WO2006119468A3 - Retinal prosthesis with separate central electrode array and peripheral electrode array - Google Patents

Retinal prosthesis with separate central electrode array and peripheral electrode array Download PDF

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Publication number
WO2006119468A3
WO2006119468A3 PCT/US2006/017282 US2006017282W WO2006119468A3 WO 2006119468 A3 WO2006119468 A3 WO 2006119468A3 US 2006017282 W US2006017282 W US 2006017282W WO 2006119468 A3 WO2006119468 A3 WO 2006119468A3
Authority
WO
WIPO (PCT)
Prior art keywords
array
resolution
sclera
retina
electrode array
Prior art date
Application number
PCT/US2006/017282
Other languages
French (fr)
Other versions
WO2006119468A2 (en
Inventor
Robert Jay Greenberg
Mark Humayun
Original Assignee
Second Sight Medical Prod Inc
Robert Jay Greenberg
Mark Humayun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Second Sight Medical Prod Inc, Robert Jay Greenberg, Mark Humayun filed Critical Second Sight Medical Prod Inc
Priority to JP2008510234A priority Critical patent/JP4913132B2/en
Priority to AU2006243786A priority patent/AU2006243786B2/en
Priority to EP06770017.9A priority patent/EP1907048B1/en
Publication of WO2006119468A2 publication Critical patent/WO2006119468A2/en
Publication of WO2006119468A3 publication Critical patent/WO2006119468A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0543—Retinal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye

Abstract

The artificial percept of light may be created by electrically stimulating the neurons of the retina. While a photolithographed array internal to the retina provides superior resolution, an array external to the retina provides easier implantation and improved manufacturability. Therefore it is advantageous to supply a high-resolution electrode array internal to the sclera, near the fovea and a lower-resolution electrode array external to the sclera near the periphery of the retina. The preferred method of manufacturing a high-resolution electrode array is through photolithography, which requires the array to be made flat. While it is possible to curve the array afterward, it is difficult and costly. I small high-resolution array can be implanted near the fovea. Due to its small size, curvature is less of an issue. A larger lower-resolution array can be molded in silicone or similar method and placed around the periphery, of the retina, where the retina is naturally lower resolution. Further, the lower-resolution array can be implanted external to the sclera reducing the number of electrical connectors passing through the sclera. Even if a separate lower-resolution array is implanted internal to the sclera, super-choroidal (between the choroid and sclera) or intra-scleral (between the layers of the sclera), it is easier to make a lower-resolution array in a curved shape.
PCT/US2006/017282 2005-05-04 2006-05-04 Retinal prosthesis with separate central electrode array and peripheral electrode array WO2006119468A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008510234A JP4913132B2 (en) 2005-05-04 2006-05-04 Artificial retina with separate central and peripheral electrode arrays
AU2006243786A AU2006243786B2 (en) 2005-05-04 2006-05-04 Retinal prosthesis with separate central electrode array and peripheral electrode array
EP06770017.9A EP1907048B1 (en) 2005-05-04 2006-05-04 Retinal prosthesis with separate central electrode array and peripheral electrode array

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67755105P 2005-05-04 2005-05-04
US60/677,551 2005-05-04

Publications (2)

Publication Number Publication Date
WO2006119468A2 WO2006119468A2 (en) 2006-11-09
WO2006119468A3 true WO2006119468A3 (en) 2006-12-21

Family

ID=36956069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/017282 WO2006119468A2 (en) 2005-05-04 2006-05-04 Retinal prosthesis with separate central electrode array and peripheral electrode array

Country Status (5)

Country Link
US (4) US7904163B2 (en)
EP (1) EP1907048B1 (en)
JP (1) JP4913132B2 (en)
AU (1) AU2006243786B2 (en)
WO (1) WO2006119468A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006119468A2 (en) * 2005-05-04 2006-11-09 Second Sight Medical Products, Inc. Retinal prosthesis with separate central electrode array and peripheral electrode array
US7877866B1 (en) * 2005-10-26 2011-02-01 Second Sight Medical Products, Inc. Flexible circuit electrode array and method of manufacturing the same
US7831309B1 (en) 2006-12-06 2010-11-09 University Of Southern California Implants based on bipolar metal oxide semiconductor (MOS) electronics
WO2009006636A2 (en) * 2007-07-05 2009-01-08 Second Sight Medical Products Return electrode for a flexible circuit electrode array
EP2185236B1 (en) 2007-07-27 2015-10-07 Second Sight Medical Products Implantable device for the brain
US8874235B1 (en) 2008-12-12 2014-10-28 Greatbatch Ltd. Self fixing spinal cord stimulation paddle lead
AU2010242526B2 (en) * 2009-04-27 2015-08-27 Centre For Eye Research Australia Limited Retinal prosthesis
US10716940B2 (en) 2009-10-20 2020-07-21 Nyxoah SA Implant unit for modulation of small diameter nerves
US9409013B2 (en) 2009-10-20 2016-08-09 Nyxoah SA Method for controlling energy delivery as a function of degree of coupling
US10751537B2 (en) 2009-10-20 2020-08-25 Nyxoah SA Arced implant unit for modulation of nerves
JP5812259B2 (en) * 2011-05-31 2015-11-11 株式会社ニデック Visual reproduction assist device
AU2013294692B2 (en) 2012-07-26 2017-09-14 Nyxoah SA Insert tool for selectively powering an implant unit
US9907967B2 (en) 2012-07-26 2018-03-06 Adi Mashiach Transcutaneous power conveyance device
US10052097B2 (en) 2012-07-26 2018-08-21 Nyxoah SA Implant unit delivery tool
US11253712B2 (en) 2012-07-26 2022-02-22 Nyxoah SA Sleep disordered breathing treatment apparatus
US9155899B2 (en) 2013-06-17 2015-10-13 Nyxoah SA Antenna buffer layer for an electromagnetic control unit
WO2016149536A1 (en) 2015-03-17 2016-09-22 Ocutrx Vision Technologies, Llc. Correction of vision defects using a visual display
US11461936B2 (en) 2015-03-17 2022-10-04 Raytrx, Llc Wearable image manipulation and control system with micro-displays and augmentation of vision and sensing in augmented reality glasses
US11956414B2 (en) 2015-03-17 2024-04-09 Raytrx, Llc Wearable image manipulation and control system with correction for vision defects and augmentation of vision and sensing
US11016302B2 (en) 2015-03-17 2021-05-25 Raytrx, Llc Wearable image manipulation and control system with high resolution micro-displays and dynamic opacity augmentation in augmented reality glasses
CN109925092A (en) * 2017-12-18 2019-06-25 深圳先进技术研究院 The artificial retina implant of silica gel packaging
EP3860703A1 (en) 2018-10-01 2021-08-11 Biovisics Medical, Inc. System and methods for controlled electrical modulation for vision therapy
WO2020112980A2 (en) 2018-11-30 2020-06-04 Biovisics Medical, Llc Head worn apparatuses for vision therapy
EP3952979A1 (en) 2019-04-10 2022-02-16 Biovisics Medical, Inc. Systems and interfaces for ocular therapy
EP3983055A1 (en) 2019-06-14 2022-04-20 Biovisics Medical, Inc. Wearable medical device
WO2021168449A1 (en) 2020-02-21 2021-08-26 Raytrx, Llc All-digital multi-option 3d surgery visualization system and control
US11916156B2 (en) 2020-04-09 2024-02-27 The Hong Kong University Of Science And Technology Method and system for optical detection using a biomimetic electrochemical eye
CN111588984B (en) * 2020-05-27 2021-02-19 微智医疗器械有限公司 Implanted retina electric stimulator and implant thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003061537A1 (en) * 2002-01-17 2003-07-31 Masachusetts Eye And Ear Infirmary Minimally invasive retinal prosthesis
US20030187491A1 (en) * 2002-03-28 2003-10-02 Robert Greenberg Variable pitch electrode array
DE102004032004A1 (en) * 2003-07-01 2005-01-20 Nidek Co., Ltd., Gamagori Visual restoration utility

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4573481A (en) 1984-06-25 1986-03-04 Huntington Institute Of Applied Research Implantable electrode array
US4628933A (en) 1985-07-23 1986-12-16 Michelson Robin P Method and apparatus for visual prosthesis
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5109844A (en) 1990-10-11 1992-05-05 Duke University Retinal microstimulation
DE19707046A1 (en) 1997-02-21 1998-08-27 Rolf Prof Dr Ing Eckmiller Learnable "Active Vision" implant encoder
US6458157B1 (en) 1997-08-04 2002-10-01 Suaning Gregg Joergen Retinal stimulator
US5935155A (en) * 1998-03-13 1999-08-10 John Hopkins University, School Of Medicine Visual prosthesis and method of using same
JP3599237B2 (en) * 1999-05-07 2004-12-08 エベルハルト・カルルス・ウニヴェルズィテート テュービンゲン ウニヴェルズィテートクリニク Retina implant and method for manufacturing the same
US7103416B2 (en) * 2001-01-16 2006-09-05 Second Sight Medical Products, Inc. Visual prosthesis including enhanced receiving and stimulating portion
US7338522B2 (en) 2001-02-13 2008-03-04 Second Sight Medical Products, Inc. Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress
US20040106965A1 (en) * 2001-06-29 2004-06-03 Chow Alan Y. Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation
US7003355B1 (en) * 2001-11-20 2006-02-21 Suaning Gregg J Vision prosthesis for the blind and method for implementing same
US6718209B2 (en) * 2002-02-05 2004-04-06 Second Sight Medical Products, Inc. Retinal prosthesis with remote return electrode
US7142909B2 (en) * 2002-04-11 2006-11-28 Second Sight Medical Products, Inc. Biocompatible bonding method and electronics package suitable for implantation
US7211103B2 (en) * 2002-04-11 2007-05-01 Second Sight Medical Products, Inc. Biocompatible bonding method and electronics package suitable for implantation
US7005179B2 (en) * 2002-07-26 2006-02-28 The Regents Of The University Of California Conductive inks for metalization in integrated polymer microsystems
JP4162526B2 (en) * 2003-03-31 2008-10-08 株式会社ニデック Visual reproduction assist device
US7571011B2 (en) * 2003-05-01 2009-08-04 Second Sight Medical Products, Inc. Adherent metal oxide coating forming a high surface area electrode
US7228181B2 (en) * 2004-04-06 2007-06-05 Second Sight Medical Products, Inc. Retinal prosthesis with side mounted inductive coil
WO2006119468A2 (en) * 2005-05-04 2006-11-09 Second Sight Medical Products, Inc. Retinal prosthesis with separate central electrode array and peripheral electrode array

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003061537A1 (en) * 2002-01-17 2003-07-31 Masachusetts Eye And Ear Infirmary Minimally invasive retinal prosthesis
US20030187491A1 (en) * 2002-03-28 2003-10-02 Robert Greenberg Variable pitch electrode array
DE102004032004A1 (en) * 2003-07-01 2005-01-20 Nidek Co., Ltd., Gamagori Visual restoration utility

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PARK D-S ET AL: "A foveated-structure CMOS retina chip for edge detection with local light adaptation", SENSORS AND ACTUATORS A, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 108, no. 1-3, 15 November 2003 (2003-11-15), pages 75 - 80, XP004475525, ISSN: 0924-4247 *

Also Published As

Publication number Publication date
AU2006243786A1 (en) 2006-11-09
EP1907048B1 (en) 2016-08-31
WO2006119468A2 (en) 2006-11-09
US20120004704A1 (en) 2012-01-05
US20060253172A1 (en) 2006-11-09
US9636496B2 (en) 2017-05-02
JP2008539891A (en) 2008-11-20
US8886329B2 (en) 2014-11-11
US20150039067A1 (en) 2015-02-05
US8036752B2 (en) 2011-10-11
US20080046032A1 (en) 2008-02-21
EP1907048A2 (en) 2008-04-09
US7904163B2 (en) 2011-03-08
JP4913132B2 (en) 2012-04-11
AU2006243786B2 (en) 2011-12-22

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