WO2007027941A3 - Compositions and methods for preparation of poorly water soluble drugs with increased stability - Google Patents
Compositions and methods for preparation of poorly water soluble drugs with increased stability Download PDFInfo
- Publication number
- WO2007027941A3 WO2007027941A3 PCT/US2006/034103 US2006034103W WO2007027941A3 WO 2007027941 A3 WO2007027941 A3 WO 2007027941A3 US 2006034103 W US2006034103 W US 2006034103W WO 2007027941 A3 WO2007027941 A3 WO 2007027941A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- water soluble
- compositions
- poorly water
- preparation
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Abstract
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ566705A NZ566705A (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
EP06802739.0A EP1928435B8 (en) | 2005-08-31 | 2006-08-30 | Compositions of poorly water soluble drugs with increased stability and methods for preparation thereof |
KR1020087007603A KR101643416B1 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
ES06802739T ES2719093T3 (en) | 2005-08-31 | 2006-08-30 | Compositions of low water soluble drugs with greater stability and methods for their preparation |
CN200680038640.5A CN101291658B (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
CA2620389A CA2620389C (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
BRPI0615292A BRPI0615292A8 (en) | 2005-08-31 | 2006-08-30 | compositions and methods for preparing poorly soluble water drugs with increased stability |
EP19150684.9A EP3527202A1 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
JP2008529288A JP5368093B2 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods of preparation of poorly water-soluble drugs with increased stability |
AU2006284657A AU2006284657B2 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
US11/513,756 US8034765B2 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
PCT/US2006/034103 WO2007027941A2 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
NZ592132A NZ592132A (en) | 2005-08-31 | 2006-08-30 | Composition comprising nanoparticles of docitaxel and a citrate |
EP11170007.6A EP2404594B1 (en) | 2005-08-31 | 2006-08-30 | Compositions comprising docetaxel with increased stability |
KR1020137019918A KR101457834B1 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
IL189600A IL189600A (en) | 2005-08-31 | 2008-02-19 | Pharmaceutical composition comprising nanoparticles comprising docetaxel in an anhydrous form |
NO20081576A NO343793B1 (en) | 2005-08-31 | 2008-03-28 | Compositions and Methods for the Preparation of Low Water Soluble Drugs with Increased Stability |
US12/402,358 US7981445B2 (en) | 2005-08-31 | 2009-03-11 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
IL247486A IL247486B (en) | 2005-08-31 | 2016-08-25 | A composition comprising nanoparticles comprising docetaxel, albumin and citrate, uses thereof, a method for it's preparation and a sealed vial and a kit comprising the composition |
NO20190526A NO344945B1 (en) | 2005-08-31 | 2019-04-24 | Compositions and methods for the preparation of low water soluble drugs with increased stability |
IL272236A IL272236A (en) | 2005-08-31 | 2020-01-26 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
NO20200320A NO20200320A1 (en) | 2005-08-31 | 2020-03-17 | Compositions and methods for the preparation of low water soluble drugs with increased stability |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71286505P | 2005-08-31 | 2005-08-31 | |
US60/712,865 | 2005-08-31 | ||
US73693105P | 2005-11-14 | 2005-11-14 | |
US73696205P | 2005-11-14 | 2005-11-14 | |
US60/736,931 | 2005-11-14 | ||
US60/736,962 | 2005-11-14 | ||
PCT/US2006/034103 WO2007027941A2 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007027941A2 WO2007027941A2 (en) | 2007-03-08 |
WO2007027941A3 true WO2007027941A3 (en) | 2007-04-26 |
Family
ID=41404560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/034103 WO2007027941A2 (en) | 2005-08-31 | 2006-08-30 | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
Country Status (13)
Country | Link |
---|---|
US (2) | US8034765B2 (en) |
EP (2) | EP1928435B8 (en) |
JP (1) | JP5368093B2 (en) |
KR (2) | KR101457834B1 (en) |
CN (1) | CN101291658B (en) |
AU (1) | AU2006284657B2 (en) |
BR (1) | BRPI0615292A8 (en) |
CA (1) | CA2620389C (en) |
ES (1) | ES2719093T3 (en) |
IL (3) | IL189600A (en) |
NO (3) | NO343793B1 (en) |
NZ (2) | NZ566705A (en) |
WO (1) | WO2007027941A2 (en) |
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US7771751B2 (en) | 2005-08-31 | 2010-08-10 | Abraxis Bioscience, Llc | Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents |
US7981445B2 (en) | 2005-08-31 | 2011-07-19 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
US8034375B2 (en) | 2005-02-18 | 2011-10-11 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US8911786B2 (en) | 2007-03-07 | 2014-12-16 | Abraxis Bioscience, Llc | Nanoparticle comprising rapamycin and albumin as anticancer agent |
US8927019B2 (en) | 2007-06-01 | 2015-01-06 | Abraxis Bioscience, Llc | Methods and compositions for treating recurrent cancer |
US8999396B2 (en) | 2006-12-14 | 2015-04-07 | Abraxis Bioscience, Llc | Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane |
US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US9370494B2 (en) | 2010-03-26 | 2016-06-21 | Abraxis Bioscience, Llc | Methods for treating hepatocellular carcinoma |
US9393318B2 (en) | 2010-03-29 | 2016-07-19 | Abraxis Bioscience, Llc | Methods of treating cancer |
US9399072B2 (en) | 2010-06-04 | 2016-07-26 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
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US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
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