WO2007034282A3 - Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists - Google Patents

Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists Download PDF

Info

Publication number
WO2007034282A3
WO2007034282A3 PCT/IB2006/002568 IB2006002568W WO2007034282A3 WO 2007034282 A3 WO2007034282 A3 WO 2007034282A3 IB 2006002568 W IB2006002568 W IB 2006002568W WO 2007034282 A3 WO2007034282 A3 WO 2007034282A3
Authority
WO
WIPO (PCT)
Prior art keywords
diaryl
heterocycle
receptor antagonists
imidazole compounds
compounds condensed
Prior art date
Application number
PCT/IB2006/002568
Other languages
French (fr)
Other versions
WO2007034282A2 (en
Inventor
Michelle Marie Claffey
Steven Wayne Goldstein
Stanley Jung
Arthur Nagel
Volker Shulze
Original Assignee
Pfizer Prod Inc
Michelle Marie Claffey
Steven Wayne Goldstein
Stanley Jung
Arthur Nagel
Volker Shulze
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Michelle Marie Claffey, Steven Wayne Goldstein, Stanley Jung, Arthur Nagel, Volker Shulze filed Critical Pfizer Prod Inc
Publication of WO2007034282A2 publication Critical patent/WO2007034282A2/en
Publication of WO2007034282A3 publication Critical patent/WO2007034282A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Aryl substituted imidazo[4,5-c] pyridine compounds are provided. These compounds are useful in pharmaceutical compositions as C3a antagonists for treating a variety of medical conditions associated with the Complement cascade. Methods for treating such conditions are also provided.
PCT/IB2006/002568 2005-09-19 2006-09-18 Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists WO2007034282A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71851705P 2005-09-19 2005-09-19
US60/718,517 2005-09-19

Publications (2)

Publication Number Publication Date
WO2007034282A2 WO2007034282A2 (en) 2007-03-29
WO2007034282A3 true WO2007034282A3 (en) 2007-05-18

Family

ID=37807741

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002568 WO2007034282A2 (en) 2005-09-19 2006-09-18 Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists

Country Status (1)

Country Link
WO (1) WO2007034282A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11566026B2 (en) 2016-12-22 2023-01-31 Incyte Corporation Heterocyclic compounds as immunomodulators

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ551144A (en) 2004-05-26 2009-12-24 Eisai R&D Man Co Ltd Cinnamide compound
DE602005019602D1 (en) 2004-10-26 2010-04-08 Eisai R&D Man Co Ltd AMORPHIC FORM OF A CINEMA ACID AMID CONNECTION
BRPI0618814A2 (en) 2005-11-24 2014-04-29 Eisai R&D Man Co Ltd COMPOUND OR PHARMACOLOGICALLY ACCEPTABLE SALT OF THE SAME, AND PHARMACEUTICAL AGENT
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
AR062095A1 (en) 2006-07-28 2008-10-15 Eisai R&D Man Co Ltd CINAMIDE COMPOUND PROFARMACO
WO2008027812A2 (en) 2006-08-28 2008-03-06 Forest Laboratories Holdings Limited Imidazopyridine and imidazopyrimidine derivatives
AU2007292924A1 (en) * 2006-09-07 2008-03-13 Biogen Idec Ma Inc. IRAK modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder
EP1964841A1 (en) * 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]azine and their use as pharmaceuticals
TW200848054A (en) 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
JP5433418B2 (en) * 2007-08-31 2014-03-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 Polycyclic compound
CA2694114C (en) 2007-09-05 2016-10-04 The Governors Of The University Of Alberta Method for the organocatalytic activation of carboxylic acids for chemical reactions using orthosubstituted arylboronic acids
JPWO2009057577A1 (en) * 2007-10-30 2011-03-10 日本メジフィジックス株式会社 Use and production methods of novel amyloid affinity compounds
US8445674B2 (en) 2009-10-21 2013-05-21 Hoffmann-La Roche Inc Heterocyclyl compounds
AU2011229423B2 (en) * 2010-03-18 2015-12-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anti-infective compounds
US8410117B2 (en) * 2010-03-26 2013-04-02 Hoffmann-La Roche Inc. Imidazopyrimidine derivatives
JP2013544891A (en) 2010-12-08 2013-12-19 ヴァンダービルト ユニバーシティー Bicyclic pyrazole compounds as allosteric modulators of the mGLUR5 receptor
JP2014508172A (en) * 2011-03-15 2014-04-03 ヴァンダービルト ユニバーシティー Substituted imidazopyrimidin-5 (6H) -ones as allosteric modulators of the MGLUR5 receptor
WO2012174591A1 (en) * 2011-06-20 2012-12-27 The University Of Queensland Prevention and treatment of acute inflammatory conditions
EP3524258A1 (en) 2011-06-22 2019-08-14 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
US8975276B2 (en) 2011-06-29 2015-03-10 Bristol-Myers Squibb Company Inhibitors of PDE10
EP2767532B1 (en) 2012-12-21 2016-07-13 National Institutes for Quantum and Radiological Science and Technology Novel compound for imaging tau protein accumulated in the brain
EP2951170B1 (en) 2013-02-04 2018-10-24 Janssen Pharmaceutica NV Flap modulators
TWI644899B (en) 2013-02-04 2018-12-21 健生藥品公司 Flap modulators
RU2665580C2 (en) * 2013-05-23 2018-08-31 Ф. Хоффманн-Ля Рош Аг 2-phenylimidazo[1,2-a]pyrimidines as imaging agents
US10933049B2 (en) 2015-06-03 2021-03-02 The University Of Queensland Mobilizing agents and uses therefor
US20170107216A1 (en) 2015-10-19 2017-04-20 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2017087777A1 (en) 2015-11-19 2017-05-26 Incyte Corporation Heterocyclic compounds as immunomodulators
CN105439965B (en) * 2015-11-20 2018-05-22 江苏恒安化工有限公司 The synthetic method of quinoxaline heterocycle and its derivative
MX2018007774A (en) 2015-12-22 2018-11-09 Incyte Corp Heterocyclic compounds as immunomodulators.
ES2906460T3 (en) 2016-05-06 2022-04-18 Incyte Corp Heterocyclic compounds as immunomodulators
TW201808902A (en) 2016-05-26 2018-03-16 美商英塞特公司 Heterocyclic compounds as immunomodulators
IL263825B (en) 2016-06-20 2022-08-01 Incyte Corp Heterocyclic compounds as immunomodulators
WO2018013789A1 (en) 2016-07-14 2018-01-18 Incyte Corporation Heterocyclic compounds as immunomodulators
ES2941716T3 (en) 2016-08-29 2023-05-25 Incyte Corp Heterocyclic compounds as immunomodulators
CN106588673B (en) * 2016-12-20 2018-06-26 金凯(辽宁)化工有限公司 A kind of preparation method of 2- methyl -5- 5 amido benzotrifluorides
CA3047980A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers
ES2899402T3 (en) 2016-12-22 2022-03-11 Incyte Corp Pyridine derivatives as immunomodulators
CA3047986A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
RS64055B1 (en) 2018-03-30 2023-04-28 Incyte Corp Heterocyclic compounds as immunomodulators
MX2020011959A (en) * 2018-05-09 2021-02-17 Aprinoia Therapeutics Ltd Heteroaryl compounds and uses thereof.
EP4219492A1 (en) 2018-05-11 2023-08-02 Incyte Corporation Heterocyclic compounds as immunomodulators
JP2022544189A (en) 2019-08-09 2022-10-17 インサイト・コーポレイション Salts of PD-1/PD-L1 inhibitors
CA3155852A1 (en) 2019-09-30 2021-04-08 Incyte Corporation Pyrido[3,2-d]pyrimidine compounds as immunomodulators
JP2023500395A (en) 2019-11-11 2023-01-05 インサイト・コーポレイション Salts and Crystal Forms of PD-1/PD-L1 Inhibitors
CA3161455A1 (en) 2019-11-13 2021-05-20 Aprinoia Therapeutics Limited Compounds for degrading tau protein aggregates and uses thereof
KR20230117573A (en) 2020-11-06 2023-08-08 인사이트 코포레이션 Methods for preparing PD-1 and PD-L1 inhibitors and salts and crystalline forms thereof
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2343748A1 (en) * 1976-03-10 1977-10-07 Metabio 2,3-DIHYDRO IMIDAZO (2,1-B) THIAZOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
EP0404190A1 (en) * 1989-06-23 1990-12-27 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
WO1999015490A1 (en) * 1997-09-23 1999-04-01 Smithkline Beecham Corporation C3a receptor ligands
JPH11116481A (en) * 1997-10-06 1999-04-27 Sumitomo Pharmaceut Co Ltd Stat6 activation inhibitor
WO2001057038A1 (en) * 2000-02-01 2001-08-09 Basf Aktiengesellschaft Heterocyclic compounds and their use as parp inhibitors
US6551723B1 (en) * 1998-08-18 2003-04-22 Fuji Photo Film Co., Ltd. Organic electroluminescence element material and organic electroluminescence element comprising same
JP2003277743A (en) * 2002-03-22 2003-10-02 Idemitsu Kosan Co Ltd Material for organic electroluminescent element and organic electroluminescent element obtained using the same
WO2004063159A1 (en) * 2003-01-10 2004-07-29 Idemitsu Kosan Co., Ltd. Nitrogenous heterocyclic derivative and organic electroluminescent element employing the same
WO2005043630A1 (en) * 2003-10-31 2005-05-12 Idemitsu Kosan Co., Ltd. Organic thin film transistor

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2343748A1 (en) * 1976-03-10 1977-10-07 Metabio 2,3-DIHYDRO IMIDAZO (2,1-B) THIAZOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
EP0404190A1 (en) * 1989-06-23 1990-12-27 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
WO1999015490A1 (en) * 1997-09-23 1999-04-01 Smithkline Beecham Corporation C3a receptor ligands
JPH11116481A (en) * 1997-10-06 1999-04-27 Sumitomo Pharmaceut Co Ltd Stat6 activation inhibitor
US6551723B1 (en) * 1998-08-18 2003-04-22 Fuji Photo Film Co., Ltd. Organic electroluminescence element material and organic electroluminescence element comprising same
WO2001057038A1 (en) * 2000-02-01 2001-08-09 Basf Aktiengesellschaft Heterocyclic compounds and their use as parp inhibitors
JP2003277743A (en) * 2002-03-22 2003-10-02 Idemitsu Kosan Co Ltd Material for organic electroluminescent element and organic electroluminescent element obtained using the same
WO2004063159A1 (en) * 2003-01-10 2004-07-29 Idemitsu Kosan Co., Ltd. Nitrogenous heterocyclic derivative and organic electroluminescent element employing the same
EP1582516A1 (en) * 2003-01-10 2005-10-05 Idemitsu Kosan Co., Ltd. Nitrogenous heterocyclic derivative and organic electroluminescent element employing the same
WO2005043630A1 (en) * 2003-10-31 2005-05-12 Idemitsu Kosan Co., Ltd. Organic thin film transistor
EP1679747A1 (en) * 2003-10-31 2006-07-12 Idemitsu Kosan Co., Ltd. Organic thin film transistor

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
A. ANDREANI, M.RAMBALDI, A. LOCATELLI, AM. ISETTA: "synthesis and mitogenic activity of new imidazo[2,1-b]thiazoles", EUR. J. MED., vol. 26, 1991, pages 335 - 337, XP009080499 *
B. MEKONNEN, G. CRANK, D. CRAIG: "a new and facile synthesis of imidazo[2,1-b]oxazoles", J. HETEROCYCLIC CHEM., vol. 34, 1997, pages 589 - 599, XP002424348 *
BARLIN G B ET AL: "IMIDAZO1,2-BPYRIDAZINES. XXI. SYNTHESES OF SOME 3-ACYLAMINOMETHYL-6-(CHLORO AND IODO)-2-(SUBSTITUTED PHENYL) IMIDAZO1,2-BPYRIDAZINES AND -IMIDAZO 1,2-APYRIDINES AND THEIR INTERACTION WITH CENTRAL AND MITOCHONDRIAL BENZODIAZEPINE RECEPTORS", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 50, 1997, pages 61 - 67, XP001007026, ISSN: 0004-9425 *
BUU-HOI, NG. PH. ET AL: "Biphenyl analogs of p-hydroxypropiophenone", RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS ET DE LA BELGIQUE , 72, 774-80 CODEN: RTCPB4; ISSN: 0370-7539, 1953, XP002016690 *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002424408, Database accession no. beilstein RN : 1022905 *
F. BARBA, B. BATANERO: "a novel and convenient electrochemical synthesis of 3,7-diaryl-2H-imidazo[2,1-b][1,3,4]oxadiazines", JOURNAL OF ORGANIC CHEMISTRY, vol. 58, no. 24, 1993, pages 6889 - 6891, XP009080473 *
FANG, CHONGBO ET AL: "Synthesis and luteal cell killing activity of 2-substituted phenyl-1,2,4- triazolo [5,1-a]pyridine derivatives", ZHONGGUO YAOWU HUAXUE ZAZHI , 12(3), 134-137, 163 CODEN: ZYHZEF; ISSN: 1005-0108, 2002, XP009080425 *
G. B. BARLIN, L.P. DAVIES, S.J. IRELAND, J. ZHANG: "Imidazo1,2-b]pyridazines. part XIII", AUST. J. CHEM., vol. 45, 1992, pages 1281 - 1300, XP009080477 *
GRANT E B ET AL: "Design, synthesis, and biological activity of diiminoisoindolines as complement component 3a antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 11, no. 21, 2001, pages 2817 - 2820, XP002984323, ISSN: 0960-894X *
ISMAIL, MOHAMED A. ET AL: "Novel Dicationic Imidazo[1,2-a]pyridines and 5,6,7,8-Tetrahydro- imidazo[1,2-a]pyridines as Antiprotozoal Agents", JOURNAL OF MEDICINAL CHEMISTRY , 47(14), 3658-3664 CODEN: JMCMAR; ISSN: 0022-2623, 2004, XP002424347 *
LIU, TAO ET AL: "Non-steroidal pregnancy-terminating agents: design, synthesis and structure-activity relationships of 2-aryl-1,2,4- triazolo [1,5-a]pyridine", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 12(17), 2411-2413 CODEN: BMCLE8; ISSN: 0960-894X, 2002, XP002424346 *
PAUCHARD, JEAN PAUL ET AL: "Anil synthesis. 17. Preparation of styryl derivatives of 2-phenyl-4H-1,2,4- triazolo [1,5-a]pyridine", HELVETICA CHIMICA ACTA , 61(1), 142-70 CODEN: HCACAV; ISSN: 0018-019X, 1978, XP002424345 *
S.N. SAWHNEY, D.R. KODALI, G.S. DHINDSA, S.P. SINGH: "synthesis & antiinflammatory activity of some arylimidazo[2,1-b]thiazolyl- & arylimidazo[2,1-b]benzothiazolyl-acetic acids", INDIAN JOURNAL OF CHEMISTRY, vol. 21b, February 1982 (1982-02-01), pages 134 - 138, XP009080136 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11566026B2 (en) 2016-12-22 2023-01-31 Incyte Corporation Heterocyclic compounds as immunomodulators

Also Published As

Publication number Publication date
WO2007034282A2 (en) 2007-03-29

Similar Documents

Publication Publication Date Title
WO2007034282A3 (en) Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists
WO2007034278A3 (en) Fused imidazole derivatives as c3a receptor antagonists
WO2006126081A3 (en) Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors
WO2007028135A3 (en) Imidazopyridine compounds
WO2006126082A3 (en) Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
WO2007073432A3 (en) Piperidine derivatives and methods of use
WO2007034279A3 (en) C3a antagonists and pharmaceutical compositions thereof
WO2007022257A3 (en) Monocyclic and bicyclic compounds and methods of use
IL185611A0 (en) Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same
WO2007027734A3 (en) Bicyclic and bridged nitrogen heterocycles
WO2007002293A3 (en) Azaindazole compounds and methods of use
WO2008048867A3 (en) Bicyclic heteroaromatic compounds
WO2007059230A3 (en) Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
WO2007052023A3 (en) Novel compounds
WO2008048589A3 (en) Compounds and methods for treatment of hcv
MX2009012567A (en) 3-(imidazolyl)-pyrazolo[3,4-b]pyridines.
MX2007006387A (en) 3-substituted pyridine derivatives as h3 antagonists.
WO2006088903A3 (en) Pyrazole compounds
ZA200709094B (en) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility
ZA200709090B (en) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility
HK1110782A1 (en) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroqe inoline derivatives as medicaments for the treatment of infertility
WO2006031782A3 (en) Salvinorin derivatives as opioid receptor ligands
WO2007104485A3 (en) Substituted imidazo[2,1-b]thiazole compounds and their use for producing drugs
IL205156A0 (en) (1,4-diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone ligands for nicotinic acetylcholine receptors, useful for the treatment of disease
WO2009076408A3 (en) 3 -carboxypropyl-aminotetralin derivatives as mu opioid receptor antagonists

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06820755

Country of ref document: EP

Kind code of ref document: A2