WO2006127852A3 - In situ heat induced antigen recovery and staining apparatus and method - Google Patents
In situ heat induced antigen recovery and staining apparatus and method Download PDFInfo
- Publication number
- WO2006127852A3 WO2006127852A3 PCT/US2006/020156 US2006020156W WO2006127852A3 WO 2006127852 A3 WO2006127852 A3 WO 2006127852A3 US 2006020156 W US2006020156 W US 2006020156W WO 2006127852 A3 WO2006127852 A3 WO 2006127852A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- slide
- individually
- reaction compartment
- reagent
- microscope
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000011084 recovery Methods 0.000 title abstract 2
- 238000010186 staining Methods 0.000 title abstract 2
- 238000011065 in-situ storage Methods 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000006193 liquid solution Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0059—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
- A61F2007/0063—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/0085—Devices for generating hot or cold treatment fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0822—Slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/14—Means for pressure control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00138—Slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0412—Block or rack elements with a single row of samples
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0609898-3A BRPI0609898A2 (en) | 2005-05-24 | 2006-05-24 | in situ antigen retrieval and staining apparatus, reaction module, method for treating a microscope slide, and reconfigurable reagent dispensing strip |
CN2006800266738A CN101228429B (en) | 2005-05-24 | 2006-05-24 | In situ heat induced antigen recovery and staining apparatus and method |
MX2007014655A MX2007014655A (en) | 2005-05-24 | 2006-05-24 | In situ heat induced antigen recovery and staining apparatus and method. |
JP2008513689A JP5335420B2 (en) | 2005-05-24 | 2006-05-24 | In situ heat-induced antigen recovery / coloring apparatus and method |
CA2609453A CA2609453C (en) | 2005-05-24 | 2006-05-24 | In situ heat induced antigen recovery and staining apparatus and method |
AU2006249956A AU2006249956A1 (en) | 2005-05-24 | 2006-05-24 | In situ heat induced antigen recovery and staining apparatus and method |
EP06771115.0A EP1888739B1 (en) | 2005-05-24 | 2006-05-24 | Automated apparatus and method for treating biological specimens on slides |
HK08112042.5A HK1120110A1 (en) | 2005-05-24 | 2008-11-03 | In situ heat induced antigen recovery and staining apparatus and method |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68404705P | 2005-05-24 | 2005-05-24 | |
US60/684,047 | 2005-05-24 | ||
US60/689,386 | 2005-06-06 | ||
US68938605P | 2005-06-10 | 2005-06-10 | |
US73074405P | 2005-10-27 | 2005-10-27 | |
US60/730,744 | 2005-10-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2006127852A2 WO2006127852A2 (en) | 2006-11-30 |
WO2006127852A3 true WO2006127852A3 (en) | 2007-03-29 |
WO2006127852A8 WO2006127852A8 (en) | 2009-10-08 |
Family
ID=37452811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/020156 WO2006127852A2 (en) | 2005-05-24 | 2006-05-24 | In situ heat induced antigen recovery and staining apparatus and method |
Country Status (10)
Country | Link |
---|---|
US (6) | US8361388B2 (en) |
EP (1) | EP1888739B1 (en) |
JP (1) | JP5335420B2 (en) |
CN (1) | CN101228429B (en) |
AU (1) | AU2006249956A1 (en) |
BR (1) | BRPI0609898A2 (en) |
CA (1) | CA2609453C (en) |
HK (1) | HK1120110A1 (en) |
MX (1) | MX2007014655A (en) |
WO (1) | WO2006127852A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9267868B2 (en) | 2008-08-29 | 2016-02-23 | Lee H. Angros | In Situ heat induced antigen recovery and staining apparatus and method |
US9354145B2 (en) | 2005-05-24 | 2016-05-31 | Lee Angros | In situ heat induced antigen recovery and staining apparatus and method |
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WO2009046227A1 (en) * | 2007-10-02 | 2009-04-09 | Theranos, Inc. | Modular point-of-care devices and uses thereof |
US20090139311A1 (en) | 2007-10-05 | 2009-06-04 | Applied Biosystems Inc. | Biological Analysis Systems, Devices, and Methods |
FR2938062B1 (en) * | 2008-11-05 | 2014-02-28 | Biomerieux Sa | DEVICE FOR PREPARING AND / OR PROCESSING A BIOLOGICAL SAMPLE |
US8067241B2 (en) * | 2009-08-26 | 2011-11-29 | General Electric Company | Method and apparatus for antigen retrieval process |
WO2012048154A1 (en) | 2010-10-06 | 2012-04-12 | Biocare Medical, Llc | Methods and systems for efficient processing of biological samples |
EP2468862A1 (en) * | 2010-12-23 | 2012-06-27 | Qiagen GmbH | Method and kit for processing wax-embedded biological samples |
US9945763B1 (en) | 2011-02-18 | 2018-04-17 | Biocare Medical, Llc | Methods and systems for immunohistochemistry heat retrieval of biological samples |
US8932543B2 (en) | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
AU2012340344B2 (en) | 2011-11-17 | 2015-10-29 | Rheonix, Inc. | Microfluidic apparatus, method, and applications |
WO2014001531A2 (en) * | 2012-06-29 | 2014-01-03 | Victorious Medical Systems Aps | A system and a dip tank for washing and target retrieval of tissue samples mounted on microscope slides |
AU2013337608B2 (en) | 2012-11-01 | 2017-07-20 | Leica Biosystems Melbourne Pty Ltd | A fluid transport system |
EP4095509A1 (en) * | 2013-12-13 | 2022-11-30 | Ventana Medical Systems, Inc. | Automated histological processing of biological specimens and associated technology |
ES2877855T3 (en) | 2013-12-13 | 2021-11-17 | Ventana Med Syst Inc | Staining reagents and other liquids for histological processing of biological samples and associated technology |
WO2015086531A1 (en) | 2013-12-13 | 2015-06-18 | Ventana Medical Systems, Inc. | Automated processing systems and methods of thermally processing microscope slides |
US10634590B2 (en) | 2014-03-11 | 2020-04-28 | Emd Millipore Corporation | IHC, tissue slide fluid exchange disposable and system |
CN104744588A (en) * | 2015-04-03 | 2015-07-01 | 福州大学 | Antigen pre-processing method for preparing antibody |
CN107615039A (en) * | 2015-05-26 | 2018-01-19 | 奥林巴斯株式会社 | Check body dyeing apparatus and check body colouring method |
US10745822B2 (en) * | 2015-07-23 | 2020-08-18 | Shoei Chemical Inc. | Method for producing metal oxide nanocrystals, method for producing multi-element oxide nanocrystals, and metal oxide nanocrystals |
CN105987839B (en) * | 2016-06-03 | 2018-09-28 | 浙江世纪康大医疗科技股份有限公司 | A kind of EDTA- citric acid antigens reparation liquid |
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US20190316993A1 (en) * | 2016-12-20 | 2019-10-17 | Diapath S.P.A. | Disposable container for stains or reagents for staining machines of biological material and staining system comprising said container |
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CN109556929A (en) * | 2018-10-18 | 2019-04-02 | 广州安必平医药科技股份有限公司 | Reaction warehouse, antigen retrieval instrument and its application method |
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US9267868B2 (en) | 2008-08-29 | 2016-02-23 | Lee H. Angros | In Situ heat induced antigen recovery and staining apparatus and method |
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CN101228429A (en) | 2008-07-23 |
CA2609453C (en) | 2014-07-08 |
US11585737B2 (en) | 2023-02-21 |
US9719895B2 (en) | 2017-08-01 |
JP2009506300A (en) | 2009-02-12 |
US20110229978A1 (en) | 2011-09-22 |
HK1120110A1 (en) | 2009-03-20 |
US9354145B2 (en) | 2016-05-31 |
US8361388B2 (en) | 2013-01-29 |
EP1888739A2 (en) | 2008-02-20 |
US8541244B2 (en) | 2013-09-24 |
AU2006249956A1 (en) | 2006-11-30 |
US10697868B2 (en) | 2020-06-30 |
US20170328820A1 (en) | 2017-11-16 |
WO2006127852A8 (en) | 2009-10-08 |
CN101228429B (en) | 2013-04-10 |
MX2007014655A (en) | 2008-04-02 |
EP1888739A4 (en) | 2012-07-18 |
US20160274007A1 (en) | 2016-09-22 |
EP1888739B1 (en) | 2021-08-11 |
WO2006127852A2 (en) | 2006-11-30 |
JP5335420B2 (en) | 2013-11-06 |
CA2609453A1 (en) | 2006-11-30 |
US20140024134A1 (en) | 2014-01-23 |
US20200326266A1 (en) | 2020-10-15 |
US20110150725A1 (en) | 2011-06-23 |
BRPI0609898A2 (en) | 2011-10-11 |
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