WO2007028003A3 - Biologically integrated electrode devices - Google Patents

Biologically integrated electrode devices Download PDF

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Publication number
WO2007028003A3
WO2007028003A3 PCT/US2006/034199 US2006034199W WO2007028003A3 WO 2007028003 A3 WO2007028003 A3 WO 2007028003A3 US 2006034199 W US2006034199 W US 2006034199W WO 2007028003 A3 WO2007028003 A3 WO 2007028003A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioelectrode
biological component
conductive substrate
integrated electrode
electrically conductive
Prior art date
Application number
PCT/US2006/034199
Other languages
French (fr)
Other versions
WO2007028003B1 (en
WO2007028003A2 (en
Inventor
David C Martin
Sarah Richardson-Burns
Kim Donghwan
Jeffrey L Hendricks
Laura Povlich
Mohammad Reza Abidian
Matthew Meier
Original Assignee
Univ Michigan
David C Martin
Sarah Richardson-Burns
Kim Donghwan
Jeffrey L Hendricks
Laura Povlich
Mohammad Reza Abidian
Matthew Meier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, David C Martin, Sarah Richardson-Burns, Kim Donghwan, Jeffrey L Hendricks, Laura Povlich, Mohammad Reza Abidian, Matthew Meier filed Critical Univ Michigan
Priority to EP06824877.2A priority Critical patent/EP1931248B1/en
Priority to CA002621174A priority patent/CA2621174A1/en
Priority to AU2006284625A priority patent/AU2006284625B2/en
Priority to JP2008529303A priority patent/JP2009506836A/en
Publication of WO2007028003A2 publication Critical patent/WO2007028003A2/en
Publication of WO2007028003A3 publication Critical patent/WO2007028003A3/en
Publication of WO2007028003B1 publication Critical patent/WO2007028003B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
    • A61B5/268—Bioelectric electrodes therefor characterised by the electrode materials containing conductive polymers, e.g. PEDOT:PSS polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
    • A61B5/266—Bioelectric electrodes therefor characterised by the electrode materials containing electrolytes, conductive gels or pastes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A61B2562/0217—Electrolyte containing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes

Abstract

Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer.
PCT/US2006/034199 2005-08-31 2006-08-31 Biologically integrated electrode devices WO2007028003A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP06824877.2A EP1931248B1 (en) 2005-08-31 2006-08-31 Biologically integrated electrode devices
CA002621174A CA2621174A1 (en) 2005-08-31 2006-08-31 Biologically integrated electrode devices
AU2006284625A AU2006284625B2 (en) 2005-08-31 2006-08-31 Biologically integrated electrode devices
JP2008529303A JP2009506836A (en) 2005-08-31 2006-08-31 Biologically integrated electrode device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71307005P 2005-08-31 2005-08-31
US60/713,070 2005-08-31
US11/512,479 US8005526B2 (en) 2005-08-31 2006-08-30 Biologically integrated electrode devices
US11/512,479 2006-08-30

Publications (3)

Publication Number Publication Date
WO2007028003A2 WO2007028003A2 (en) 2007-03-08
WO2007028003A3 true WO2007028003A3 (en) 2007-10-11
WO2007028003B1 WO2007028003B1 (en) 2007-11-29

Family

ID=37809567

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/034199 WO2007028003A2 (en) 2005-08-31 2006-08-31 Biologically integrated electrode devices

Country Status (6)

Country Link
US (1) US8005526B2 (en)
EP (2) EP2514359A3 (en)
JP (1) JP2009506836A (en)
AU (1) AU2006284625B2 (en)
CA (1) CA2621174A1 (en)
WO (1) WO2007028003A2 (en)

Families Citing this family (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7266457B1 (en) * 1999-05-21 2007-09-04 Hesperos, Llc High throughput functional genomics
EP2650907A3 (en) 2004-06-04 2014-10-08 The Board of Trustees of the University of Illinois Methods and devices for fabricating and assembling printable semiconductor elements
EP1888161A4 (en) * 2005-06-06 2009-04-29 Nano Biosensors Ltd Microelectrode, applications thereof and method of manufacturing the same
US8805547B2 (en) * 2005-06-30 2014-08-12 Domestic Legacy Limited Partnership Extra-cochlear implanted hearing aid device
US9084546B2 (en) * 2005-08-31 2015-07-21 The Regents Of The University Of Michigan Co-electrodeposited hydrogel-conducting polymer electrodes for biomedical applications
US9233846B2 (en) 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
US7519409B2 (en) * 2005-12-29 2009-04-14 Medtronic, Inc. Implantable cell/tissue-based biosensing device
US20100006431A1 (en) * 2006-02-06 2010-01-14 Gordon George Wallace Self-Powered Sensing Devices
US7650194B2 (en) * 2006-03-22 2010-01-19 Fritsch Michael H Intracochlear nanotechnology and perfusion hearing aid device
US8181540B2 (en) * 2006-03-28 2012-05-22 University Of Southern California Measurement of sliding friction-induced vibrations for biomimetic tactile sensing
US7658119B2 (en) * 2006-03-28 2010-02-09 University Of Southern California Biomimetic tactile sensor
US8936794B2 (en) * 2006-08-25 2015-01-20 The Regents Of The University Of Michigan Conducting polymer nanotube actuators for precisely controlled release of medicine and bioactive molecules
RU2463088C2 (en) * 2006-09-26 2012-10-10 Сапиенс Стиринг Брейн Стимулейшн Б.В. Method and device for tissue stimulation
US9018019B2 (en) * 2006-10-04 2015-04-28 President And Fellows Of Harvard College Engineered conductive polymer films to mediate biochemical interactions
WO2008140562A2 (en) 2006-11-03 2008-11-20 Trustees Of Tufts College Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same
US20100046902A1 (en) 2006-11-03 2010-02-25 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
JP2010509645A (en) 2006-11-03 2010-03-25 トラスティーズ オブ タフツ カレッジ Biopolymer optical device having nano pattern formed thereon and method for producing the same
WO2008127402A2 (en) * 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer sensor and method of manufacturing the same
US7813811B2 (en) * 2007-02-08 2010-10-12 Neuropace, Inc. Refillable reservoir lead systems
US7844345B2 (en) * 2007-02-08 2010-11-30 Neuropace, Inc. Drug eluting lead systems
US20100196203A1 (en) 2007-02-20 2010-08-05 Gurdial Singh Sanghera Formation of Lipid Bilayers
EP2139813A4 (en) * 2007-03-23 2010-03-31 Univ Columbia Quantum dot labeled stem cells for use in providing pacemaker function
US8272278B2 (en) 2007-03-28 2012-09-25 University Of Southern California Enhancements to improve the function of a biomimetic tactile sensor
WO2008122044A2 (en) * 2007-04-02 2008-10-09 Georgia Tech Research Corporation Implantable device for communicating with biological tissue
JP2010528267A (en) * 2007-05-18 2010-08-19 ユニバーシティ オブ サザン カリフォルニア Biomimetic tactile sensor for grip control
US20090131995A1 (en) * 2007-06-14 2009-05-21 Northstar Neuroscience, Inc. Microdevice-based electrode assemblies and associated neural stimulation systems, devices, and methods
US7894914B2 (en) * 2007-08-28 2011-02-22 Cardiac Pacemakers, Inc. Medical device electrodes including nanostructures
US7991480B2 (en) 2007-08-28 2011-08-02 Cardiac Pacemakers, Inc. Medical device electrodes having cells disposed on nanostructures
US20100248389A1 (en) * 2007-09-20 2010-09-30 University Of Utah Research Foundation Electrochemical deposition of polymers on metal substrates
US7899552B2 (en) * 2007-10-15 2011-03-01 Cardiac Pacemakers, Inc. Conductive composite electrode material
EP2205312B1 (en) * 2007-10-19 2015-12-02 Cardiac Pacemakers, Inc. Fibrous electrode material
WO2009061823A1 (en) 2007-11-05 2009-05-14 Trustees Of Tufts College Fabrication of silk fibroin photonic structures by nanocontact imprinting
WO2009075761A2 (en) * 2007-12-12 2009-06-18 Cardiac Pacemakers, Inc. Electrically conducting scaffolds for cell-based pacing
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
US20090292325A1 (en) * 2008-05-02 2009-11-26 Cederna Paul S Hybrid bioelectrical interface device
US8772041B2 (en) 2008-05-22 2014-07-08 The Regents Of The University Of California Membrane precursors and membranes formed therefrom
US20110135697A1 (en) * 2008-06-18 2011-06-09 Trustees Of Tufts College Edible holographic silk products
WO2010014686A1 (en) 2008-07-30 2010-02-04 Aleva Neurotherapeutics, S.A. Apparatus and method for optimized stimulation of a neurological target
EP2323709A2 (en) * 2008-08-14 2011-05-25 Boston Scientific Scimed, Inc. Medical devices having electrodeposited conductive polymer coatings
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
WO2010042653A1 (en) 2008-10-07 2010-04-15 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US8389862B2 (en) 2008-10-07 2013-03-05 Mc10, Inc. Extremely stretchable electronics
EP2604313B1 (en) 2008-11-12 2014-09-17 Ecole Polytechnique Federale de Lausanne Microfabricated neurostimulation device
WO2010126640A2 (en) 2009-02-12 2010-11-04 Trustees Of Tufts College Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
JP2012533780A (en) 2009-07-20 2012-12-27 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ Implantable absorptive reflector made of protein only
US20110021899A1 (en) * 2009-07-23 2011-01-27 Surmodics, Inc. Conductive polymer coatings
EP2474054A4 (en) 2009-08-31 2013-03-13 Tufts University Trustees Of Tufts College Silk transistor devices
WO2011034939A1 (en) 2009-09-15 2011-03-24 Rush University Medical Center Energy-releasing carbon nanotube transponder and method of using same
WO2011041727A1 (en) 2009-10-01 2011-04-07 Mc10, Inc. Protective cases with integrated electronics
US9314181B2 (en) 2009-11-03 2016-04-19 Vivaquant Llc Method and apparatus for detection of heartbeat characteristics
US9008800B2 (en) * 2009-11-23 2015-04-14 Case Western Reserve University Separated-interface nerve electrode
WO2011066552A2 (en) * 2009-11-30 2011-06-03 University Of South Florida Cubic silicon carbide implantable neural prosthetic
JP2013512062A (en) 2009-12-01 2013-04-11 エコーレ ポリテクニーク フェデラーレ デ ローザンヌ Microfabricated surface nerve stimulation device and methods of making and using the same
JP6046491B2 (en) 2009-12-16 2016-12-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ In vivo electrophysiology using conformal electronics
US8666471B2 (en) 2010-03-17 2014-03-04 The Board Of Trustees Of The University Of Illinois Implantable biomedical devices on bioresorbable substrates
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
EP2521650A4 (en) 2010-01-05 2013-05-15 Univ California Droplet bilayer formation using throughput liquid handling techniques
WO2011100059A1 (en) 2010-02-12 2011-08-18 Georgetown University Polymer film bioelectrodes and methods of making and using the same
WO2011106526A2 (en) * 2010-02-24 2011-09-01 The Research Foundation Of State University Of New York Method of electrochemical formation of noble nanoparticles in a chitosan matrix
AU2011224383B2 (en) * 2010-03-09 2014-01-30 Heraeus Medical Components Llc Electrically conductive and mechanically supportive materials for biomedical leads
EP2554365A4 (en) * 2010-03-26 2017-08-09 Tohoku University Porous structure provided with pattern that is composed of conductive polymer, and method for producing same
US8909348B2 (en) 2010-03-30 2014-12-09 Domestic Legacy Limited Partnership Cochlear implant stabilization and positioning device
AU2011234422B2 (en) 2010-04-01 2015-11-05 Ecole Polytechnique Federale De Lausanne (Epfl) Device for interacting with neurological tissue and methods of making and using the same
CN103079462A (en) 2010-06-18 2013-05-01 密执安大学评议会 Implantable micro-component electrodes
WO2012006320A1 (en) 2010-07-06 2012-01-12 President And Fellows Of Harvard College Photosensitive cardiac rhythm modulation systems
GB201012808D0 (en) * 2010-07-29 2010-09-15 Chameleon Biosurfaces Ltd Implantable electrode
EP2606530B1 (en) 2010-08-20 2017-04-26 Rhodia Operations Polymer compositions, polymer films, polymer gels, polymer foams, and electronic devices containing such films, gels, and foams
US9299476B2 (en) 2010-10-22 2016-03-29 Newsouth Innovations Pty Limited Polymeric material
TWI451863B (en) * 2010-11-06 2014-09-11 Nat Univ Tsing Hua Retina stimulation apparatus and a manufacturing method thereof
AU2011328900B2 (en) 2010-11-16 2015-03-19 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treatment of dry eye
US9821159B2 (en) 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
WO2012075120A2 (en) 2010-11-30 2012-06-07 University Of South Florida Graphene electrodes on a planar cubic silicon carbide (3c-sic) long term implantable neuronal prosthetic device
US9414758B1 (en) * 2011-01-12 2016-08-16 Vivaquant Llc Apparatus, system and methods for sensing and processing physiological signals
US9808616B2 (en) 2011-01-14 2017-11-07 The Regents Of The University Of Michigan Regenerative peripheral nerve interface
EP2688638B1 (en) * 2011-03-25 2015-01-21 Med-El Elektromedizinische Geraete GmbH Implantable auditory prosthesis with temporary connector
AU2012239966B2 (en) * 2011-04-07 2015-11-26 Oculeve, Inc. Stimulation devices and methods
US9765934B2 (en) 2011-05-16 2017-09-19 The Board Of Trustees Of The University Of Illinois Thermally managed LED arrays assembled by printing
WO2012166686A2 (en) 2011-05-27 2012-12-06 Mc10, Inc. Electronic, optical and/or mechanical apparatus and systems and methods for fabricating same
WO2012167096A2 (en) 2011-06-03 2012-12-06 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
FI20115759A0 (en) * 2011-07-19 2011-07-19 Polar Electro Oy sports Clothing
US9782091B2 (en) 2011-07-25 2017-10-10 Neuronexus Technologies, Inc. Opto-electrical device for artifact reduction
EP2736594B1 (en) 2011-07-25 2016-09-14 NeuroNexus Technologies, Inc. Neuromodulation transfection system with passive fluid delivery
US9700736B2 (en) 2011-07-25 2017-07-11 Neuronexus Technologies, Inc. Neuromodulation transfection system with active fluid delivery
US20140127791A1 (en) * 2011-07-28 2014-05-08 Siemens Aktiengesellschaft Diagnostic device
EP2750754B1 (en) * 2011-09-02 2021-03-24 The Regents of the University of California Microneedle arrays for biosensing and drug delivery
EP2578207A3 (en) 2011-10-05 2015-10-07 Jacob J. Schmidt Masking apertures enabling automation and solution exchange in sessile droplet lipid bilayers
CN104040417B (en) 2011-11-15 2017-07-18 阿什温-乌沙斯公司 Complementary polymeric electrochromic device
KR101310767B1 (en) * 2011-11-23 2013-09-25 한국과학기술연구원 Tetrode for measuring bio-signal and method of manufacturing the same
KR101979354B1 (en) 2011-12-01 2019-08-29 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 Transient devices designed to undergo programmable transformations
WO2013086512A2 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Muscle chips and methods of use thereof
CN103157180B (en) * 2011-12-15 2015-04-01 清华大学 Pacemaker electrode wire and pacemaker
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
US9554484B2 (en) 2012-03-30 2017-01-24 The Board Of Trustees Of The University Of Illinois Appendage mountable electronic devices conformable to surfaces
WO2013169207A1 (en) * 2012-05-07 2013-11-14 Agency For Science, Technology And Research Neuro-probe device, implantable electronic device and method of forming a neuro-probe device
US10195434B2 (en) 2012-06-15 2019-02-05 Case Western Reserve University Treatment of pain using electrical nerve conduction block
EP3572121A1 (en) 2012-06-15 2019-11-27 Case Western Reserve University Therapy delivery devices and methods for non-damaging neural tissue conduction block
US9320465B2 (en) 2012-06-25 2016-04-26 International Business Machines Corporation Bio-chips and nano-biochips
US10265161B2 (en) 2012-08-07 2019-04-23 Regeneye L. L. C. Ocular collar stent for treating narrowing of the irideocorneal angle
US9308082B2 (en) 2012-08-07 2016-04-12 RegenEye, L.L.C. Ocular collar stent for treating narrowing of the irideocorneal angle
US9974645B2 (en) 2012-08-07 2018-05-22 RegenEye, L.L.C. Method of reducing the occurrence of macular and neuroretinal degenerations by alleviating age related retinal stresses as a contributing factor in a mammalian eye
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
ES2470495B1 (en) 2012-12-19 2015-05-14 Universidad De Castilla La Mancha Materials, methods and devices to stimulate and direct the proliferation and migration of neural progenitors and axonal and dendritic growth
US9532150B2 (en) 2013-03-05 2016-12-27 Wisconsin Alumni Research Foundation Eardrum supported nanomembrane transducer
WO2014138709A1 (en) 2013-03-08 2014-09-12 Oculeve, Inc. Devices and methods for treating dry eye in animals
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
KR102358124B1 (en) 2013-03-11 2022-02-08 큐 헬스 인코퍼레이티드 Systems and methods for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
EP2967817B1 (en) 2013-03-12 2021-03-10 Oculeve, Inc. Implant delivery devices and systems
EP2973606B1 (en) 2013-03-15 2019-05-08 Biotectix LLC Implantable electrode comprising a conductive polymeric coating
US9207515B2 (en) 2013-03-15 2015-12-08 Ashwin-Ushas Corporation, Inc. Variable-emittance electrochromic devices and methods of preparing the same
AU2014253754C1 (en) 2013-04-19 2015-07-30 Oculeve, Inc. Nasal stimulation devices and methods
US20150238764A1 (en) 2013-05-10 2015-08-27 Case Western Reserve University Systems and methods for preventing noise in an electric waveform for neural stimulation, block, or sensing
WO2014186802A1 (en) * 2013-05-17 2014-11-20 Biotectix, LLC Impregnation of a non-conductive material with an intrinsically conductive polymer
WO2014204429A1 (en) * 2013-06-17 2014-12-24 The Massachusetts Institute Of Technology Methods and apparatus for stimulating and recording neural activity
DE102013211837A1 (en) * 2013-06-21 2014-12-24 Gilupi Gmbh Catheter with detection device for the real-time detection of a sample material
AU2014315246B2 (en) * 2013-09-06 2016-09-22 Med-El Elektromedizinische Geraete Gmbh Electrode contact with hydrogel covering
US10166386B2 (en) 2013-10-14 2019-01-01 The Board Of Regents Of The University Of Oklahoma Implantable electrode assembly
KR20150046878A (en) * 2013-10-23 2015-05-04 한국전자통신연구원 Mesoporous neuronal electrode using surfactant of making the same
WO2015071912A1 (en) * 2013-11-17 2015-05-21 Ramot At Tel-Aviv University Ltd. Electronic scaffold and uses thereof
WO2015178980A2 (en) 2014-02-18 2015-11-26 President And Fellows Of Harvard College Anisotropic muscular tissue devices with integrated electrical force readouts
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
CN106470673B (en) 2014-02-25 2020-01-31 奥库利维公司 Polymer formulations for nasolacrimal stimulation
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
US11311718B2 (en) 2014-05-16 2022-04-26 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
CN106455985B (en) 2014-05-16 2019-09-17 阿莱瓦神经治疗股份有限公司 With the device and production and preparation method thereof of nerve fiber interaction
EP3673952A1 (en) 2014-07-25 2020-07-01 Oculeve, Inc. Stimulation patterns for treating dry eye
US9474894B2 (en) 2014-08-27 2016-10-25 Aleva Neurotherapeutics Deep brain stimulation lead
US9403011B2 (en) 2014-08-27 2016-08-02 Aleva Neurotherapeutics Leadless neurostimulator
CA2958744C (en) * 2014-08-27 2023-09-19 Neuronano Ab Method of implantation of a medical device into neural tissue
US10997871B2 (en) 2014-09-24 2021-05-04 President And Fellows Of Harvard College Contractile function measuring devices, systems, and methods of use thereof
EP3006055B1 (en) * 2014-10-10 2020-02-19 Albert-Ludwigs-Universität Freiburg Improved biomaterials for neuronal implants and use of said biomaterials in the diagnosis and therapy of neuronal diseases
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
EP3209371A4 (en) 2014-10-22 2018-10-24 Oculeve, Inc. Implantable nasal stimulator systems and methods
US9737712B2 (en) 2014-10-22 2017-08-22 Oculeve, Inc. Stimulation devices and methods for treating dry eye
EP3209370A4 (en) 2014-10-22 2018-05-30 Oculeve, Inc. Contact lens for increasing tear production
US20170326381A1 (en) * 2014-11-12 2017-11-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Wireless micro/nano- stimulation opto-electrode for excitable tissue
US10314725B2 (en) 2014-11-13 2019-06-11 The Regents Of The University Of Michigan Method for amplifying signals from individual nerve fascicles
WO2016079696A2 (en) 2014-11-19 2016-05-26 Biotectix, LLC Conductive polymer coatings for three dimensional substrates
KR102344486B1 (en) * 2015-03-19 2021-12-29 한국전자통신연구원 Neural electrode for measuring neural signal and method for manufacturing thereof
CN108136174B (en) 2015-04-17 2022-02-25 穆贾拉医疗私人有限公司 Implantable neurostimulation device
KR20180033468A (en) 2015-06-01 2018-04-03 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 Miniaturized electronic systems with wireless power and local communication capabilities
WO2016196673A1 (en) 2015-06-01 2016-12-08 The Board Of Trustees Of The University Of Illinois Alternative approach to uv sensing
CN117310193A (en) 2015-07-17 2023-12-29 克忧健康公司 Systems and methods for enhanced detection and analyte quantification
US9632059B2 (en) 2015-09-03 2017-04-25 Ashwin-Ushas Corporation, Inc. Potentiostat/galvanostat with digital interface
US9482880B1 (en) 2015-09-15 2016-11-01 Ashwin-Ushas Corporation, Inc. Electrochromic eyewear
EP3359244B1 (en) 2015-10-06 2020-12-23 Case Western Reserve University High-charge capacity electrodes to deliver direct current nerve conduction block
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
WO2017087759A1 (en) 2015-11-18 2017-05-26 President And Fellows Of Harvard College Cartridge-based system for long term culture of cell clusters
WO2017090050A1 (en) * 2015-11-29 2017-06-01 Ramot At Tel-Aviv University Ltd. Sensing electrode and method of fabricating the same
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
US10864373B2 (en) 2015-12-15 2020-12-15 Case Western Reserve University Systems for treatment of a neurological disorder using electrical nerve conduction block
WO2017103930A1 (en) 2015-12-16 2017-06-22 Ramot At Tel-Aviv University Ltd. Particles comprising decellularized omentum
CN105445169B (en) * 2015-12-21 2019-02-05 江苏大学 A kind of bacterial counting
CN109069824B (en) 2016-02-02 2022-09-16 阿莱瓦神经治疗股份有限公司 Treatment of autoimmune diseases using deep brain stimulation
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
EP3419715B1 (en) * 2016-02-26 2021-09-15 Neuronano AB Method of implantation of cell aggregates and tissue fragments
CN108697887B (en) * 2016-02-26 2022-10-25 神经毫微股份公司 Method for providing an implant site in soft tissue
WO2017181068A1 (en) * 2016-04-14 2017-10-19 The Trustees Of The University Of Pennsylvania Implantable living electrodes and methods for use thereof
WO2017192572A1 (en) 2016-05-02 2017-11-09 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
US11045646B2 (en) 2016-06-27 2021-06-29 Board Of Regents, The University Of Texas System Softening nerve cuff electrodes
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
US20180031517A1 (en) * 2016-07-29 2018-02-01 South Dakota Board Of Regents Devices, Systems and Methods for Use of Electrical Ion Sensors Based on Metal-Organic Supercontainers
CN107840955B (en) * 2016-09-21 2020-06-23 天津大学 Conductive adhesive and preparation method thereof
US20190309433A1 (en) * 2016-10-10 2019-10-10 Biolinq, Inc. Electro-Deposited Conducting Polymers For The Realization Of Solid-State Reference Electrodes For Use In Intracutaneous And Subcutaneous Analyte-Selective Sensors
US10801906B2 (en) * 2016-11-14 2020-10-13 Nutech Ventures Hydrogel microphone
CN110022755A (en) 2016-12-02 2019-07-16 奥库利维公司 Device and method for xerophthalmia prediction and treatment recommendations
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
WO2018146656A1 (en) * 2017-02-13 2018-08-16 University Of Florida Research Foundation, Inc. Sharklet topographies to control neural cell interactions with implanted electrodes
WO2018187237A1 (en) 2017-04-03 2018-10-11 Presidio Medical, Inc. Systems and methods for direct current nerve conduction block
US11103145B1 (en) 2017-06-14 2021-08-31 Vivaquant Llc Physiological signal monitoring and apparatus therefor
CN107638176B (en) * 2017-09-08 2020-05-08 浙江大学 Application of hydrogel in preparation of electrode for detecting electroencephalogram of cerebral cortex
US20200261726A1 (en) * 2017-10-05 2020-08-20 The Board Of Trustees Of The Leland Stanford Junior University Conductive Polymer Implant, combining electrical and chemical stimulation to improve neural recovery
US11629318B2 (en) 2017-10-20 2023-04-18 President And Fellows Of Harvard College Methods for producing mature adipocytes and methods of use thereof
JP6991572B2 (en) * 2018-01-18 2022-01-12 国立大学法人 東京大学 Barrier function measurement system for artificial 3D tissue, barrier function measurement method for artificial 3D tissue, and drug evaluation method using artificial 3D tissue
AU2019225810A1 (en) 2018-02-20 2020-09-10 Presidio Medical, Inc. Methods and systems for nerve conduction block
WO2019166618A1 (en) * 2018-03-01 2019-09-06 Universität Basel Vizerektorat Forschung Neural probe for electrostimulation or recording and fabrication process for such a probe
US10702692B2 (en) 2018-03-02 2020-07-07 Aleva Neurotherapeutics Neurostimulation device
US11000686B1 (en) 2018-04-27 2021-05-11 Verily Life Sciences Llc Platinum/iridium surface patterning by laser to improve neuromodulation electrode performance
EP3813925A4 (en) 2018-07-01 2022-04-13 Presidio Medical, Inc. Systems and methods for nerve conduction block
AU2019253784B2 (en) 2018-10-30 2022-03-31 Indian Oil Corporation Limited Engineered electrode for electrobiocatalysis and process to construct the same
US20220177942A1 (en) 2019-03-12 2022-06-09 Universitat Politecnica De Catalunya A method, an electrochemical sensor and a system for selective detection of infections
AU2020239385A1 (en) 2019-03-12 2021-08-26 Oxford Nanopore Technologies Plc Nanopore sensing device and methods of operation and of forming it
US11931142B1 (en) 2019-03-19 2024-03-19 VIVAQUANT, Inc Apneic/hypopneic assessment via physiological signals
CN110604560B (en) * 2019-06-19 2021-08-24 北京大学 Method for connecting electronic material and hydrogel substrate
US20210038773A1 (en) * 2019-08-07 2021-02-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Silica nanoparticle doped conductive polymer
US11730964B2 (en) 2019-11-24 2023-08-22 Presidio Medical, Inc. Pulse generation and stimulation engine systems
WO2021163964A1 (en) * 2020-02-20 2021-08-26 北京大学 Preparation method for conductive hydrogel and cell impedance sensing measurement method thereof
EP4048152B1 (en) 2020-07-29 2023-12-20 Biolinq Incorporated Continuous analyte monitoring system with microneedle array
RS20201065A1 (en) 2020-09-04 2022-03-31 Inst Biosens Istrazivacko Razvojni Inst Za Informacione Tehnologije Biosistema Planar electrode for biosensors realized using repetitive fractal geometry
GB202019249D0 (en) * 2020-12-07 2021-01-20 Univ Southampton Reference electrode & ION selective membrane
CN112932494A (en) * 2021-01-29 2021-06-11 南方科技大学 Epidermis dry electrode and manufacturing method thereof and epidermis electric signal acquisition device
EP4314817A1 (en) * 2021-04-01 2024-02-07 Janssen Biotech, Inc. Drug material interactions using quartz crystal microbalance sensors
US11857344B2 (en) 2021-05-08 2024-01-02 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
CN114343651A (en) * 2021-12-09 2022-04-15 中国科学院深圳先进技术研究院 Flexible contact with gradient porosity, gel semi-dry electrode containing flexible contact and electroencephalogram cap containing flexible contact
CN115215953B (en) * 2022-07-15 2023-10-24 江西司托迈医疗科技有限公司 Self-assembled redox polymers, sensors and methods of making the same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6095148A (en) * 1995-11-03 2000-08-01 Children's Medical Center Corporation Neuronal stimulation using electrically conducting polymers
US6294245B1 (en) * 1999-09-22 2001-09-25 Agilent Technologies, Inc. Method for depositing electrically conducting polymer films via electrochemical deposition of precursor polymers
US20050033132A1 (en) * 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
US20050048651A1 (en) * 1997-11-06 2005-03-03 Frida Ryttsen Method and apparatus for spatially confined electroporation
US6890715B1 (en) * 1999-08-18 2005-05-10 The California Institute Of Technology Sensors of conducting and insulating composites

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341221A (en) 1980-10-07 1982-07-27 Medtronic, Inc. Shielded recording electrode system
US4585652A (en) 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US5130412A (en) 1989-08-08 1992-07-14 Southwest Research Institute Electrochemical drug release and article
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US5031621A (en) 1989-12-06 1991-07-16 Grandjean Pierre A Nerve electrode with biological substrate
US5092332A (en) 1990-02-22 1992-03-03 Medtronic, Inc. Steroid eluting cuff electrode for peripheral nerve stimulation
AU6486494A (en) * 1993-06-24 1995-01-05 Siemens Aktiengesellschaft Compound and method of applying anti-fouling coatings on medical devices
US5513636A (en) * 1994-08-12 1996-05-07 Cb-Carmel Biotechnology Ltd. Implantable sensor chip
US5788833A (en) 1995-03-27 1998-08-04 California Institute Of Technology Sensors for detecting analytes in fluids
US5925038A (en) 1996-01-19 1999-07-20 Ep Technologies, Inc. Expandable-collapsible electrode structures for capacitive coupling to tissue
GB9702277D0 (en) 1997-02-04 1997-03-26 Innes John Centre Modified electrodes and their use
FR2766092B1 (en) 1997-07-16 1999-10-08 Centre Nat Rech Scient IMPLANTABLE DEVICE COATED WITH A POLYMER CAPABLE OF RELEASING BIOLOGICALLY ACTIVE SUBSTANCES
AU747878B2 (en) 1998-04-09 2002-05-30 California Institute Of Technology Electronic techniques for analyte detection
US20020099438A1 (en) * 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
SE512579C2 (en) * 1998-07-09 2000-04-03 Forskarpatent I Linkoeping Ab Polymer gel electrode, and process for its preparation
US6197881B1 (en) 1999-08-18 2001-03-06 Biopixel Ltd. Electrically conductive copolymers and their preparation
AU782639B2 (en) 1999-12-10 2005-08-18 Massachusetts Institute Of Technology Microchip devices for delivery of molecules and methods of fabrication thereof
US6730212B1 (en) 2000-10-03 2004-05-04 Hrl Laboratories, Llc Sensor for chemical and biological materials
EP1373609A1 (en) * 2001-03-26 2004-01-02 University College London Method for forming hardened tubes and sheets
AU2002258637A1 (en) 2001-03-27 2002-10-08 Board Of Regents The University Of Texas System Biodegradable, electrically conductiong polymer for tissue engineering applications
US7381538B2 (en) * 2001-06-01 2008-06-03 Colorado State University Research Foundation (Csurf) Optical biosensor with enhanced activity retention for detection of halogenated organic compounds
US6946597B2 (en) 2002-06-22 2005-09-20 Nanosular, Inc. Photovoltaic devices fabricated by growth from porous template
US20050234513A1 (en) * 2003-11-05 2005-10-20 Phillip Alexander Implantable neuronal networks
US7689260B2 (en) * 2003-11-06 2010-03-30 The Regents Of The University Of Colorado Shape-memory polymer coated electrodes
US7045205B1 (en) 2004-02-19 2006-05-16 Nanosolar, Inc. Device based on coated nanoporous structure
US20060160100A1 (en) 2005-01-19 2006-07-20 Agency For Science, Technology And Research Enzymatic electrochemical detection assay using protective monolayer and device therefor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6095148A (en) * 1995-11-03 2000-08-01 Children's Medical Center Corporation Neuronal stimulation using electrically conducting polymers
US20050033132A1 (en) * 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
US20050048651A1 (en) * 1997-11-06 2005-03-03 Frida Ryttsen Method and apparatus for spatially confined electroporation
US6890715B1 (en) * 1999-08-18 2005-05-10 The California Institute Of Technology Sensors of conducting and insulating composites
US6294245B1 (en) * 1999-09-22 2001-09-25 Agilent Technologies, Inc. Method for depositing electrically conducting polymer films via electrochemical deposition of precursor polymers

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