WO2006119933A1 - Measurement of binding rate of a binding substance and an analyte - Google Patents
Measurement of binding rate of a binding substance and an analyte Download PDFInfo
- Publication number
- WO2006119933A1 WO2006119933A1 PCT/EP2006/004244 EP2006004244W WO2006119933A1 WO 2006119933 A1 WO2006119933 A1 WO 2006119933A1 EP 2006004244 W EP2006004244 W EP 2006004244W WO 2006119933 A1 WO2006119933 A1 WO 2006119933A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- binding
- rate
- sonication
- analyte
- measurements
- Prior art date
Links
- 238000009739 binding Methods 0.000 title claims abstract description 103
- 230000027455 binding Effects 0.000 title claims abstract description 99
- 238000005259 measurement Methods 0.000 title claims abstract description 49
- 239000012491 analyte Substances 0.000 title claims abstract description 34
- 239000000126 substance Substances 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 57
- 238000000527 sonication Methods 0.000 claims description 45
- 239000002245 particle Substances 0.000 claims description 8
- 238000013213 extrapolation Methods 0.000 claims description 7
- 239000003446 ligand Substances 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 230000001900 immune effect Effects 0.000 claims description 2
- 238000012935 Averaging Methods 0.000 claims 1
- 230000031700 light absorption Effects 0.000 claims 1
- 238000002525 ultrasonication Methods 0.000 abstract description 14
- 238000003018 immunoassay Methods 0.000 abstract description 9
- 238000003556 assay Methods 0.000 abstract description 7
- 238000006243 chemical reaction Methods 0.000 description 19
- 238000002604 ultrasonography Methods 0.000 description 12
- 230000004520 agglutination Effects 0.000 description 9
- 238000002835 absorbance Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 239000004816 latex Substances 0.000 description 4
- 229920000126 latex Polymers 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000007620 mathematical function Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102100024952 Protein CBFA2T1 Human genes 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 238000007818 agglutination assay Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005558 fluorometry Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000004848 nephelometry Methods 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2606548A CA2606548C (en) | 2005-05-09 | 2006-05-05 | Measurement of binding rate of a binding substance and an analyte |
DK06724740T DK1880217T3 (en) | 2005-05-09 | 2006-05-05 | Measurement of binding rate for a binding substance and an analyte |
CN2006800159346A CN101171515B (en) | 2005-05-09 | 2006-05-05 | Method of measuring binding rate using sonication |
PL06724740T PL1880217T3 (en) | 2005-05-09 | 2006-05-05 | Measurement of binding rate of a binding substance and an analyte |
US11/919,728 US8133693B2 (en) | 2005-05-09 | 2006-05-05 | Measurement of binding rate of a binding substance and an analyte |
DE602006008293T DE602006008293D1 (en) | 2005-05-09 | 2006-05-05 | MEASURE THE BINDING SPEED OF A BONDING SUBSTANCE AND AN ANALYTE |
JP2008510468A JP4927824B2 (en) | 2005-05-09 | 2006-05-05 | Measurement of binding rates of binding substances and analytes |
AT06724740T ATE438855T1 (en) | 2005-05-09 | 2006-05-05 | MEASURING THE BINDING SPEED OF A BINDING SUBSTANCE AND AN ANALYTE |
AU2006246008A AU2006246008B2 (en) | 2005-05-09 | 2006-05-05 | Measurement of binding rate of a binding substance and an analyte |
EP06724740A EP1880217B1 (en) | 2005-05-09 | 2006-05-05 | Measurement of binding rate of a binding substance and an analyte |
NO20076299A NO20076299L (en) | 2005-05-09 | 2007-12-06 | Painting the binding rate of a binding substance and an analyte |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0509419.8 | 2005-05-09 | ||
GB0509419A GB2426050A (en) | 2005-05-09 | 2005-05-09 | Method of measuring binding rate using sonication |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006119933A1 true WO2006119933A1 (en) | 2006-11-16 |
Family
ID=34685297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/004244 WO2006119933A1 (en) | 2005-05-09 | 2006-05-05 | Measurement of binding rate of a binding substance and an analyte |
Country Status (15)
Country | Link |
---|---|
US (1) | US8133693B2 (en) |
EP (1) | EP1880217B1 (en) |
JP (1) | JP4927824B2 (en) |
CN (1) | CN101171515B (en) |
AT (1) | ATE438855T1 (en) |
AU (1) | AU2006246008B2 (en) |
CA (1) | CA2606548C (en) |
DE (1) | DE602006008293D1 (en) |
DK (1) | DK1880217T3 (en) |
ES (1) | ES2328397T3 (en) |
GB (1) | GB2426050A (en) |
NO (1) | NO20076299L (en) |
PL (1) | PL1880217T3 (en) |
PT (1) | PT1880217E (en) |
WO (1) | WO2006119933A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2015072A1 (en) * | 2007-07-12 | 2009-01-14 | LEK Pharmaceuticals D.D. | Ultrasound elution of biological ligands |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8263415B2 (en) * | 2006-09-14 | 2012-09-11 | Ge Healthcare Bio-Sciences Ab | Method of determining analyte concentration |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0137678A1 (en) * | 1983-08-29 | 1985-04-17 | Syntex (U.S.A.) Inc. | Ultrasonic enhanced immuno-reactions |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4157871A (en) * | 1976-06-02 | 1979-06-12 | Beckman Instruments, Inc. | System for rate immunonephelometric analysis |
US4268171A (en) * | 1977-07-18 | 1981-05-19 | Beckman Instruments, Inc. | Method determining concentration in rate nephelometric immunochemical analysis |
US4204837A (en) * | 1978-03-14 | 1980-05-27 | Beckman Instruments, Inc. | Method of rate immunonephelometric analysis |
US4205954A (en) * | 1978-05-26 | 1980-06-03 | Warner-Lambert Company | Kinetic latex agglutinometry |
US4766083A (en) * | 1982-04-04 | 1988-08-23 | Wako Pure Chemical Industries, Ltd. | Method for the photometric determination of biological agglutination |
US4615984A (en) | 1984-02-23 | 1986-10-07 | Becton Dickinson & Company | Dissociation of ligand-binder complex using ultrasound |
IL75648A0 (en) * | 1984-07-05 | 1985-10-31 | Gen Probe Inc | Accelerated nucleic acid reassociation method |
US4762413A (en) * | 1984-09-07 | 1988-08-09 | Olympus Optical Co., Ltd. | Method and apparatus for measuring immunological reaction with the aid of fluctuation in intensity of scattered light |
US4835110A (en) * | 1985-12-23 | 1989-05-30 | Beckman Instruments, Inc. | Method for enhancing analysis timing in kinetic nephelometry |
GB8905807D0 (en) | 1989-03-14 | 1989-04-26 | Health Lab Service Board | Particle aggregation |
DE69027560T2 (en) * | 1989-08-23 | 1997-01-09 | Canon Kk | Method of measuring an immunologically active material and device suitable for this |
GB2265004B (en) | 1992-03-10 | 1996-01-10 | Univ Cardiff | Immuno-agglutination assay using ultrasonic standing wave field |
US5371021A (en) * | 1992-07-17 | 1994-12-06 | Beckman Instruments, Inc. | Initial rate photometric method for immunoassay |
WO1996017247A1 (en) * | 1994-11-29 | 1996-06-06 | Analogic Corporation | Particle agglutination assay system |
US5527710A (en) * | 1994-12-02 | 1996-06-18 | Igen, Inc. | Rate measurements of biomolecular reactions using electrochemiluminescence |
EP0849596B1 (en) * | 1996-12-19 | 2006-02-15 | Dade Behring Marburg GmbH | Immunodissociation for improving the immunochemical determination of an analyte |
US6413783B1 (en) * | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
US6086821A (en) * | 1999-03-29 | 2000-07-11 | The United States Of America As Represented By The Secretary Of The Navy | Ultrasonic force differentiation assay |
DE10005301A1 (en) * | 2000-02-07 | 2001-08-09 | Trutnau Hans Heinrich | Analytical measuring and evaluating process used in immunology, biology and pharmacology comprises adding a ligand to an analyte, recording the association phase, changing and evaluating the analyte molecules, and further processing |
US7348182B2 (en) * | 2000-10-03 | 2008-03-25 | Mirari Biosciences, Inc. | Directed microwave chemistry |
US20040265871A1 (en) * | 2003-04-11 | 2004-12-30 | Angelsen Bjorn A.J. | Ultrasound stimulated DNA hybridization |
US7373255B2 (en) * | 2003-06-06 | 2008-05-13 | Biacore Ab | Method and system for determination of molecular interaction parameters |
JP2007516843A (en) * | 2003-10-20 | 2007-06-28 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | Nanoscale conversion system for detecting molecular interactions |
US7183119B2 (en) * | 2004-11-15 | 2007-02-27 | Eastman Kodak Company | Method for sensitive detection of multiple biological analytes |
-
2005
- 2005-05-09 GB GB0509419A patent/GB2426050A/en not_active Withdrawn
-
2006
- 2006-05-05 JP JP2008510468A patent/JP4927824B2/en not_active Expired - Fee Related
- 2006-05-05 EP EP06724740A patent/EP1880217B1/en active Active
- 2006-05-05 PL PL06724740T patent/PL1880217T3/en unknown
- 2006-05-05 CN CN2006800159346A patent/CN101171515B/en not_active Expired - Fee Related
- 2006-05-05 DK DK06724740T patent/DK1880217T3/en active
- 2006-05-05 US US11/919,728 patent/US8133693B2/en active Active
- 2006-05-05 AU AU2006246008A patent/AU2006246008B2/en not_active Ceased
- 2006-05-05 PT PT06724740T patent/PT1880217E/en unknown
- 2006-05-05 ES ES06724740T patent/ES2328397T3/en active Active
- 2006-05-05 DE DE602006008293T patent/DE602006008293D1/en active Active
- 2006-05-05 CA CA2606548A patent/CA2606548C/en not_active Expired - Fee Related
- 2006-05-05 AT AT06724740T patent/ATE438855T1/en active
- 2006-05-05 WO PCT/EP2006/004244 patent/WO2006119933A1/en active Application Filing
-
2007
- 2007-12-06 NO NO20076299A patent/NO20076299L/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0137678A1 (en) * | 1983-08-29 | 1985-04-17 | Syntex (U.S.A.) Inc. | Ultrasonic enhanced immuno-reactions |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2015072A1 (en) * | 2007-07-12 | 2009-01-14 | LEK Pharmaceuticals D.D. | Ultrasound elution of biological ligands |
WO2009007463A1 (en) * | 2007-07-12 | 2009-01-15 | Lek Pharmaceuticals D.D. | Ultrasound elution of biological ligands |
Also Published As
Publication number | Publication date |
---|---|
JP4927824B2 (en) | 2012-05-09 |
EP1880217B1 (en) | 2009-08-05 |
NO20076299L (en) | 2007-12-06 |
PT1880217E (en) | 2009-08-31 |
PL1880217T3 (en) | 2010-01-29 |
GB2426050A (en) | 2006-11-15 |
CA2606548C (en) | 2014-09-09 |
ES2328397T3 (en) | 2009-11-12 |
US20090215200A1 (en) | 2009-08-27 |
JP2008541070A (en) | 2008-11-20 |
EP1880217A1 (en) | 2008-01-23 |
CN101171515B (en) | 2012-06-27 |
AU2006246008A1 (en) | 2006-11-16 |
AU2006246008B2 (en) | 2011-09-29 |
GB0509419D0 (en) | 2005-06-15 |
ATE438855T1 (en) | 2009-08-15 |
US8133693B2 (en) | 2012-03-13 |
DE602006008293D1 (en) | 2009-09-17 |
DK1880217T3 (en) | 2009-12-07 |
CN101171515A (en) | 2008-04-30 |
CA2606548A1 (en) | 2006-11-16 |
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