 2008-09-10 | 2011-05-10 | Edison Pharmaceuticals Inc | Treatment of pervasive developmental disorders with redox-active therapeutics. |
WO2010065649A1 (en) * | 2008-12-02 | 2010-06-10 | Allergan, Inc. | Injection device |
JP2012525399A (en) | 2009-04-28 | 2012-10-22 | エジソン ファーマシューティカルズ, インコーポレイテッド | Treatment of Leber hereditary optic neuropathy and dominant hereditary optic atrophy using tocotrienol quinone |
CN102724951A (en) | 2009-11-09 | 2012-10-10 | 阿勒根公司 | Compositions and methods for stimulating hair growth |
EP2563352A4 (en) * | 2010-04-27 | 2013-11-13 | Edison Pharmaceuticals Inc | Formulations of quinones for the treatment of ophthalmic diseases |
CN103459368B (en) * | 2011-02-14 | 2016-06-08 | 阿勒根公司 | The ester derivant of bimatoprost compositions and method |
CN103748139B (en) | 2011-06-23 | 2016-08-17 | 帝斯曼知识产权资产管理有限公司 | For delivering the micron particle comprising biodegradable polyester-amide copolymer or the nano-particle of bioactivator |
US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
US20130190324A1 (en) * | 2011-12-23 | 2013-07-25 | The Regents Of The University Of Colorado, A Body Corporate | Topical ocular drug delivery |
EP2844268A4 (en) * | 2012-04-20 | 2015-11-25 | Univ Howard | Method of treating an ocular disease and compositions effective for treating an ocular disease |
CA2901280A1 (en) | 2013-02-15 | 2014-08-21 | Allergan, Inc. | Sustained drug delivery implant |
CN106061490A (en) | 2013-10-09 | 2016-10-26 | 列奥尼达斯·A·约翰逊 | Methods and compositions for treating and preventing signs or symptoms of eye disease |
WO2015060812A1 (en) * | 2013-10-21 | 2015-04-30 | Howard University | Treating ocular disease with efflux transporter inhibitors |
PT3351239T (en) | 2013-10-31 | 2020-07-03 | Allergan Inc | Prostamide-containing intraocular implants and methods of use thereof |
CN107106509B (en) | 2014-12-18 | 2021-11-30 | 帝斯曼知识产权资产管理有限公司 | Drug delivery system for delivering acid sensitive drugs |
WO2016109457A1 (en) * | 2014-12-29 | 2016-07-07 | Orange County Glaucoma | Compositions and methods for treating glaucoma |
KR101723168B1 (en) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | Medium Composition for Preparing Botulinum Toxin |
CN113024369A (en) | 2015-12-17 | 2021-06-25 | Ptc医疗公司 | Compounds for the treatment of oxidative stress disorders |
US20230277521A1 (en) * | 2022-03-07 | 2023-09-07 | Harrow Ip, Llc | Extended-release pharmaceutical compositions for treating eye conditions |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003048190A2 (en) * | 2001-12-04 | 2003-06-12 | The Curators Of The University Of Missouri | Acyclovir-peptide analogs |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995003009A1 (en) * | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
US5443505A (en) * | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US6294563B1 (en) * | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
US6369116B1 (en) * | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
US6669951B2 (en) * | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
US6726918B1 (en) * | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
DE60114229T2 (en) * | 2000-11-29 | 2006-07-06 | Allergan, Inc., Irvine | PREVENTING TRANSPLANT DISCHARGE IN THE EYE |
EP1418903A2 (en) * | 2001-04-23 | 2004-05-19 | The Board of Regents of the University of Texas System | Prostanoids augment ocular drug penetration |
CN1313155C (en) | 2002-03-18 | 2007-05-02 | 诺瓦提斯公司 | Topical composition comprising a cyclofructan, a carrier and a drug |
JP2004279509A (en) * | 2003-03-13 | 2004-10-07 | Toyota Motor Corp | Method and system for advertisement distribution, center, and advertisement display device |
KR101091461B1 (en) * | 2003-11-07 | 2011-12-07 | 센주 세이야꾸 가부시키가이샤 | Pharmaceutical composition containing prostaglandin |
US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US7931909B2 (en) | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
CA2602440A1 (en) | 2005-09-16 | 2007-04-05 | Allergan, Inc. | Compositions and methods for the intraocular transport of therapeutic agents |
-
2006
- 2006-08-23 CA CA002602440A patent/CA2602440A1/en not_active Abandoned
- 2006-08-23 EP EP06802088A patent/EP1924292A2/en not_active Withdrawn
- 2006-08-23 BR BRPI0616041-7A patent/BRPI0616041A2/en not_active Application Discontinuation
- 2006-08-23 AU AU2006295305A patent/AU2006295305B2/en not_active Ceased
- 2006-08-23 JP JP2008531128A patent/JP5122460B2/en not_active Expired - Fee Related
- 2006-08-23 WO PCT/US2006/032765 patent/WO2007037849A2/en active Application Filing
- 2006-08-23 CA CA2850858A patent/CA2850858A1/en not_active Abandoned
- 2006-09-15 US US11/521,872 patent/US7714024B2/en active Active
-
2010
- 2010-03-23 US US12/730,102 patent/US8637571B2/en active Active
-
2012
- 2012-09-04 JP JP2012194322A patent/JP5567082B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003048190A2 (en) * | 2001-12-04 | 2003-06-12 | The Curators Of The University Of Missouri | Acyclovir-peptide analogs |
US20050043246A1 (en) * | 2001-12-04 | 2005-02-24 | The Curators Of The University Of Missouri | Acyclovir-peptide analogs |
Non-Patent Citations (4)
Title |
---|
CUNHA-VAZ J G: "The blood-ocular barriers: past, present, and future.", DOCUMENTA OPHTHALMOLOGICA. ADVANCES IN OPHTHALMOLOGY 1997, vol. 93, no. 1-2, 1997, pages 149 - 157, XP002447887, ISSN: 0012-4486 * |
DUYVURI S ET AL: "Drug delivery to the retina: challenges and opportunities", EXPERT OPINION ON BIOLOGICAL THERAPY, ASHLEY, LONDON, GB, vol. 3, no. 1, 2003, pages 46 - 56, XP008082736, ISSN: 1471-2598 * |
HAN ET AL: "Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 273, no. 11, 1998, pages 6001 - 6004, XP002147114, ISSN: 0021-9258 * |
KIM IN-BEOM ET AL: "Immunocytochemical localization of Aquaporin 1 in the rat retina", NEUROSCIENCE LETTERS, vol. 244, no. 1, 6 March 1998 (1998-03-06), pages 52 - 54, XP002447954, ISSN: 0304-3940 * |
Also Published As
Publication number | Publication date |
---|---|
JP5122460B2 (en) | 2013-01-16 |
AU2006295305A1 (en) | 2007-04-05 |
CA2602440A1 (en) | 2007-04-05 |
AU2006295305B2 (en) | 2013-01-31 |
US7714024B2 (en) | 2010-05-11 |
BRPI0616041A2 (en) | 2011-06-07 |
JP5567082B2 (en) | 2014-08-06 |
US20070066541A1 (en) | 2007-03-22 |
CA2850858A1 (en) | 2007-04-05 |
JP2009508857A (en) | 2009-03-05 |
EP1924292A2 (en) | 2008-05-28 |
WO2007037849A2 (en) | 2007-04-05 |
US20100222587A1 (en) | 2010-09-02 |
JP2013014600A (en) | 2013-01-24 |
US8637571B2 (en) | 2014-01-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007037849A3 (en) | Compositions and methods for the intraocular transport of therapeutic agents | |
WO2008034013A3 (en) | Medical devices and methods of making the same | |
WO2007133290A3 (en) | Anti-ox40l antibodies and methods using same | |
WO2008052187A3 (en) | Antibodies and immunoconjugates and uses therefor | |
WO2007130697A3 (en) | Anti-ephb4 antibodies and methods using same | |
WO2007127834A3 (en) | Compositions and methods of preparation thereof | |
WO2006124713A3 (en) | 4-biarylyl-1-phenylazetidin-2-ones | |
WO2007146965A3 (en) | Compounds for the treatment of periodontal disease | |
WO2007140371A8 (en) | Antibodies and immunoconjugates and uses therefor | |
WO2007044026A3 (en) | Compositions comprising modified collagen and uses therefore | |
WO2008060705A8 (en) | Anti-dll4 antibodies and methods using same | |
WO2006127768A3 (en) | Microscale micropatterned engineered in vitor tissue | |
WO2008121767A3 (en) | Stitched polypeptides | |
WO2005110396A3 (en) | Nitrated lipids and methods of making and using thereof | |
WO2008100805A3 (en) | Anti-robo4 antibodies and uses therefor | |
EP1971372A4 (en) | Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same | |
WO2006115847A3 (en) | Coated endoprostheses | |
WO2006119329A3 (en) | Compositions and methods for the treatment of neurodegenerative diseases | |
WO2006026759A3 (en) | Humanized anti-beta7 antagonists and uses therefor | |
WO2006133271A3 (en) | Compositions and methods relating to target-specific photodynamic therapy | |
WO2008027600A3 (en) | Imatinib compositions | |
WO2007075987A3 (en) | Active surface coupled polymerases | |
WO2008066630A3 (en) | Methods for reprogramming adult somatic cells and uses thereof | |
WO2005108428A3 (en) | Cd40 splice variants and their uses | |
WO2007127506A3 (en) | Anti-ephrinb2 antibodies and methods using same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) | ||
ENP | Entry into the national phase |
Ref document number: 2602440 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006295305 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2006295305 Country of ref document: AU Date of ref document: 20060823 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006802088 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2008531128 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: PI0616041 Country of ref document: BR Kind code of ref document: A2 Effective date: 20080314 |