WO2007002238A3 - Drug/polymer composite materials and methods of making the same - Google Patents

Drug/polymer composite materials and methods of making the same Download PDF

Info

Publication number
WO2007002238A3
WO2007002238A3 PCT/US2006/024221 US2006024221W WO2007002238A3 WO 2007002238 A3 WO2007002238 A3 WO 2007002238A3 US 2006024221 W US2006024221 W US 2006024221W WO 2007002238 A3 WO2007002238 A3 WO 2007002238A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
polymer composite
methods
composite materials
making
Prior art date
Application number
PCT/US2006/024221
Other languages
French (fr)
Other versions
WO2007002238A2 (en
Inventor
Jim Mcclain
James Deyoung
Original Assignee
Micell Technologies Inc
Jim Mcclain
James Deyoung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micell Technologies Inc, Jim Mcclain, James Deyoung filed Critical Micell Technologies Inc
Priority to CA2613280A priority Critical patent/CA2613280C/en
Priority to EP06773731.2A priority patent/EP1898878B1/en
Publication of WO2007002238A2 publication Critical patent/WO2007002238A2/en
Publication of WO2007002238A3 publication Critical patent/WO2007002238A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Abstract

A method of forming a drug/polymer composite material is carried out by combining a drug material with a polymer material under pressure in the presence of a densified gas solvent (e.g., carbon dioxide) to form the drug/polymer composite material. Drug/polymer composite materials and shaped articles (e.g., subcutaneous drug depots) which may be produced by a process are also described, along with methods of use thereof.
PCT/US2006/024221 2005-06-22 2006-06-21 Drug/polymer composite materials and methods of making the same WO2007002238A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2613280A CA2613280C (en) 2005-06-22 2006-06-21 Drug/polymer composite materials and methods of making the same
EP06773731.2A EP1898878B1 (en) 2005-06-22 2006-06-21 Drug/polymer composite materials and methods of making the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/158,724 US20070009564A1 (en) 2005-06-22 2005-06-22 Drug/polymer composite materials and methods of making the same
US11/158,724 2005-06-22

Publications (2)

Publication Number Publication Date
WO2007002238A2 WO2007002238A2 (en) 2007-01-04
WO2007002238A3 true WO2007002238A3 (en) 2007-05-10

Family

ID=37595812

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/024221 WO2007002238A2 (en) 2005-06-22 2006-06-21 Drug/polymer composite materials and methods of making the same

Country Status (4)

Country Link
US (2) US20070009564A1 (en)
EP (1) EP1898878B1 (en)
CA (2) CA2613280C (en)
WO (1) WO2007002238A2 (en)

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US9486431B2 (en) 2008-07-17 2016-11-08 Micell Technologies, Inc. Drug delivery medical device
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EP1898878A4 (en) 2012-10-31
CA2613280A1 (en) 2007-01-04
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US20190151453A1 (en) 2019-05-23
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