WO2007004300A1 - Cosmetic product - Google Patents

Cosmetic product Download PDF

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Publication number
WO2007004300A1
WO2007004300A1 PCT/JP2005/012479 JP2005012479W WO2007004300A1 WO 2007004300 A1 WO2007004300 A1 WO 2007004300A1 JP 2005012479 W JP2005012479 W JP 2005012479W WO 2007004300 A1 WO2007004300 A1 WO 2007004300A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
collagen
ceramide
hyaluronic acid
cosmetic product
Prior art date
Application number
PCT/JP2005/012479
Other languages
French (fr)
Japanese (ja)
Inventor
Yoshinori Shirono
Original Assignee
Dr.Ci:Labo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr.Ci:Labo Co., Ltd. filed Critical Dr.Ci:Labo Co., Ltd.
Priority to PCT/JP2005/012479 priority Critical patent/WO2007004300A1/en
Priority to JP2007523317A priority patent/JPWO2007004300A1/en
Publication of WO2007004300A1 publication Critical patent/WO2007004300A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11Encapsulated compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/007Preparations for dry skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/412Microsized, i.e. having sizes between 0.1 and 100 microns

Definitions

  • the present invention relates to a cosmetic product having an excellent moisturizing effect and capable of improving the moisture and tension of the skin.
  • the conventional gel-like basic cosmetics as described above are used to improve skin tension and moisture. Is also effective.
  • the present invention has been proposed to meet the above-described demand, and an object of the present invention is to provide a cosmetic product that can improve skin tension and moisture by being applied to the skin.
  • the cosmetic product of the present invention comprises a minute container (nanocapsule: trade name Nanosphere) made of hyaluronic acid, and contains the collagen and ceramide in the minute container, and the minute container containing the collagen and ceramide. Is contained in a gel-like basic cosmetic product in an amount of 0.1 to 5% by weight. It is characterized by.
  • the gel-like basic cosmetic product preferably contains ceramide, collagen, and hyaluronic acid.
  • the gel-like basic cosmetics contain vitamin C, laminaria taroroika extract (amber ocean), and pervetianacanalicurata extract.
  • the content of vitamin C is kept to a relatively small amount, and the content of laminaria taroroika extract (amber ocean) and Z or pervetia canariculata extract is 5% by weight or less.
  • a minute container (power capsule: nanocapsule) is composed of hyaluronic acid, and collagen and ceramide are incorporated in the minute container.
  • the inner capsule penetrates to the inner layer (for example, the dermis layer) of the skin surface (stratum corneum or epidermis layer).
  • a minute container (capsule) is formed! /
  • the peptide structure of hyaluronic acid is used as an enzyme in the body. More decomposed, decomposed hyaluronic acid, collagen and ceramide diffuse in the inner layer of the epidermis (for example, dermis layer) and exert an effect of moisturizing and moisturizing from the inside of skin (moisturizing effect or moisture effect) To do.
  • the gel-like basic cosmetic is composed of ceramide, collagen, hyaluronic acid, vitamin C, laminaria taroroleuca extract, pervetia canariculata extract, and ceramide, collagen, hyaluron If the blending ratio of the acid is made much higher than that of the conventional basic cosmetic (gel), the moisturizing property of the gel-type basic cosmetic itself is much higher than that of the conventional product.
  • a minute container or a capsule permeates the skin, and exerts an inner force moisture effect on the skin.
  • ceramide, collagen, and hyaluronic acid contained in gel-like basic cosmetics exert a moisturizing effect from the outside (skin side) of the skin.
  • the inside of the skin nanocapsules and their built-in components
  • the outside of the skin depending on the ingredients blended in the gel
  • it can exert an effect of moisturizing and moisturizing the skin (moisturizing effect or moisture effect).
  • moisturizing effect or moisture effect the so-called “double moisture effect” can be exhibited.
  • the cosmetic of the present invention can naturally moisturize from the inside of the skin.
  • the present invention is very effective for the purpose of imparting tension and moisture to “dry skin”.
  • the gel-like basic cosmetic contains vitamin C, laminaria taroloika kiss (amber ocean), and pervetia canarikurata extract, these components are all Because of its so-called “whitening” effect, it has the effect of beautifying the skin.
  • Laminaria taroroika extract has the effect of rejuvenating the skin
  • Pervetianakana lyclata extract has the effect of activating fibroblasts.
  • 1 to 6 show one embodiment of the present invention functionally and schematically.
  • reference numeral 10 denotes a small container or capsule (a “nano” level size capsule: for example, a product manufactured and sold by Corety Power Company under the trade name “Nanosphere”).
  • the fine capsule 10 is composed of hyaluronic acid.
  • the minute capsule has a spherical shape, and its diameter is 300 ⁇ ! ⁇ 700nm.
  • the microcapsule 10 includes collagen 12 and ceramide 14.
  • collagen 12 and ceramide 14 are represented as a single sphere, but such representation is simplified for ease of understanding. A possible amount of collagen 12 and ceramide 14 is incorporated.
  • Hyaluronic acid microcapsules 10 incorporating collagen 12 and ceramide 14 are added to gel-like basic cosmetic product 20 (arrow D) and mixed uniformly as shown in FIG.
  • a conventionally known mixing technique can be applied to the mixing method.
  • the gel-like basic cosmetic 20 is also blended with collagen 22, ceramide 24, hyaluronic acid 26 power S, and it is blended with the gel-like basic cosmetic 20 (in other words, it is not a microcapsule).
  • the forms of collagen 22, ceramide 24, and hyaluronic acid 26 are shown in Figure 2 with the same crossed star!
  • the cosmetic 30 of the present invention is completed by mixing the microcapsules 10 into the gel-like basic cosmetic 20 (FIG. 3).
  • the cosmetic product 30 of the present invention is configured in a gel form, and as shown in FIG. 3, the microcapsules 10 made of hyaluronic acid containing collagen 12 and ceramide 14 (shown by small circles in FIGS. 3 and 4). ) And collagen 22, ceramide 24, and hyaluronic acid 26 (shown as crosses in FIGS. 3 and 4) that were previously included in the gel-like basic cosmetic 20 separately from the microcapsule 10. ing.
  • FIG. 4 is a partial cross-sectional view showing a state in which the cosmetic 30 according to the embodiment is applied to the skin.
  • the skin to which cosmetic 30 is applied is composed of stratum corneum A, epidermis layer B, and dermis layer C.
  • the dermis layer C shows only a part thereof.
  • the cosmetic 30 is pre-mixed with the gel basic cosmetic 20.
  • Collagen 22, ceramide 24, and hyaluronic acid 26 (cross star) (not microcapsules) remain on the surface of stratum corneum A (upper in Fig. 4).
  • microcapsules 10 (white small circles) permeate stratum corneum A and epidermis layer B and penetrate to dermis layer C.
  • the size (or particle size) of ⁇ 700 nm is selected as a size that can reach the dermis layer C through the stratum corneum A and the epidermis layer B.
  • the hyaluronic acid microcapsules 10 that have reached the dermis layer C have the peptide structure of hyaluronic acid shredded by the enzyme 40 present in the dermis layer, and the molecular weight is reduced. This is a relatively small state (indicated by reference numeral 10P).
  • the hyaluronic acid constituting the microcapsule 10 is shredded, so that the collagen 12 and the ceramide 14 incorporated in the capsule 10 jump out of the capsule 10 (see arrow E) and diffuse in the dermis layer C.
  • hyaluronic acid having a peptide structure is subdivided to such an extent that it can be incorporated in a nanocapsule, the effect of improving "moisture moisture” and “skin elasticity” can no longer be exhibited. . Therefore, microcapsules were produced with hyaluronic acid.
  • the molecular weight is smaller than in the nanocapsule state! /, But this improves the “moisturizing!” And “skin elasticity”. ! The molecular weight is large enough to exert the effect (the state indicated by 10P in FIGS. 5 and 6). In other words, if hyaluronic acid is not made into a microcapsule, the expected action (moisturation of skin, skin firmness) will not be achieved, and hyaluronic acid is expected for the first time by subdividing the microcapsule with an enzyme. To exert the effect.
  • Hyaluronic acid 10P, collagen 12, and ceramide 14 moisturize the skin from the inner side of the skin (the dermis layer C side).
  • the cosmetic 30 As described above, in the skin to which the cosmetic 30 according to the illustrated embodiment is applied, it is preliminarily blended in the gel-like basic cosmetic 20 from the surface side of the skin (the stratum corneum A side).
  • Collagen 22, Ceramide 24, Hyaluronic Acid 26 (Cross Stars) provides a moisturizing and skin-strengthening effect (moisture effect), and the inner side of the skin (the dermis layer C side) has very little force
  • the hyaluronic acid 10P that constitutes the capsule and the collagen 12 and ceramide 14 incorporated in the microcapsule exert an effect of moisturizing and stretching the skin (moisture effect).
  • the skin is moisturized and stretched both from the surface side of the skin (the stratum corneum A side) and from the inside of the skin (the dermal layer C side).
  • the effect that brings about is demonstrated.
  • the cosmetic product 30 according to the illustrated embodiment has a much more moisturizing effect than a conventional cosmetic product (for example, a cosmetic product manufactured and sold by the applicant under the trade name "Sealab Aqua Collagen Gel”). Became a good cosmetic. In other words, the skin is much moisturized compared to conventional cosmetics.
  • a conventional cosmetic product for example, a cosmetic product manufactured and sold by the applicant under the trade name "Sealab Aqua Collagen Gel”
  • a time difference can be generated between the timing at which the moisture effect is exhibited in the skin surface layer portion and the timing at which the moisture effect is exhibited inside the skin. As a whole, the time during which the moisture effect is exerted can be lengthened.
  • Spherical microcapsules with a diameter of 300nm to 700nm are manufactured with hyaluronic acid and contain collagen and ceramide inside.
  • the diameter of the microcapsule when the diameter of the microcapsule is too large, it cannot penetrate the stratum corneum and the epidermis layer and reach the dermis layer. On the other hand, when the diameter of the microcapsule is too large, it becomes difficult to form the capsule and to accommodate the collagen and ceramide inside the capsule.
  • the amount or ratio of collagen and ceramide is not particularly limited as long as both can be accommodated in a single microcapsule.
  • Hyaluronic acid microcapsules containing collagen and ceramide are mixed and mixed.
  • the gel-like basic cosmetic product is not particularly limited as long as it is a “basic cosmetic product” in the ordinary sense.
  • the amount of capsules (hyaluronic acid microcapsules containing collagen and ceramide) added to the gel-like basic cosmetic is 0.1% to 5% by weight.
  • Hyaluronic acid-containing microcapsules containing collagen and ceramide contain too little weight (less than 0.1% by weight) and penetrate into the stratum corneum and epidermis layer, from the dermis layer (skin The effect of moisturizing and stretching the skin (from the inside of the skin) (moisture effect) is not fully demonstrated.
  • the amount of capsules (hyaluronic acid microcapsules containing collagen and ceramide) added to the gel-like basic cosmetic was determined to be in the range of 0.1 to 5% by weight.
  • the accurate threshold value was set at 0.1% by weight at which the improvement of skin moisture and tension was actually confirmed as the lower limit of force that was considered to be 0.08% to 0.1% by weight.
  • the coating amount of the hyaluronic acid microcapsules containing collagen and ceramide is increased from 3.5% by weight to 6.5% by weight every 0.5% by weight, and applied to the skin. Was checked.
  • the applicability to the skin was determined by whether or not 70% of the subjects felt discomfort (foreign material sensation) when subjects applied to the skin. That is, when 70% or more of the subjects felt uncomfortable or foreign object feeling during application, it was determined that “I felt a foreign object feeling” (X in Table 2). If it was less than%, it was determined that there was no “foreign object sensation” (circles in Table 2).
  • the gel-like basic cosmetic contains hyaluronic acid that does not constitute a microcapsule, collagen and ceramide that are not contained in the microcapsule.
  • the content is about 1.2 to 1.8 times that of conventional cosmetics (for example, the cosmetic product “Sealab Aqua Collagen Gel” manufactured and sold by the applicant).
  • the content of ceramide, collagen, and hyaluronic acid in the gel-like basic cosmetic is low, the moisture effect from the front side (skin layer side) of the skin may not be sufficiently exhibited.
  • conventional cosmetics for example, the brand name “Shi Lab Aqua Aqua” manufactured and sold by the applicant.
  • the gel-like basic cosmetic product itself becomes hard and uncomfortable for the user when placed on the skin. End up.
  • the sticky feeling increases.
  • the amount of collagen and hyaluronic acid is large, the basic cosmetic product becomes hard, and the amount of oil, ceramide, increases and the feeling of stickiness increases.
  • the content of ceramide, collagen, and hyaluronic acid in the gel-like basic cosmetics is the same as that of conventional cosmetics (for example, the cosmetic product “Sealab Aquacollagen Gel” manufactured and sold by the applicant). ) Must be less than twice.
  • the collagen contained in the microcapsule is a collagen tripeptide having a molecular weight of about 280, and the collagen contained in the gel basic cosmetic product has a molecular weight of 5000.
  • Collagen tripeptides with a low molecular weight penetrate well into tissues inside the skin, whereas collagen with a high molecular weight (including microcollagen in addition to normal collagen) This is because the effect of covering and preventing drying is exhibited satisfactorily. That is, a collagen tripeptide having a small molecular weight (with a molecular weight of about 280) is incorporated in a microcapsule made of hyaluronic acid and is suitable for penetrating the inside of the skin. On the other hand, collagen having a large molecular weight (ordinary collagen and microcollagen) is suitable for being previously contained in a gel-like basic cosmetic product.
  • the gel-like basic cosmetic further contains vitamin C, laminaria taroloica extract (amber ocean), which is an extract from seaweed, and Pervetianacari crata extract, which is also a seaweed extract.
  • Vitamin C has a so-called “whitening” effect. However, since it oxidizes, the content must be kept to a very small amount.
  • Laminaria taro leuca extract Amber Ocean
  • Pervetiana canary crata extract which are seaweed extracts, are whitening ingredients comparable to bioantage.
  • the Laminaria taroroika extract is a seaweed extract, but has the same action as DHEA (Anchoring Ginsing Hormone), that is, the action of rejuvenating the skin.
  • Pervetianacaricrata extract has the effect of activating fibroblasts. The applicant applied a sample with a pervetia canarikurata extract content of 2% to 3% by weight, and the experiment showed that the activity of the fibroblasts increased from 0% to 115%. It has gained.
  • Laminaria taro leuca extract (Amber Ocean) and Pervetianacana crata extract are seaweed extracts, and if the content is too large, the entire cosmetic product becomes brown and gives off a strange odor.
  • Experiment 3 described below, when the total content of Laminaria taroroika extract (Amber Ocean) and Pervetianacana crutta echex exceeds 5% by weight, a bad odor is detected. I was able to do it.
  • Spherical microcapsules with a diameter of 300 nm to 700 nm are manufactured with hyaluronic acid, and collagen and ceramide are accommodated inside. Then, 3.0% by weight of capsules (microcapsules made of hyaluronic acid containing collagen and ceramide) is added to the gel-like basic cosmetics.
  • the hyaluronic acid that does not make up the product, collagen that is not contained in the microcapsules, and ceramide are 1.5 times the amount of conventional cosmetics (the cosmetics that are manufactured and sold by the applicant, the product name “Sealab Aqua Collagen Gel”). Contains the amount.
  • a cosmetic test having such a composition was compared with a conventional cosmetic product (a cosmetic product manufactured and sold by the applicant under the name “Sealab Aqua Collagen Gel”).
  • FIG. 1 is a schematic diagram of a microcapsule that is a main component of an embodiment of the present invention.
  • FIG. 2 is a schematic diagram of a process of mixing the microcapsules of FIG. 1 with basic cosmetics.
  • FIG. 3 is a schematic diagram of a cosmetic product according to an embodiment of the present invention.
  • FIG. 4 is a schematic diagram showing the action when the cosmetic of FIG. 3 is applied to the skin.
  • FIG. 5 is a schematic diagram showing the action when the microcapsules of FIG. 1 reach the dermis layer.
  • FIG. 6 is a schematic diagram showing the action of the cosmetic product according to the embodiment of the present invention.

Abstract

It is intended to provide a cosmetic product which can improve skin fitness and skin moisture by applying it on the skin. To achieve the object, the cosmetic product of the invention is characterized by forming a micro-vessel or capsule with hyaluronic acid, encapsulating collagen and ceramide in the microcapsule, and incorporating the microcapsule, in which collagen and ceramide are encapsulated, in a gelled basic cosmetic product in an amount of 0.1 to 5% by weight. Here, the gelled basic cosmetic product preferably contains ceramide, collagen, hyaluronic acid, vitamin C, Laminaria chroleuca extract and Pelvetia canaliculata extract. With the cosmetic product of the invention, the microcapsule itself penetrates into the skin and exerts a moisturizing effect from the inside of the skin. On the other hand, the ceramide, collagen or hyaluronic acid contained in the gelled basic cosmetic product exerts a moisturizing effect from the outside of the skin. That is, according to the invention, a moisturizing effect is exerted from the outside and the inside of the skin.

Description

明 細 書  Specification
化粧品  Cosmetics
技術分野  Technical field
[0001] 本発明は、保湿効果に優れたィ匕粧品であって、肌の潤いや張りを改善することが 出来る化粧品に関する。  [0001] The present invention relates to a cosmetic product having an excellent moisturizing effect and capable of improving the moisture and tension of the skin.
背景技術  Background art
[0002] 現在、種々の化粧品が巿販されて 、る。  [0002] Currently, various cosmetics are on the market.
ここで、ゲル状の基礎ィ匕粧品であって、コラーゲン、セラミド、ヒアルロン酸を配合し ており、コラーゲン、セラミド、ヒアルロン酸がシヮの原因となる肌のプリーツに作用し てシヮを除去する化粧品が市販されている(例えば、本出願人が製造、販売している 商品名「シーラボアクアコラーゲンゲル」なる化粧品)。  Here, it is a gel-like basic cosmetic that contains collagen, ceramide, and hyaluronic acid. Collagen, ceramide, and hyaluronic acid act on the pleats that cause wrinkles and remove wrinkles. Cosmetics are commercially available (for example, cosmetics manufactured and sold by the present applicant under the trade name “Sealab Aqua Collagen Gel”).
[0003] 近年、「肌を綺麗にする」旨の要請が非常に高くなつており、単にシヮを除去するだ けではなぐ塗布するのみで肌の張りや肌の潤いを改善出来る様な化粧品が要望さ れるに到っている。 [0003] In recent years, there has been a very high demand for "clean skin", and cosmetics that can improve skin tension and moisture by simply applying it without removing wrinkles. Has been requested.
上述した様な従来のゲル状の基礎ィ匕粧品(例えば、本出願人が製造、販売してい る商品名「シーラボアクアコラーゲンゲル」なる化粧品)は、肌の張りや肌の潤いの改 善にも効果を有するものである。  The conventional gel-like basic cosmetics as described above (for example, the cosmetics manufactured and sold by the applicant of the present invention, “Colaba Aqua Collagen Gel”) are used to improve skin tension and moisture. Is also effective.
しかし、従来の化粧品では、ユーザーの肌に塗布するのみで、ユーザーが希望す る程度まで肌の張りや肌の潤いを改善することは難し力つた。  However, with conventional cosmetics, it was difficult to improve skin tension and moisture to the extent desired by the user simply by applying it to the user's skin.
発明の開示  Disclosure of the invention
発明が解決しょうとする課題  Problems to be solved by the invention
[0004] 本発明は上述した要請に応えるべく提案されたものであり、皮膚に塗布することに より肌の張りや肌の潤いを改善することが出来る化粧品の提供を目的としている。 課題を解決するための手段 [0004] The present invention has been proposed to meet the above-described demand, and an object of the present invention is to provide a cosmetic product that can improve skin tension and moisture by being applied to the skin. Means for solving the problem
[0005] 本発明の化粧品は、ヒアルロン酸で微小な容器 (ナノカプセル:商品名ナノスフィァ )を構成し、係る微小な容器内にコラーゲン及びセラミドを内蔵し、コラーゲン及びセ ラミドを内蔵した微小な容器を、ゲル状の基礎ィ匕粧品に、 0. 1〜5重量%含有したこ とを特徴としている。 [0005] The cosmetic product of the present invention comprises a minute container (nanocapsule: trade name Nanosphere) made of hyaluronic acid, and contains the collagen and ceramide in the minute container, and the minute container containing the collagen and ceramide. Is contained in a gel-like basic cosmetic product in an amount of 0.1 to 5% by weight. It is characterized by.
[0006] 本発明において、前記ゲル状の基礎化粧品は、セラミド、コラーゲン、ヒアルロン酸 を含有して ヽるのが好適である。  In the present invention, the gel-like basic cosmetic product preferably contains ceramide, collagen, and hyaluronic acid.
[0007] さらに、前記ゲル状の基礎ィ匕粧品中には、ビタミン C、ラミナリアオタロロイカエキス( アンバーオーシャン)、ペルべチアカナリクラタエキスを含有しているのが好ましい。 ここで、ビタミン Cの含有量は比較的微量に留め、ラミナリアオタロロイカエキス (アン バーオーシャン)及び Z又はペルべチアカナリクラタエキスの含有量は 5重量%以下 であるのが好ましい。 [0007] Further, it is preferable that the gel-like basic cosmetics contain vitamin C, laminaria taroroika extract (amber ocean), and pervetianacanalicurata extract. Here, it is preferable that the content of vitamin C is kept to a relatively small amount, and the content of laminaria taroroika extract (amber ocean) and Z or pervetia canariculata extract is 5% by weight or less.
発明の効果  The invention's effect
[0008] 上述した構成を具備する本発明の化粧品によれば、ヒアルロン酸で微小な容器 (力 プセル:ナノカプセル)を構成し、係る微小な容器内にコラーゲン及びセラミドを内蔵 しており、微小な容器けノカプセル)自体が皮膚の表面 (角質層や表皮層)よりも内 側の層(例えば、真皮層)まで浸透する。  [0008] According to the cosmetic product of the present invention having the above-described configuration, a minute container (power capsule: nanocapsule) is composed of hyaluronic acid, and collagen and ceramide are incorporated in the minute container. The inner capsule) penetrates to the inner layer (for example, the dermis layer) of the skin surface (stratum corneum or epidermis layer).
そして、皮膚の表面 (角質層や表皮層)よりも内側の層(例えば、真皮層)内では、 微小な容器 (カプセル)を構成して!/、るヒアルロン酸のペプチド構造が体内の酵素に より分解されて、分解されたヒアルロン酸、コラーゲン及びセラミドが表皮内側の層( 例えば、真皮層)内を拡散して、皮膚の内側から張りと潤いを与える効果 (保湿効果 或いはモイスチャー効果)を発揮するのである。  In the inner layer (for example, the dermis layer) of the skin surface (stratum corneum or epidermis layer), a minute container (capsule) is formed! / The peptide structure of hyaluronic acid is used as an enzyme in the body. More decomposed, decomposed hyaluronic acid, collagen and ceramide diffuse in the inner layer of the epidermis (for example, dermis layer) and exert an effect of moisturizing and moisturizing from the inside of skin (moisturizing effect or moisture effect) To do.
[0009] また、前記ゲル状の基礎ィ匕粧品を、セラミド、コラーゲン、ヒアルロン酸、ビタミン C、 ラミナリアオタロロイカエキス、ペルべチアカナリクラタエキスを含有して構成し、且つ、 セラミド、コラーゲン、ヒアルロン酸の配合割合を、従来の基礎化粧品(ゲル)に比べ て遥かに多く構成すれば、ゲル状の基礎化粧品自体の保湿性が従来品に比較して 遥かに高くなる。  [0009] In addition, the gel-like basic cosmetic is composed of ceramide, collagen, hyaluronic acid, vitamin C, laminaria taroroleuca extract, pervetia canariculata extract, and ceramide, collagen, hyaluron If the blending ratio of the acid is made much higher than that of the conventional basic cosmetic (gel), the moisturizing property of the gel-type basic cosmetic itself is much higher than that of the conventional product.
[0010] ここで、上述した通り、微小な容器或いはカプセル (ナノカプセル)自体が皮膚に浸 透し、皮膚の内側力 モイスチャー効果を発揮する。一方、ゲル状の基礎化粧品に 含有されているセラミド、コラーゲン、ヒアルロン酸は、皮膚の外側(表皮側)からモイ スチヤー効果を発揮する。  [0010] Here, as described above, a minute container or a capsule (nanocapsule) permeates the skin, and exerts an inner force moisture effect on the skin. On the other hand, ceramide, collagen, and hyaluronic acid contained in gel-like basic cosmetics exert a moisturizing effect from the outside (skin side) of the skin.
その結果、本発明の化粧品によれば皮膚の内側(ナノカプセル及びその内蔵成分 による)と、皮膚の外側 (ゲルに配合された成分による)とから、肌に張りと潤いを与え る効果 (保湿効果或いはモイスチャー効果)を発揮することが出来る。換言すれば、 本発明によれば、 、わゆる「ダブルモイスチャー効果」を発揮することが出来るのであ る。 As a result, according to the cosmetic of the present invention, the inside of the skin (nanocapsules and their built-in components) ) And the outside of the skin (depending on the ingredients blended in the gel), it can exert an effect of moisturizing and moisturizing the skin (moisturizing effect or moisture effect). In other words, according to the present invention, the so-called “double moisture effect” can be exhibited.
[0011] その結果、本発明の化粧品は、皮膚の内側から自然に保湿を図ることが出来る。そ れに加えて、本発明は、「乾燥肌」に張りと潤いを与えるという用途については、非常 に効果がある。  As a result, the cosmetic of the present invention can naturally moisturize from the inside of the skin. In addition to this, the present invention is very effective for the purpose of imparting tension and moisture to “dry skin”.
[0012] これにカ卩えて、前記ゲル状の基礎化粧品中に、ビタミン C、ラミナリアオタロロイカェ キス(アンバーオーシャン)、ペルべチアカナリクラタエキスを含有すれば、これ等の 成分は、何れも、いわゆる「美白」効果を発揮するものであるため、肌を美しくする効 果がある。  [0012] In addition to this, if the gel-like basic cosmetic contains vitamin C, laminaria taroloika kiss (amber ocean), and pervetia canarikurata extract, these components are all Because of its so-called “whitening” effect, it has the effect of beautifying the skin.
また、ラミナリアオタロロイカエキスは、肌を若返らせる作用を奏し、ペルべチアカナ リクラタエキスは、繊維芽細胞を活性化させる作用効果を奏する。  Laminaria taroroika extract has the effect of rejuvenating the skin, and Pervetianakana lyclata extract has the effect of activating fibroblasts.
発明を実施するための最良の形態  BEST MODE FOR CARRYING OUT THE INVENTION
[0013] 以下、添付図面を参照して、本発明の実施形態について説明する。 Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings.
図 1〜図 6は、本発明の 1実施形態を作用的且つ模式的に示している。  1 to 6 show one embodiment of the present invention functionally and schematically.
[0014] 図 1において、符号 10で示すのは微小な容器或いはカプセル(「ナノ」レベルのサ ィズのカプセル:例えば、商品名「ナノスフィァ」としてコレティ力社で製造'販売してい る商品)であり、該微小なカプセル 10はヒアルロン酸で構成されて 、る。 In FIG. 1, reference numeral 10 denotes a small container or capsule (a “nano” level size capsule: for example, a product manufactured and sold by Corety Power Company under the trade name “Nanosphere”). The fine capsule 10 is composed of hyaluronic acid.
ここで、微小なカプセルは例えば球形をしており、その径寸法は 300ηπ!〜 700nm である。  Here, for example, the minute capsule has a spherical shape, and its diameter is 300ηπ! ~ 700nm.
[0015] 微小カプセル 10には、コラーゲン 12及びセラミド 14を包含している。  [0015] The microcapsule 10 includes collagen 12 and ceramide 14.
図 1〜図 6では、コラーゲン 12及びセラミド 14が単一の球として表現されているが、 係る表現は理解を容易にするため簡略ィ匕したためであり、微小カプセル 10には、 1 分子ではなぐ可能な量のコラーゲン 12、セラミド 14が内蔵されている。  In FIGS. 1 to 6, collagen 12 and ceramide 14 are represented as a single sphere, but such representation is simplified for ease of understanding. A possible amount of collagen 12 and ceramide 14 is incorporated.
[0016] コラーゲン 12及びセラミド 14が内蔵されたヒアルロン酸製の微小カプセル 10は、図 2で示す様に、ゲル状の基礎化粧品 20へ添加され (矢印 D)、均一に混合される。混 合の手法については、従来公知の混合技術を適用することが出来る。 ここで、ゲル状の基礎化粧品 20にも、コラーゲン 22、セラミド 24、ヒアルロン酸 26力 S 配合されており、ゲル状の基礎ィ匕粧品 20に配合されている (換言すれば微小カプセ ルではない形態の)コラーゲン 22、セラミド 24、ヒアルロン酸 26については、図 2にお Vヽては同一の十字星印で示されて!/、る。 [0016] Hyaluronic acid microcapsules 10 incorporating collagen 12 and ceramide 14 are added to gel-like basic cosmetic product 20 (arrow D) and mixed uniformly as shown in FIG. A conventionally known mixing technique can be applied to the mixing method. Here, the gel-like basic cosmetic 20 is also blended with collagen 22, ceramide 24, hyaluronic acid 26 power S, and it is blended with the gel-like basic cosmetic 20 (in other words, it is not a microcapsule). The forms of collagen 22, ceramide 24, and hyaluronic acid 26 are shown in Figure 2 with the same crossed star!
なお、ゲル状の基礎ィ匕粧品 20の配合については、実施例を参照して、詳細は後述 する。  The formulation of the gel-like basic cosmetic 20 will be described later in detail with reference to Examples.
[0017] 微小カプセル 10をゲル状の基礎ィ匕粧品 20へ混合することにより、本発明の化粧品 30が完成する(図 3)。  [0017] The cosmetic 30 of the present invention is completed by mixing the microcapsules 10 into the gel-like basic cosmetic 20 (FIG. 3).
本発明の化粧品 30はゲル状に構成されており、図 3で示す様に、コラーゲン 12及 びセラミド 14が内蔵されたヒアルロン酸製の微小カプセル 10 (図 3、図 4では小さな丸 印で示す)と、微小カプセル 10とは別個に予めゲル状の基礎ィ匕粧品 20に包含され ていたコラーゲン 22、セラミド 24、ヒアルロン酸 26 (図 3、図 4では十字星印で示す)と 力 配合されている。  The cosmetic product 30 of the present invention is configured in a gel form, and as shown in FIG. 3, the microcapsules 10 made of hyaluronic acid containing collagen 12 and ceramide 14 (shown by small circles in FIGS. 3 and 4). ) And collagen 22, ceramide 24, and hyaluronic acid 26 (shown as crosses in FIGS. 3 and 4) that were previously included in the gel-like basic cosmetic 20 separately from the microcapsule 10. ing.
[0018] 次に、図 1〜図 3で説明した実施形態の作用について、図 4〜図 6を参照して説明 する。  Next, the operation of the embodiment described in FIGS. 1 to 3 will be described with reference to FIGS. 4 to 6.
図 4は、実施形態に係る化粧品 30を皮膚に塗布した状態を一部断面図にて示して いる。  FIG. 4 is a partial cross-sectional view showing a state in which the cosmetic 30 according to the embodiment is applied to the skin.
化粧品 30を塗布した皮膚は、角質層 A、表皮層 B、真皮層 Cとから構成されている The skin to which cosmetic 30 is applied is composed of stratum corneum A, epidermis layer B, and dermis layer C.
。なお、図 4において、真皮層 Cは、その一部のみを示している。 . In FIG. 4, the dermis layer C shows only a part thereof.
[0019] 図 4において、化粧品 30において、予めゲル状の基礎ィ匕粧品 20に配合されている In FIG. 4, the cosmetic 30 is pre-mixed with the gel basic cosmetic 20.
(微小カプセルではない)コラーゲン 22、セラミド 24、ヒアルロン酸 26 (十字星印)に ついては、角質層 Aの表面(図 4中、上方)に留まっている。  Collagen 22, ceramide 24, and hyaluronic acid 26 (cross star) (not microcapsules) remain on the surface of stratum corneum A (upper in Fig. 4).
これに対して、微小カプセル 10 (白い小さな丸印)は、角質層 A、表皮層 Bを透過し て、真皮層 Cまで浸透する。換言すれば、微小カプセル 10の 300ηπ!〜 700nmとい うサイズ (或いは粒径)は、角質層 A、表皮層 Bを透過して、真皮層 Cまで到達可能な サイズとして選定されて 、るのである。  In contrast, microcapsules 10 (white small circles) permeate stratum corneum A and epidermis layer B and penetrate to dermis layer C. In other words, 300 ηπ of the microcapsule 10! The size (or particle size) of ˜700 nm is selected as a size that can reach the dermis layer C through the stratum corneum A and the epidermis layer B.
[0020] 真皮層 Cに到達したヒアルロン酸製の微小カプセル 10は、図 5で示す様に、真皮 層に存在する酵素 40により、ヒアルロン酸のペプチド構造が細断され、分子量が比 較的小さ ヽ状態 (符号 10Pで示す)となる。 [0020] As shown in Fig. 5, the hyaluronic acid microcapsules 10 that have reached the dermis layer C have the peptide structure of hyaluronic acid shredded by the enzyme 40 present in the dermis layer, and the molecular weight is reduced. This is a relatively small state (indicated by reference numeral 10P).
そして、微小カプセル 10を構成するヒアルロン酸が細断されることにより、カプセル 10に内蔵されたコラーゲン 12及びセラミド 14はカプセル 10から飛び出し (矢印 E参 照)、真皮層 C内を拡散する。  The hyaluronic acid constituting the microcapsule 10 is shredded, so that the collagen 12 and the ceramide 14 incorporated in the capsule 10 jump out of the capsule 10 (see arrow E) and diffuse in the dermis layer C.
[0021] ここで、ペプチド構造を有するヒアルロン酸は、ナノカプセルに内蔵可能な程度まで 細分化されてしまうと、「肌の潤い」や「肌のハリ」を向上するという効果を発揮できなく なる。そのため、ヒアルロン酸で微小なカプセルを製造したのである。  [0021] Here, if the hyaluronic acid having a peptide structure is subdivided to such an extent that it can be incorporated in a nanocapsule, the effect of improving "moisture moisture" and "skin elasticity" can no longer be exhibited. . Therefore, microcapsules were produced with hyaluronic acid.
ここで、微小カプセルを酵素で細断した場合には、ナノカプセルを形成している状 態よりは分子量が小さ!/、が、「肌の潤!、」や「肌のハリ」を向上すると!、う効果を発揮す る程度には分子量が大きな状態(図 5、図 6において、符号 10Pで示す状態)となる。 換言すれば、ヒアルロン酸は微小カプセルとしなければ、期待される作用(肌の潤 い、肌のハリ)を奏せず、係る微小カプセルを酵素により細分されることにより、初めて 、ヒアルロン酸は期待される効果を発揮する。  Here, when the microcapsules are shredded with an enzyme, the molecular weight is smaller than in the nanocapsule state! /, But this improves the “moisturizing!” And “skin elasticity”. ! The molecular weight is large enough to exert the effect (the state indicated by 10P in FIGS. 5 and 6). In other words, if hyaluronic acid is not made into a microcapsule, the expected action (moisturation of skin, skin firmness) will not be achieved, and hyaluronic acid is expected for the first time by subdividing the microcapsule with an enzyme. To exert the effect.
[0022] そして、ヒアルロン酸、コラーゲン、セラミドは、共に、肌の潤!、、肌のハリを助長する 効果を発揮するものであり、図 5及び図 6で示す様に真皮層 Cに拡散したヒアルロン 酸 10P、コラーゲン 12、セラミド 14は、皮膚の内側 (真皮層 C側)から肌の潤い、肌の ノ、リをもたらすのである。  [0022] And hyaluronic acid, collagen, and ceramide all have the effect of promoting skin moisture! And skin firmness, and diffused into the dermis layer C as shown in Figs. Hyaluronic acid 10P, collagen 12, and ceramide 14 moisturize the skin from the inner side of the skin (the dermis layer C side).
[0023] 一方、上述した通り、ヒアルロン酸 10P、コラーゲン 12、セラミド 14が真皮層 Cに拡 散している皮膚においては、その角質層 Aで、予めゲル状の基礎ィ匕粧品 20に配合さ れている(微小カプセルではない)コラーゲン 22、セラミド 24、ヒアルロン酸 26 (十字 星印)が留まっており、やはり、肌の潤い、肌の張りをもたらす効果を発揮する。  [0023] On the other hand, as described above, in the skin where hyaluronic acid 10P, collagen 12, and ceramide 14 are diffused in the dermis layer C, the stratum corneum A is preliminarily formulated in the gel basic cosmetic product 20. Collagen 22 (not microcapsules), ceramide 24, and hyaluronic acid 26 (cross star) remain, and they also exert the effect of moisturizing and stretching the skin.
[0024] 上述した通り、図示の実施形態に係る化粧品 30を塗布された皮膚においては、皮 膚の表面側(角質層 A側)からは予めゲル状の基礎ィ匕粧品 20に配合されて ヽるコラ 一ゲン 22、セラミド 24、ヒアルロン酸 26 (十字星印)により肌の潤い、肌の張りをもたら す効果 (モイスチャー効果)が発揮され、皮膚の内側 (真皮層 C側)力もは微小カプセ ルを構成していたヒアルロン酸 10Pと、微小カプセルに内蔵されていたコラーゲン 12 及びセラミド 14とにより、肌の潤い、肌の張りをもたらす効果 (モイスチャー効果)が発 揮される。 すなわち、図示の実施形態に係る化粧品 30を塗布された皮膚においては、皮膚の 表面側 (角質層 A側)からも、皮膚の内側 (真皮層 C側)からも、肌の潤い、肌の張りを もたらす効果 (モイスチャー効果)が発揮されるのである。 [0024] As described above, in the skin to which the cosmetic 30 according to the illustrated embodiment is applied, it is preliminarily blended in the gel-like basic cosmetic 20 from the surface side of the skin (the stratum corneum A side). Collagen 22, Ceramide 24, Hyaluronic Acid 26 (Cross Stars) provides a moisturizing and skin-strengthening effect (moisture effect), and the inner side of the skin (the dermis layer C side) has very little force The hyaluronic acid 10P that constitutes the capsule and the collagen 12 and ceramide 14 incorporated in the microcapsule exert an effect of moisturizing and stretching the skin (moisture effect). That is, in the skin to which the cosmetic 30 according to the illustrated embodiment is applied, the skin is moisturized and stretched both from the surface side of the skin (the stratum corneum A side) and from the inside of the skin (the dermal layer C side). The effect that brings about (moisture effect) is demonstrated.
[0025] そして、図示の実施形態に係る化粧品 30は、従来の化粧品(例えば、出願人が製 造 ·販売している商品名「シーラボアクアコラーゲンゲル」なる化粧品)に比べて、遥か に保湿効果が良好な化粧品となった。すなわち、従来の化粧品に比較して、遥かに 肌が潤うのである。 [0025] The cosmetic product 30 according to the illustrated embodiment has a much more moisturizing effect than a conventional cosmetic product (for example, a cosmetic product manufactured and sold by the applicant under the trade name "Sealab Aqua Collagen Gel"). Became a good cosmetic. In other words, the skin is much moisturized compared to conventional cosmetics.
[0026] また、予めゲル状の基礎ィ匕粧品 20に配合されているコラーゲン 22、セラミド 24、ヒ アルロン酸 26は、皮膚に塗布されると直ちに角質層 Aを被覆して、肌が乾燥しない 様に潤わせる。これに対して、微小カプセルを構成していたヒアルロン酸 10Pと、微 小カプセルに内蔵されていたコラーゲン 12及びセラミド 14とは、真皮層 Cで拡散する まで 12時間程度を必要とする。  [0026] Collagen 22, ceramide 24, and hyaluronic acid 26, which are pre-mixed in the gel-like basic cosmetic 20 in advance, immediately coat the stratum corneum A when applied to the skin, and the skin does not dry. Moisten like On the other hand, the hyaluronic acid 10P constituting the microcapsule and the collagen 12 and ceramide 14 incorporated in the microcapsule require about 12 hours to diffuse in the dermis layer C.
すなわち、図示の実施形態によれば、皮膚表層部でモイスチャー効果を発揮する タイミングと、皮膚の内側でモイスチャー効果を発揮するタイミングとの間に、時間差 を生じさせることが出来る。そして、全体として、モイスチャー効果が発揮される時間 を長くすることが出来るのである。  That is, according to the illustrated embodiment, a time difference can be generated between the timing at which the moisture effect is exhibited in the skin surface layer portion and the timing at which the moisture effect is exhibited inside the skin. As a whole, the time during which the moisture effect is exerted can be lengthened.
実施例  Example
[0027] 次に、図 1〜図 6で説明した化粧品 30の実施例を説明する。  Next, an example of the cosmetic 30 described with reference to FIGS. 1 to 6 will be described.
直径 300nm〜700nmの球形の微小なカプセル(商品名「ナノスフィァ」としてコレ ティカ社で製造'販売している商品)をヒアルロン酸で製造し、その内部にコラーゲン 及びセラミドを収容する。  Spherical microcapsules with a diameter of 300nm to 700nm (product name “Nanosphere” manufactured and sold by Coretica) are manufactured with hyaluronic acid and contain collagen and ceramide inside.
ここで、微小カプセルの径が大き過ぎる場合には、角質層及び表皮層を浸透して 真皮層にまで到達することが出来ない。一方、余りに微小カプセルの径カ 、さ過ぎる 場合には、カプセル状に成形することや、カプセル内部にコラーゲン及びセラミドを 収容することが困難となる。  Here, when the diameter of the microcapsule is too large, it cannot penetrate the stratum corneum and the epidermis layer and reach the dermis layer. On the other hand, when the diameter of the microcapsule is too large, it becomes difficult to form the capsule and to accommodate the collagen and ceramide inside the capsule.
コラーゲン、セラミドの量或いは比率については、両者が単一の微小カプセルに収 容できるのであれば、特に限定条件はない。  The amount or ratio of collagen and ceramide is not particularly limited as long as both can be accommodated in a single microcapsule.
[0028] コラーゲン及びセラミドを収容したヒアルロン酸製の微小カプセルを添カ卩 ·混合する ゲル状の基礎ィ匕粧品は、通常の意味における「基礎ィ匕粧品」であれば、特に、限定 はしない。 [0028] Hyaluronic acid microcapsules containing collagen and ceramide are mixed and mixed. The gel-like basic cosmetic product is not particularly limited as long as it is a “basic cosmetic product” in the ordinary sense.
そして、ゲル状の基礎ィ匕粧品に対して、カプセル (コラーゲン及びセラミドを収容し たヒアルロン酸製の微小カプセル)の添カ卩量は、重量%で、 0. 1%〜5%である。  Further, the amount of capsules (hyaluronic acid microcapsules containing collagen and ceramide) added to the gel-like basic cosmetic is 0.1% to 5% by weight.
[0029] コラーゲン及びセラミドを収容したヒアルロン酸製の微小カプセルの添カ卩量力 少な 過ぎると (0. 1重量%未満であると)、角質層及び表皮層を浸透して、真皮層から (皮 膚の内側から)肌の潤!、や張りを助長する効果 (モイスチャー効果)が十分に発揮さ れない。 [0029] Hyaluronic acid-containing microcapsules containing collagen and ceramide contain too little weight (less than 0.1% by weight) and penetrate into the stratum corneum and epidermis layer, from the dermis layer (skin The effect of moisturizing and stretching the skin (from the inside of the skin) (moisture effect) is not fully demonstrated.
[0030] 一方、コラーゲン及びセラミドを収容したヒアルロン酸製の微小カプセルの添カロ量 が多過ぎると (5重量%を超えると)、化粧品が皮膚に対して塗布し難くなる傾向が出 るのである。  [0030] On the other hand, if the amount of added calories of hyaluronic acid microcapsules containing collagen and ceramide is too large (exceeding 5% by weight), cosmetics tend to be difficult to apply to the skin. .
これに加えて、コラーゲン及びセラミドを収容したヒアルロン酸製の微小カプセルの 添加量が増加すると、製造コストが高騰化するという問題が存在する。  In addition to this, when the amount of hyaluronic acid microcapsules containing collagen and ceramide is increased, there is a problem that the manufacturing cost increases.
以上により、ゲル状の基礎ィ匕粧品に対するカプセル (コラーゲン及びセラミドを収容 したヒアルロン酸製の微小カプセル)の添加量は、 0. 1重量%〜5重量%という範囲 を決定した。  Based on the above, the amount of capsules (hyaluronic acid microcapsules containing collagen and ceramide) added to the gel-like basic cosmetic was determined to be in the range of 0.1 to 5% by weight.
[0031] 上述したコラーゲン及びセラミドを収容したヒアルロン酸製の微小カプセルの添カロ 量の上限値及び下限値を確認した実験が、次に述べる「実験例 1」、「実験例 2」であ る。  [0031] Experiments for confirming the upper limit and lower limit of the amount of added calories of the hyaluronic acid microcapsules containing collagen and ceramide described above are "Experiment 1" and "Experiment 2" described below. .
実験例 1  Experimental example 1
[0032] コラーゲン及びセラミドを収容したヒアルロン酸製の微小カプセルの添カ卩量を、 0. 0 6重量%から 0. 14重量%まで、 0. 02重量%ずつ増加させて、肌の潤いや張りを助 長する効果 (モイスチャー効果)をチ ックした。  [0032] The amount of the added capsule of hyaluronic acid microcapsules containing collagen and ceramide is increased by 0.02% by weight from 0.06% by weight to 0.14% by weight. The effect of promoting tension (moisture effect) was clicked.
効果の検証は、被験者の皮膚表面の拡大写真を比較することで行い、 70%以上 の被験者において改善が見られた場合を「改善した」(表 1では〇印)と判定し、改善 が見られた被験者数が被験者全体の 70%未満である場合は「改善が観測できず」( 表 1では X印)と判定した。  The effect was verified by comparing magnified photographs of the skin surface of the subjects. When improvement was observed in more than 70% of the subjects, it was judged as “improved” (indicated by a circle in Table 1). If the number of subjects received was less than 70% of all subjects, it was determined that “no improvement could be observed” (X in Table 1).
表 1 カプセル添加量(α ) 0.06 0.08 0.08 0.10 0.12 0.14 table 1 Capsule addition (α) 0.06 0.08 0.08 0.10 0.12 0.14
肌への潤い及び張り X X X 〇 〇 〇  Moisturizing and tensioning skin X X X ○ ○ ○
0…肌の潤い及び張りが改善した  0… Improved skin moisture and tension
X■·■肌の潤い及び張りの改善が観測出来ず  X ■■■ Cannot observe improvement of skin moisture and tension
a:添加量は、ゲル状の基礎化粧品に対する  a: The amount added is based on gel-type basic cosmetics
微小カプセル添加量の重量%  % By weight of microcapsules added
[0033] 表 1で示す通り、 0. 08重量%までは、被験者の肌の潤い及び張りの改善は観察で きな力つた力 微小カプセルの添力卩量を 0. 1重量%以上としたものについては、肌の 潤い及び張りの改善が観察された。 [0033] As shown in Table 1, up to 0.08% by weight, the force that could not be observed in the improvement of the skin's moisture and tension. The amount of force applied to the microcapsules was set to 0.1% by weight or more. As for the thing, improvement of skin moisture and tension was observed.
正確な閾値は、 0. 08重量%〜0. 1重量%と思われる力 下限値としては、肌の潤 い及び張りの改善が実際に確認された 0. 1重量%とした。  The accurate threshold value was set at 0.1% by weight at which the improvement of skin moisture and tension was actually confirmed as the lower limit of force that was considered to be 0.08% to 0.1% by weight.
実験例 2  Example 2
[0034] コラーゲン及びセラミドを収容したヒアルロン酸製の微小カプセルの添カ卩量を、 3. 5 重量%〜6. 5重量%まで、 0. 5重量%毎に増加させて、皮膚に対する塗布性をチェ ックした。  [0034] The coating amount of the hyaluronic acid microcapsules containing collagen and ceramide is increased from 3.5% by weight to 6.5% by weight every 0.5% by weight, and applied to the skin. Was checked.
皮膚に対する塗布性は、被験者が皮膚に塗布する際に、被験者総数の 70%の被 験者が違和感 (異物感)を覚えるか否かにより判定した。すなわち、 70%以上の被験 者が塗布に際して違和感或いは異物感を覚えた場合には「異物感を覚えた」(表 2で は X印)と判定し、違和感或いは異物感を覚えた被験者が 70%未満であれば「異物 感無し」(表 2では〇印)と判定した。  The applicability to the skin was determined by whether or not 70% of the subjects felt discomfort (foreign material sensation) when subjects applied to the skin. That is, when 70% or more of the subjects felt uncomfortable or foreign object feeling during application, it was determined that “I felt a foreign object feeling” (X in Table 2). If it was less than%, it was determined that there was no “foreign object sensation” (circles in Table 2).
表 2  Table 2
Figure imgf000009_0001
Figure imgf000009_0001
〇· ·■被験者に異物感無し  〇 ··· No feeling of foreign body in subject
X · · ·被験者が異物感を覚えた  X · · · Subject feels a foreign body
ひ:(表 1と同じ)  Hi: (Same as Table 1)
[0035] 表 2で示す様に、 5. 5重量%の段階で被験者は塗布時に違和感或いは異物感を 覚えた。従って、正確な閾値は 5. 0重量%〜5. 5重量%の間に存在する。ここで、 上限値としては、被験者が塗布時に違和感或いは異物感を覚えな 、ことが確認でき た 5. 0重量%とする。 [0035] As shown in Table 2, at a level of 5.5% by weight, the subject feels uncomfortable or foreign matter when applied remembered. Thus, an exact threshold exists between 5.0% and 5.5% by weight. Here, the upper limit is set to 5.0% by weight, which confirms that the subject does not feel uncomfortable or foreign matter at the time of application.
[0036] 再び、図 1〜図 6で説明したィ匕粧品 30の実施例について説明する。 [0036] The embodiment of the cosmetic 30 described with reference to FIGS. 1 to 6 will be described again.
ゲル状の基礎ィ匕粧品には、微小カプセルを構成しないヒアルロン酸、微小カプセル に収容されないコラーゲン及びセラミドが含有されている。ここで、その含有量は、従 来の化粧品(例えば、出願人が製造'販売している商品名「シーラボアクアコラーゲン ゲル」なる化粧品)の 1. 2〜1. 8倍程度含まれている。  The gel-like basic cosmetic contains hyaluronic acid that does not constitute a microcapsule, collagen and ceramide that are not contained in the microcapsule. Here, the content is about 1.2 to 1.8 times that of conventional cosmetics (for example, the cosmetic product “Sealab Aqua Collagen Gel” manufactured and sold by the applicant).
[0037] ゲル状の基礎ィ匕粧品中のセラミド、コラーゲン、ヒアルロン酸の含有量が少な 、と、 皮膚の表側 (角質層側)からのモイスチャー効果が十分に発揮されない恐れがある。 一方、ゲル状の基礎ィ匕粧品中のセラミド、コラーゲン、ヒアルロン酸の含有量が多過 ぎる場合、例えば、従来の化粧品(例えば、出願人が製造'販売している商品名「シ 一ラボアクアコラーゲンゲル」なる化粧品)の 2倍を超える程度に含まれている場合に は、ゲル状の基礎ィ匕粧品自体が固くなり、肌の上に載せた時に使用者に対して不快 感を与えてしまう。また、粘着感 (いわゆる「ベタツキ感」)が増加する。 [0037] If the content of ceramide, collagen, and hyaluronic acid in the gel-like basic cosmetic is low, the moisture effect from the front side (skin layer side) of the skin may not be sufficiently exhibited. On the other hand, when the content of ceramide, collagen, and hyaluronic acid in the gel-like basic cosmetics is excessive, for example, conventional cosmetics (for example, the brand name “Shi Lab Aqua Aqua” manufactured and sold by the applicant). If it is contained in more than twice the amount of cosmetic (collagen gel), the gel-like basic cosmetic product itself becomes hard and uncomfortable for the user when placed on the skin. End up. In addition, the sticky feeling (so-called “stickiness”) increases.
ここで、コラーゲン、ヒアルロン酸が多いと基礎ィ匕粧品が固くなり、オイル分であるセ ラミドが多 、とべタツキ感が増すのである。  Here, if the amount of collagen and hyaluronic acid is large, the basic cosmetic product becomes hard, and the amount of oil, ceramide, increases and the feeling of stickiness increases.
換言すれば、ゲル状の基礎ィ匕粧品中のセラミド、コラーゲン、ヒアルロン酸の含有量 は、従来の化粧品(例えば、出願人が製造'販売している商品名「シーラボアクアコラ 一ゲンゲル」なる化粧品)の 2倍未満でなければならな 、。  In other words, the content of ceramide, collagen, and hyaluronic acid in the gel-like basic cosmetics is the same as that of conventional cosmetics (for example, the cosmetic product “Sealab Aquacollagen Gel” manufactured and sold by the applicant). ) Must be less than twice.
[0038] 実施例では、コラーゲンについては、微小なカプセルに内蔵するコラーゲンは、分 子量が 280程度のコラーゲントリペプチドを用い、ゲル状の基礎ィ匕粧品に含有するコ ラーゲンとしては、分子量 5000程度の通常のコラーゲン或いは分子量が 1300から 1500程度のマイクロコラーゲンを用いて!/、る。 [0038] In the examples, the collagen contained in the microcapsule is a collagen tripeptide having a molecular weight of about 280, and the collagen contained in the gel basic cosmetic product has a molecular weight of 5000. Use normal collagen or microcollagen with a molecular weight of about 1300 to 1500!
分子量の小さな (分子量 280程度の)コラーゲントリペプチドは皮膚内側の組織内 によく浸透するのに対して、分子量の大きなコラーゲン (通常のコラーゲン以外にマイ クロコラーゲンをも含む)は、角質表層部を被覆して乾燥を防止する効果を良好に発 揮するからである。 すなわち、分子量の小さな (分子量 280程度の)コラーゲントリペプチドは、ヒアルロ ン酸製の微小カプセルに内蔵されて、皮膚の内側に浸透するのに適している。一方 、分子量の大きなコラーゲン(通常のコラーゲン及びマイクロコラーゲン)は、ゲル状 の基礎ィ匕粧品に予め含有されるのに適している。 Collagen tripeptides with a low molecular weight (about 280 molecular weight) penetrate well into tissues inside the skin, whereas collagen with a high molecular weight (including microcollagen in addition to normal collagen) This is because the effect of covering and preventing drying is exhibited satisfactorily. That is, a collagen tripeptide having a small molecular weight (with a molecular weight of about 280) is incorporated in a microcapsule made of hyaluronic acid and is suitable for penetrating the inside of the skin. On the other hand, collagen having a large molecular weight (ordinary collagen and microcollagen) is suitable for being previously contained in a gel-like basic cosmetic product.
[0039] ゲル状の基礎ィ匕粧品中には、さらに、ビタミン C、海藻からのエキスであるラミナリア オタロロイカエキス(アンバーオーシャン)、同じく海藻エキスであるペルべチアカナリ クラタエキスを含有して 、る。 [0039] The gel-like basic cosmetic further contains vitamin C, laminaria taroloica extract (amber ocean), which is an extract from seaweed, and Pervetianacari crata extract, which is also a seaweed extract.
ビタミン Cはいわゆる「美白」効果を発揮するものである。但し、酸化するので、含有 量は微量に留める必要がある。  Vitamin C has a so-called “whitening” effect. However, since it oxidizes, the content must be kept to a very small amount.
海藻エキスであるラミナリアオタロロイカエキス(アンバーオーシャン)及びペルべチ ァカナリクラタエキスは、バイオアンテージに匹敵する美白成分である。  Laminaria taro leuca extract (Amber Ocean) and Pervetiana canary crata extract, which are seaweed extracts, are whitening ingredients comparable to bioantage.
[0040] さらに、ラミナリアオタロロイカエキスは、海藻エキスでありながら、 DHEA (アンチェ 一ジンジングホルモン)と同様の作用、すなわち、肌を若返らせる作用を奏する。 そして、ペルべチアカナリクラタエキスは、繊維芽細胞を活性化させる作用効果を 奏する。出願人は、ペルべチアカナリクラタエキスの含有量が 2重量%〜3重量%の 試料を塗布したところ、塗布した箇所の繊維芽細胞の活性が 0%から 115%まで増 カロした実験例を得ている。 [0040] Further, the Laminaria taroroika extract is a seaweed extract, but has the same action as DHEA (Anchoring Ginsing Hormone), that is, the action of rejuvenating the skin. Pervetianacaricrata extract has the effect of activating fibroblasts. The applicant applied a sample with a pervetia canarikurata extract content of 2% to 3% by weight, and the experiment showed that the activity of the fibroblasts increased from 0% to 115%. It has gained.
[0041] なお、ラミナリアオタロロイカエキス(アンバーオーシャン)及びペルべチアカナリクラ タエキスの添加量は、共に 5重量%以下とした。 [0041] The amount of laminaria taro leuca extract (amber ocean) and Pervetianacana crata extract was both 5 wt% or less.
ラミナリアオタロロイカエキス(アンバーオーシャン)及びペルべチアカナリクラタエキ スは海藻エキスであるため、その含有量が多くなり過ぎると、化粧品全体が茶色くなり 、且つ、異臭を発するからである。出願人の実験 (以下に述べる「実験例 3」)によれ ば、ラミナリアオタロロイカエキス(アンバーオーシャン)及びペルべチアカナリクラタエ キスの合計の含有量が 5重量%を超えると、異臭を感知する事が出来た。  This is because Laminaria taro leuca extract (Amber Ocean) and Pervetianacana crata extract are seaweed extracts, and if the content is too large, the entire cosmetic product becomes brown and gives off a strange odor. According to the applicant's experiment ("Experiment 3" described below), when the total content of Laminaria taroroika extract (Amber Ocean) and Pervetianacana crutta echex exceeds 5% by weight, a bad odor is detected. I was able to do it.
実験例 3  Experimental example 3
[0042] 基礎化粧品に添加するラミナリアオタロロイカエキス (アンバーオーシャン)とペルべ チアカナリクラタエキスとの合計の量を、 3. 5重量%〜6. 0重量%まで、 0. 5重量% ずつ変化させて、被験者が異臭を感知するか否力を実験した。 ここで、全体の 30%以上の被験者が異臭を感知した場合に「異臭有り(表 3では X 印)」と判定し、異臭を感知した被験者が 30%未満であれば「異臭無し (表 3では〇 印)」と判定した。 [0042] The total amount of Laminaria taro leuca extract (Amber Ocean) and Pervetianakana Kurita extract added to basic cosmetics is changed by 0.5% by weight from 3.5% to 6.0% by weight. Then, the experiment was conducted to determine whether or not the subject perceives a strange odor. Here, when 30% or more of the subjects sensed a bad odor, it was judged that there was a bad odor (X in Table 3). If less than 30% of the subjects sensed a bad odor, “no bad odor (Table 3 In this case, it was judged as “O”).
表 3
Figure imgf000012_0001
Table 3
Figure imgf000012_0001
異臭無し  No off-flavor
> ■■·異臭有り  > ■
含有量■■ .ラミナリアォクロロイカエキスと  Content ■■ Laminaria chloro squid extract and
ペルべチアカナリクラタエキスとの  With Pervetianakana Kurata Extract
含有量の合計の重量%  % Of total content
[0043] ラミナリアオタロロイカエキスとペルべチアカナリクラタエキスとの含有量の合計が 5. [0043] The total content of Laminaria taro leuca extract and Pervetianakana krita extract is 5.
0重量%までは「異臭無し(〇)」であった力 5. 5重量%以上だと異臭が感知された ( X )。従って、正確な閾値は 5. 0重量%〜5. 5重量%に存在すると思われる。しか し、 5. 0重量%までは異臭が感知されないことが確認されたので、ラミナリアオタロロ イカエキスとペルべチアカナリクラタエキスとの含有量の合計については、 5. 0重量 A force that was “no off-flavor (○)” up to 0% by weight 5.5. Thus, the exact threshold appears to be between 5.0% and 5.5% by weight. However, because it was confirmed that no off-flavor was detected up to 5.0% by weight, the total content of Laminaria taro extract and Pervetianacana crata extract was 5.0%.
%を超えな 、ことが必要と結論した。 It was concluded that it was necessary not to exceed%.
実験例 4  Example 4
[0044] 直径 300nm〜700nmの球形の微小なカプセル(商品名「ナノスフィァ」としてコレ ティカ社で製造'販売している商品)をヒアルロン酸で製造し、その内部にコラーゲン 及びセラミドを収容する。そして、ゲル状の基礎ィ匕粧品に対して、 3. 0重量%のカブ セル (コラーゲン及びセラミドを収容したヒアルロン酸製の微小カプセル)を添加する ゲル状の基礎ィ匕粧品には、微小カプセルを構成しないヒアルロン酸、微小カプセル に収容されないコラーゲン及びセラミドが、従来の化粧品(出願人が製造'販売して いる商品名「シーラボアクアコラーゲンゲル」なる化粧品)に比較して、 1. 5倍の量を 含有している。  [0044] Spherical microcapsules with a diameter of 300 nm to 700 nm (product name “Nanosphere” manufactured and sold by Koretica) are manufactured with hyaluronic acid, and collagen and ceramide are accommodated inside. Then, 3.0% by weight of capsules (microcapsules made of hyaluronic acid containing collagen and ceramide) is added to the gel-like basic cosmetics. The hyaluronic acid that does not make up the product, collagen that is not contained in the microcapsules, and ceramide are 1.5 times the amount of conventional cosmetics (the cosmetics that are manufactured and sold by the applicant, the product name “Sealab Aqua Collagen Gel”). Contains the amount.
それと共に、ゲル状の基礎ィ匕粧品には、若干量のビタミン Cと、ラミナリアォクロロイ 力エキス及びペルべチアカナリクラタエキスを、基礎ィ匕粧品に対して、各々 2. 0重量 %を含有した。 At the same time, a certain amount of vitamin C, laminaria chloroi force extract and pervetia kana rikrata extract are added to the basic cosmetic product by 2.0% each. % Contained.
この様な配合を有する (実施例に係る)化粧品を、従来の化粧品(出願人が製造- 販売している商品名「シーラボアクアコラーゲンゲル」なる化粧品)と比較試験を行つ た。  A cosmetic test having such a composition (according to the example) was compared with a conventional cosmetic product (a cosmetic product manufactured and sold by the applicant under the name “Sealab Aqua Collagen Gel”).
[0045] 比較試験では、実施例に係る化粧品と、従来の化粧品とを 100人の被験者の各々 の左右の手の甲に塗布し、肌の潤い、肌の張り、肌の美しさ(いわゆる「美白」)の 3項 目に関して、何れの化粧品が効果的であるかについて、被験者に回答させた。係る 回答結果が、表 4に示されている。  [0045] In the comparative test, the cosmetic product according to the example and the conventional cosmetic product were applied to the backs of the left and right hands of each of 100 subjects to moisturize the skin, stretch the skin, and make the skin beautiful (so-called “whitening”). For the third item of), the subjects were asked which cosmetics would be effective. The results of such responses are shown in Table 4.
表 4  Table 4
Figure imgf000013_0001
Figure imgf000013_0001
本品 → 実施例に係る化粧品  This product → Cosmetics according to the embodiment
従来品 → 本出願人が現在販売している化粧品  Conventional product → Cosmetics currently sold by the applicant
[0046] 表 4から明らかな様に、「肌の潤い」、「肌の張り」、「肌の美しさ」の 3項目について、 何れも、実施例に係る化粧品の方が効果があると判定した被験者が圧倒的に多かつ た。 [0046] As is clear from Table 4, it was determined that the cosmetic products according to the examples were more effective for the three items of “moisturizing skin”, “skin tension”, and “beauty of skin”. There were an overwhelming number of subjects.
ここで、各項目について、回答の合計数が 100人にならないのは、「無回答」が存 在した力 である。  Here, for each item, the total number of responses does not reach 100 because of “no response”.
また、「肌の潤い」、「肌の張り」、「肌の美しさ」の 3項目について、多少のばらつきが 存在するのは、前記回答は、あくまでも被験者の「感想」であり、感覚的なものである ことに起因すると判断される。  In addition, there is a slight variation in the three items of “Moisturization”, “Strength of skin”, and “Beauty of skin”. It is judged that it is caused by
実験例 4の結果 (表 4)力もも、実施例に係る化粧品は、「肌の潤い」、「肌の張り」、「 肌の美しさ」の 3項目について、特に肌の潤いと張りという保湿性について、非常に良 好であることが明らかになった。  Results of Experimental Example 4 (Table 4) The cosmetics according to the example for the strength and moisturizing of the three items of “Moisturizing skin”, “Skin tension” and “Skin beauty” are especially moisturizing and tensioning. It became clear that the sex was very good.
[0047] なお、図示の実施形態や、上述した実施例及び実験例はあくまでも例示であり、本 発明の技術的範囲を限定する趣旨の記述ではない旨を付記する。 図面の簡単な説明 [0047] It should be noted that the illustrated embodiment and the above-described examples and experimental examples are merely examples, and are not intended to limit the technical scope of the present invention. Brief Description of Drawings
[0048] [図 1]本発明の実施形態の主成分である微小カプセルの模式図。  FIG. 1 is a schematic diagram of a microcapsule that is a main component of an embodiment of the present invention.
[図 2]図 1の微小カプセルを基礎ィ匕粧品に添カ卩 ·混合する工程の模式図。  FIG. 2 is a schematic diagram of a process of mixing the microcapsules of FIG. 1 with basic cosmetics.
[図 3]本発明の実施形態に係る化粧品の模式図。  FIG. 3 is a schematic diagram of a cosmetic product according to an embodiment of the present invention.
[図 4]図 3の化粧品を皮膚に塗布した際の作用を示す模式図。  FIG. 4 is a schematic diagram showing the action when the cosmetic of FIG. 3 is applied to the skin.
[図 5]図 1の微小カプセルが真皮層に到達した際の作用を示す模式図。  FIG. 5 is a schematic diagram showing the action when the microcapsules of FIG. 1 reach the dermis layer.
[図 6]本発明の実施形態に係る化粧品の作用を示す模式図。  FIG. 6 is a schematic diagram showing the action of the cosmetic product according to the embodiment of the present invention.
符号の説明  Explanation of symbols
[0049] 10 ··微小カプセル (微小容器)  [0049] 10 ··· Microcapsules (microcontainers)
12 22···コラーゲン  12 22 Collagen
14 24···セラミド  14 24 Ceramide
10P 26···ヒアルロン酸  10P 26 ··· Hyaluronic acid
20 •ゲル状の基礎ィ匕粧品  20 • Gel-like basic cosmetics
30 •実施形態に係る化粧品  30 • Cosmetics according to embodiments
Α· 皮膚の角質層  Α The stratum corneum of the skin
Β·  Β
C- 40 '真皮層に存在する酵素  C-40 'Enzyme present in the dermis layer

Claims

請求の範囲 The scope of the claims
[1] ヒアルロン酸で微小な容器を構成し、係る微小な容器内にコラーゲン及びセラミドを 内蔵し、コラーゲン及びセラミドを内蔵した微小な容器を、ゲル状の基礎ィ匕粧品に、 0 . 1〜5重量%含有したことを特徴とする化粧品。  [1] A minute container is composed of hyaluronic acid, collagen and ceramide are incorporated in the minute container, and the minute container containing collagen and ceramide is used as a gel-like basic cosmetic product. Cosmetics characterized by containing 5% by weight.
[2] 前記ゲル状の基礎ィ匕粧品は、セラミド、コラーゲン、ヒアルロン酸を含有して 、る請求 項 1の化粧品。  [2] The cosmetic according to claim 1, wherein the gel-like basic cosmetic contains ceramide, collagen, and hyaluronic acid.
[3] 前記ゲル状の基礎化粧品中には、ビタミン C、ラミナリアオタロロイカエキス、ペルべ チアカナリクラタエキスを含有している請求項 2の化粧品。  [3] The cosmetic according to claim 2, wherein the gel-like basic cosmetic contains vitamin C, laminaria taroroika extract, and pervetianakana kratta extract.
PCT/JP2005/012479 2005-07-06 2005-07-06 Cosmetic product WO2007004300A1 (en)

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JP2009161458A (en) * 2007-12-28 2009-07-23 Rohto Pharmaceut Co Ltd Incorporation promoter of ascorbic acids into cell
WO2009136651A1 (en) * 2008-05-09 2009-11-12 Fujifilm Corporation Topical composition for external use and process for producing the same
EP2317981A1 (en) * 2008-07-24 2011-05-11 Amorepacific Corporation Multi-layered lamellar granule and skin external application composition containing same
JP2014051464A (en) * 2012-09-07 2014-03-20 Panasonic Corp Bio-active molecule encapsulating particle, bio-active pharmaceutical drug, method for permeation of bio-active molecule encapsulating particle into living body, and dissipating apparatus of bio-active molecule encapsulating particle and air cleaning device
JP2014129314A (en) * 2012-12-30 2014-07-10 Shinshu Univ Base material for sheet-like pack, sheet-like pack, and method for manufacturing base material for sheet-like pack
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US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
AU2013203710B2 (en) * 2007-11-30 2016-09-29 Allergan Industrie, Sas Polysaccharide gel formulation
US9737633B2 (en) 2011-06-03 2017-08-22 Allergan, Inc. Dermal filler compositions including antioxidants
US11083684B2 (en) 2011-06-03 2021-08-10 Allergan Industrie, Sas Dermal filler compositions
WO2023161415A1 (en) * 2022-02-28 2023-08-31 Merck Patent Gmbh Cosmetic use of a composition comprising an aqueous seaweed extract of pelvetia canaliculata for increasing gloss of skin

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JP2014129314A (en) * 2012-12-30 2014-07-10 Shinshu Univ Base material for sheet-like pack, sheet-like pack, and method for manufacturing base material for sheet-like pack
WO2023161415A1 (en) * 2022-02-28 2023-08-31 Merck Patent Gmbh Cosmetic use of a composition comprising an aqueous seaweed extract of pelvetia canaliculata for increasing gloss of skin

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