WO2007033318A3 - Continuous spectroscopic measurement of total hemoglobin - Google Patents

Continuous spectroscopic measurement of total hemoglobin Download PDF

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Publication number
WO2007033318A3
WO2007033318A3 PCT/US2006/035830 US2006035830W WO2007033318A3 WO 2007033318 A3 WO2007033318 A3 WO 2007033318A3 US 2006035830 W US2006035830 W US 2006035830W WO 2007033318 A3 WO2007033318 A3 WO 2007033318A3
Authority
WO
WIPO (PCT)
Prior art keywords
total hemoglobin
multiple wavelengths
spectroscopic measurement
measuring
comparison
Prior art date
Application number
PCT/US2006/035830
Other languages
French (fr)
Other versions
WO2007033318A2 (en
Inventor
Michael J Higgins
Original Assignee
Edwards Lifesciences Corp
Michael J Higgins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edwards Lifesciences Corp, Michael J Higgins filed Critical Edwards Lifesciences Corp
Priority to JP2008530038A priority Critical patent/JP2009507569A/en
Priority to EP06803589A priority patent/EP1924195A2/en
Priority to CA2610753A priority patent/CA2610753C/en
Publication of WO2007033318A2 publication Critical patent/WO2007033318A2/en
Publication of WO2007033318A3 publication Critical patent/WO2007033318A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal

Abstract

Methods for measuring the total hemoglobin of whole blood include measuring reflective light at multiple wavelengths within the visible spectrum, calculating light absorbance at each of the multiple wavelengths, performing a comparison in a change in like absorbance between the multiple wavelengths, and/or relating the comparison to total hemoglobin. A system for measuring total hemoglobin of whole blood may include at least one light source, a catheter, optical fibers, at least one photodetector, data processing circuitry, and/or a display unit.
PCT/US2006/035830 2005-09-13 2006-09-13 Continuous spectroscopic measurement of total hemoglobin WO2007033318A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008530038A JP2009507569A (en) 2005-09-13 2006-09-13 Continuous spectroscopic measurement of total hemoglobin
EP06803589A EP1924195A2 (en) 2005-09-13 2006-09-13 Continuous spectroscopic measurement of total hemoglobin
CA2610753A CA2610753C (en) 2005-09-13 2006-09-13 Continuous spectroscopic measurement of total hemoglobin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71669505P 2005-09-13 2005-09-13
US60/716,695 2005-09-13

Publications (2)

Publication Number Publication Date
WO2007033318A2 WO2007033318A2 (en) 2007-03-22
WO2007033318A3 true WO2007033318A3 (en) 2007-05-03

Family

ID=37499523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/035830 WO2007033318A2 (en) 2005-09-13 2006-09-13 Continuous spectroscopic measurement of total hemoglobin

Country Status (6)

Country Link
US (3) US7426407B2 (en)
EP (1) EP1924195A2 (en)
JP (1) JP2009507569A (en)
CN (1) CN101232843A (en)
CA (2) CA2824033A1 (en)
WO (1) WO2007033318A2 (en)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892178B1 (en) * 2009-09-28 2011-02-22 Impact Sports Technologies, Inc. Monitoring device for an interactive game
US20070081626A1 (en) * 2005-02-14 2007-04-12 Peter Rule Method and apparatus for enhancing accuracy of an analyte detection system
US20070083094A1 (en) * 2005-10-11 2007-04-12 Colburn Joel C Medical sensor and technique for using the same
US20070106134A1 (en) 2005-11-10 2007-05-10 O'neil Michael P Medical sensor and technique for using the same
US10188348B2 (en) 2006-06-05 2019-01-29 Masimo Corporation Parameter upgrade system
WO2008030927A2 (en) * 2006-09-06 2008-03-13 Optiscan Biomedical Corporation Infusion flow interruption method and apparatus
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8449834B2 (en) * 2006-09-25 2013-05-28 Covidien Lp Carbon dioxide detector having borosilicate substrate
US8431087B2 (en) 2006-09-25 2013-04-30 Covidien Lp Carbon dioxide detector having borosilicate substrate
US8431088B2 (en) * 2006-09-25 2013-04-30 Covidien Lp Carbon dioxide detector having borosilicate substrate
US8420405B2 (en) 2006-09-25 2013-04-16 Covidien Lp Carbon dioxide detector having borosilicate substrate
US8396524B2 (en) * 2006-09-27 2013-03-12 Covidien Lp Medical sensor and technique for using the same
US8175667B2 (en) 2006-09-29 2012-05-08 Nellcor Puritan Bennett Llc Symmetric LED array for pulse oximetry
US8068891B2 (en) 2006-09-29 2011-11-29 Nellcor Puritan Bennett Llc Symmetric LED array for pulse oximetry
US7880626B2 (en) 2006-10-12 2011-02-01 Masimo Corporation System and method for monitoring the life of a physiological sensor
KR101031932B1 (en) * 2007-01-29 2011-04-29 박종일 A method of multispectral imaging and an apparatus thereof
EP1987762A1 (en) * 2007-05-03 2008-11-05 F.Hoffmann-La Roche Ag Oximeter
US8412293B2 (en) * 2007-07-16 2013-04-02 Optiscan Biomedical Corporation Systems and methods for determining physiological parameters using measured analyte values
DE102007035847A1 (en) 2007-07-31 2009-02-05 Iprm Intellectual Property Rights Management Ag Catheter system with optical probe and method for applying an optical probe to a catheter system
US8577434B2 (en) * 2007-12-27 2013-11-05 Covidien Lp Coaxial LED light sources
US9560994B2 (en) 2008-03-26 2017-02-07 Covidien Lp Pulse oximeter with adaptive power conservation
US9339221B1 (en) 2009-03-24 2016-05-17 Vioptix, Inc. Diagnosing intestinal ischemia based on oxygen saturation measurements
US8571619B2 (en) * 2009-05-20 2013-10-29 Masimo Corporation Hemoglobin display and patient treatment
US9579039B2 (en) 2011-01-10 2017-02-28 Masimo Corporation Non-invasive intravascular volume index monitor
EP2498675A1 (en) * 2009-11-12 2012-09-19 Nellcor Puritan Bennett LLC Systems and methods for combined physiological sensors
KR101247371B1 (en) 2009-11-24 2013-03-26 연세대학교 산학협력단 Method for mesuring intra/extracellular hemoglobin difference of erythrocyte using photothermal effect
US20130052136A1 (en) * 2010-03-23 2013-02-28 Fresenius Medical Care Deutschland Gmbh Methods and apparatuses for predicting the effects of erythropoiesis stimulating agents, and for determining a dose to be administered
US8553223B2 (en) 2010-03-31 2013-10-08 Covidien Lp Biodegradable fibers for sensing
WO2011137115A1 (en) * 2010-04-29 2011-11-03 Eye02 Scan Llc Determination of oxygen saturation in a tissue of visual system
JPWO2012014551A1 (en) * 2010-07-27 2013-09-12 コニカミノルタ株式会社 Detection device and detection method for intermolecular interaction
CN101915741B (en) * 2010-08-03 2012-05-30 宁波大学 Portable hemoglobin solution measurement system and measurement method thereof
HUE035444T2 (en) * 2010-08-03 2018-05-28 Fresenius Medical Care Deutschland Gmbh Method and apparatuses for predicting the effects of erythropoesis stimulating agents (ESA), and for determining a dose to be administered
US8649838B2 (en) 2010-09-22 2014-02-11 Covidien Lp Wavelength switching for pulse oximetry
WO2012047851A1 (en) 2010-10-08 2012-04-12 Edwards Lifesciences Corporation Continuous measurement of total hemoglobin
US20130310668A1 (en) * 2010-10-08 2013-11-21 Edwards Lifesciences Corporation System, method and computer program product for optical measurement of blood parameters
US8818473B2 (en) 2010-11-30 2014-08-26 Covidien Lp Organic light emitting diodes and photodetectors
US9341515B2 (en) * 2011-02-11 2016-05-17 University Of Central Florida Research Foundation, Inc. Optical absorbance measurement apparatus, method, and applications
CN102160777B (en) * 2011-03-10 2013-07-03 中国人民解放军第三军医大学第一附属医院 Body fluid bioinformation fiber dynamic testing system
EP2549264A1 (en) 2011-07-18 2013-01-23 Siemens Healthcare Diagnostics Products GmbH Method and system for determining the concentration of substances in bodily fluids
US8623660B2 (en) * 2011-09-30 2014-01-07 Lifescan Scotland Limited Hand-held test meter with phase-shift-based hematocrit measurement circuit
EP2780705B1 (en) 2011-11-16 2018-09-19 Becton, Dickinson and Company Methods and systems for detecting an analyte in a sample
JP5901327B2 (en) * 2012-02-09 2016-04-06 キヤノン株式会社 Developing device, process cartridge, and image forming apparatus
JP5901012B2 (en) * 2012-02-13 2016-04-06 国立大学法人 東京医科歯科大学 Blood information measuring method and apparatus
US20150029492A1 (en) * 2012-04-09 2015-01-29 Mec Dynamics Corporation Measurement of total hemoglobin in whole blood
TWI472746B (en) * 2012-07-19 2015-02-11 Nat Univ Chung Cheng Multiplex fiber optical biosensor and detection method by using the same
CN103630506B (en) * 2012-08-20 2016-10-26 台医光电科技股份有限公司 Detection module and detection device
CN103908262B (en) * 2012-12-28 2016-04-27 财团法人工业技术研究院 Physiological signal measuring apparatus and physiological signal measurements method
BR112015010695B1 (en) 2013-01-11 2023-03-07 Becton, Dickinson And Company MICROFLUID DEVICE AND METHOD FOR PERFORMING A LIQUID SAMPLE TEST, METHOD FOR FORMING A MICROFLUID DEVICE, SYSTEM AND KIT
US10690684B2 (en) * 2013-05-10 2020-06-23 Majelco Medical, Inc. Apparatus and system for measuring volume of blood loss
WO2014183003A1 (en) * 2013-05-10 2014-11-13 University Of Utah Research Foundation Devices, systems, and methods for measuring blood loss
WO2015009970A1 (en) 2013-07-18 2015-01-22 Erythron Llc Spectroscopic measurements with parallel array detector
CN103471982B (en) * 2013-08-23 2015-11-25 深圳中科强华科技有限公司 A kind of blood cell analysis chip, analyser and analytical approach
ES2856191T3 (en) 2013-11-06 2021-09-27 Becton Dickinson Co Microfluidic devices and methods of using them
BR112016010721B1 (en) 2013-11-13 2021-06-01 Becton, Dickinson And Company METHOD AND SYSTEM OF ANALYSIS OF A SAMPLE FOR AN ANALYTE
US10188330B1 (en) 2014-02-05 2019-01-29 Covidien Lp Methods and systems for determining a light drive parameter limit in a physiological monitor
EP4218559A1 (en) 2014-02-25 2023-08-02 ICU Medical, Inc. Patient monitoring system with gatekeeper signal
WO2015131151A2 (en) 2014-02-28 2015-09-03 Erythron, Llc Method and apparatus for determining markers of health by analysis of blood
US10098576B2 (en) 2014-03-14 2018-10-16 Covidien Lp Regional saturation shock detection method and system
SG11201606297UA (en) 2014-10-14 2016-08-30 Becton Dickinson Co Blood sample management using open cell foam
BR112017007534B1 (en) 2014-10-14 2022-09-27 Becton, Dickinson And Company SPECIMEN TRANSFER DEVICE, SPECIMEN TRANSFER AND TESTING SYSTEM COMPRISING SUCH SPECIMEN TRANSFER AND LANCET DEVICE AND DEVICE
US10231667B2 (en) 2014-10-31 2019-03-19 Koninklijke Philips N.V. Non-invasive dehydration monitoring
US10126433B2 (en) * 2014-11-10 2018-11-13 Halliburton Energy Services, Inc. Energy detection apparatus, methods, and systems
EP3051271A1 (en) * 2015-01-27 2016-08-03 Siemens Healthcare Diagnostics Products GmbH Method for assaying lipids and other interferents in body fluid samples
EP3154697B1 (en) 2015-03-10 2018-06-20 Becton, Dickinson and Company Biological fluid micro-sample management device
WO2016168090A1 (en) 2015-04-14 2016-10-20 Nueon, Inc. Method and apparatus for determining markers of health by analysis of blood
JP6406135B2 (en) * 2015-06-10 2018-10-17 Tdk株式会社 Biological signal measuring device
CA2996863C (en) 2015-09-01 2021-04-13 Becton, Dickinson And Company Depth filtration device for separating specimen phases
JP6674553B2 (en) 2015-10-19 2020-04-01 アイシーユー・メディカル・インコーポレーテッド Hemodynamic monitoring system with detachable display unit
ES2923758T3 (en) * 2016-02-04 2022-09-30 Nova Biomedical Corp System and method for the measurement of the optical absorbance of whole blood
WO2017165403A1 (en) 2016-03-21 2017-09-28 Nueon Inc. Porous mesh spectrometry methods and apparatus
WO2017180656A1 (en) * 2016-04-11 2017-10-19 Alfred Akerman Apparatus and system for measuring volume of blood loss
US9788770B1 (en) * 2016-04-14 2017-10-17 Verily Life Sciences Llc Continuous monitoring of tumor hypoxia using near-infrared spectroscopy and tomography with a photonic mixer device
WO2018085699A1 (en) 2016-11-04 2018-05-11 Nueon Inc. Combination blood lancet and analyzer
RU2649048C1 (en) * 2016-11-25 2018-03-29 Самсунг Электроникс Ко., Лтд. Compact spectrometer system intended for non-invasive measurement of spectra of absorption and transmission of specimens of biological material
CN106668968A (en) * 2016-12-30 2017-05-17 北京迈淩医疗技术发展有限公司 Hematodialysis device capable of determining relative blood volume
EP3606428A4 (en) * 2017-04-04 2020-04-22 Cas Medical Systems, Inc. Method and apparatus for non-invasively measuring circulatory hemoglobin
CN107688012A (en) * 2017-07-06 2018-02-13 浙江工业大学 A kind of fluorescent signals detection method
US10674916B2 (en) * 2017-07-10 2020-06-09 The Florida International University Board Of Trustees Integrated NIR and visible light scanner for co-registered images of tissues
US10352922B2 (en) * 2017-08-16 2019-07-16 Thermo Finnigan Llc System and method of measuring hematocrit
KR102534002B1 (en) * 2018-02-14 2023-05-19 삼성전자주식회사 Electronic device including a sensor for sensing biometric information using a plurality of receiving units and control method thereof
US11125738B2 (en) 2018-11-06 2021-09-21 Thermo Finnigan Llc Blood sample analysis systems and methods
EP3887800B1 (en) * 2018-11-30 2024-04-17 Institut National De La Sante Et De La Recherche Medicale - Inserm Method for determining one content in protein and associated devices and methods
CN111812043B (en) * 2019-04-10 2023-07-07 瑞爱生医股份有限公司 Mobile device with heme detection function
US11243216B2 (en) * 2019-05-08 2022-02-08 Taiwan Redeye Biomedical Inc. Mobile device having hemoglobin detecting function and hemoglobin detecting method
US10883927B2 (en) * 2019-06-05 2021-01-05 Taiwan Redeye Biomedical Inc. Hemoglobin detecting device
CN110537925B (en) * 2019-08-27 2021-05-28 河南大学 Optical fiber leading-in type oxygen saturation detection device and method
CN110537926B (en) * 2019-08-27 2021-04-20 河南大学 Needle, device and method for detecting hemoglobin concentration and blood oxygen saturation
FR3112390B1 (en) * 2020-07-08 2022-06-24 I Sep Apparatus for determining the hemoglobin or hematocrit level of a circulating fluid
CA3184950A1 (en) * 2020-07-08 2022-01-13 Stephane Chollet Device for determining the level of haemoglobin or haematocrit of a circulating liquid
US11191460B1 (en) 2020-07-15 2021-12-07 Shani Biotechnologies LLC Device and method for measuring blood components

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6064474A (en) * 1998-02-06 2000-05-16 Optical Sensors, Inc. Optical measurement of blood hematocrit incorporating a self-calibration algorithm
US6103197A (en) * 1996-07-12 2000-08-15 Avl Medical Instruments Ag Method and apparatus for optically determining total hemoglobin concentration
US6473632B1 (en) * 1999-06-16 2002-10-29 Hutchinson Technology Incorporated Total hemoglobin concentration measurement
US20030009090A1 (en) * 2001-04-19 2003-01-09 Jeon Kye-Jin Method and apparatus for noninvasively monitoring hemoglobin concentration and oxygen saturation
US20030123047A1 (en) * 2001-12-28 2003-07-03 Joakim Pettersson Analysis method and system therefor

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4114604A (en) * 1976-10-18 1978-09-19 Shaw Robert F Catheter oximeter apparatus and method
CA1089252A (en) * 1976-10-18 1980-11-11 John M. Sperinde Optical catheter not requiring individual calibration
US4295470A (en) * 1976-10-18 1981-10-20 Oximetrix, Inc. Optical catheters and method for making same
DE2815074C2 (en) 1978-04-07 1983-03-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Spectrophotometers for medical purposes
DE3328862A1 (en) 1982-09-16 1985-02-28 Siemens AG, 1000 Berlin und 8000 München Tissue photometry method and device, in particular for quantatively determining the blood oxygen saturation from photometric measurements
US4623248A (en) * 1983-02-16 1986-11-18 Abbott Laboratories Apparatus and method for determining oxygen saturation levels with increased accuracy
US4650327A (en) * 1985-10-28 1987-03-17 Oximetrix, Inc. Optical catheter calibrating assembly
US4776340A (en) 1987-03-23 1988-10-11 Spectramed, Inc. Hematocrit measurement by differential optical geometry in a short-term diagnostic cardiovascular catheter, and application to correction of blood-oxygen measurement
JPH06103257B2 (en) 1988-12-19 1994-12-14 大塚電子株式会社 Method and apparatus for measuring absorption coefficient of substance using light scattering
US5061632A (en) 1989-01-31 1991-10-29 Board Of Regents, The University Of Texas System Capillary tube hemoglobinometer and oximeter
WO1991001678A1 (en) 1989-07-27 1991-02-21 National Research Development Corporation Oximeters
CA2025330C (en) 1989-09-18 2002-01-22 David W. Osten Characterizing biological matter in a dynamic condition using near infrared spectroscopy
US5393371A (en) 1989-12-18 1995-02-28 Litton Systems, Inc. Integrated optics chips and laser ablation methods for attachment of optical fibers thereto for LiNbO3 substrates
US5372136A (en) 1990-10-06 1994-12-13 Noninvasive Medical Technology Corporation System and method for noninvasive hematocrit monitoring
WO1992021283A1 (en) 1991-06-06 1992-12-10 Somanetics Corporation Optical cerebral oximeter
US5413100A (en) 1991-07-17 1995-05-09 Effets Biologiques Exercice Non-invasive method for the in vivo determination of the oxygen saturation rate of arterial blood, and device for carrying out the method
US5277181A (en) 1991-12-12 1994-01-11 Vivascan Corporation Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis
JP2898489B2 (en) 1991-12-17 1999-06-02 アー・フアウ・エル・メデイカル・インストルメンツ・アクチエンゲゼルシヤフト Equipment for spectrophotometric analysis
US5280786A (en) * 1992-01-21 1994-01-25 Fiberoptic Sensor Technologies, Inc. Fiberoptic blood pressure and oxygenation sensor
US5355880A (en) 1992-07-06 1994-10-18 Sandia Corporation Reliable noninvasive measurement of blood gases
US5672875A (en) 1992-07-15 1997-09-30 Optix Lp Methods of minimizing scattering and improving tissue sampling in non-invasive testing and imaging
JP3464697B2 (en) 1993-12-21 2003-11-10 興和株式会社 Oxygen saturation meter
US5553615A (en) * 1994-01-31 1996-09-10 Minnesota Mining And Manufacturing Company Method and apparatus for noninvasive prediction of hematocrit
CA2259254C (en) * 1996-07-08 2008-02-19 Animas Corporation Implantable sensor and system for in vivo measurement and control of fluid constituent levels
US6544193B2 (en) * 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
US5782756A (en) 1996-09-19 1998-07-21 Nellcor Puritan Bennett Incorporated Method and apparatus for in vivo blood constituent analysis
US6006119A (en) 1998-02-04 1999-12-21 Polestar Technologies, Inc. Non-invasive optical measurement of blood hematocrit
US6990365B1 (en) 1998-07-04 2006-01-24 Edwards Lifesciences Apparatus for measurement of blood analytes
US6842635B1 (en) 1998-08-13 2005-01-11 Edwards Lifesciences Llc Optical device
US7047054B2 (en) * 1999-03-12 2006-05-16 Cas Medical Systems, Inc. Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation monitoring
US6167297A (en) * 1999-05-05 2000-12-26 Benaron; David A. Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
AU2001254566A1 (en) 2000-04-13 2001-10-30 National Research Council Of Canada Ltd. Tissue viability/health monitor utilizing near infrared spectroscopy
JP2002102230A (en) * 2000-09-29 2002-04-09 Keio Gijuku Organismic light measuring device and organismic light measuring method
US6711426B2 (en) * 2002-04-09 2004-03-23 Spectros Corporation Spectroscopy illuminator with improved delivery efficiency for high optical density and reduced thermal load

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103197A (en) * 1996-07-12 2000-08-15 Avl Medical Instruments Ag Method and apparatus for optically determining total hemoglobin concentration
US6064474A (en) * 1998-02-06 2000-05-16 Optical Sensors, Inc. Optical measurement of blood hematocrit incorporating a self-calibration algorithm
US6473632B1 (en) * 1999-06-16 2002-10-29 Hutchinson Technology Incorporated Total hemoglobin concentration measurement
US20030009090A1 (en) * 2001-04-19 2003-01-09 Jeon Kye-Jin Method and apparatus for noninvasively monitoring hemoglobin concentration and oxygen saturation
US20030123047A1 (en) * 2001-12-28 2003-07-03 Joakim Pettersson Analysis method and system therefor

Also Published As

Publication number Publication date
WO2007033318A2 (en) 2007-03-22
US7319894B2 (en) 2008-01-15
US7426407B2 (en) 2008-09-16
CA2610753C (en) 2014-04-29
US8483789B2 (en) 2013-07-09
US20070060810A1 (en) 2007-03-15
JP2009507569A (en) 2009-02-26
US20070060809A1 (en) 2007-03-15
CA2824033A1 (en) 2007-03-22
US20080108887A1 (en) 2008-05-08
CN101232843A (en) 2008-07-30
CA2610753A1 (en) 2007-03-22
EP1924195A2 (en) 2008-05-28

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