WO2006122165A3 - Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates - Google Patents

Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates Download PDF

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Publication number
WO2006122165A3
WO2006122165A3 PCT/US2006/018019 US2006018019W WO2006122165A3 WO 2006122165 A3 WO2006122165 A3 WO 2006122165A3 US 2006018019 W US2006018019 W US 2006018019W WO 2006122165 A3 WO2006122165 A3 WO 2006122165A3
Authority
WO
WIPO (PCT)
Prior art keywords
alpha
adrenergic receptor
materials
receptor agonists
eye
Prior art date
Application number
PCT/US2006/018019
Other languages
French (fr)
Other versions
WO2006122165A2 (en
Inventor
Patric M Hughes
James A Burke
Joan-En Chang-Lin
Original Assignee
Allergan Inc
Patric M Hughes
James A Burke
Joan-En Chang-Lin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc, Patric M Hughes, James A Burke, Joan-En Chang-Lin filed Critical Allergan Inc
Priority to EP06752463.7A priority Critical patent/EP1879553B1/en
Priority to BRPI0608978-0A priority patent/BRPI0608978A2/en
Priority to JP2008511301A priority patent/JP2008540552A/en
Priority to AU2006244083A priority patent/AU2006244083A1/en
Priority to ES06752463T priority patent/ES2798259T3/en
Priority to EP20150705.0A priority patent/EP3656374A1/en
Priority to CA2603069A priority patent/CA2603069C/en
Publication of WO2006122165A2 publication Critical patent/WO2006122165A2/en
Publication of WO2006122165A3 publication Critical patent/WO2006122165A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/10Ophthalmic agents for accommodation disorders, e.g. myopia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component which includes an alpha 2 adrenergic receptor agonist that is cleared from the anterior segment of an individual's eye to which the material is administered. The alpha 2 adrenergic receptor agonist may have a vitreal half-life greater than about three hours. The present materials are effective in treating an ocular condition(s) that affect the anterior segment of an eye, or the anterior and posterior segment of the eye. The materials are suitable for intravitreal or periocular administration and can provide prolonged drug delivery and therapeutic benefits to patients to which the materials have been administered. The alpha 2 adrenergic receptor agonists can be provided in liquid-containing formulations and/or bioerodible and/or non-bioerodible polymeric implants and microparticles. Methods of making and using the present materials are also described.
PCT/US2006/018019 2005-05-10 2006-05-09 Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates WO2006122165A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP06752463.7A EP1879553B1 (en) 2005-05-10 2006-05-09 Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates
BRPI0608978-0A BRPI0608978A2 (en) 2005-05-10 2006-05-09 eye therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates
JP2008511301A JP2008540552A (en) 2005-05-10 2006-05-09 Ophthalmic treatment using alpha-2 adrenergic receptor agonists with increased anterior clearance rate
AU2006244083A AU2006244083A1 (en) 2005-05-10 2006-05-09 Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates
ES06752463T ES2798259T3 (en) 2005-05-10 2006-05-09 Ocular therapy using alpha 2 adrenergic receptor agonists that have improved anterior clearance rates
EP20150705.0A EP3656374A1 (en) 2005-05-10 2006-05-09 Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates
CA2603069A CA2603069C (en) 2005-05-10 2006-05-09 Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67977105P 2005-05-10 2005-05-10
US60/679,771 2005-05-10

Publications (2)

Publication Number Publication Date
WO2006122165A2 WO2006122165A2 (en) 2006-11-16
WO2006122165A3 true WO2006122165A3 (en) 2007-05-31

Family

ID=37397258

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/018019 WO2006122165A2 (en) 2005-05-10 2006-05-09 Ocular therapy using alpha-2 adrenergic receptor agonists having enhanced anterior clearance rates

Country Status (8)

Country Link
US (3) US7931909B2 (en)
EP (2) EP3656374A1 (en)
JP (3) JP2008540552A (en)
AU (1) AU2006244083A1 (en)
BR (1) BRPI0608978A2 (en)
CA (1) CA2603069C (en)
ES (1) ES2798259T3 (en)
WO (1) WO2006122165A2 (en)

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US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
US9138480B2 (en) 2009-11-09 2015-09-22 Allergan, Inc. Compositions and methods for stimulating hair growth
US9198885B2 (en) 2005-07-14 2015-12-01 Neothetics, Inc. Lipolytic methods for regional adiposity comprising salmeterol or formoterol
US9597531B2 (en) 2010-11-24 2017-03-21 Neothetics, Inc. Selective, lipophilic, and long-acting beta agonist monotherapeutic formulations and methods for the cosmetic treatment of adiposity and contour bulging

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Publication number Priority date Publication date Assignee Title
US9198885B2 (en) 2005-07-14 2015-12-01 Neothetics, Inc. Lipolytic methods for regional adiposity comprising salmeterol or formoterol
US9370498B2 (en) 2005-07-14 2016-06-21 Neothetics, Inc. Methods of using lipolytic formulations for regional adipose tissue treatment
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
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US9597531B2 (en) 2010-11-24 2017-03-21 Neothetics, Inc. Selective, lipophilic, and long-acting beta agonist monotherapeutic formulations and methods for the cosmetic treatment of adiposity and contour bulging

Also Published As

Publication number Publication date
AU2006244083A1 (en) 2006-11-16
ES2798259T3 (en) 2020-12-10
US7931909B2 (en) 2011-04-26
EP1879553A2 (en) 2008-01-23
JP2015013863A (en) 2015-01-22
CA2603069C (en) 2014-01-28
WO2006122165A2 (en) 2006-11-16
JP2012046530A (en) 2012-03-08
JP2008540552A (en) 2008-11-20
US20080112922A1 (en) 2008-05-15
US20080112923A1 (en) 2008-05-15
EP1879553B1 (en) 2020-02-12
CA2603069A1 (en) 2006-11-16
EP3656374A1 (en) 2020-05-27
US20060257452A1 (en) 2006-11-16
BRPI0608978A2 (en) 2010-02-17

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