WO2007027234A3 - Enzyme detection technique - Google Patents

Enzyme detection technique Download PDF

Info

Publication number
WO2007027234A3
WO2007027234A3 PCT/US2006/016907 US2006016907W WO2007027234A3 WO 2007027234 A3 WO2007027234 A3 WO 2007027234A3 US 2006016907 W US2006016907 W US 2006016907W WO 2007027234 A3 WO2007027234 A3 WO 2007027234A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
chromatographic medium
enzyme
color
absorbent material
Prior art date
Application number
PCT/US2006/016907
Other languages
French (fr)
Other versions
WO2007027234A2 (en
Inventor
Xuedong Song
Original Assignee
Kimberly Clark Co
Xuedong Song
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co, Xuedong Song filed Critical Kimberly Clark Co
Priority to EP06758960.6A priority Critical patent/EP1920067B1/en
Publication of WO2007027234A2 publication Critical patent/WO2007027234A2/en
Publication of WO2007027234A3 publication Critical patent/WO2007027234A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Abstract

A diagnostic test kit for detecting the presence or absence of an enzyme (e.g., leukocyte esterase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the enzyme to release a nucleophilic aromatic compound. The kit also comprises a lateral flow device that comprises a chromatographic medium. The chromatographic medium defines a detection zone within which is contained a first reagent (e.g., diazonium ion) that is capable of reacting with the nucleophilic aromatic compound to form a second reagent (e.g., aromatic azo compound). The second reagent exhibits a color that is different than the color of the first reagent. The lateral flow device also includes an absorbent material located adjacent to the chromatographic medium, the absorbent material receiving the test sample after flowing through the chromatographic medium.
PCT/US2006/016907 2005-08-31 2006-04-27 Enzyme detection technique WO2007027234A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06758960.6A EP1920067B1 (en) 2005-08-31 2006-04-27 Enzyme detection technique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/217,097 US7504235B2 (en) 2005-08-31 2005-08-31 Enzyme detection technique
US11/217,097 2005-08-31

Publications (2)

Publication Number Publication Date
WO2007027234A2 WO2007027234A2 (en) 2007-03-08
WO2007027234A3 true WO2007027234A3 (en) 2007-06-07

Family

ID=36850080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016907 WO2007027234A2 (en) 2005-08-31 2006-04-27 Enzyme detection technique

Country Status (3)

Country Link
US (4) US7504235B2 (en)
EP (1) EP1920067B1 (en)
WO (1) WO2007027234A2 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US20070121113A1 (en) * 2004-12-22 2007-05-31 Cohen David S Transmission-based optical detection systems
US8241263B2 (en) 2005-08-26 2012-08-14 Medline Industries, Inc. Absorbent article
EP1920253A2 (en) * 2005-08-31 2008-05-14 Kimberly-Clark Worldwide, Inc. Detection of proteases secreted from pathogenic microorganisms
US7504235B2 (en) 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US8789756B2 (en) * 2006-02-25 2014-07-29 Roche Diagnostics Operations, Inc. Test element coding apparatuses, systems and methods
US8758989B2 (en) 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
GB2437311A (en) * 2006-04-07 2007-10-24 Mologic Ltd A protease detection product
US8044257B2 (en) * 2006-10-30 2011-10-25 Kimberly-Clark Worldwide, Inc. Absorbent article containing lateral flow assay device
US7897360B2 (en) 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
US7935538B2 (en) * 2006-12-15 2011-05-03 Kimberly-Clark Worldwide, Inc. Indicator immobilization on assay devices
WO2009121079A2 (en) * 2008-03-26 2009-10-01 Kapp John Test device and method for testing for vaginal infections
US20100290948A1 (en) * 2009-05-15 2010-11-18 Xuedong Song Absorbent articles capable of indicating the presence of urinary tract infections
CA3047243C (en) 2010-10-19 2022-04-12 Medline Industries, Inc. Absorbent articles and methods of manufacturing the same
CA2841976C (en) 2011-07-22 2021-05-11 Access Bio, Inc. A single-pad strip for an improved lateral flow assay and a test device using the same
CN103858009B (en) 2011-09-16 2016-05-18 克里多生物医药私人有限公司 Molecular diagnosis checkout equipment and using method
USD716938S1 (en) 2011-10-19 2014-11-04 Medline Industries, Inc. Absorbent core
US9486368B2 (en) 2013-12-05 2016-11-08 Medline Industries, Inc. Disposable hygienic article with means for diagnostic testing
US10226388B2 (en) 2014-04-21 2019-03-12 Medline Industries, Inc. Stretch breathable protective absorbent article using tri-laminate
US9622922B2 (en) 2014-04-21 2017-04-18 Medline Industries, Inc. Stretch breathable protective absorbent article using bilaminate
TWI526129B (en) 2014-11-05 2016-03-11 Elite Material Co Ltd Multilayer printed circuit boards with dimensional stability
US9885663B2 (en) * 2015-10-25 2018-02-06 Adriel Sumathipala Portable, rapid, and inexpensive diagnostic tests for cardiac disease risk
USD825075S1 (en) 2016-02-23 2018-08-07 Flora Bioscience, Inc. Test strip holding device
US11104933B1 (en) 2016-03-22 2021-08-31 Cleu Diagnostics, Llc Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay
USD827857S1 (en) * 2016-12-29 2018-09-04 Euroimmun Medizinische Labordiagnostika Ag Pathology tissue slide
USD821606S1 (en) * 2016-12-29 2018-06-26 Euroimmun Medizinische Labordiagnostika Ag Pathology tissue slide
AU2018345841A1 (en) 2017-10-06 2020-05-21 The Research Foundation For The State University For The State Of New York Selective optical aqueous and non-aqueous detection of free sulfites
CN107884575A (en) * 2017-11-01 2018-04-06 上海凯创生物技术有限公司 Amino terminal-pro brain natriuretic peptide detection reagent card, kit and application thereof
TWI666439B (en) * 2018-09-04 2019-07-21 東吳大學 Detection device for detecting leukocyte esterase
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
WO2022148866A1 (en) 2021-01-08 2022-07-14 Alpspitz Bioscience Gmbh Use of biomarkers for predicting the clinical and/or treatment outcome of a human subject

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698600A1 (en) * 1994-08-22 1996-02-28 Bayer Corporation Composition, method and test device for determining the presence of leukocyte cells, esterase or protease in a test sample
WO1999027364A1 (en) * 1997-11-24 1999-06-03 Quidel Corporation Enzyme substrate delivery and product registration in one-step enzyme immunoassays
WO2004011906A2 (en) * 2002-07-30 2004-02-05 University Of Florida Diagnostic system for differentiating sputum from saliva
WO2005057214A1 (en) * 2003-11-21 2005-06-23 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
WO2007027353A2 (en) * 2005-08-31 2007-03-08 Kimberly-Clark Worldwide, Inc. Detection of proteases secreted from pathogenic microorganisms

Family Cites Families (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
GB1128371A (en) * 1965-10-04 1968-09-25 Miles Lab Diagnostic composition
US3634198A (en) 1968-02-27 1972-01-11 Andrew Truhan Detection of urinary tract infections
US3772076A (en) * 1970-01-26 1973-11-13 Hercules Inc Reaction products of epihalohydrin and polymers of diallylamine and their use in paper
US3700623A (en) * 1970-04-22 1972-10-24 Hercules Inc Reaction products of epihalohydrin and polymers of diallylamine and their use in paper
BE787605A (en) 1971-08-19 1973-02-16 Merck Patent Gmbh NITRITE CLEARANCE AGENT
US4140580A (en) * 1976-05-03 1979-02-20 Mcdonnell Douglas Corporation Broth for indicating presence of candida yeast and other yeasts and fungi
US4275785A (en) * 1977-03-28 1981-06-30 Industrial Blast Coil Corporation Heat exchange tubing blade assembly
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
DE2854987A1 (en) * 1978-12-20 1980-06-26 Boehringer Mannheim Gmbh DIAGNOSTIC AGENTS FOR DETECTING PROTEOLYTIC ENZYMS AND CHROMOGENS SUITABLE FOR THIS
DE2905531A1 (en) 1979-02-14 1981-01-08 Boehringer Mannheim Gmbh DIAGNOSTIC AGENT FOR DETECTING LEUCOCYTES IN BODY LIQUIDS
EP0146654A3 (en) 1980-06-20 1986-08-20 Unilever Plc Processes and apparatus for carrying out specific binding assays
ATE8130T1 (en) 1980-08-25 1984-07-15 Kabivitrum Ab PEPTIDE SUBSTRATES FOR DETERMINING PROTEASE ACTIVITY.
IL61951A (en) 1981-01-21 1984-01-31 Univ Ben Gurion Method and apparatus for detecting nitrite ions in fluids
US4874695A (en) * 1983-03-08 1989-10-17 American Home Products Corp. Rapid indentification of yeast and other fungal microorganisms by enzyme detection
EP0127797B1 (en) * 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation
US4537657A (en) * 1983-08-26 1985-08-27 Hercules Incorporated Wet strength resins
GB8406752D0 (en) 1984-03-15 1984-04-18 Unilever Plc Chemical and clinical tests
US4743560A (en) 1984-03-26 1988-05-10 Becton Dickinson And Company Solid phase assay
DE3413078A1 (en) 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. CHROMOGENEIC AMINO ACID AND PEPTIDESTERS, METHOD FOR THE PRODUCTION THEREOF, USE OF THESE COMPOUNDS IN ANALYZING METHODS AND MEANS FOR DETECTING ESTEROLYTIC AND / OR PROTEOLYTIC ENZYMES
DE3413077A1 (en) 1984-04-06 1985-10-17 Miles Laboratories, Inc., Elkhart, Ind. CHROMOGENEIC AMINO ACID AND PEPTIDESTERS, METHOD FOR THE PRODUCTION THEREOF, USE OF THESE COMPOUNDS IN ANALYZING METHODS AND MEANS FOR DETECTING ESTEROLYTIC AND / OR PROTEOLYTIC ENZYMES
US4657855A (en) 1984-04-06 1987-04-14 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample
US4704460A (en) 1984-04-06 1987-11-03 Miles Laboratories, Inc. Novel compounds for detecting the presence of hydrolytic analytes in a test sample
US4637979A (en) 1984-04-06 1987-01-20 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent
JPS6130768A (en) 1984-07-23 1986-02-13 Eiken Kagaku Kk Composition for measuring nitrite
US4622298A (en) 1984-08-09 1986-11-11 Becton, Dickinson And Company Detection and quantitation of microorganisms, leukocytes and squamous epithelial cells in urine
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
TW203120B (en) 1985-10-04 1993-04-01 Abbott Lab
US5585279A (en) * 1986-01-23 1996-12-17 Davidson; Robert S. Time-resolved luminescence binding assays using a fluorescent transition metal label other than ruthenium
US4859581A (en) * 1986-03-10 1989-08-22 Board Of Regents, The University Of Texas System Endoglycosidase assay
US5591581A (en) * 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
EP0272320B1 (en) * 1986-06-17 1994-03-23 Baxter Diagnostics Inc. Homogeneous fluoroassay methods employing fluorescent background rejection
US4835099A (en) 1986-11-20 1989-05-30 Becton, Dickinson And Company Signal enhancement in immunoassay by modulation of enzymatic catalysis
US4954435A (en) 1987-01-12 1990-09-04 Becton, Dickinson And Company Indirect colorimetric detection of an analyte in a sample using ratio of light signals
US4920046A (en) 1987-02-20 1990-04-24 Becton, Dickinson And Company Process, test device, and test kit for a rapid assay having a visible readout
CA1303983C (en) 1987-03-27 1992-06-23 Robert W. Rosenstein Solid phase assay
USRE38430E1 (en) 1987-03-27 2004-02-17 Becton, Dickinson And Company Solid phase chromatographic immunoassay
JPH0684970B2 (en) * 1987-03-31 1994-10-26 株式会社京都医科学研究所 Method of detecting occult blood in feces
DE3856542T2 (en) 1987-04-27 2003-10-30 Inverness Medical Switzerland Test device for carrying out specific binding tests
US4904583A (en) 1987-05-26 1990-02-27 Becton, Dickinson And Company Cascade immunoassay by multiple binding reactions
US5120643A (en) 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US4956302A (en) 1987-09-11 1990-09-11 Abbott Laboratories Lateral flow chromatographic binding assay device
SE8703682L (en) * 1987-09-24 1989-03-25 Wallac Oy HOMOGENIC DETERMINATION METHOD USING AFFINITY REACTIONS
US5073340A (en) 1987-10-08 1991-12-17 Becton, Dickinson And Company Depositing a binder on a solid support
US4978625A (en) 1987-10-19 1990-12-18 Becton, Dickinson And Company Fluorescence immunoassay using water insoluble dyes
US5275785A (en) 1987-10-30 1994-01-04 Unilever Patent Holdings B.V. Test device for detecting an analyte in a liquid sample
US5670381A (en) 1988-01-29 1997-09-23 Abbott Laboratories Devices for performing ion-capture binding assays
EP0400086B1 (en) * 1988-02-08 1993-01-27 University College Cardiff Consultants Ltd. Detection of diamines in biological fluids
US5573919A (en) 1988-06-02 1996-11-12 Carter-Wallace Assay using an absorbent material
US6124107A (en) 1988-06-10 2000-09-26 Merck & Co., Inc. Assay for marker of human polymorphonuclear leukocyte elastase activity
AU2684488A (en) 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
US5075077A (en) 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
US5252459A (en) 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles
MY104234A (en) 1988-11-17 1994-02-28 Becton Dickinson Co Immunoassay on a preblocked solid surface
US5208143A (en) 1988-11-17 1993-05-04 Becton, Dickinson And Company Immunoassay on a preblocked solid surface
US5252484A (en) * 1988-11-29 1993-10-12 Minnesota Mining And Manufacturing Company Rapid read-out biological indicator
US6352862B1 (en) 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
US5185127A (en) 1989-09-21 1993-02-09 Becton, Dickinson And Company Test device including flow control means
US5075078A (en) 1989-10-05 1991-12-24 Abbott Laboratories Self-performing immunochromatographic device
US6274324B1 (en) 1989-12-01 2001-08-14 Unilever Patent Holdings B.V. Specific binding reagent comprising a variable domain protein linked to a support or tracer
FR2659982B1 (en) * 1990-03-23 1995-10-20 Serbio USE OF CHROMOGENIC SUBSTRATES IN THE DETERMINATION OF CANDIDA.
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5139934A (en) * 1990-05-25 1992-08-18 Becton, Dickinson And Company Substrate composition and method for solid phase urease immunoassay
US5292652A (en) * 1990-10-05 1994-03-08 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
US5428690A (en) 1991-09-23 1995-06-27 Becton Dickinson And Company Method and apparatus for automated assay of biological specimens
DE69313611T2 (en) * 1992-07-02 1998-01-08 Erkki Soini BIOS-SPECIFIC MULTIPARAMETER ANALYSIS PROCEDURE
FI92882C (en) * 1992-12-29 1995-01-10 Medix Biochemica Ab Oy Disposable test strip and process for its manufacture
US5416003A (en) 1993-04-14 1995-05-16 Litmus Concepts, Inc. Reporter enzyme release technology: methods of assaying for the presence of aspartic proteases and other hydrolytic enzyme activities
US5516700A (en) 1993-05-28 1996-05-14 Chimera Research And Chemical, Inc. Automated urinalysis method
US5468236A (en) 1993-06-09 1995-11-21 Kimberly-Clark Corporation Disposable absorbent product incorporating chemically reactive substance
US5415994A (en) 1993-08-02 1995-05-16 Quidel Corporation Lateral flow medical diagnostic assay device with sample extraction means
US5464741A (en) * 1993-10-08 1995-11-07 Henwell, Inc. Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays
US6451619B1 (en) * 1994-06-29 2002-09-17 Inverness Medical Switzerland Gmbh Monitoring methods and devices for use therein
GB9419267D0 (en) 1994-09-23 1994-11-09 Unilever Plc Assay devices
US20010046668A1 (en) * 1994-10-21 2001-11-29 G.D. Searle & Co. Fluorescence polarization method for determining protease activity
US5571684A (en) * 1994-11-07 1996-11-05 Litmus Concepts, Inc. Assay for proline iminopeptidase and other hydrolytic activities
CA2161574A1 (en) 1994-11-15 1996-05-16 James Noffsinger Methodology for colorimetrically determining the concentration of white blood cells in a biological fluid
AU4117696A (en) 1994-11-24 1996-06-17 Unipath Limited Recovery of and uses of specific binding agents
US5866434A (en) * 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US5567596A (en) 1994-12-29 1996-10-22 Research Foundation Of State University Of New York Rapid assay of activators and inhibitors of clotting
GB9505425D0 (en) 1995-03-17 1995-05-03 Unilever Plc Assay devices
US6319676B1 (en) * 1995-05-02 2001-11-20 Carter Wallace, Inc. Diagnostic detection device and method
DE69638321D1 (en) 1995-10-11 2011-03-03 Luminex Corp SIMULTANEOUS MULTI-ANALYSIS OF CLINICAL SAMPLES
US5788863A (en) 1995-12-13 1998-08-04 Becton Dickinson And Company Apparatus and method for conducting an assay using reverse flow through a membrane
US6551791B1 (en) 1995-12-21 2003-04-22 University Of Florida Rapid diagnostic method for distinguishing allergies and infections and nasal secretion collection unit
US5945281A (en) 1996-02-02 1999-08-31 Becton, Dickinson And Company Method and apparatus for determining an analyte from a sample fluid
CA2245664A1 (en) * 1996-02-08 1997-08-14 Australian Membrane And Biotechnology Research Institute Enzyme detection biosensors
CA2248558A1 (en) 1996-03-15 1997-09-18 Yale University Methods and means of detecting nitric oxide synthase
GB9609024D0 (en) * 1996-05-01 1996-07-03 Idg Uk Ltd Compounds
EP0901630B1 (en) 1996-05-23 2003-08-20 Inverness Medical Switzerland GmbH Improvements in or relating to specific binding assays
US6004530A (en) * 1996-06-04 1999-12-21 Roche Diagnostics Gmbh Use of metallo-porphyrin conjugates for the detection of biological substances
US6444423B1 (en) * 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
KR980010425A (en) 1996-07-30 1998-04-30 안홍원 Compositions and measuring instruments for the detection of urine leukocytes and proteolytic enzymes
US5998221A (en) 1996-09-25 1999-12-07 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
US6194220B1 (en) 1996-09-25 2001-02-27 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
US5798273A (en) 1996-09-25 1998-08-25 Becton Dickinson And Company Direct read lateral flow assay for small analytes
ES2187622T3 (en) 1996-09-27 2003-06-16 Inverness Medical Switzerland REAGENTS AND TEST DEVICES.
ES2168444T3 (en) 1996-09-27 2002-06-16 Inverness Medical Switzerland MANUFACTURE OF TEST STRIPS.
DE69626016T2 (en) 1996-09-27 2004-01-08 Inverness Medical Switzerland Gmbh Test kit and devices
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US6194221B1 (en) 1996-11-19 2001-02-27 Wyntek Diagnostics, Inc. Hybrid one-step immunochromatographic device and method of use
US6979576B1 (en) 1997-07-25 2005-12-27 Shu-Ching Cheng Methods of use of one step immunochromatographic device for Streptococcus A antigen
US5854011A (en) * 1996-12-19 1998-12-29 Idexx Laboratories Incorporated Method and components for the detection of yeasts and/or molds in a sample
GB9700759D0 (en) 1997-01-15 1997-03-05 Carbury Herne Limited Assay device
US6057165A (en) 1997-02-07 2000-05-02 Becton, Dickinson And Company Quality control procedure for membrane flow-through diagnostic assay devices
GB2322192B (en) 1997-02-14 2001-01-31 Unilever Plc Assay devices
WO1998039471A1 (en) * 1997-03-07 1998-09-11 Tropix, Inc. Protease inhibtor assay
GB2323166B (en) 1997-03-12 2001-04-11 Johnson & Johnson Medical Method and apparatus for mapping the condition of a wound
US6613583B1 (en) * 1997-06-27 2003-09-02 Igen International, Inc. Electrochemiluminescent label based on multimetallic assemblies
US5989924A (en) 1997-09-30 1999-11-23 Becton, Dickinson And Company Device for determining an analyte in a sample
US6077669A (en) 1997-11-04 2000-06-20 Becton Dickinson And Company Kit and method for fluorescence based detection assay
US6004821A (en) 1998-03-07 1999-12-21 Levine; Robert A. Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample
US6017723A (en) 1998-03-27 2000-01-25 Long Island Jewish Medical Center Method for isolating inhibitors of protease activity
GB9807134D0 (en) 1998-04-02 1998-06-03 Unilever Plc Test methods devices and test kits
US6224107B1 (en) * 1998-05-04 2001-05-01 Reba Hall Smith Pocketbook book
US6030840A (en) * 1998-06-15 2000-02-29 Nen Life Sciences, Inc. Neutral enhancement of lanthanides for time resolved fluorescence
FI982422A0 (en) * 1998-11-09 1998-11-09 Arctic Diagnostics Oy Porphyrin compounds, their conjugates and assay methods based on the use of said conjugate
US6261779B1 (en) * 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
US6402918B1 (en) * 1998-11-16 2002-06-11 Joseph B. Schlenoff Apparatus for capillary electrophoresis and associated method
US6528652B1 (en) 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
AU3508600A (en) * 1999-02-26 2000-09-14 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
US6472141B2 (en) * 1999-05-21 2002-10-29 Caliper Technologies Corp. Kinase assays using polycations
US6514769B2 (en) 1999-07-29 2003-02-04 Jin Po Lee Multiple analyte assay device with sample integrity monitoring system
US6203496B1 (en) 1999-08-12 2001-03-20 Michael R. Gael Apparatus with reagents for detection of medical conditions
US6485926B2 (en) 1999-12-22 2002-11-26 Fuji Photo Film Co., Ltd. Method for measuring protease activity
JP2001349892A (en) 2000-04-03 2001-12-21 Unilever Nv Test method and device
US6689618B1 (en) 2000-04-03 2004-02-10 Shuenn Tzong Chen Method and test strip of detecting oxidizing adulterant in urine
JP2001349891A (en) 2000-04-03 2001-12-21 Unilever Nv Test method and device
US6627459B1 (en) 2000-04-19 2003-09-30 Applied Biotech, Inc. Immunoassay controls
US6537823B1 (en) 2000-04-24 2003-03-25 Sciteck Diagnostics, Inc. Method for detection of bromine in urine using liquid chemistry dry chemistry test pads and lateral flow
US6528321B1 (en) * 2000-06-26 2003-03-04 Beckman Coulter, Inc. Opposable-element chromatographic assay device for detection of analytes in whole blood samples
EP1299412A2 (en) * 2000-06-30 2003-04-09 Incyte Genomics, Inc. Protein modification and maintenance molecules
AU2001279135A1 (en) * 2000-07-31 2002-02-13 Maxygen, Inc. Biosensors, reagents and diagnostic applications of directed evolution
US7052831B2 (en) 2000-09-29 2006-05-30 Becton Dickinson And Company Detection of multiple analytes from a single sample using a multi-well, multi-analyte flow-through diagnostic test device
US6653149B1 (en) 2000-10-16 2003-11-25 Applied Biotech Inc. Specimen collection device and method
US6524864B2 (en) 2000-12-28 2003-02-25 Aurora L. Fernandez Decastro Test strip for simultaneous detection of a plurality of analytes
US6818452B2 (en) 2001-04-23 2004-11-16 Branan Medical Corp. Lateral flow contact test apparatus
US7291477B2 (en) * 2001-07-03 2007-11-06 Xenotope Diagnostics, Inc. Method and device for trichomonas detection
US6669908B2 (en) 2001-07-25 2003-12-30 Applied Biotech, Inc. Urine test device
US20040219694A1 (en) 2001-09-11 2004-11-04 Chittock Roger Steward Lateral flow test format for enzyme assays
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
US20030119073A1 (en) 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20050109951A1 (en) * 2001-12-27 2005-05-26 Falk Fish Novel device, system and method for fluorescence detection
US7091049B2 (en) 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
WO2004003527A1 (en) 2002-06-27 2004-01-08 Unipath Limited Assay reader
US6875185B2 (en) 2002-07-29 2005-04-05 Branan Medical Corporation Integrated confirmation sample in a body fluid test device and method of using
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7432105B2 (en) 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7041469B2 (en) * 2002-10-10 2006-05-09 Quidel Corporation Assays for trichomonal and other hydrolases
US20040106190A1 (en) 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US20040121334A1 (en) 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
US7459314B2 (en) 2003-02-13 2008-12-02 Inverness Medical Switzerland Gmbh Lateral flow immunoassay controls
US7239394B2 (en) * 2003-06-04 2007-07-03 Inverness Medical Switzerland Gmbh Early determination of assay results
US7315378B2 (en) * 2003-06-04 2008-01-01 Inverness Medical Switzerland Gmbh Optical arrangement for assay reading device
JP2005056604A (en) 2003-08-06 2005-03-03 Hitachi Displays Ltd Self-luminous flat display device
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards
US7837663B2 (en) * 2003-10-16 2010-11-23 Kimberly-Clark Worldwide, Inc. Odor controlling article including a visual indicating device for monitoring odor absorption
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7592020B2 (en) * 2003-12-05 2009-09-22 Kimberly-Clark Worldwide, Inc. Personal care products with visual indicator of vaginitis
US20050136550A1 (en) 2003-12-19 2005-06-23 Kimberly-Clark Worldwide, Inc. Flow control of electrochemical-based assay devices
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
WO2005066359A1 (en) 2003-12-31 2005-07-21 Applera Corporation Multiplex protease profiling
GB2422664A (en) 2005-01-28 2006-08-02 Ethicon Inc Device for detecting an enzyme in a sample
US20050191704A1 (en) * 2004-03-01 2005-09-01 Kimberly-Clark Worldwide, Inc. Assay devices utilizing chemichromic dyes
US20050220712A1 (en) 2004-04-01 2005-10-06 Wright Daniel G Method for determining mucosal neutrophil counts in neutropenia patents
DE602005013947D1 (en) * 2004-04-16 2009-05-28 Idexx Lab Inc ANTIBODY TO DOG PANCREASLIPASE
US20060019265A1 (en) 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7247375B2 (en) 2004-04-30 2007-07-24 Kimberly-Clark Worldwide, Inc. Polymeric matrices for the encapsulation of phosphorescent molecules for analytical applications
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7906276B2 (en) 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
US7662562B2 (en) * 2004-08-10 2010-02-16 Becton, Dickinson And Company Method for rapid identification of microorganisms
US20060127459A1 (en) * 2004-12-15 2006-06-15 Lei Huang Urogenital infection inhibition
US7939342B2 (en) 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
US7439079B2 (en) 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
US7504235B2 (en) * 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US8003399B2 (en) * 2005-08-31 2011-08-23 Kimberly-Clark Worldwide, Inc. Nitrite detection technique
US7829347B2 (en) * 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
US7279136B2 (en) 2005-12-13 2007-10-09 Takeuchi James M Metering technique for lateral flow assay devices
US20070134747A1 (en) * 2005-12-14 2007-06-14 Kimberly-Clark Worldwide, Inc. Detection of secreted lipase proteins from Candida species
GB2435511A (en) 2006-02-23 2007-08-29 Mologic Ltd Protease detection
US8758989B2 (en) 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
GB2437311A (en) 2006-04-07 2007-10-24 Mologic Ltd A protease detection product

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698600A1 (en) * 1994-08-22 1996-02-28 Bayer Corporation Composition, method and test device for determining the presence of leukocyte cells, esterase or protease in a test sample
WO1999027364A1 (en) * 1997-11-24 1999-06-03 Quidel Corporation Enzyme substrate delivery and product registration in one-step enzyme immunoassays
WO2004011906A2 (en) * 2002-07-30 2004-02-05 University Of Florida Diagnostic system for differentiating sputum from saliva
WO2005057214A1 (en) * 2003-11-21 2005-06-23 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
WO2007027353A2 (en) * 2005-08-31 2007-03-08 Kimberly-Clark Worldwide, Inc. Detection of proteases secreted from pathogenic microorganisms

Also Published As

Publication number Publication date
US7575887B2 (en) 2009-08-18
US7504235B2 (en) 2009-03-17
WO2007027234A2 (en) 2007-03-08
US20070048815A1 (en) 2007-03-01
US8609401B2 (en) 2013-12-17
US20090305395A1 (en) 2009-12-10
US20070048816A1 (en) 2007-03-01
EP1920067B1 (en) 2015-06-03
US20090181416A1 (en) 2009-07-16
EP1920067A2 (en) 2008-05-14

Similar Documents

Publication Publication Date Title
WO2007027234A3 (en) Enzyme detection technique
WO2010131127A3 (en) Absorbent articles capable of indicating the presence of urinary tract infections
WO2008030305A3 (en) Methods and kits for detecting cerebrospinal fluid in a sample
WO2006117161A3 (en) New labelling strategies for the sensitive detection of analytes
WO2009058902A3 (en) Methods and devices for analyte detection
WO2005093414A3 (en) Assay devices utilizing chemichromic dyes
WO2005086744A3 (en) Body fluid analyte meter & cartridge system for performing combined general chemical and specific binding assays
WO2007005666A3 (en) System and method of analyte detection using differential receptors
WO2008026102A3 (en) Detection of hydrogen peroxide released by enzyme-catalyzed oxidation of an analyte
WO2008133727A3 (en) Sequential analysis of biological samples with bleaching of intermediate fluorescent signals
WO2006088904A3 (en) Fecal sample test device and methods of use
WO2007082302A3 (en) Detection, separation or isolation of target molecules using a microchannel apparatus
WO2008008785A3 (en) Ultra-sensitive detection of analytes
WO2008066607A3 (en) Device for detection of molecules in biological fluids
WO2008039946A3 (en) Integrated meter for analyzing biological samples
WO2008019324A3 (en) Method for detecting fluorescent signals in a biological sample
WO2007114986A3 (en) Cooperative probes and methods of using them
WO2008085538A3 (en) New assay platforms and detection methodology using surface enhanced raman scattering (sers) upon specific biochemical interactions
ATE428929T1 (en) REAGENT, EQUIPMENT AND METHOD FOR SAMPLE ANALYSIS
NO20042579L (en) Method for detecting analytes using magnetic colloidal particles
WO2005116611A3 (en) Flow assay device comprising dry reagent cake
WO2010052307A3 (en) Test element for detecting an analyte in a sample
WO2007133586A3 (en) Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets
WO2007149065A3 (en) Methods and apparatuses for detecting chemical or biological agents
WO2007113590A3 (en) Fluorescent assay

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006758960

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE