WO2006130402A3 - High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers - Google Patents
High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers Download PDFInfo
- Publication number
- WO2006130402A3 WO2006130402A3 PCT/US2006/020020 US2006020020W WO2006130402A3 WO 2006130402 A3 WO2006130402 A3 WO 2006130402A3 US 2006020020 W US2006020020 W US 2006020020W WO 2006130402 A3 WO2006130402 A3 WO 2006130402A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polymers
- high refractive
- hydrophilic
- ophthalmic devices
- index
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1806—C6-(meth)acrylate, e.g. (cyclo)hexyl (meth)acrylate or phenyl (meth)acrylate
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
Abstract
A hydrophilic, aromatic-based monomer has an aromatic group substituted with at least one hydrophilic substituent and a reactive functional group. Polymers comprising such a hydrophilic, aromatic-based monomers avoid or reduce the risk of forming vacuoles of absorbed water. Furthermore, such polymers have high refractive index, and, thus, are advantageously used for making ophthalmic devices, such as intraocular lenses, contact lenses, corneal rings, corneal inlays, and keratoprostheses.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06771023A EP1885290A2 (en) | 2005-05-27 | 2006-05-24 | High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/139,276 | 2005-05-27 | ||
US11/139,276 US7495061B2 (en) | 2005-05-27 | 2005-05-27 | High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006130402A2 WO2006130402A2 (en) | 2006-12-07 |
WO2006130402A3 true WO2006130402A3 (en) | 2007-03-08 |
Family
ID=37331447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/020020 WO2006130402A2 (en) | 2005-05-27 | 2006-05-24 | High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers |
Country Status (3)
Country | Link |
---|---|
US (3) | US7495061B2 (en) |
EP (1) | EP1885290A2 (en) |
WO (1) | WO2006130402A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101170966A (en) | 2005-04-01 | 2008-04-30 | 科罗拉多州立大学董事会 | A graft fixation device and method |
US7495061B2 (en) * | 2005-05-27 | 2009-02-24 | Bausch + Lomb Incorporated | High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers |
TWI449520B (en) | 2007-04-30 | 2014-08-21 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials containing phenylene-siloxane macromers |
ATE511530T1 (en) * | 2007-07-25 | 2011-06-15 | Alcon Inc | HIGH REFRACTIVE INDEX MATERIALS FOR OPHTHALMIC DEVICES |
TW200920330A (en) | 2007-10-02 | 2009-05-16 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials containing an alkyl ethoxylate |
TW200916130A (en) | 2007-10-02 | 2009-04-16 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials containing an alkylphenol ethoxylate |
TWI426931B (en) | 2007-10-03 | 2014-02-21 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials |
TWI461186B (en) | 2007-10-05 | 2014-11-21 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials |
TWI426932B (en) | 2007-10-05 | 2014-02-21 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials |
WO2009070438A1 (en) | 2007-11-30 | 2009-06-04 | Bausch & Lomb Incorporated | Optical material and method for modifying the refractive index |
US20140232025A1 (en) * | 2011-03-07 | 2014-08-21 | The Regents Of The University Of Colorado | Manufacturing method for shape memory polymer intraocular devices |
US9427493B2 (en) | 2011-03-07 | 2016-08-30 | The Regents Of The University Of Colorado | Shape memory polymer intraocular lenses |
US8912300B2 (en) * | 2011-06-13 | 2014-12-16 | Dic Corporation | Radical polymerizable composition, cured product, and plastic lens |
Citations (6)
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US4304895A (en) * | 1973-06-20 | 1981-12-08 | Wesley-Jessen, Inc. | Ultraviolet absorbing corneal contact lenses |
US4528311A (en) * | 1983-07-11 | 1985-07-09 | Iolab Corporation | Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles |
JPH09165422A (en) * | 1995-12-15 | 1997-06-24 | Mitsubishi Rayon Co Ltd | Composition for plastic lens |
US5674960A (en) * | 1990-11-07 | 1997-10-07 | Nestle S.A. | Flexible high refractive index, cross-linked, acrylic copolymers |
WO1999052570A1 (en) * | 1998-04-15 | 1999-10-21 | Alcon Laboratories, Inc. | Intraocular lens coating compositions |
WO1999053348A1 (en) * | 1998-04-15 | 1999-10-21 | Alcon Laboratories, Inc. | High refractive index ophthalmic device materials prepared using a post-polymerization cross-linking method |
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US3737979A (en) * | 1971-08-05 | 1973-06-12 | Anaconda American Brass Co | Method of manufacturing longitudinally welded strips of different thicknesses and widths |
US5236969A (en) * | 1987-04-02 | 1993-08-17 | Bausch & Lomb Incorporated | Polymer compositions for contact lenses |
ES2183953T3 (en) | 1995-06-07 | 2003-04-01 | Alcon Lab Inc | IMPROVED MATERIALS OF HIGH REFRACTION OPTIONAL LENSES. |
JP3648846B2 (en) | 1995-07-25 | 2005-05-18 | ユニマテック株式会社 | Acrylic copolymer elastomer, blended rubber thereof and blended rubber composition |
SE9600006D0 (en) * | 1996-01-02 | 1996-01-02 | Pharmacia Ab | Foldable intraocular lens materials |
US5922821A (en) * | 1996-08-09 | 1999-07-13 | Alcon Laboratories, Inc. | Ophthalmic lens polymers |
US5891931A (en) | 1997-08-07 | 1999-04-06 | Alcon Laboratories, Inc. | Method of preparing foldable high refractive index acrylic ophthalmic device materials |
US6015842A (en) | 1997-08-07 | 2000-01-18 | Alcon Laboratories, Inc. | Method of preparing foldable hydrophilic ophthalmic device materials |
BE1011539A3 (en) * | 1997-11-07 | 1999-10-05 | Solvay | Method of manufacturing organic compound. |
JP2002511597A (en) | 1998-04-15 | 2002-04-16 | アルコン ラボラトリーズ, インコーポレイテッド | High refractive index ophthalmic device materials |
US6313187B2 (en) | 1998-04-15 | 2001-11-06 | Alcon Manufacturing, Ltd. | High refractive index ophthalmic device materials prepared using a post-polymerization cross-linking method |
US6353069B1 (en) | 1998-04-15 | 2002-03-05 | Alcon Manufacturing, Ltd. | High refractive index ophthalmic device materials |
US6541572B2 (en) | 1998-04-23 | 2003-04-01 | Alcon Manufacturing, Ltd. | Method of making high refractive index ophthalmic device materials |
US6776932B1 (en) | 1998-06-12 | 2004-08-17 | Getronics Wang Co. Llc | Polymeric optical articles |
WO2000002932A1 (en) | 1998-07-10 | 2000-01-20 | S. C. Johnson Commercial Markets, Inc. | Process for producing polymers by free radical polymerization and condensation reaction, and apparatus and products related thereto |
US6329485B1 (en) | 1998-12-11 | 2001-12-11 | Bausch & Lomb Incorporated | High refractive index hydrogel compositions for ophthalmic implants |
DE69915114T2 (en) | 1998-12-11 | 2004-09-09 | Biocompatibles Uk Ltd., Farnham | CROSSLINKED POLYMERS AND REFRACTOR DEVICE MOLDED FROM THESE |
EP1035142A1 (en) | 1999-03-09 | 2000-09-13 | Nidek Co., Ltd. | Acrylic copolymer materials suitable for ophthalmic devices |
SE9900935D0 (en) | 1999-03-16 | 1999-03-16 | Pharmacia & Upjohn Bv | Macromolecular compounds |
US6281319B1 (en) | 1999-04-12 | 2001-08-28 | Surgidev Corporation | Water plasticized high refractive index polymer for ophthalmic applications |
US6723815B2 (en) | 1999-09-02 | 2004-04-20 | Alcon, Inc. | Covalently-bound, hydrophilic coating compositions for surgical implants |
US6632905B2 (en) | 1999-09-02 | 2003-10-14 | Alcon Universal Ltd. | Covalently-bound, hydrophilic coating compositions for surgical implants |
US6695880B1 (en) | 2000-10-24 | 2004-02-24 | Johnson & Johnson Vision Care, Inc. | Intraocular lenses and methods for their manufacture |
US6703466B1 (en) * | 2001-06-18 | 2004-03-09 | Alcon, Inc. | Foldable intraocular lens optics having a glassy surface |
US6737448B2 (en) | 2002-06-03 | 2004-05-18 | Staar Surgical Company | High refractive index, optically clear and soft hydrophobic acrylamide copolymers |
US6852793B2 (en) | 2002-06-19 | 2005-02-08 | Bausch & Lomb Incorporated | Low water content, high refractive index, flexible, polymeric compositions |
EP1857477B1 (en) | 2005-03-09 | 2012-06-27 | Hoya Corporation | (meth)acrylate compound, process for production of the compound, (meth)acrylate copolymer, process for production of the copolymer, and soft intraocular lens |
US7495061B2 (en) | 2005-05-27 | 2009-02-24 | Bausch + Lomb Incorporated | High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers |
US7714039B2 (en) | 2006-07-21 | 2010-05-11 | Alcon, Inc. | Low-tack ophthalmic and otorhinolaryngological device materials |
-
2005
- 2005-05-27 US US11/139,276 patent/US7495061B2/en active Active
-
2006
- 2006-05-24 EP EP06771023A patent/EP1885290A2/en not_active Withdrawn
- 2006-05-24 WO PCT/US2006/020020 patent/WO2006130402A2/en active Application Filing
-
2008
- 2008-04-01 US US12/060,322 patent/US20080183006A1/en not_active Abandoned
- 2008-11-19 US US12/273,624 patent/US7781496B2/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4304895A (en) * | 1973-06-20 | 1981-12-08 | Wesley-Jessen, Inc. | Ultraviolet absorbing corneal contact lenses |
US4528311A (en) * | 1983-07-11 | 1985-07-09 | Iolab Corporation | Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles |
US5674960A (en) * | 1990-11-07 | 1997-10-07 | Nestle S.A. | Flexible high refractive index, cross-linked, acrylic copolymers |
US5861031A (en) * | 1990-11-07 | 1999-01-19 | Nestle, S.A. | Intraocular lens from arylalkyl(meth)acrylate polymer(s) |
JPH09165422A (en) * | 1995-12-15 | 1997-06-24 | Mitsubishi Rayon Co Ltd | Composition for plastic lens |
WO1999052570A1 (en) * | 1998-04-15 | 1999-10-21 | Alcon Laboratories, Inc. | Intraocular lens coating compositions |
WO1999053348A1 (en) * | 1998-04-15 | 1999-10-21 | Alcon Laboratories, Inc. | High refractive index ophthalmic device materials prepared using a post-polymerization cross-linking method |
Non-Patent Citations (7)
Title |
---|
A.L.MEYERS ET AL: "Nucleophilic Annulations of Aromatics", J.ORG.CHEM., vol. 46, 1981, pages 783 - 788, XP009074888 * |
A.SEN ET AL: "Possible Antimoebic Agents", JOURN.INDIAN.CHEM.SOC., vol. 35, no. 8, 1958, pages 613 - 615, XP009074880 * |
H.OHIGASHI ET AL: "Chavicol, as a Larva-growth Inhibitor, from Viburnum japonicum Spreng", AGR. BIOL. CHEM., vol. 40, no. 11, 1976, pages 2283 - 2287, XP009074910 * |
K.UNEYAMA ET AL: "Synthesis of 4-(4-Hydroxy-2,6-dimethylphenyl)-1,2-butanediol and 4-(4-hydroxy-2,6-dimethylphenyl)-2-butanol", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 49, no. 9, 1976, pages 2649 - 2650, XP009074909 * |
N.S.NARASIMHAN ET AL: "Synthetic Applications of Lithiation Reactions", INDIAN.J.CHEM., vol. 7, 1969, pages 536 - 537, XP009074881 * |
P.YATES ET AL: "Tandem wessely oxidation and intramolecular Diels-Alder reactions", CAN.J.CHEM., vol. 66, no. 1, 1988, pages 1 - 10, XP009074911 * |
SCHLOSSER M ET AL: "About the Physiological Size of Fluorine Substituents: Comparison of Sensorially Active Compounds with Fluorine and Methyl Substituted Analogues", January 1996, TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, PAGE(S) 99-108, ISSN: 0040-4020, XP004104587 * |
Also Published As
Publication number | Publication date |
---|---|
US20080183006A1 (en) | 2008-07-31 |
US20090076187A1 (en) | 2009-03-19 |
EP1885290A2 (en) | 2008-02-13 |
US20060270749A1 (en) | 2006-11-30 |
US7781496B2 (en) | 2010-08-24 |
WO2006130402A2 (en) | 2006-12-07 |
US7495061B2 (en) | 2009-02-24 |
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